P Gressens

Summary

Country: France

Publications

  1. ncbi Vasoactive intestinal peptide shortens both G1 and S phases of neural cell cycle in whole postimplantation cultured mouse embryos
    P Gressens
    Service de Neuropédiatrie and INSERM CRI 97 01, Hôpital Robert Debré and Faculté Xavier Bichat, Paris, France
    Eur J Neurosci 10:1734-42. 1998
  2. pmc Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain
    P Gressens
    Service de Neuropediatrie, Hôpital Robert Debré and Faculté Xavier Bichat, F 75019 Paris, France
    J Clin Invest 100:390-7. 1997
  3. ncbi Maternal protein restriction early in rat pregnancy alters brain development in the progeny
    P Gressens
    Laboratoire de Neurobiologie et de Physiologie du developpement, INSERM CRI 96 03, Hopital Robert Debre, Paris, France
    Brain Res Dev Brain Res 103:21-35. 1997
  4. ncbi VIP neuroprotection against excitotoxic lesions of the developing mouse brain
    P Gressens
    Service de Neuropédiatrie and INSERM E 9935, Hopital Robert Debre, Paris, France
    Ann N Y Acad Sci 897:109-24. 1999
  5. ncbi Neuroprotection of the developing brain by systemic administration of vasoactive intestinal peptide derivatives
    P Gressens
    Service de Neuropédiatrie and Institut National de la Santé et de la Recherche Médicale CRI 97 01, Hopital Robert Debre, Paris, France
    J Pharmacol Exp Ther 288:1207-13. 1999
  6. ncbi Central role of microglia in neonatal excitotoxic lesions of the murine periventricular white matter
    S L Tahraoui
    INSERM E 9935, , Paris, France
    Brain Pathol 11:56-71. 2001
  7. doi IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis
    R H Fontaine
    INSERM, U676, Paris, France
    Cell Death Differ 15:1542-52. 2008
  8. doi Neuroprotective effects of NAP against excitotoxic brain damage in the newborn mice: implications for cerebral palsy
    P Sokolowska
    INSERM, U676, Paris, France
    Neuroscience 173:156-68. 2011
  9. ncbi Pathophysiology of neonatal brain lesions: lessons from animal models of excitotoxicity
    B Mesples
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, Paris, France
    Acta Paediatr 94:185-90. 2005
  10. ncbi Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection
    M A Dommergues
    INSERM E 9935, Service de Neurologie Pediatrique, Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
    Neuroscience 121:619-28. 2003

Collaborators

Detail Information

Publications40

  1. ncbi Vasoactive intestinal peptide shortens both G1 and S phases of neural cell cycle in whole postimplantation cultured mouse embryos
    P Gressens
    Service de Neuropédiatrie and INSERM CRI 97 01, Hôpital Robert Debré and Faculté Xavier Bichat, Paris, France
    Eur J Neurosci 10:1734-42. 1998
    ....
  2. pmc Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain
    P Gressens
    Service de Neuropediatrie, Hôpital Robert Debré and Faculté Xavier Bichat, F 75019 Paris, France
    J Clin Invest 100:390-7. 1997
    ..VIP and neurotrophic analogs, acting through a cAMP-independent mechanism and inducing ADNF release, could represent new avenues in the understanding and prevention of human cerebral palsy...
  3. ncbi Maternal protein restriction early in rat pregnancy alters brain development in the progeny
    P Gressens
    Laboratoire de Neurobiologie et de Physiologie du developpement, INSERM CRI 96 03, Hopital Robert Debre, Paris, France
    Brain Res Dev Brain Res 103:21-35. 1997
    ..However, the almost complete normalization in adults of brain architecture and differentiation as well as our physiological data strongly suggest a remarkable plasticity of the developing brain following an early aggression...
  4. ncbi VIP neuroprotection against excitotoxic lesions of the developing mouse brain
    P Gressens
    Service de Neuropédiatrie and INSERM E 9935, Hopital Robert Debre, Paris, France
    Ann N Y Acad Sci 897:109-24. 1999
    ..However, co-treatment with ibotenate, VIP, and anti-ADNF antibodies did not abolish VIP-induced protection, suggesting that ADNF does not mediate VIP protective properties in the present model...
  5. ncbi Neuroprotection of the developing brain by systemic administration of vasoactive intestinal peptide derivatives
    P Gressens
    Service de Neuropédiatrie and Institut National de la Santé et de la Recherche Médicale CRI 97 01, Hopital Robert Debre, Paris, France
    J Pharmacol Exp Ther 288:1207-13. 1999
    ..VIP analogs may have therapeutic potential in human premature babies at high risk for PVL...
  6. ncbi Central role of microglia in neonatal excitotoxic lesions of the murine periventricular white matter
    S L Tahraoui
    INSERM E 9935, , Paris, France
    Brain Pathol 11:56-71. 2001
    ..Assuming that similar pathophysiologic mechanisms are present in human pre- term infants, microglia and NMDA receptors could represent key targets for treatment of PVL...
  7. doi IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis
    R H Fontaine
    INSERM, U676, Paris, France
    Cell Death Differ 15:1542-52. 2008
    ..Together, these data suggest that IL-9/IL-9 receptor signaling pathway represents a novel endogenous antiapoptotic mechanism for cortical neurons by controlling JAK/STAT and Bax levels...
  8. doi Neuroprotective effects of NAP against excitotoxic brain damage in the newborn mice: implications for cerebral palsy
    P Sokolowska
    INSERM, U676, Paris, France
    Neuroscience 173:156-68. 2011
    ....
  9. ncbi Pathophysiology of neonatal brain lesions: lessons from animal models of excitotoxicity
    B Mesples
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, Paris, France
    Acta Paediatr 94:185-90. 2005
    ..This paper reviews experimental data obtained in animal models of neonatal excitotoxic brain lesions that closely mimic some of the lesions found in human cerebral palsy...
  10. ncbi Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection
    M A Dommergues
    INSERM E 9935, Service de Neurologie Pediatrique, Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
    Neuroscience 121:619-28. 2003
    ....
  11. ncbi Growth factor properties of VIP during early brain development. Whole embryo culture and in vivo studies
    P Gressens
    Laboratoire de Neurologie du Développement, Hopital Robert Debre, Paris, France
    Ann N Y Acad Sci 814:152-60. 1997
    ..These data demonstrate that VIP regulates mitogenic activity in the premigratory neuroepithelium. Although this effect is limited to a short ontogenic period, blockade of VIP by a specific antagonist induces a severe microcephaly...
  12. ncbi Methylphenidate and MK-801, an N-methyl-d-aspartate receptor antagonist: shared biological properties
    I Husson
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
    Neuroscience 125:163-70. 2004
    ..Additional studies to identify some potential positive as well as negative consequences of exposure to these drugs during brain development in clinical settings are warranted...
  13. ncbi Neuroprotective properties of tianeptine: interactions with cytokines
    F Plaisant
    INSERM E 9935, Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
    Neuropharmacology 44:801-9. 2003
    ..Thus tianeptine has neuroprotective effects against hypoxia in tissue culture and against the deleterious effects of cytokines in cortex and white matter, but not against NMDA receptor-mediated excitotoxicity...
  14. pmc Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain
    V Laudenbach
    , , Paris, France
    J Clin Invest 107:457-66. 2001
    ..These data point to potential new avenues for neuroprotection in human preterm infants at high risk of brain lesions...
  15. ncbi Environmental factors and disturbances of brain development
    P Gressens
    INSERM E 9935 and Service de Neurologie Pédiatrique, Hopital Robert Debre, Paris, France
    Semin Neonatol 6:185-94. 2001
    ..Finally, the impact of the neonatal environment on brain development in very pre-term infants is probably underestimated...
  16. ncbi Caffeine does not affect excitotoxic brain lesions in newborn mice
    N Bahi
    , , Paris, France
    Eur J Paediatr Neurol 5:161-5. 2001
    ..In this model, caffeine exposure did not worsen white matter lesions. These data suggest that neonatal caffeine administration might not affect clastic lesions in pre-term infants...
  17. ncbi [Pathophysiology of periventricular leukomalacia]
    F Plaisant
    INSERM U 676, Hopital Robert Debre, 48, boulevard Serurier, 75019 Paris, France
    Arch Pediatr 12:734-6. 2005
  18. doi [Long-term cerebral effects of perinatal inflammation]
    V Chhor
    INSERM U676, Hopital Robert Debre, 48, boulevard Serurier, 75019 Paris, France
    Arch Pediatr 19:946-52. 2012
    ..As gliosis appears to be involved in the acute and chronic effects of perinatal inflammation, modulating the glial phenotype may be an effective strategy to prevent damage to the brain...
  19. ncbi [Post-lesional plasticity after traumatic brain injury]
    V Degos
    INSERM, U676, Hopital Robert Debre, Paris, France
    Arch Pediatr 14:522-3. 2007
  20. doi [Inflammation and acute brain injuries in intensive care]
    V Degos
    Unité Inserm U676, Hopital Robert Debre, 48, boulevard Serrurier, 75019 Paris, France
    Ann Fr Anesth Reanim 27:1008-15. 2008
    ..Neuroprotection strategies in acute neuroinflammation will be reported with a focus on anaesthetic agents and the inflammation cascade...
  21. ncbi Classical conditioning of breathing pattern after two acquisition trials in 2-day-old mice
    E Durand
    Laboratoire de Neurologie et Physiologie du Développement, INSERM E9935, Hopital Robert Debre, 75019 Paris, France
    J Appl Physiol 94:812-8. 2003
    ..Our results confirm the sensitivity of breathing to conditioning and indirectly support the hypothesis that learned feedforward processes may complement feedback pathways during postnatal maturation of respiratory control...
  22. pmc Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung's disease
    V Lelievre
    INSERM, U676, Paris, France
    Peptides 28:1688-99. 2007
    ..Physiologically, the VIP(-/-) mice showed an impairment in intestinal transit. Moreover, unlike WT C57BL/6 mice, a significant percentage of VIP(-/-) mice died in the first postnatal year with overt stenosis of the gut...
  23. ncbi Caffeine-induced telencephalic vesicle evagination in early post-implantation mouse embryos involves cAMP-dependent protein kinase (PKA) inhibition
    N Sahir
    INSERM E 9935, , Paris, France
    Cereb Cortex 11:343-9. 2001
    ....
  24. doi Expanding the clinical and neuroradiologic phenotype of primary microcephaly due to ASPM mutations
    S Passemard
    Department of Clinical Genetics, U676, Hopital Robert Debre, APHP, 75019 Paris, France
    Neurology 73:962-9. 2009
    ..To determine the spectrum of clinical, neuropsychological, and neuroradiologic features in patients with autosomal recessive primary microcephaly (MCPH) due to ASPM gene mutations...
  25. ncbi Prenatal isolated mild ventriculomegaly: outcome in 167 cases
    J Ouahba
    Department of Prenatal Diagnosis, Robert Debre Hospital, Paris, France
    BJOG 113:1072-9. 2006
    ..To define the contribution of prenatal investigation and evaluate the prognosis of isolated mild ventriculomegaly (IMV)...
  26. ncbi Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease
    M Cohen-Tannoudji
    Unite de Biologie du Developpement, Institut Pasteur, Paris, France
    Mamm Genome 6:844-9. 1995
    ..They should also provide a valuable animal model in which to test new forms of therapy, and in particular gene delivery into the central nervous system...
  27. ncbi Melatonin prevents learning disorders in brain-lesioned newborn mice
    M Bouslama
    INSERM, U676, Robert Debre Hospital, 48 Bvd Serurier, 75019 Paris, France
    Neuroscience 150:712-9. 2007
    ..Thus, melatonin, which easily crosses the blood-brain barrier and has been proven safe in children, may be effective in preventing learning disabilities caused by perinatal brain injuries in human preterm infants...
  28. ncbi Deleterious effects of IL-9-activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain
    J Patkai
    , , 75019 Paris, France
    Pediatr Res 50:222-30. 2001
    ..Neuroprotective strategies targeting mast cells may be useful in some neonates at risk for cerebral palsy...
  29. pmc Severe microcephaly induced by blockade of vasoactive intestinal peptide function in the primitive neuroepithelium of the mouse
    P Gressens
    Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    J Clin Invest 94:2020-7. 1994
    ..Thus, VIP regulates brain growth in vivo and inhibition of its action provides new insight into a molecular mechanism for microcephaly...
  30. ncbi Neuroprotective effects of leptin in vivo and in vitro
    E Dicou
    INSERM E9935, , , F-75019 Paris, France
    Neuroreport 12:3947-51. 2001
    ..These findings are the first evidence for a role of leptin in neuroprotection...
  31. ncbi The neuronal migration defect in mice with Zellweger syndrome (Pex5 knockout) is not caused by the inactivity of peroxisomal beta-oxidation
    M Baes
    Laboratory of Clinical Chemistry, Faculty of Pharmaceutical Sciences, KU Leuven, Belgium
    J Neuropathol Exp Neurol 61:368-74. 2002
    ..This does not exclude that the inactivity of this metabolic pathway contributes to the brain pathology in mice and patients with complete absence of functional peroxisomes...
  32. ncbi A mouse model for Zellweger syndrome
    M Baes
    Laboratory of Clinical Chemistry, Kathlieke Universiteit Leuven, Belgium
    Nat Genet 17:49-57. 1997
    ..They displayed intrauterine growth retardation, were severely hypotonic at birth and died within 72 hours. Analysis of the neocortex revealed impaired neuronal migration and maturation and extensive apoptotic death of neurons...
  33. ncbi [Genetic and clinical aspects of lissencephaly]
    A Verloes
    INSERM U676, Paris
    Rev Neurol (Paris) 163:533-47. 2007
    ..The epilepsy is often resistant to treatment. The encephalopathy associated with lissencephaly is often very severe and affected children are completely dependent on the carer...
  34. ncbi The neuropeptide pituitary adenylate cyclase-activating polypeptide exerts anti-apoptotic and differentiating effects during neurogenesis: focus on cerebellar granule neurones and embryonic stem cells
    A Falluel-Morel
    INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research IFRMP 23, University of Rouen, Mont Saint Aignan, France
    J Neuroendocrinol 19:321-7. 2007
    ....
  35. ncbi Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    B Oosthuyse
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, B 3000, Belgium
    Nat Genet 28:131-8. 2001
    ..Acute ischemia is known to cause nonselective neuronal death. Our results indicate that chronic vascular insufficiency and, possibly, insufficient Vegf-dependent neuroprotection lead to the select degeneration of motor neurons...
  36. ncbi Treatment-induced prevention of learning deficits in newborn mice with brain lesions
    M Bouslama
    INSERM U676, Robert Debre Hospital, 48 Bvd Serurier, 75019 Paris, France
    Neuroscience 141:795-801. 2006
    ..This demonstrates, for the first time, that neuroprotective treatment can protect some features of early cognition...
  37. ncbi Neurotoxic effects of fluorinated glucocorticoid preparations on the developing mouse brain: role of preservatives
    O Baud
    , , F-75019 Paris, France
    Pediatr Res 50:706-11. 2001
    ..These experimental findings suggest that injectable dexamethasone should be used with caution during the perinatal period...
  38. ncbi Patterns of cerebral inflammatory response in a rabbit model of intrauterine infection-mediated brain lesion
    T Debillon
    Service de Neonatologie, Hopital Mere Enfant, 9 quai Moncousu, CHRU, 44 093 Nantes 01, France
    Brain Res Dev Brain Res 145:39-48. 2003
    ....
  39. ncbi Delayed white matter injury in a murine model of shaken baby syndrome
    C Bonnier
    Service de Neurologie Pediatrique, University of Louvain Medical School, Bruxelles, Belgium
    Brain Pathol 12:320-8. 2002
    ..This study showed that shaking immature mice produced white matter injury mimicking several aspects of human shaken baby syndrome and provided evidence that excess release of glutamate plays a role in the pathophysiology of the lesions...
  40. ncbi Effect of maternal antibiotic treatment on fetal periventricular white matter cell death in a rabbit intrauterine infection model
    T Debillon
    Service de Neonatologie, Hopital Mere Enfant, CHRU Nantes, Nantes, France
    Acta Paediatr 92:81-6. 2003
    ..To evaluate the effects of maternal antibiotic treatment on fetal brain cell death in a rabbit intrauterine infection model...