- Regulation of dopamine D1 receptor dynamics within the postsynaptic density of hippocampal glutamate synapsesLaurent Ladépêche
Univ de Bordeaux, Interdisciplinary Institute for Neuroscience, Unité Mixte de recherche UMR 5297, Bordeaux, France Centre National de la Recherche Scientifique CNRS, IINS UMR 5297, Bordeaux, France
PLoS ONE 8:e74512. 2013..Together, these data provide direct evidence that the interaction between D1R and NMDAR in synapses participate in the building of the dopamine-receptor-mediated signalling, and most likely to the glutamate-dopamine cross-talk. ..
- Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant moleculeH Zhang
Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, Bordeaux, France
Mol Psychiatry 18:471-84. 2013..Collectively, these data provide the first evidence that a therapeutically used drug targets the surface diffusion of AMPAR through a CaMKII-stargazin-PSD-95 pathway, to promote long-term synaptic plasticity...
- Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitisLenka Mikasova
CNRS, Interdisciplinary Institute for Neurosciences UMR 5297, Universite de Bordeaux, 146 rue Leo Saignat, Bordeaux, France
Brain 135:1606-21. 2012....
- NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein ReelinLaurent Groc
Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5091, 33077 Bordeaux, France
J Neurosci 27:10165-75. 2007..Our data reveal a new mode of control of synaptic NMDAR assembly at postnatal hippocampal synapses and an unprecedented role of ECM proteins in regulating glutamate receptor surface diffusion...
- Surface trafficking of neurotransmitter receptor: comparison between single-molecule/quantum dot strategiesLaurent Groc
Physiologie Cellulaire de la Synapse, Unité Mixte de Recherche 5091, Centre National de la Recherche Scientifique, Universite Bordeaux 2, 33077 Bordeaux, France
J Neurosci 27:12433-7. 2007
- NMDA receptor surface mobility depends on NR2A-2B subunitsLaurent Groc
Physiologie Cellulaire de la Synapse, Unité Mixte de Recherche UMR 5091, Centre National de la Recherche Scientifique CNRS, Universite Bordeaux 2, 33077 Bordeaux, France
Proc Natl Acad Sci U S A 103:18769-74. 2006..This suggests that the switch in synaptic NMDAR subtypes depends on the regulation of the receptor surface trafficking...
- Measurement and characteristics of neurotransmitter receptor surface trafficking (Review)Laurent Groc
Physiologie Cellulaire de la Synapse, Universite Bordeaux, Bordeaux, France
Mol Membr Biol 25:344-52. 2008..Because our knowledge on neurotransmitter receptor surface diffusion is fairly recent, open questions and experimental challenges facing the field are highlighted throughout the review...
- Surface trafficking of N-methyl-D-aspartate receptors: physiological and pathological perspectivesL Groc
Physiologie Cellulaire de la Synapse, UMR 5091 Centre National de la Recherche Scientifique, Universite Bordeaux 2, 146 rue Leo Saignat, 33077 Bordeaux, Cedex, France
Neuroscience 158:4-18. 2009....
- AMPA signalling in nascent glutamatergic synapses: there and not there!Laurent Groc
Physiologie Cellulaire de la Synapse, CNRS UMR 5091, Universite Bordeaux 2, 33077 Bordeaux, France
Trends Neurosci 29:132-9. 2006..Thus, the AMPA receptor silence of nascent glutamatergic synapses depends on the synaptic activation history rather than on the nascent state itself...
- The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiationLaurent Groc
Physiologie Cellulaire de Synapse, UMR 5091 CNRS, Universite Bordeaux 2, Bordeaux 33077, France
Nat Neurosci 11:868-70. 2008..Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking...
- Compensatory dendritic growth of CA1 pyramidal cells following growth impairment in the neonatal periodLaurent Groc
Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
Eur J Neurosci 18:1332-6. 2003..These results suggest that the early hippocampal activity controls the growth rate but is not necessary for the generation of an adult normal basal dendritic tree...
- [Optical control of neuronal network activity]Laurent Groc
Unité Physiologie Cellulaire de la Synapse, UMR 5091 CNRS, Universite Bordeaux 2, Bordeaux 33077, France
Med Sci (Paris) 23:585-7. 2007
- Surface mobility of postsynaptic AMPARs tunes synaptic transmissionMartin Heine
CNRS, UMR 5091, Universite Bordeaux, Bordeaux, France
Science 320:201-5. 2008..Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses...
- In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cellsLaurent Groc
Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
Eur J Neurosci 16:1931-8. 2002..The apical dendrite, the axons, or the soma grew normally during activity deprivation. Thus, the in vivo neural activity in the neonate hippocampus seems to promote neuronal growth by initiating novel branches...
- In vivo evidence for an activity-independent maturation of AMPA/NMDA signaling in the developing hippocampusL Groc
Department of Physiology, Goteborg University, Box 432, Medicinaregatan 11, 405 30 Goteborg, Sweden
Neuroscience 121:65-72. 2003..Thus, although critical for certain aspects of neuronal development, correlated neural activity in the neonatal hippocampus does not seem to promote incorporation of AMPA receptors at pure NMDA synapses...
- Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptorsLaurent Groc
UMR 5091 CNRS Université Bordeaux 2, Bordeaux 33077, France
Nat Neurosci 7:695-6. 2004..Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes...
- The interaction between Stargazin and PSD-95 regulates AMPA receptor surface traffickingCecile Bats
Physiologie Cellulaire de la Synapse, UMR 5091 CNRS Institut François Magendie, Universite Bordeaux, Bordeaux 33077, France
Neuron 53:719-34. 2007..These results propose a model in which the Stargazin-PSD-95 interaction plays a key role to trap and transiently stabilize diffusing AMPARs in the postsynaptic density...
- Glutamate synapse in developing brain: an integrative perspective beyond the silent stateEric Hanse
Department of Physiology, Goteborg University, Goteborg 40530, Sweden
Trends Neurosci 32:532-7. 2009....
- Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteinsLucie Bard
Laboratory for Cellular Physiology of the Synapse, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5091, 33077 Bordeaux, France
Proc Natl Acad Sci U S A 107:19561-6. 2010..These data reveal an unexpected role of the NR2 subunit divalent arrangement in providing specific anchoring within synapses, highlighting the need to study such dynamic interactions in native conditions...
- Spontaneous unitary synaptic activity in CA1 pyramidal neurons during early postnatal development: constant contribution of AMPA and NMDA receptorsLaurent Groc
Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, 405 30 Goteborg, Sweden
J Neurosci 22:5552-62. 2002..These findings suggest that the vast majority of nascent glutamatergic synapses express both functional AMPA and NMDA receptors in the neonatal hippocampus...
- Early establishment of multiple release site connectivity between interneurons and pyramidal neurons in the developing hippocampusLaurent Groc
Institute of Physiology and Pharmacology, Department of Physiology, Box 432, Medicinaregatan 11, Goteborg University, 40530 Goteborg, Sweden
Eur J Neurosci 17:1873-80. 2003..The present result thus suggests different mechanisms to govern the maturation of excitatory and inhibitory synaptic transmissions...
- Behavioral and neurochemical repercussions of hippocampal network activity blockade during the neonatal periodHenrik Ponten
Department of Pharmacology, Goteborg University, Sweden
Brain Res Dev Brain Res 155:81-6. 2005..We found no significant differences in either behavioral or biochemical pattern, indicating that an early neonate neural activity blockade does not induce behavioral alterations in pre- and post-puberty rats...
- Probing the dynamics of protein-protein interactions at neuronal contacts by optical imagingOlivier Thoumine
CNRS UMR 5091, Institut Magendie, Universite Bordeaux 2, 33077 Bordeaux, France
Chem Rev 108:1565-87. 2008
- Altered surface trafficking of presynaptic cannabinoid type 1 receptor in and out synaptic terminals parallels receptor desensitizationLenka Mikasova
Institut National de la Santé et de la Recherche Médicale U862 Laboratory Physiopathology of Synaptic Plasticity, Neurocentre Magendie, 146 rue Leo Saignat, 33077 Bordeaux, France
Proc Natl Acad Sci U S A 105:18596-601. 2008..The results suggest that decrease of mobility may be one of the core mechanisms underlying the desensitization of CB1R, the most abundant G protein-coupled receptor in the brain...
- Pathological apoptosis in the developing brainKlas Blomgren
Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
Apoptosis 12:993-1010. 2007..Here we review our current knowledge of the mechanisms involved, with special focus on the potential for therapeutic intervention tailored to the needs of the developing brain...
- Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activityMichael D Ehlers
Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Neuron 54:447-60. 2007..Thus, local activity restricts GluR1 mobility on a submicron scale, defining an input-specific mechanism for regulating AMPA receptor composition and abundance...
- Multiple routes for glutamate receptor trafficking: surface diffusion and membrane traffic cooperate to bring receptors to synapsesLaurent Cognet
Centre de Physique Moleculaire Optique et Hertzienne, CNRS UMR 5798 and Université Bordeaux 1, 351 Cours de la Liberation, 33405 Talence Cedex, France
Sci STKE 2006:pe13. 2006..Together, these approaches have demonstrated that glutamate receptors diffuse at high rates in the neuronal membrane and suggest a key role for surface diffusion in the regulation of receptor numbers at synapses...
- AMPA and NMDA glutamate receptor trafficking: multiple roads for reaching and leaving the synapseLaurent Groc
UMR 5091 CNRS Université de Bordeaux 2 Physiologie Cellulaire de la Synapse, Institut Francois Magendie, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
Cell Tissue Res 326:423-38. 2006..We focus on new findings that shed light on the regulation of receptor cycling events and surface trafficking and the way that this might reshape our thinking about the specific regulation of receptor accumulation at synapses...
- Single nanoparticle photothermal tracking (SNaPT) of 5-nm gold beads in live cellsDavid Lasne
Centre de Physique Moleculaire Optique et Hertzienne, CNRS UMR 5798 and Université Bordeaux 1, Talence Cedex, France
Biophys J 91:4598-604. 2006..Single Nanoparticle Photothermal Tracking has the unique potential to record arbitrary long trajectory of membrane proteins using nonfluorescent nanometer-sized labels...
- Kainic acid lesion-induced nigral neuronal deathJane A Foster
William T Gossett Neurology Laboratories, Henry Ford Health System, 1 Ford Place, 4D, Detroit, MI 48202, USA
J Chem Neuroanat 26:65-73. 2003..This experimental procedure is useful for studying mechanisms underlying protracted death of nigral DA neurons and may provide valuable mechanistic information relevant to understanding the etiology of PD...
- Nitric oxide synthase inhibition during development: effect on apoptotic death of dopamine neuronsLaurent Groc
William T Gossett Neurology Laboratories, Henry Ford Hospital, Detroit, MI, USA
Brain Res Dev Brain Res 138:147-53. 2002..However, those treatments did not rescue dopamine neurons from developmental death, suggesting that NO is not involved in vivo in developmental death of these neurons or in the overall development of the SNc...
- Roles of Ras-Erk in apoptosis of PC12 cells induced by trophic factor withdrawal or oxidative stressHao Jiang
William T Gossett Neurology Laboratories, Henry Ford Health System, Detroit, MI 48202 USA
J Mol Neurosci 25:133-40. 2005..These results suggest that the Ras-Erk pathway is critical in mediating protection against apoptotic cell death induced by either trophic factor withdrawal or increased oxidative stress...