Philippe Gripon

Summary

Country: France

Publications

  1. doi request reprint A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation
    Maria Quasdorff
    Molecular Infectiology at the Center for Molecular Medicine Cologne, Institute for Medical Microbiology, Goldenfelsstr 19 21, 50935 Cologne, Germany
    Cell Microbiol 10:1478-90. 2008
  2. pmc Infection of a human hepatoma cell line by hepatitis B virus
    Philippe Gripon
    Institut National de la Santé et de la Recherche Médicale INSERM U522, Hopital de Pontchaillou, 35033 Rennes, France
    Proc Natl Acad Sci U S A 99:15655-60. 2002
  3. ncbi request reprint Recent contributions of in vitro models to our understanding of hepatitis C virus life cycle
    Morgane Régeard
    INSERM, U522, IFR 140, Hopital de Pontchaillou, Rennes, France
    FEBS J 274:4705-18. 2007
  4. pmc The translocation motif of hepatitis B virus envelope proteins is dispensable for infectivity
    Charlotte Lepère
    INSERM U522, Hopital de Pontchaillou, Avenue Henri le Guilloux, Rennes Cedex 35033, France
    J Virol 81:7816-8. 2007
  5. ncbi request reprint The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis
    Lars Erdtmann
    INSERM U522, Hopital de Pontchaillou, 35033 Rennes Cedex, France
    J Biol Chem 278:18256-64. 2003
  6. ncbi request reprint Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor
    Virginie Cerec
    INSERM, U522, CHU Pontchaillou, F 35033 Rennes, France
    Hepatology 45:957-67. 2007
  7. ncbi request reprint Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line
    Marc Le Vee
    INSERM U620, Faculte de Pharmacie, Rennes, France
    Eur J Pharm Sci 28:109-17. 2006
  8. ncbi request reprint Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line
    Marie Berengere Troadec
    INSERM U522, IFR 140, University of Rennes 1, CHRU Pontchaillou, 35033 Rennes Cedex, France
    Genomics 87:93-103. 2006
  9. ncbi request reprint Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta
    Marc Le Vee
    Institut National de la Santé et de la Recherche Médicale U620, Faculty of Pharmacy, Rennes, France
    Drug Metab Dispos 36:217-22. 2008
  10. ncbi request reprint Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans
    Andreas Schulze
    Department of Molecular Virology, Otto Meyerhof Zentrum OMZ, University of Heidelberg, Heidelberg, Germany
    Hepatology 46:1759-68. 2007

Collaborators

  • Herve Lerat
  • Lars Erdtmann
  • David Gilot
  • Christian Trepo
  • Stephan Urban
  • Dina Kremsdorf
  • B Stieger
  • Olivier Loreal
  • Bruno Turlin
  • P Brissot
  • U Drebber
  • Marc Le Vee
  • Christiane Guguen-Guillouzo
  • Charlotte Lepère
  • Morgane Régeard
  • Denise Glaise
  • Maria Quasdorff
  • Olivier Fardel
  • Virginie Cerec
  • Jacques Le Seyec
  • Andreas Schulze
  • Marie Berengere Troadec
  • Matthias Engelke
  • Jean Pierre Gangneux
  • Tobias Goeser
  • Hans Peter Dienes
  • Felix Bohne
  • Marianna Hösel
  • Uta Zedler
  • Ulrike Protzer
  • Margarete Odenthal
  • Dirk Stippel
  • Serban Morosan
  • Maud Trotard
  • Anne Corlu
  • Bernard Drenou
  • Delphine Garnier
  • Nathalie Theret
  • Karim Boudjema
  • Isabelle Guisle
  • Kerry Mills
  • Emilie Guerin
  • Emilie Jigorel
  • Martina Schnolzer
  • Martine Le Cunff
  • Petra Simon
  • Patricia Leroyer
  • Pierre Zindy
  • Lenaick Detivaud
  • Nolwenn Le Meur
  • Jean J Leger
  • Guillaume Lamirault
  • Stefan Seitz
  • Hélène Duval
  • Yannick Reinhard
  • Olivier Lemenand
  • Claude Guiguen

Detail Information

Publications14

  1. doi request reprint A concerted action of HNF4alpha and HNF1alpha links hepatitis B virus replication to hepatocyte differentiation
    Maria Quasdorff
    Molecular Infectiology at the Center for Molecular Medicine Cologne, Institute for Medical Microbiology, Goldenfelsstr 19 21, 50935 Cologne, Germany
    Cell Microbiol 10:1478-90. 2008
    ..Thus, a concerted action of HNF4alpha and HNF1alpha, which also determines morphological and functional differentiation of hepatocytes, links HBV replication to hepatocyte differentiation...
  2. pmc Infection of a human hepatoma cell line by hepatitis B virus
    Philippe Gripon
    Institut National de la Santé et de la Recherche Médicale INSERM U522, Hopital de Pontchaillou, 35033 Rennes, France
    Proc Natl Acad Sci U S A 99:15655-60. 2002
    ..HepaRG cells therefore represent a tool for deciphering the mechanism of HBV entry. Moreover, their close resemblance to normal human hepatocytes makes them suitable for many applications including drug metabolism studies...
  3. ncbi request reprint Recent contributions of in vitro models to our understanding of hepatitis C virus life cycle
    Morgane Régeard
    INSERM, U522, IFR 140, Hopital de Pontchaillou, Rennes, France
    FEBS J 274:4705-18. 2007
    ..This review describes the different in vitro models developed to study hepatitis C virus, their contribution to current knowledge of the virus biology and their future research applications...
  4. pmc The translocation motif of hepatitis B virus envelope proteins is dispensable for infectivity
    Charlotte Lepère
    INSERM U522, Hopital de Pontchaillou, Avenue Henri le Guilloux, Rennes Cedex 35033, France
    J Virol 81:7816-8. 2007
    ..In this study we have used two different mutated viruses containing a truncated TLM and showed their ability to infect human hepatocytes in primary culture, thus demonstrating the dispensability of the TLM for HBV infectivity...
  5. ncbi request reprint The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis
    Lars Erdtmann
    INSERM U522, Hopital de Pontchaillou, 35033 Rennes Cedex, France
    J Biol Chem 278:18256-64. 2003
    ..We suggest that NS2 interferes with the CIDE-B-induced death pathway and participates in HCV strategies to subvert host cell defense...
  6. ncbi request reprint Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor
    Virginie Cerec
    INSERM, U522, CHU Pontchaillou, F 35033 Rennes, France
    Hepatology 45:957-67. 2007
    ..Moreover, they highlight possible mechanisms by which transdifferentiation and proliferation of unipotent hepatocytes might cooperate in the development of mixed and differentiated tumors...
  7. ncbi request reprint Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line
    Marc Le Vee
    INSERM U620, Faculte de Pharmacie, Rennes, France
    Eur J Pharm Sci 28:109-17. 2006
    ..These data, associated with the known high expression of drug metabolizing enzymes in HepaRG cells, highlight the interest of such hepatoma cells for analysing hepatic drug detoxification pathways...
  8. ncbi request reprint Hepatocyte iron loading capacity is associated with differentiation and repression of motility in the HepaRG cell line
    Marie Berengere Troadec
    INSERM U522, IFR 140, University of Rennes 1, CHRU Pontchaillou, 35033 Rennes Cedex, France
    Genomics 87:93-103. 2006
    ..These results provide new insights in the understanding of the relationship between iron and hepatocyte differentiation during iron-related hepatic diseases...
  9. ncbi request reprint Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta
    Marc Le Vee
    Institut National de la Santé et de la Recherche Médicale U620, Faculty of Pharmacy, Rennes, France
    Drug Metab Dispos 36:217-22. 2008
    ..Such IL-1beta effects may likely participate in both cholestasis and alterations of hepatic detoxification pathways caused by inflammation in humans...
  10. ncbi request reprint Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans
    Andreas Schulze
    Department of Molecular Virology, Otto Meyerhof Zentrum OMZ, University of Heidelberg, Heidelberg, Germany
    Hepatology 46:1759-68. 2007
    ..This interaction initializes the multistep entry process of HBV and cannot be bypassed by alternative routes...
  11. ncbi request reprint Characterization of a hepatitis B and hepatitis delta virus receptor binding site
    Matthias Engelke
    Department of Molecular Virology, Otto Meyerhof Zentrum OMZ, University of Heidelberg, Heidelberg, Germany
    Hepatology 43:750-60. 2006
    ..This step is exceptionally sensitive toward inactivation by acylated HBVpreS1 peptides, which therefore represent a novel group of entry inhibitors that could be used for the treatment of hepatitis B and D...
  12. ncbi request reprint In vitro and ex vivo permissivity of hepatocytes for Leishmania donovani
    Jean Pierre Gangneux
    Institut National de la Sante et de la Recherche Medicale, INSERM, U 522, 35000 Rennes, France
    J Eukaryot Microbiol 52:489-91. 2005
    ..This slight infection under our experimental conditions resulted in limited damage to hepatocytes. These results bring into question a possible role for hepatocytes as a parasite reservoir during latent infection...
  13. pmc Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein
    Philippe Gripon
    Institut National de la Santé et de la Recherche Médicale INSERM U522, Hopital de Pontchaillou, Rennes, France
    J Virol 79:1613-22. 2005
    ..Our data both shed light on the molecular mechanism of HBV entry into hepatocytes and provide a basis for the development of potent hepadnaviral entry inhibitors as a novel therapeutic concept for the treatment of hepatitis Beta...
  14. pmc Inhibition of duck hepatitis B virus infection by a myristoylated pre-S peptide of the large viral surface protein
    Stephan Urban
    Zentrum fur Molekulare Biologie, Universität Heidelberg ZMBH, 69120 Heidelberg, Germany
    J Virol 76:1986-90. 2002
    ..Ishikawa and D. Ganem, Proc. Natl. Acad. Sci. USA 92:6259-6263, 1995), we suggest that it is related to the postulated host-discriminating cofactor of infection...