Christo Goridis

Summary

Country: France

Publications

  1. ncbi request reprint Specification of catecholaminergic and serotonergic neurons
    Christo Goridis
    CNRS UMR 8542, Departement de Biologie, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Nat Rev Neurosci 3:531-41. 2002
  2. doi request reprint Phox2b, congenital central hypoventilation syndrome and the control of respiration
    Christo Goridis
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Semin Cell Dev Biol 21:814-22. 2010
  3. doi request reprint Central chemoreception: lessons from mouse and human genetics
    Christo Goridis
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Respir Physiol Neurobiol 173:312-21. 2010
  4. doi request reprint Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons
    Veronique Dubreuil
    Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 29:14836-46. 2009
  5. ncbi request reprint Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype
    Marie Rose Hirsch
    CNRS UMR 8542 Ecole normale supérieure, 46 rue d Ulm, 75005 Paris, France
    Dev Biol 303:687-702. 2007
  6. doi request reprint PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models
    Jeanne Amiel
    INSERM U781, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Respir Physiol Neurobiol 168:125-32. 2009
  7. doi request reprint In Vitro studies of non poly alanine PHOX2B mutations argue against a loss-of-function mechanism for congenital central hypoventilation
    Delphine Trochet
    INSERM U781 et Département de Génétique, Hopital Necker Enfants Malades, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Hum Mutat 30:E421-31. 2009
  8. pmc Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors
    Patrick Pla
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Neural Dev 3:14. 2008
  9. pmc A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons
    Veronique Dubreuil
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Proc Natl Acad Sci U S A 105:1067-72. 2008
  10. doi request reprint A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics
    Marie Rose Hirsch
    Institut de Biologie de l Ecole Normale Supérieure IBENS, CNRS UMR8197, Inserm U1024, 75005, Paris, France
    Genesis 51:506-14. 2013

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Specification of catecholaminergic and serotonergic neurons
    Christo Goridis
    CNRS UMR 8542, Departement de Biologie, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Nat Rev Neurosci 3:531-41. 2002
    ..Another is that most factors that specify neurotransmitter identity also control other features of the neuronal phenotype...
  2. doi request reprint Phox2b, congenital central hypoventilation syndrome and the control of respiration
    Christo Goridis
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Semin Cell Dev Biol 21:814-22. 2010
    ..Such knowledge will enable new genetic approaches towards elucidating how respiratory networks are assembled and configured in normal and pathological conditions...
  3. doi request reprint Central chemoreception: lessons from mouse and human genetics
    Christo Goridis
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Respir Physiol Neurobiol 173:312-21. 2010
    ....
  4. doi request reprint Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons
    Veronique Dubreuil
    Departement de Biologie, Ecole Normale Superieure, 75005 Paris, France
    J Neurosci 29:14836-46. 2009
    ..Together, our results provide genetic evidence for the essential role of the Phox2b-expressing RTN neurons both in establishing a normal respiratory rhythm before birth and in providing chemosensory drive...
  5. ncbi request reprint Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype
    Marie Rose Hirsch
    CNRS UMR 8542 Ecole normale supérieure, 46 rue d Ulm, 75005 Paris, France
    Dev Biol 303:687-702. 2007
    ..Hence, Phox2 expression is a key step in determining the peripheral axonal phenotype and thus the decision to stay within the neural tube or to project out of it...
  6. doi request reprint PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models
    Jeanne Amiel
    INSERM U781, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Respir Physiol Neurobiol 168:125-32. 2009
    ..To date, the reason for the selective vulnerability of RTN/pFRG neurons to PHOX2B protein dysfunction remains unexplained...
  7. doi request reprint In Vitro studies of non poly alanine PHOX2B mutations argue against a loss-of-function mechanism for congenital central hypoventilation
    Delphine Trochet
    INSERM U781 et Département de Génétique, Hopital Necker Enfants Malades, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Hum Mutat 30:E421-31. 2009
    ..Therefore, PHOX2B misfolding is not the only mechanism leading to dysfunction of the ventilatory autonomic system...
  8. pmc Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors
    Patrick Pla
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Neural Dev 3:14. 2008
    ..How Phox2b exerts its pleiotropic functions, both as a proneural gene and a neuronal subtype determinant, has remained unknown...
  9. pmc A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons
    Veronique Dubreuil
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Proc Natl Acad Sci U S A 105:1067-72. 2008
    ....
  10. doi request reprint A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics
    Marie Rose Hirsch
    Institut de Biologie de l Ecole Normale Supérieure IBENS, CNRS UMR8197, Inserm U1024, 75005, Paris, France
    Genesis 51:506-14. 2013
    ....
  11. doi request reprint Homozygous mutation of the PHOX2B gene in congenital central hypoventilation syndrome (Ondine's Curse)
    Delphine Trochet
    Université Paris 5 Descartes, INSERM U 781, AP HP, Hopital Necker Enfant Malades, Paris, France
    Hum Mutat 29:770. 2008
    ..This observation adds the concept of mutational threshold per se to the discussion about dominant and recessive alleles...
  12. pmc Breathing with phox2b
    Veronique Dubreuil
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Philos Trans R Soc Lond B Biol Sci 364:2477-83. 2009
    ..Together with the previously established Phox2b dependency of other respiratory neurons (which we review briefly here), our new data highlight a key role of this transcription factor in setting up the circuits for breathing automaticity...
  13. ncbi request reprint Ascl1/Mash1 is required for the development of central serotonergic neurons
    Alexandre Pattyn
    CNRS UMR 8542, Ecole Normale Superieure, 75005 Paris, France
    Nat Neurosci 7:589-95. 2004
    ..Thus Ascl1, which is essential for noradrenergic differentiation, is also a determinant of the serotonergic phenotype...
  14. pmc Generation and characterization of Rgs4 mutant mice
    Nicolas Grillet
    CNRS UMR 8542, Department of Biology, Ecole Normale Superieure, 46 rue d Ulm, 75005, Paris, France
    Mol Cell Biol 25:4221-8. 2005
    ....
  15. ncbi request reprint The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis
    Veronique Dubreuil
    CNRS UMR 8542, Departement de Biologie, Ecole Normale Superieure, 46, rue d Ulm, 75230 Paris Cedex 05, France
    Development 129:5241-53. 2002
    ..These results provide insights into the mechanisms by which a homeodomain transcription factor through interaction with other factors controls both generic and type-specific features of neuronal differentiation...
  16. ncbi request reprint Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction
    Delphine Trochet
    Universite Paris Descartes, Faculté de Médecine INSERM AP HP, Hopital Necker Enfants Malades, INSERM U 393, Paris, France
    Hum Mol Genet 14:3697-708. 2005
    ..Such a tendency to protein misfolding could explain loss of transactivation for alanine expansion mutations. However, additional mechanisms such as toxic gain-of-function may play a role in the pathogenic process...
  17. pmc Precraniate origin of cranial motoneurons
    Héloïse D Dufour
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Proc Natl Acad Sci U S A 103:8727-32. 2006
    ..These data unveil that the postmetamorphic ascidian brain, assumed to be a derived feature, in fact corresponds to the vertebrate hindbrain and push back the evolutionary origin of cranial nerves to before the origin of craniates...
  18. pmc Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation
    Eva Coppola
    TIGEM Telethon Institute of Genetics and Medicine, Napoli, Italy, and MRC Centre for Developmental Neurobiology, King s College Guy s Campus, London, UK
    EMBO J 24:4392-403. 2005
    ..Therefore, our analysis strongly indicates that biochemical differences between the proteins rather than temporal regulation of their expression account for the specific function of each paralogue...
  19. ncbi request reprint The role of Phox2B in chromaffin cell development
    Katrin Huber
    Neuroanatomy, Interdisciplinary Center for Neurosciences, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Dev Biol 279:501-8. 2005
    ..5. We conclude that Phox2B regulates very early events in the differentiation of adrenal chromaffin cells distinct to steps, which essentially require MASH-1...