P Gorwood

Summary

Country: France

Publications

  1. ncbi The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia
    Caroline Dubertret
    Service de Psychiatrie Adulte, Faculty of Bichat Claude Bernard, Louis Mourier hospital AP HP, 178 rue des Renouillers, 92701 Colombes Cedex, France
    Schizophr Res 67:75-85. 2004
  2. ncbi The genetics of addiction: alcohol-dependence and D3 dopamine receptor gene
    P Gorwood
    Hopital Louis Mourier, Service de Psychiatrie Adultes, 178, rue des Renouillers, 92700 Colombes, France
    Pathol Biol (Paris) 49:710-7. 2001
  3. ncbi Generalized anxiety disorder and major depressive disorder comorbidity: an example of genetic pleiotropy?
    P Gorwood
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, CNRS UMR 7593, 178, rue des Renouillers, 92700 Colombes cedex, France
    Eur Psychiatry 19:27-33. 2004
  4. ncbi Eating disorders, serotonin transporter polymorphisms and potential treatment response
    Philip Gorwood
    Service de Psychiatrie, Hôpital Louis Mourier AP HP, 178 rue des Renouillers, 92700 Colombes, France
    Am J Pharmacogenomics 4:9-17. 2004
  5. ncbi Rheumatoid arthritis and schizophrenia: a negative association at a dimensional level
    P Gorwood
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, 178 rue des Renouillers, 92700 Colombes, France
    Schizophr Res 66:21-9. 2004
  6. ncbi Reappraisal of the serotonin 5-HT(1B) receptor gene in alcoholism: of mice and men
    Philip Gorwood
    Hopital Louis Mourier, Service de Psychiatrie, Colombes, France
    Brain Res Bull 57:103-7. 2002
  7. ncbi The 5-HT(2A) -1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres
    P Gorwood
    CHU Louis Mourier, Assistance Publique des Hopitaux de Paris, 178, rue des Renouillers 92701 Colombes cedex, France
    Mol Psychiatry 7:90-4. 2002
  8. ncbi Biological markers for suicidal behavior in alcohol dependence
    P Gorwood
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, 178 rue des Renouillers, 92700 Colombes, France
    Eur Psychiatry 16:410-7. 2001
  9. ncbi [From stressful life events to anxiety disorders]
    P Gorwood
    Service du Professeur Adès, Hôpital Louis Mourier AP HP, Colombes
    Rev Prat 49:S11-3. 1999
  10. ncbi [Contribution of genetics to the concept of risk status for alcohol dependence]
    P Gorwood
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, Colombes
    J Soc Biol 194:43-9. 2000

Collaborators

Detail Information

Publications51

  1. ncbi The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia
    Caroline Dubertret
    Service de Psychiatrie Adulte, Faculty of Bichat Claude Bernard, Louis Mourier hospital AP HP, 178 rue des Renouillers, 92701 Colombes Cedex, France
    Schizophr Res 67:75-85. 2004
    ..As the analysis of the other markers within the DRD2 gene does not improve the strength of the association, our data are in favor of a specific role of the 3' chromosomic region of the DRD2 gene in the vulnerability to schizophrenia...
  2. ncbi The genetics of addiction: alcohol-dependence and D3 dopamine receptor gene
    P Gorwood
    Hopital Louis Mourier, Service de Psychiatrie Adultes, 178, rue des Renouillers, 92700 Colombes, France
    Pathol Biol (Paris) 49:710-7. 2001
    ..There is good evidence that gene coding for the dopamine receptor D3 does not play a major role in the genetic vulnerability to alcoholism...
  3. ncbi Generalized anxiety disorder and major depressive disorder comorbidity: an example of genetic pleiotropy?
    P Gorwood
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, CNRS UMR 7593, 178, rue des Renouillers, 92700 Colombes cedex, France
    Eur Psychiatry 19:27-33. 2004
    ....
  4. ncbi Eating disorders, serotonin transporter polymorphisms and potential treatment response
    Philip Gorwood
    Service de Psychiatrie, Hôpital Louis Mourier AP HP, 178 rue des Renouillers, 92700 Colombes, France
    Am J Pharmacogenomics 4:9-17. 2004
    ..SLC6A4 genotyping would allow physicians to individualize selective serotonin reuptake therapy for their patients...
  5. ncbi Rheumatoid arthritis and schizophrenia: a negative association at a dimensional level
    P Gorwood
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, 178 rue des Renouillers, 92700 Colombes, France
    Schizophr Res 66:21-9. 2004
    ....
  6. ncbi Reappraisal of the serotonin 5-HT(1B) receptor gene in alcoholism: of mice and men
    Philip Gorwood
    Hopital Louis Mourier, Service de Psychiatrie, Colombes, France
    Brain Res Bull 57:103-7. 2002
    ....
  7. ncbi The 5-HT(2A) -1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres
    P Gorwood
    CHU Louis Mourier, Assistance Publique des Hopitaux de Paris, 178, rue des Renouillers 92701 Colombes cedex, France
    Mol Psychiatry 7:90-4. 2002
    ..Previous results may have been exposed to stratification bias (which we controlled by the TDT method) and/or the risk of type 1 error (from which we were less exposed because of the sample size)...
  8. ncbi Biological markers for suicidal behavior in alcohol dependence
    P Gorwood
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, 178 rue des Renouillers, 92700 Colombes, France
    Eur Psychiatry 16:410-7. 2001
    ..Considering the complex but significant impact of alcohol on serotonin metabolism and turnover, it is likely that serotonin mediates a large part of the proneness of ethanol to commit impulsive-aggressive behavior...
  9. ncbi [From stressful life events to anxiety disorders]
    P Gorwood
    Service du Professeur Adès, Hôpital Louis Mourier AP HP, Colombes
    Rev Prat 49:S11-3. 1999
    ..Numerous factors are involved in the deleterious effect of a stressful life event, explaining why the modalities of the answer are so dramatically variable between different subjects...
  10. ncbi [Contribution of genetics to the concept of risk status for alcohol dependence]
    P Gorwood
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, Colombes
    J Soc Biol 194:43-9. 2000
    ..Thirdly, the quality of the withdrawal process is partly explained by the existence of a specific genotype of the dopamine transport gene...
  11. ncbi Family-based association study of the serotonin-6 receptor gene (C267T polymorphism) in schizophrenia
    C Dubertret
    Service de Psychiatrie Adultes, Faculty of medicine Bichat Claude Bernard, Hôpital Louis Mourier AP HP, 178 rue des Renouillers, 92701 Colombes Cedex, France
    Am J Med Genet B Neuropsychiatr Genet 126:10-5. 2004
    ..These data do not support the idea that the 5-HT(6) receptor gene plays a major role in the etiopathogenesis of schizophrenia...
  12. ncbi 5-HT(2A) gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa
    A Kipman
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, 178, rue des Renouillers, 92700 Colombes, France
    Eur Psychiatry 17:227-9. 2002
    ..Taking into account vulnerability genes, but also genes modifying the expression of the disorder, will help to disentangle the complexity of the etiological factors involved in anorexia nervosa...
  13. ncbi Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients
    C Dubertret
    Service de Psychiatrie Adulte Pr ADES, Hôpital Louis Mourier AP HP, 178 rue des Renouillers, 92701 Cedex, Colombes, France
    Schizophr Res 49:203-12. 2001
    ..This haplotype may be more specifically involved in the disorder's onset at a later age in some patients, or, alternatively, may be implicated as a modifying factor acting on age of onset...
  14. ncbi Genetics and anorexia nervosa: a review of candidate genes
    P Gorwood
    Psychiatric Department, Hospital Louis Mourier, Colombes, France
    Psychiatr Genet 8:1-12. 1998
    ..Attention is paid to psychological dimensions, clinical symptoms, co-morbidity frequency, pharmacological data, and biological measures that characterize anorexia nervosa...
  15. ncbi The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol-withdrawal seizure
    Philip Gorwood
    Service de Psychiatrie, Hopital Louis Mourier, Assistance Publique Hopitaux de Paris AP HP, Colombes, France
    Biol Psychiatry 53:85-92. 2003
    ..Interestingly, an association was found between the DAT gene (9-copy repeat) and the risk for these symptoms in two previous case-control studies...
  16. ncbi The CNR1 gene as a pharmacogenetic factor for antipsychotics rather than a susceptibility gene for schizophrenia
    Nora Hamdani
    AP HP, Hôpital Louis Mourier Paris VII, Service de Psychiatrie, 178 rue des Renouillers, 92700 Colombes, France
    Eur Neuropsychopharmacol 18:34-40. 2008
    ..The G allele of the CNR1 gene polymorphisms could be a psychopharmacogenetic rather than a vulnerability factor regarding schizophrenia and its treatment...
  17. ncbi Negative symptoms of schizophrenia could explain discrepant data on the association between the 5-HT2A receptor gene and response to antipsychotics
    Nora Hamdani
    Hôpital Louis Mourier AP HP, Service de Psychiatrie, 178 rue des Renouillers, 92700 Colombes, France
    Neurosci Lett 377:69-74. 2005
    ..This data indicate that negative symptoms are worth being systematically assessed in pharmacogenetic studies aimed at analysing candidate genes in schizophrenia...
  18. ncbi Clinical characteristics of familial versus sporadic alcoholism in a sample of male and female patients
    F Limosin
    Service de Psychiatrie, Hopital Louis Mourier, 178 rue des Renouillers, 92701 Colombes Cedex, France
    Eur Psychiatry 16:151-6. 2001
    ....
  19. ncbi Impulsiveness as the intermediate link between the dopamine receptor D2 gene and alcohol dependence
    F Limosin
    Department of Psychiatry, Albert Chenevier Hospital, Creteil, France
    Psychiatr Genet 13:127-9. 2003
    ..For instance, recent evidence in rats showed that DRD2 antagonists might increase impulsivity in decreasing the value of delayed rewards...
  20. ncbi [Alcohol dependence and polymorphisms of serotonin-related genes]
    Philip Gorwood
    Service de Psychiatrie, Hopital Louis Mourier, 178, rue des Renouillers, 92700 Colombes, France
    Med Sci (Paris) 20:1132-8. 2004
    ....
  21. ncbi Family-based association study of the 5-HT transporter gene and schizophrenia
    Caroline Dubertret
    Service de Psychiatrie Adultes, Faculty of medicine Bichat Claude Bernard, Louis Mourier hospital AP HP, Colombes Cedex, France
    Int J Neuropsychopharmacol 8:87-92. 2005
    ..03). As the haplotype analyses did not improve the strength of the association, our data provide convergent evidence for a significant role of the 5-HTTLPR promoter polymorphism of the 5-HTT gene in the vulnerability to schizophrenia...
  22. ncbi The A9 allele of the dopamine transporter gene increases the risk of visual hallucinations during alcohol withdrawal in alcohol-dependent women
    Frederic Limosin
    Department of Psychiatry, Albert Chenevier Hospital, 40 rue de Mesly, F 94000 Creteil, France
    Neurosci Lett 362:91-4. 2004
    ..Our results suggest that the A9 allele of the DAT gene is involved in vulnerability to alcohol withdrawal complications in women, but that these complications differ from those associated with this polymorphism in alcohol-dependent men...
  23. ncbi Association between dopamine receptor D1 gene DdeI polymorphism and sensation seeking in alcohol-dependent men
    Frederic Limosin
    Department of Psychiatry, Albert Chenevier Hospital, France
    Alcohol Clin Exp Res 27:1226-8. 2003
    ..Moreover, it is suggested that higher levels of sensation seeking could be associated with a modification of sensitivity to dopamine in postsynaptic receptors...
  24. ncbi Male limited association of the dopamine receptor D2 gene TaqI a polymorphism and alcohol dependence
    Frederic Limosin
    Service de Psychiatrie du Pr Rouillon, Hôpital Albert Chenevier AP HP, Creteil, France
    Am J Med Genet 112:343-6. 2002
    ..Recent evidence for gender difference in dopamine D2-like receptor levels and affinity may explain this discrepancy...
  25. doi [Comorbid addictions in bipolar disorder]
    P Gorwood
    AP HP CHU Louis Mourier, Service de Psychiatrie du Pr Ades, 178 rue des Renouillers, Colombes
    Encephale 34:S138-42. 2008
  26. ncbi Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk
    Beatrice Bonnier
    Hôpital Mignot, Service de Psychiatrie, Le Chesney, France
    Biol Psychiatry 51:762-5. 2002
    ..The implication of serotonin in suicide and affective disease explains why the 5-HT(2A) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results...
  27. ncbi The role of brief motivational intervention on self-efficacy and abstinence in a cohort of patients with alcohol dependence
    Lucia Romo
    Hôpital Louis Mourier AP HP, and Université Paris X Nanterre, France
    Int J Psychiatry Med 39:313-23. 2009
    ..Brief interventions are effective in reducing heavy drinking in the general population but few studies examined whether it is also effective in alcohol dependent patients, and whether brief intervention increases self-efficacy...
  28. ncbi Meeting everyday challenges: antipsychotic therapy in the real world
    Philip Gorwood
    AP HP, Hopital Louis Mourier, Colombes, France
    Eur Neuropsychopharmacol 16:S156-62. 2006
    ..Such naturalistic studies will continue to provide important data on the real-world effectiveness of atypical antipsychotics with respect to key outcomes such as treatment continuation and prolonged recovery...
  29. ncbi The human genetics of anorexia nervosa
    Philip Gorwood
    Service de Psychiatrie, Hôpital Louis Mourier AP HP, 178 rue des Renouillers, 92700, Colombes, France
    Eur J Pharmacol 480:163-70. 2003
    ..In order to explain the high heterogeneity between the nine studies yet performed, an alternative explanation such as a "modifying the phenotype" effect is proposed...
  30. doi Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism
    Gilles Maussion
    INSERM U675, IFR2, Faculte de Medecine Xavier Bichat, Universite Denis Diderot Paris 7, Paris, France
    Hum Mol Genet 17:2541-51. 2008
    ..As expected for a gene encoding a key polarity determinant Par-1 protein kinase, MARK1 is involved in axon-dendrite specification. Thus, MARK1 overexpression in humans may be responsible for subtle changes in dendritic functioning...
  31. pmc Excess of transmission of the G allele of the -1438A/G polymorphism of the 5-HT2A receptor gene in patients with schizophrenia responsive to antipsychotics
    Dalila Benmessaoud
    Etablissement Hospitalier Spécialisé Psychiatrique M Boucebci Cheraga, Alger, Algeria
    BMC Psychiatry 8:40. 2008
    ....
  32. doi The short allele of the serotonin transporter promoter polymorphism influences relapse in alcohol dependence
    Emmanuel Pinto
    Department of Psychiatry, University of Liege, CHU Sart Tilman B35, B 4000 Liege, Belgium
    Alcohol Alcohol 43:398-400. 2008
    ..The short (S) allele of the serotonin transporter gene promoter polymorphism (5-HTTLPR) contributes to the risk of alcohol dependence and co-occurring clinical features. We studied the putative link between this allele and relapse...
  33. doi Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders
    Josep Maria Mercader
    Genes and Disease Program, Center for Genomic Regulation, 08003 Barcelona, Catalonia, Spain
    Hum Mol Genet 17:1234-44. 2008
    ..The reported data, in addition to the previous reported findings for BDNF and NTRK2, point neurotrophin signaling genes as key regulators of eating behavior and their altered cross-regulation as susceptibility factors for EDs...
  34. ncbi The 3' part of the dopamine transporter gene DAT1/SLC6A3 is associated with withdrawal seizures in patients with alcohol dependence
    Yann Le Strat
    INSERM U675, IFR02, Faculté de Médecine Xavier Bichat Université, Henri Huchard, Paris, France
    Alcohol Clin Exp Res 32:27-35. 2008
    ..We investigated whether polymorphisms within the DAT1 gene are associated with WS taking into account some of the confounding factors such as the severity of alcohol dependence...
  35. ncbi Eating disorders: an overview of treatment responses and the potential impact of vulnerability genes and endophenotypes
    Nicolas Ramoz
    1INSERM U675, Universite Paris 7, IFR02, Faculte de Medecine Xavier Bichat, Paris, France
    Expert Opin Pharmacother 8:2029-44. 2007
    ....
  36. doi Toxic effects of depression on brain function: impairment of delayed recall and the cumulative length of depressive disorder in a large sample of depressed outpatients
    Philip Gorwood
    INSERM U675, Faculty of Medicine Bichat IFR02, 16 rue Henri Huchard, 75018 Paris, France
    Am J Psychiatry 165:731-9. 2008
    ..The purpose of this study was to assess the generalizability of the impact of depression on hippocampal function...
  37. ncbi Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations
    Marta Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
    Hum Mol Genet 13:1205-12. 2004
    ..These are the first two variants associated with the pathophysiology of ED in different populations and support a role for BDNF in the susceptibility to aberrant eating behaviors...
  38. ncbi Clinical and etiopathogenic specificities of the French concept of psychose hallucinatoire chronique compared to schizophrenia
    Caroline Dubertret
    INSERM U288, Faculty of Pitié Salpétrière Hospital, Paris, France
    Schizophr Bull 30:173-84. 2004
    ..This study provides evidence that PHC may be a possible diagnosis in clinical practice, although it is difficult to reach a conclusion on its relationship with schizophrenia...
  39. ncbi Male-specific association between the 5-HTTLPR S allele and suicide attempts in alcohol-dependent subjects
    Frederic Limosin
    Department of Psychiatry, Albert Chenevier Hospital, 40, rue de Mesly, F 94000 Creteil, France
    J Psychiatr Res 39:179-82. 2005
    ..05). There seems to be an allelic association between the 5-HTTLPR S allele and suicidal behavior in alcohol-dependent subjects, but this relationship is restricted to male subjects...
  40. ncbi Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations
    Marta Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
    Eur J Hum Genet 13:428-34. 2005
    ..These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI...
  41. ncbi Case-control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosa
    Elena Cellini
    Department of Neurology and Psychiatric Sciences, University of Florence, Florence, Italy
    Psychiatr Genet 16:51-2. 2006
  42. ncbi Lifetime positive symptoms in patients with schizophrenia and cannabis abuse are partially explained by co-morbid addiction
    Caroline Dubertret
    INSERM U675, Institut Fédératif de Recherche IFR 02, Faculty of Xavier Bichat 16 rue Henri Huchard, 75018 Paris, France
    Schizophr Res 86:284-90. 2006
    ..Distinguishing the effects of co-occurring addictive disorder(s) in patients with schizophrenia and cannabis dependence may thus be important when attempting to analyse the impact of cannabis abuse...
  43. ncbi Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset
    Roland M Dardennes
    Universite Paris Descartes, Faculte de Medecine, Hopital Sainte Anne, 1 rue Cabanis, 75674 Paris Cedex 14, France
    Psychoneuroendocrinology 32:106-13. 2007
    ....
  44. doi [Role of genetics in psychiatric treatment]
    Nora Hamdani
    INSERM U675, Faculte Xavier Bichat, F 75018 Paris, France
    Presse Med 37:902-11. 2008
    ..Psychopharmacogenetic studies currently assess patients' capacity for acetylation or detoxification, coded by the NAT gene, whose genetic variants affect the metabolism of many psychotropic drugs...
  45. ncbi Life events exposure before a treated major depressive episode depends on the number of past episodes
    Emmanuelle Corruble
    Department of Psychiatry, Assistance Publique Hopitaux de Paris, Bicetre University Hospital, INSERM U 669, Paris XI University, 78 rue du General Leclerc, 94230 Le Kremlin Bicêtre, France
    Eur Psychiatry 21:364-6. 2006
    ..A linear decline of average life events exposure is observed for more frequent past episodes, even when age, gender and severity are taken into account...
  46. doi Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction
    Sabah Kelai
    INSERM U675, School of Medicine Xavier Bichat, University Denis Diderot, Paris VII, France
    Neuroreport 19:751-5. 2008
    ..Thus, NRXN3 adhesion molecules may play an important role in the synaptic plasticity of neurons involved in the indirect pathways of basal ganglia, in which they regulate reward-related learning...
  47. ncbi Clinical assessment in psychiatric genetics
    Philip Gorwood
    Service de Psychiatrie Pr Ades, Hôpital Louis Mourier 92700 Colombes, France
    Methods Mol Med 77:99-126. 2003
  48. ncbi Nrsf silencing induces molecular and subcellular changes linked to neuronal plasticity
    Aude Marie Lepagnol-Bestel
    INSERM 675, IFRO2, Faculte de Medecine Xavier Bichat, Universite Paris, Paris, France
    Neuroreport 18:441-6. 2007
    ..These genes are bona fide candidates known to be involved in dendrite and axonal outgrowth. This approach could be adapted to high-throughput techniques for determination of the mammalian neurite outgrowth gene repertoire...
  49. ncbi Escitalopram prevents relapse in older patients with major depressive disorder
    Philip Gorwood
    From INSERM U675, Paris, France
    Am J Geriatr Psychiatry 15:581-93. 2007
    ..The present study investigated the efficacy and tolerability of escitalopram in the prevention of relapse of major depressive disorder (MDD) in older patients who had responded to acute treatment with escitalopram...
  50. ncbi Gene-environment interactions in addictive disorders: epidemiological and methodological aspects
    Philip Gorwood
    INSERM U675, Institut Fédératif de Recherche IFR 02, Faculte Xavier Bichat, 16, rue Henri Huchard, 75018 Paris, France
    C R Biol 330:329-38. 2007
    ..e. more efficient, prevention strategies...