Pierre Gressens

Summary

Country: France

Publications

  1. ncbi request reprint Pathogenesis of migration disorders
    Pierre Gressens
    INSERM U676, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Curr Opin Neurol 19:135-40. 2006
  2. pmc G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration
    Vincent Degos
    INSERM, U676, Hopital Robert Debre, Paris, France
    Ann Neurol 73:667-78. 2013
  3. ncbi request reprint Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice
    Fadia Medja
    INSERM U676, Service de Neurologie Pediatrique, Paris, France
    Brain 129:3209-23. 2006
  4. ncbi request reprint Mechanisms of VIP-induced neuroprotection against neonatal excitotoxicity
    Claire Marie Rangon
    INSERM U 676, Hopital Robert Debre, 48 Blvd Sérurier, 75019 Paris, France
    Ann N Y Acad Sci 1070:512-7. 2006
  5. doi request reprint Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression
    Vincent Degos
    INSERM, U676, Paris, France, Universite Paris 7, Paris, France
    Anesthesiology 118:1123-32. 2013
  6. doi request reprint Microglial reaction in axonal crossroads is a hallmark of noncystic periventricular white matter injury in very preterm infants
    Catherine Verney
    INSERM U676, Hopital Robert Debre, 48 Blvd Sérurier, 75019 Paris, France
    J Neuropathol Exp Neurol 71:251-64. 2012
  7. doi request reprint The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis
    Kim Da Destot-Wong
    INSERM U676, Hopital Robert Debre, 75019 Paris, France
    Neuropharmacology 57:277-86. 2009
  8. doi request reprint Implanted neurosphere-derived precursors promote recovery after neonatal excitotoxic brain injury
    Luigi Titomanlio
    INSERM, U676, Hopital Robert Debre, Paris, France
    Stem Cells Dev 20:865-79. 2011
  9. ncbi request reprint Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice
    Bettina Mesples
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, 75019 Paris, France
    Neurobiol Dis 18:193-205. 2005
  10. ncbi request reprint Chronic mild stress during gestation worsens neonatal brain lesions in mice
    Claire Marie Rangon
    INSERM, Unité 676, 75019 Paris, France
    J Neurosci 27:7532-40. 2007

Detail Information

Publications92

  1. ncbi request reprint Pathogenesis of migration disorders
    Pierre Gressens
    INSERM U676, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Curr Opin Neurol 19:135-40. 2006
    ..This review will highlight some of the most recent findings in the deciphering of the molecular machinery controlling neuronal migration...
  2. pmc G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration
    Vincent Degos
    INSERM, U676, Hopital Robert Debre, Paris, France
    Ann Neurol 73:667-78. 2013
    ..The concept of inflammation-induced sensitization is emerging in the field of perinatal brain injury, stroke, Alzheimer disease, and multiple sclerosis. However, mechanisms underpinning this process remain unidentified...
  3. ncbi request reprint Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice
    Fadia Medja
    INSERM U676, Service de Neurologie Pediatrique, Paris, France
    Brain 129:3209-23. 2006
    ..In a broader context, these results also raise potential implications for the prevention of neurodegenerative diseases involving glutamate-mediated excitotoxic neuronal death...
  4. ncbi request reprint Mechanisms of VIP-induced neuroprotection against neonatal excitotoxicity
    Claire Marie Rangon
    INSERM U 676, Hopital Robert Debre, 48 Blvd Sérurier, 75019 Paris, France
    Ann N Y Acad Sci 1070:512-7. 2006
    ..These data suggest that, in this model, VIP-induced neuroprotection is mediated by VPAC2 receptors. The pharmacology of this VPAC2 receptor seems unconventional as PACAP does not mimic VIP effects and PHI acts with a comparable potency...
  5. doi request reprint Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression
    Vincent Degos
    INSERM, U676, Paris, France, Universite Paris 7, Paris, France
    Anesthesiology 118:1123-32. 2013
    ..Because adrenergic receptor agonists can modulate BDNF expression, our goal was to examine whether dexmedetomidine's neuroprotective effects are mediated by BDNF modulation in mouse perinatal brain injury...
  6. doi request reprint Microglial reaction in axonal crossroads is a hallmark of noncystic periventricular white matter injury in very preterm infants
    Catherine Verney
    INSERM U676, Hopital Robert Debre, 48 Blvd Sérurier, 75019 Paris, France
    J Neuropathol Exp Neurol 71:251-64. 2012
    ..These data show that the growing axonal crossroad areas are highly vulnerable to PWMI in very preterm infants and highlight differences in glial activation patterns between very preterm and preterm infants...
  7. doi request reprint The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis
    Kim Da Destot-Wong
    INSERM U676, Hopital Robert Debre, 75019 Paris, France
    Neuropharmacology 57:277-86. 2009
    ....
  8. doi request reprint Implanted neurosphere-derived precursors promote recovery after neonatal excitotoxic brain injury
    Luigi Titomanlio
    INSERM, U676, Hopital Robert Debre, Paris, France
    Stem Cells Dev 20:865-79. 2011
    ..Although further studies are warranted, cell therapy could be a future therapeutic strategy for neonates with acute excitotoxic brain injury...
  9. ncbi request reprint Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice
    Bettina Mesples
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, 75019 Paris, France
    Neurobiol Dis 18:193-205. 2005
    ..The identification of this pathway, if confirmed in human neonates, might have important implications for understanding and preventing cerebral palsy...
  10. ncbi request reprint Chronic mild stress during gestation worsens neonatal brain lesions in mice
    Claire Marie Rangon
    INSERM, Unité 676, 75019 Paris, France
    J Neurosci 27:7532-40. 2007
    ..These findings suggest that stress during gestation, which may mimic low-level stress in human pregnancy, could be a novel risk factor for cerebral palsy...
  11. doi request reprint Characterization of the postconditioning effect of dexmedetomidine in mouse organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation
    Souhayl Dahmani
    Department of Anesthesia and Pain Management, INSERM U 676, Robert Debre University Hospital, Paris 7 Paris Diderot University, 48 Boulevard Serurier, Paris, France
    Anesthesiology 112:373-83. 2010
    ..The role of the focal adhesion and extracellular-regulated kinases pathways in these effects were examined in both postconditioning and preconditioning...
  12. ncbi request reprint Topiramate prevents excitotoxic damage in the newborn rodent brain
    Ignacio Sfaello
    INSERM U 676, Hopital Robert Debre, 48 Boulevard Serurier, F 75019 Paris, France
    Neurobiol Dis 20:837-48. 2005
    ..Diazepam, phenytoin, and carbamazepine had no neuroprotective effect in this model. The present study provides experimental support for the consideration of TPM as a candidate therapy for excitotoxic perinatal brain lesions...
  13. ncbi request reprint VPAC2 receptors mediate vasoactive intestinal peptide-induced neuroprotection against neonatal excitotoxic brain lesions in mice
    Claire Marie Rangon
    INSERM U 676, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    J Pharmacol Exp Ther 314:745-52. 2005
    ....
  14. ncbi request reprint BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge
    Isabelle Husson
    INSERM E 9935 and Service de Neuropédiatrie, Hopital Robert Debre, F 75019 Paris, France
    Cereb Cortex 15:250-61. 2005
    ..Altogether, these data showed that BDNF neuroprotection against neonatal excitotoxicity is dependent upon the type of activated glutamate receptors, the lesion localization and the developmental stage...
  15. ncbi request reprint The effects of AMPA receptor antagonists in models of stroke and neurodegeneration
    Pierre Gressens
    INSERM U676 and Service de Neurologie Pédiatrique, Hopital Robert Debre, 48 Blvd Sérurier, 75019 Paris, France
    Eur J Pharmacol 519:58-67. 2005
    ..In contrast, GYKI 52466 did not antagonize cortical and white matter damage induced by ibotenic acid. These models allow quantification of the effects of AMPA receptor antagonists in vitro and in vivo...
  16. ncbi request reprint Patterns of excitotoxin-induced brain lesions in the newborn rabbit: a neuropathological and MRI correlation
    Ignacio Sfaello
    INSERM U676 and Service de Neurologie Pédiatrique, Hopital Robert Debre, Paris, France
    Dev Neurosci 27:160-8. 2005
    ....
  17. ncbi request reprint Transient inhibition of astrocytogenesis in developing mouse brain following postnatal caffeine exposure
    Luc Desfrere
    INSERM, U676, 75019 Paris, France
    Pediatr Res 62:604-9. 2007
    ..Although no obvious neuritic abnormalities (microtubule-associated protein 2 and synaptophysin immunostaining) were observed, postnatal caffeine treatment could have long-term consequences on brain function...
  18. pmc Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat
    Julien Pansiot
    INSERM, Hopital Robert Debre, Paris, France
    PLoS ONE 5:e10916. 2010
    ..Inhaled nitric oxide (iNO) is one of the most promising therapies used in neonates. However, little information is known about its impact on the developing brain submitted to excitotoxic challenge...
  19. ncbi request reprint Gestational hypoxia induces white matter damage in neonatal rats: a new model of periventricular leukomalacia
    Olivier Baud
    Laboratoire de Neurobiologie du Developpement, INSERM E9935, Service de Néonatologie et Service de Neurologie, Hopital Robert Debre, Paris, France
    Brain Pathol 14:1-10. 2004
    ..We speculate that protracted prenatal hypoxia in rat induces white matter damage occurring through local inflammatory response and oxidative stress linked to re-oxygenation during the perinatal period...
  20. doi request reprint Inflammation processes in perinatal brain damage
    Vincent Degos
    Hopital Robert Debre, INSERM, U676, 48 Blvd Sérurier, 75019 Paris, France
    J Neural Transm 117:1009-17. 2010
    ..In this review, we provide an overview of current concepts regarding perinatal brain damage and the role of inflammation in the disease pathomechanism...
  21. doi request reprint Bench to cribside: the path for developing a neuroprotectant
    Nelina Ramanantsoa
    INSERM U676, Hopital Robert Debre, 48 Blvd Sérurier, 75019, Paris, France
    Transl Stroke Res 4:258-77. 2013
    ..We hope these new tools and an integrated bench to cribside strategic plan will facilitate the fulfillment of our overarching goal, improving the long-term brain health and quality of life for infants suffering perinatal brain injury. ..
  22. ncbi request reprint Effects of interleukin-10 on neonatal excitotoxic brain lesions in mice
    Bettina Mesples
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, 48 Blvd Sérurier, F 75019 Paris, France
    Brain Res Dev Brain Res 141:25-32. 2003
    ..Altogether, these data suggest that, in newborn mice, exogenous interleukin-10 can be neuroprotective when acting in an inflammatory context...
  23. doi request reprint Somatostatin receptors type 2 and 5 expression and localization during human pituitary development
    Stephane Peineau
    Medical Research Council Centre for Synaptic Plasticity S P, University of Bristol, School of Physiology and Pharmacology, Bristol BS8 1TD, United Kingdom Inserm S P, F G, Z C, S J, A F, L S, N d R, P G, S A, P D, U676, 75019 Paris, France University Paris Diderot S P, F G, Z C, S J, A F, L S, N d R, P G, S A, P D, Sorbonne Paris Cité, UMR676, 75019 Paris, France and Institute of Pharmacology and Toxicology S S, Jena University Hospital, Friedrich Schiller University Jena, Germany
    Endocrinology 155:33-9. 2014
    ..Whereas sst2 receptors might play a primary role in the differentiation and regulation of TSH, LH, and FSH cells, sst5 receptors appear to be mainly involved in GH regulation from birth onward. ..
  24. ncbi request reprint Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions
    Souhayl Dahmani
    Institut National de la Santé et de la Recherche Médicale U 676, Hopital Robert Debre, Paris, France
    Anesthesiology 103:969-77. 2005
    ..Therefore, we examined the cellular mechanisms involved in this effect and its sensitivity to oxygen-glucose deprivation (OGD) in rat hippocampal slices...
  25. doi request reprint Use of human umbilical cord blood mononuclear cells to prevent perinatal brain injury: a preclinical study
    Jeremie Dalous
    Inserm UMR 676, Universite Paris Diderot, PRES Sorbonne Paris Cité, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
    Stem Cells Dev 22:169-79. 2013
    ..We found that the intraperitoneal injection of high amounts of hUCB-MNCs aggravated WMD and was associated with systemic inflammation...
  26. ncbi request reprint Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice
    Frank Plaisant
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, Paris, France
    Free Radic Biol Med 34:862-72. 2003
    ....
  27. ncbi request reprint Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain
    Eleni Dicou
    INSERM E9935, Hopital Robert Debre, Paris, France
    Brain Res 970:221-5. 2003
    ..Administration of CX614 to neonatal mice was followed by upregulation of hippocampal and cortical BDNF expression...
  28. ncbi request reprint In vitro induction of neural differentiation of embryonic stem (ES) cells closely mimics molecular mechanisms of embryonic brain development
    Michele Cazillis
    INSERM U676, Paris, France
    Pediatr Res 59:48R-53R. 2006
    ..In parallel, this review emphasizes the striking similarities that exist between genetically programmed embryonic development of the nervous system and the differentiation of ES cells in vitro...
  29. doi request reprint Systemic inflammation disrupts the developmental program of white matter
    Geraldine Favrais
    INSERM U676, Denis Diderot Faculty of Medicine, University of Paris 7, Paris, France
    Ann Neurol 70:550-65. 2011
    ..The goal of the present study was to test the hypothesis that moderate systemic inflammation is sufficient to alter white matter development...
  30. ncbi request reprint Caffeine induces sonic hedgehog gene expression in cultured astrocytes and neurons
    Nadia Sahir
    INSERM E 9935, Hopital Robert Debre, Paris, France
    J Mol Neurosci 24:201-5. 2004
    ..Using real-time PCR, the results showed that caffeine induced robust overexpression of Shh mRNA in both cell types without significantly modifying PKA RI alpha gene expression...
  31. doi request reprint Hedgehog rushes to the rescue of the developing cerebellum
    Olivier Baud
    INSERM, U676, Hopital Robert Debre, Paris 75019, France
    Sci Transl Med 3:105ps40. 2011
    ..In this issue of Science Translational Medicine, a pair of papers investigate--in patients and in a reliable animal model--the effects of glucocorticoids on cerebellar development after premature birth...
  32. ncbi request reprint Involvement of VIP and PACAP in neonatal brain lesions generated by a combined excitotoxic/inflammatory challenge
    Geraldine Favrais
    INSERM U676, Hopital Robert Debre, 48, boulevard Serurier, 75019 Paris, France
    Peptides 28:1727-37. 2007
    ..Therefore, development of therapeutic tools inducing/sustaining the activation of VIP/VPAC(1) signaling cascade may lead to future preventive treatments for inflammatory conditions during pregnancy...
  33. pmc Melatonin promotes oligodendroglial maturation of injured white matter in neonatal rats
    Paul Olivier
    INSERM, AVENIR R05230HS, Hopital Robert Debre, Paris, France
    PLoS ONE 4:e7128. 2009
    ..To investigate the effects of melatonin treatment in a rat model of white matter damage (WMD) in the developing brain. Additionally, we aim to delineate the cellular mechanisms of melatonin effect on the oligodendroglial cell lineage...
  34. doi request reprint Ciprofloxacin prevents myelination delay in neonatal rats subjected to E. coli sepsis
    Gauthier Loron
    Institut National de la Santé et de la Recherche Médicale AVENIR, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, France
    Ann Neurol 69:341-51. 2011
    ..We hypothesized that CIP, in addition to its antibacterial activity, could exert a neuroprotective effect by modulating white matter inflammation in response to sepsis...
  35. doi request reprint [Interaction of glucocorticoids and the Sonic Hedgehog pathway during brain development]
    Olivier Baud
    AP HP, Service de Réanimation et Pédiatrie Néonatales, Hopital Robert Debre, 48, boulevard Serurier, 75019 Paris, France Inserm Avenir R05230HS, Paris, France
    Med Sci (Paris) 25:713-7. 2009
    ..These data should lead to the development of novel molecules (either GC or Shh agonists) both -efficient and neuroprotective...
  36. doi request reprint Agomelatine, a melatonin receptor agonist with 5-HT(2C) receptor antagonist properties, protects the developing murine white matter against excitotoxicity
    Pierre Gressens
    INSERM, U676, Paris, F 75019, France
    Eur J Pharmacol 588:58-63. 2008
    ..Agomelatine, acting through melatonin receptors, could represent a promising new drug for treating human periventricular leukomalacia and have beneficial effects on neuroplasticity...
  37. ncbi request reprint Apoptosis-inducing factor deficiency induces early mitochondrial degeneration in brain followed by progressive multifocal neuropathology
    Vincent El Ghouzzi
    Institut National de la Sante et de la Recherche Medicale, U676, Paris, France
    J Neuropathol Exp Neurol 66:838-47. 2007
    ....
  38. pmc VIP-induced neuroprotection of the developing brain
    Sandrine Passemard
    INSERM, U676, Paris, France
    Curr Pharm Des 17:1036-9. 2011
    ..Unraveling cellular and molecular targets of VIP effects against perinatal white matter lesions could provide a more general rationale to understand the neuroprotection of the developing white matter against excitotoxic insults...
  39. doi request reprint 1,2-ethane bis-1-amino-4-benzamidine is active against several brain insult and seizure challenges through anti-NMDA mechanisms targeting the 3H-TCP binding site and antioxidant action
    Joseph Vamecq
    INSERM UNIV 045131, Faculty of Medicine, Research Branch, University of Lille 2, France
    Eur J Med Chem 45:3101-10. 2010
    ..4 microM). Taken as a whole, present data emphasise the suitability of bis-benzamidines as templates for designing brain protective compounds...
  40. ncbi request reprint Antiepileptic popular ketogenic diet: emerging twists in an ancient story
    Joseph Vamecq
    INSERM UNIV 045131, Neuropaediatrics, Salengro University Hospital, CHRU Lille, 59037 Lille, France
    Prog Neurobiol 75:1-28. 2005
    ....
  41. ncbi request reprint Neuronal migration disorders
    Pierre Gressens
    INSERM LI676, Paris, F 75019 France
    J Child Neurol 20:969-71. 2005
    ..The present review focuses on animal models of neuronal migration disorders...
  42. doi request reprint In vivo assessment of experimental neonatal excitotoxic brain lesion with USPIO-enhanced MR imaging
    Marianne Alison
    INSERM U676, Hopital Robert Debre, AP HP, 48 Bd Serurier, 75019, Paris, France
    Eur Radiol 20:2204-12. 2010
    ....
  43. doi request reprint Increased MMP-9 and TIMP-1 in mouse neonatal brain and plasma and in human neonatal plasma after hypoxia-ischemia: a potential marker of neonatal encephalopathy
    Nathalie Bednarek
    INSERM, Hopital Robert Debre, Paris, France
    Pediatr Res 71:63-70. 2012
    ..We evaluated the effectiveness of matrix metalloproteinases (MMPs) and their naturally occurring tissue inhibitors of metalloproteinases (TIMPs) in predicting neonatal encephalopathy (NE) damage in newborns...
  44. pmc Early microglial colonization of the human forebrain and possible involvement in periventricular white-matter injury of preterm infants
    Catherine Verney
    INSERM U676, Hopital Robert Debre, 48 Boulevard Serurier, Paris, France
    J Anat 217:436-48. 2010
    ....
  45. doi request reprint Dynamics of somatostatin type 2A receptor cargoes in living hippocampal neurons
    Benjamin Lelouvier
    Institut National de la Sante et de la Recherche Medicale, Unité 676, 75019 Paris, France
    J Neurosci 28:4336-49. 2008
    ....
  46. ncbi request reprint Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine
    Vincent Laudenbach
    Laboratoire de Neurologie du Développement, Institut National de la Santé de la Recherche Médicale E9935, Hopital Robert Debre, Paris, France
    Anesthesiology 96:134-41. 2002
    ..alpha(2)-Adrenoceptor agonists are protective in models of brain ischemia in adults. The authors sought to determine whether they prevent perinatal excitotoxic neuronal damage...
  47. ncbi request reprint Ventilatory control in newborn mice prenatally exposed to cocaine
    Fanny Autret
    Laboratoire de Neurologie et Physiologie du Développement, INSERM E9935, Hopital Robert Debre, Paris, France
    Pediatr Pulmonol 34:434-41. 2002
    ..25 +/- 23%).Thus, breathing control was impaired by prenatal cocaine exposure, possibly because of abnormal development of neurotransmitter systems, such as the dopamine and serotonin systems...
  48. pmc Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction
    Riyad El-Khoury
    INSERM, UMR 676, Hopital Robert Debre, Paris, France
    PLoS Genet 9:e1003182. 2013
    ..Therefore, the MitAOX mice represent a valuable tool in order to investigate the ability of AOX to counteract the panoply of mitochondrial-inherited diseases originating from oxidative phosphorylation defects...
  49. ncbi request reprint Fetal MRI: obstetrical and neurological perspectives
    Pierre Gressens
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, 48 Blvd Sérurier, Paris, France
    Pediatr Radiol 34:682-4. 2004
    ..New imaging techniques such as diffusion-weighted imaging, magnetic resonance spectroscopy or functional MRI applied to the fetus represent promising tools in this perspective...
  50. ncbi request reprint Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain
    Olivier Baud
    Institut National de la Santé et de la Recherche Médicale E9935, Laboratoire de Neurologie du Développement, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    J Comp Neurol 465:445-54. 2003
    ..The transient pattern of expression of MCTs throughout the perinatal period suggests a potential relationship with the maturation of the blood-brain barrier...
  51. ncbi request reprint [Neural differentiation of murine embryonic stem cells ES]
    Michele Cazillis
    INSERM U 676, Physiopathologie et neuroprotection des atteintes du cerveau en développement, Hopital Robert Debre, 48, boulevard Serurier, 75935 Paris Cedex 19, France
    Med Sci (Paris) 21:484-90. 2005
    ....
  52. doi request reprint Cytokine responses to quantiferon peptides in pediatric tuberculosis: a pilot study
    Marine Armand
    Laboratory of Immunology, Robert Debre Hospital, Assistance Publique Hopitaux de Paris AP HP, Univ Paris Diderot, Sorbonne Paris Cité, 75019 Paris, France
    J Infect 68:62-70. 2014
    ..Detailed understanding of tuberculosis (TB) immunopathology and cytokine/chemokine responses can ultimately lead to the development of new diagnostic tools, especially useful in children where TB diagnosis remains challenging...
  53. ncbi request reprint Drug companies and neuroprotection of the newborn: any hope for a love story?
    Pierre Gressens
    INSERM, U676, Universite Paris 7, Faculté de Médecine Denis Diderot, IFR02 and IFR25, AP HP, Hopital Robert Debre, Service de Neurologie Pédiatrique Paris, France
    Acta Paediatr 96:485-6. 2007
  54. doi request reprint Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research
    Niccolo Curatolo
    INSERM U676, Universite Paris 7, 75019 Paris, France
    Pediatr Res 70:584-8. 2011
    ..As the existing literature suggests that the route of administration of PUFA may be crucial, future studies should involve oral administration to provide relevant clinical information...
  55. ncbi request reprint Ventricular dilatations
    Catherine Garel
    Department of Paediatric Imaging, Robert Debre Hospital, 48 Boulevard Serurier, 75019 Paris, France
    Childs Nerv Syst 19:517-23. 2003
    ..Ventricular dilatation is generally defined on ultrasounds (US) or MRI as an atrium larger than 10 to 12 mm on axial or coronal planes. After 22 weeks, this measure is independent of the term...
  56. ncbi request reprint Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries
    Vincent Laudenbach
    Laboratoire de Neurologie du Développement, INSERM E9935, Hopital Robert Debre, Paris, France
    FASEB J 16:423-5. 2002
    ..Neuroprotective strategies must consider these opposite properties of distinct nAChR isoforms in neonates...
  57. doi request reprint Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury
    Catherine I Rousset
    INSERM U930, Universite Francois Rabelais, and Neonatology Hôpital Clocheville, CHRU Tours, Tours, France
    J Neuropathol Exp Neurol 67:994-1000. 2008
    ....
  58. ncbi request reprint Novel 2-alkylamino-1,4-benzoxazine derivatives as potent neuroprotective agents: structure-activity relationship studies
    Estelle Blattes
    UMR 8638 CNRS Université René Descartes, Synthese et Structure de Molecules d Interet Pharmacologique, Faculte des Sciences Pharmaceutiques et Biologiques, 4 avenue de l Observatoire, 75270 Paris Cedex 06, France
    J Med Chem 48:1282-6. 2005
    ..Accordingly, 3l proved to be effective in an animal model of excitotoxic lesions in newborn mice...
  59. doi request reprint Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice
    Christina Doverhag
    Department of Physiology and Neuroscience, Perinatal Center, Sahlgrenska Academy, Goteborg University, Sweden
    Neurobiol Dis 31:133-44. 2008
    ..The ROS-generating enzyme NADPH oxidase (Nox2) is present in inflammatory cells and contributes to brain injury in adult animal models...
  60. ncbi request reprint Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata
    Pedro Brites
    Academic Medical Center, Laboratory of Genetic Metabolic Diseases F0 224, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Hum Mol Genet 12:2255-67. 2003
    ..These findings demonstrate that Pex7 knockout mice provide an important model to study the role of peroxisomal functioning in the pathogenesis of the human disorder...
  61. ncbi request reprint Role of tissue-derived plasminogen activator (t-PA) in an excitotoxic mouse model of neonatal white matter lesions
    Olivier Hennebert
    MERCI, UPRES EA 2122, Faculty of Medicine and Pharmacy, Rouen University, Rouen, France
    J Neuropathol Exp Neurol 63:53-63. 2004
    ..Inactivation of t-PA might confer protection by prolonged hemostasis. The role of t-PA in cyst expansion suggests a new approach to the development of neuroprotective strategies in infants with developing WM lesions...
  62. ncbi request reprint Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues
    Anneleen Janssen
    Laboratory of Clinical Chemistry, K U Leuven, 3000 Leuven, Belgium
    J Neurosci 23:9732-41. 2003
    ....
  63. ncbi request reprint Potent mammalian cerebroprotection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols
    Joseph Vamecq
    INSERM UNIV 045131, Neuropaediatrics Department of Professor Louis Vallée, Salengro University Hospital, CHRU Lille, 59037 Lille, France
    Eur J Neurosci 18:1110-20. 2003
    ..recycling (thiol-disulphide exchange) properties of the oxidized form of an antioxidant compound are as important as the antioxidant potential exhibited by a bioactive reduced antioxidant in certain neuroprotective processes...
  64. ncbi request reprint Fructose-1,6-biphosphate prevents excitotoxic neuronal cell death in the neonatal mouse brain
    Marta Rogido
    Division of Neonatology, Emory University, Atlanta, GA, USA
    Brain Res Dev Brain Res 140:287-97. 2003
    ..This data extends the neuroprotective profile of FBP in neonatal brain injury and identifies gray matter lesions involving N-methyl-D-aspartate receptors as a major target for this promising drug...
  65. ncbi request reprint Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge
    Isabelle Husson
    Service de Neuropédiatrie and INSERM E 9935, Hopital Robert Debre, Paris, France
    Ann Neurol 51:82-92. 2002
    ..Melatonin and derivatives that block cAMP production through activation of melatonin receptors could represent new avenues for treating human periventricular leukomalacia...
  66. doi request reprint Neuroprotective strategies for the neonatal brain
    Vincent Degos
    INSERM, U676, Paris, France
    Anesth Analg 106:1670-80. 2008
    ..Improved understanding of the pathophysiological mechanisms involved in perinatal brain lesions helps to identify potential targets for neuroprotective interventions, as discussed in this review...
  67. ncbi request reprint Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice
    Geraldine Favrais
    INSERM, U676, Paris, France
    Neurobiol Dis 25:496-505. 2007
    ..Some of these deleterious effects could involve an autocrine/paracrine loop leading to a disruption of the balance between pro- and anti-inflammatory cytokines in the brain...
  68. ncbi request reprint The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype
    Andrea Paris
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Anesth Analg 102:456-61. 2006
    ..This effect was completely abolished in alpha2A-KO mice, suggesting that the neuroprotective effect is mediated via the alpha2A-adrenoceptor subtype...
  69. ncbi request reprint Melatonin reduces inflammation and cell death in white matter in the mid-gestation fetal sheep following umbilical cord occlusion
    Anne Karin Welin
    Department of Obstetrics and Gynecology, Sahlgrenska Academy, Goteborg University, 405 30 Goteborg, Sweden
    Pediatr Res 61:153-8. 2007
    ..In conclusion, this study shows that melatonin attenuates cell death in the fetal brain in association with a reduced inflammatory response in the blood and the brain following intrauterine asphyxia in mid-gestation fetal sheep...
  70. ncbi request reprint Neocortical and cerebellar developmental abnormalities in conditions of selective elimination of peroxisomes from brain or from liver
    Olga Krysko
    Laboratory for Cell Metabolism, K U Leuven, Leuven, Belgium
    J Neurosci Res 85:58-72. 2007
    ..In conclusion, these data demonstrate that absence of peroxisomal function both from liver and brain impairs cortical neuronal migration and maturation of the cerebellum, but different pathogenic mechanisms might be involved...
  71. ncbi request reprint Systemic application of granulocyte-colony stimulating factor and stem cell factor exacerbates excitotoxic brain injury in newborn mice
    Matthias Keller
    Department of Neonatology, Medical University Innsbruck, Austria
    Pediatr Res 59:549-53. 2006
    ..We conclude that G-CSF and SCF should be used cautiously in newborn infants with brain lesions; if they are used, long term neurologic and neurodevelopmental follow-up is warranted...
  72. ncbi request reprint Lentiviral-mediated gene transfer of brain-derived neurotrophic factor is neuroprotective in a mouse model of neonatal excitotoxic challenge
    Alexis Pierre Bemelmans
    CNRS, UMR 7091, Batiment CERVI, Hopital de la Pitie Salpetriere, Paris, France
    J Neurosci Res 83:50-60. 2006
    ..Altogether, the present study shows that viral-mediated gene transfer of BDNF to newborn mouse brain is feasible and affords significant neuroprotection against an excitotoxic insult...
  73. ncbi request reprint Neuronal damage accompanies perinatal white-matter damage
    Alan Leviton
    Department of Neurology, Children s Hospital Boston, Boston, MA, USA
    Trends Neurosci 30:473-8. 2007
    ..Together, these advances support the untested hypothesis that white-matter damage in the preterm newborn is accompanied by the death of neurons as they migrate through the dangerous minefield of white matter undergoing injury...
  74. ncbi request reprint Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice
    Matthias Keller
    Department of Pediatrics IV, Neonatology, Neuropediatrics and Metabolic Diseases, Medical University Innsbruck, Austria, and INSERM U 676 and Service de Neurologie Pediatrique, Hopital Robert Debre 48, Paris, France
    Neurobiol Dis 24:357-66. 2006
    ..Minor hematopoetic effects were observed following EPO treatment. We conclude that a single dose of EPO is sufficient to reduce excitotoxic brain injury and may therefore possess therapeutic relevance in the clinical setting...
  75. ncbi request reprint Epilepsy and neuroprotection: an illustrated review
    Alexis Arzimanoglou
    Epilepsy Unit, Child Neurology and Metabolic Diseases Departmentand INSERM E9935, University Hospital Robert Debré, Paris, France
    Epileptic Disord 4:173-82. 2002
    ..The review is designed to inform clinicians about the basic issues related to the subject, thus allowing them to follow the ongoing debate and participate with pertinent questions. (Published with video sequences)...
  76. ncbi request reprint T3 replacement does not prevent excitotoxic cell death but reduces developmental neuronal apoptosis in newborn mice
    Gergely Sarkozy
    Department of Paediatrics IV, Neonatology, Neuropediatrics and Metabolic Diseases, Medical University Innsbruck, Anichstrasse 35, Innsbruck, Austria
    Eur J Paediatr Neurol 11:129-35. 2007
    ..At present, there are no effective or causal therapies available. Thyroid hormones play an essential role in brain development and are reported to be decreased in pre-terms and following brain injury in adults...
  77. doi request reprint Dextromethorphan is protective against sensitized N-methyl-D-aspartate receptor-mediated excitotoxic brain damage in the developing mouse brain
    Matthias Keller
    Department of Pediatrics IV, Neonatology, Neuropediatrics and Metabolic Diseases, Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Eur J Neurosci 27:874-83. 2008
    ..Although functional parameters were not measured, our data corroborate reports that DM is neuroprotective and that it may therefore improve functional outcome following perinatal brain injury...
  78. ncbi request reprint Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain
    Pierre Gressens
    INSERM, U676, Paris, France
    Brain Pathol 18:10-20. 2008
    ..Longer survival studies are necessary to verify the safety of hypothermia in the developing brain...
  79. ncbi request reprint Prenatal ischemia and white matter damage in rats
    Paul Olivier
    INSERM U676 Université Paris7, Robert Debré Pediatric Hospital, France
    J Neuropathol Exp Neurol 64:998-1006. 2005
    ..Defective myelination, as assessed by myelin-binding-protein labeling, was detected until adulthood. The diffuse white matter damage in growth-retarded rats replicated the main features of white matter damage in human preterm infants...
  80. ncbi request reprint Injectable dexamethasone administration enhances cortical GABAergic neuronal differentiation in a novel model of postnatal steroid therapy in mice
    Olivier Baud
    Laboratoire de Neurobiologie de Dévelopment, INSERM E9935, Paris, France
    Pediatr Res 57:149-56. 2005
    ..In conclusion, in a murine model of postnatal steroid therapy, injectable DXM induced a selective increase in GABAergic neurons in the cerebral cortex...
  81. ncbi request reprint Immunohistochemical expression of prion protein (PrPC) in the human forebrain during development
    Homa Adle-Biassette
    AP HP, Hopital Bichat Claude Bernard, Service d anatomie pathologie, Universite Paris 7, Faculté de Médecine Denis Diderot, Paris, France
    J Neuropathol Exp Neurol 65:698-706. 2006
    ..In conclusion, the early expression of PrPC in the axonal field may suggest a specific role for this molecule in axonal growth during development. Moreover, PrPC may play a role in early microglial cell development...
  82. ncbi request reprint Distribution and differentiation of microglia in the human encephalon during the first two trimesters of gestation
    Anne Monier
    INSERM, U676, Paris, F 75019 France
    J Comp Neurol 499:565-82. 2006
    ..From the middle of the second trimester onward microglial cells colonized the entire cerebral parenchyma, developed a ramified morphology, and downregulated their surface antigens, but remained more numerous in the white matter...
  83. pmc Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage
    Basma Shouman
    INSERM, U676, Paris France
    Br J Pharmacol 148:442-51. 2006
    ..The present study provides experimental support for the role of endocannabinoids as a candidate therapy for excitotoxic perinatal brain lesions...
  84. ncbi request reprint The impact of neonatal intensive care practices on the developing brain
    Pierre Gressens
    Service de Neurologie Pédiatrique and INSERM E 9935, Hopital Robert Debre, Paris, France
    J Pediatr 140:646-53. 2002
  85. ncbi request reprint Neonatal hypoxic preconditioning involves vascular endothelial growth factor
    Vincent Laudenbach
    Institut National de la Sante et de la Recherche Medicale, AVENIR Research Group, IFRMP23, University of Rouen, Department of Neonatal Pediatrics and Intensive Care, Rouen University Hospital, France
    Neurobiol Dis 26:243-52. 2007
    ..Thus, exogenous as well as endogenous VEGF reduces excitotoxic brain lesions in the developing mouse. The VEGF/VEGFR2/Flk1 pathway is involved in the neuroprotective response to HxP...
  86. ncbi request reprint Growth factors and plasticity
    Stephane V Sizonenko
    Service du développement et de la croissance, Departement de Pediatrie, Faculte de Medecine, Geneva, Switzerland
    Semin Fetal Neonatal Med 12:241-9. 2007
    ..g. melatonin or erythropoietin, might reach clinical trials in the near future...
  87. ncbi request reprint Entry and distribution of microglial cells in human embryonic and fetal cerebral cortex
    Anne Monier
    Institut National de la Santé et de la Recherche Médicale U676, Paris, France
    J Neuropathol Exp Neurol 66:372-82. 2007
    ..The spatiotemporal organization of microglia in the immature white and grey matter suggests that these cells may play active roles in developmental processes and in injury to the developing brain...
  88. ncbi request reprint Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice
    Emmanuelle Lagrue
    INSERM, U619, Tours, F 37000 France
    Pediatr Res 62:14-9. 2007
    ..Lamotrigine, a widely used and well-tolerated molecule in young patients, could represent a valuable adjuvant therapy in various energy deficiency conditions during childhood...
  89. ncbi request reprint VIP and PACAP induce selective neuronal differentiation of mouse embryonic stem cells
    Michele Cazillis
    INSERM E0350, Hopital St Antoine, 184 Rue du Fg St Antoine, 75012 Paris, France
    Eur J Neurosci 19:798-808. 2004
    ..It opens an exciting new field for neuropeptide regulation of tissue ontogenesis...
  90. ncbi request reprint Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells
    Manoj Kumar
    National Brain Research Centre, Manesar, Gurgaon 122050, India
    Stem Cells Dev 16:667-81. 2007
    ..Our results show for the first time the expression of Ngn2 during the differentiation of hES cells...
  91. pmc Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage
    Olaf Dammann
    Division of Newborn Medicine, Department of Pediatrics, Tufts New England Medical Center, Boston, Mass, USA
    Neonatology 93:182-7. 2008
    ..We outline how NRG-1 might be involved in perinatal brain damage pathomechanisms and suggest that NRG-1 might be one target for intervention...
  92. doi request reprint The PPARgamma agonist FMOC-L-leucine protects both mature and immature brain
    Pierre Maurois
    CNRS UMR 8162, Centre Chirurgical Marie Lannelongue, F 92350 Le Plessis Robinson, Faculte de Pharmacie, Universite Paris Sud 11, Chatenay Malabry, France
    Biomed Pharmacother 62:259-63. 2008
    ..Targeting PPARs might be thus a promising way to protect immature brain...