Francois A Giuliano

Summary

Country: France

Publications

  1. ncbi Impact of medical treatments for benign prostatic hyperplasia on sexual function
    Francois Giuliano
    Academic Hospital of Bicêtre, University of Paris South, France
    BJU Int 97:34-8; discussion 44-5. 2006
  2. doi Combination of alfuzosin and tadalafil exerts in vitro an additive relaxant effect on human corpus cavernosum
    Stephanie Oger
    Pelvipharm, Paris, France
    J Sex Med 5:935-45. 2008
  3. ncbi Neural control of erection
    Francois Giuliano
    PELVIPHARM Laboratoire, Domaine CNRS, Bat 5, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Physiol Behav 83:189-201. 2004
  4. ncbi [Male sexual dysfunction and its treatment in neurourology]
    F Giuliano
    Service de Medecine Physique et de Readaptation, Raymond Poincaré, Université Versailles Saint Quentin en Yvelines, Garches, France
    Prog Urol 17:619-21. 2007
  5. doi Tadalafil once daily improves ejaculatory function, erectile function, and sexual satisfaction in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia and erectile dysfunction: results from a randomized, placebo- and tamsulosin
    Francois Giuliano
    Neuro Uro Andrology Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    J Sex Med 10:857-65. 2013
  6. doi The mechanism of action of phosphodiesterase type 5 inhibitors in the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia
    Francois Giuliano
    Neuro Uro Andrology Department of Physical Medicine and Rehabilitation, Raymond Poincaré Academic Hospital, Garches, Versailles Saint Quentin en Yvelines University, Garches, France
    Eur Urol 63:506-16. 2013
  7. doi Pharmacology for the treatment of premature ejaculation
    Francois Giuliano
    Service de Medecine Physique et de Readaptation, Hopital Raymond Poincare, 104 Bd Raymond Poincaré, 92380 Garches, France
    Pharmacol Rev 64:621-44. 2012
  8. doi The pharmacological treatment of premature ejaculation
    Francois Giuliano
    Department of Physical Medicine andRehabilitation, AP HP, Raymond Poincare Hospital, Garches, France
    BJU Int 102:668-75. 2008
  9. ncbi Hemodynamic interaction study between the alpha1-blocker alfuzosin and the phosphodiesterase-5 inhibitor tadalafil in middle-aged healthy male subjects
    Francois Giuliano
    Neuro urology unit, Department of Neurological Rehabilitation, Raymond Poincare Hospital, Garches, France
    Urology 67:1199-204. 2006
  10. ncbi Efficacy and safety of vardenafil in men with erectile dysfunction caused by spinal cord injury
    F Giuliano
    Department of Urology, Academic Hospital of Bicêtre, Le Kremlin Bicetre, France
    Neurology 66:210-6. 2006

Collaborators

Detail Information

Publications75

  1. ncbi Impact of medical treatments for benign prostatic hyperplasia on sexual function
    Francois Giuliano
    Academic Hospital of Bicêtre, University of Paris South, France
    BJU Int 97:34-8; discussion 44-5. 2006
    ..In conclusion, because treatment options for managing BPH have different effects on sexuality, the sexual dimension should be considered when assessing patients' expectations and the choice of treatment...
  2. doi Combination of alfuzosin and tadalafil exerts in vitro an additive relaxant effect on human corpus cavernosum
    Stephanie Oger
    Pelvipharm, Paris, France
    J Sex Med 5:935-45. 2008
    ..Aim. Evaluation of the effect of alfuzosin, tadalafil or the combination of both on human corpus cavernosum...
  3. ncbi Neural control of erection
    Francois Giuliano
    PELVIPHARM Laboratoire, Domaine CNRS, Bat 5, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Physiol Behav 83:189-201. 2004
    ..Pro-erectile effects of phosphodiesterase type 5 inhibitors, acting in the penis, and of melanocortin agonists, acting in the brain, illustrate these recent developments...
  4. ncbi [Male sexual dysfunction and its treatment in neurourology]
    F Giuliano
    Service de Medecine Physique et de Readaptation, Raymond Poincaré, Université Versailles Saint Quentin en Yvelines, Garches, France
    Prog Urol 17:619-21. 2007
    ..This article presents the disorders most frequently encountered in spinal cord injury and the main approaches to management...
  5. doi Tadalafil once daily improves ejaculatory function, erectile function, and sexual satisfaction in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia and erectile dysfunction: results from a randomized, placebo- and tamsulosin
    Francois Giuliano
    Neuro Uro Andrology Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    J Sex Med 10:857-65. 2013
    ....
  6. doi The mechanism of action of phosphodiesterase type 5 inhibitors in the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia
    Francois Giuliano
    Neuro Uro Andrology Department of Physical Medicine and Rehabilitation, Raymond Poincaré Academic Hospital, Garches, Versailles Saint Quentin en Yvelines University, Garches, France
    Eur Urol 63:506-16. 2013
    ....
  7. doi Pharmacology for the treatment of premature ejaculation
    Francois Giuliano
    Service de Medecine Physique et de Readaptation, Hopital Raymond Poincare, 104 Bd Raymond Poincaré, 92380 Garches, France
    Pharmacol Rev 64:621-44. 2012
    ..Anesthetics applied on the glans penis have the ability to lengthen the time to ejaculation. Targeting oxytocinergic, neurokinin-1, dopaminergic, and opioid receptors represent future avenues to delaying ejaculation...
  8. doi The pharmacological treatment of premature ejaculation
    Francois Giuliano
    Department of Physical Medicine andRehabilitation, AP HP, Raymond Poincare Hospital, Garches, France
    BJU Int 102:668-75. 2008
    ..Phosphodiesterase-5 inhibitors have also been evaluated for treating PE, as have topical anaesthetics and the narcotic analgesic tramadol...
  9. ncbi Hemodynamic interaction study between the alpha1-blocker alfuzosin and the phosphodiesterase-5 inhibitor tadalafil in middle-aged healthy male subjects
    Francois Giuliano
    Neuro urology unit, Department of Neurological Rehabilitation, Raymond Poincare Hospital, Garches, France
    Urology 67:1199-204. 2006
    ..PDE-5 inhibitors are the first-line treatment of choice for erectile dysfunction. When co-administered with alpha1-blockers, PDE-5 inhibitors could induce orthostatic hypotension...
  10. ncbi Efficacy and safety of vardenafil in men with erectile dysfunction caused by spinal cord injury
    F Giuliano
    Department of Urology, Academic Hospital of Bicêtre, Le Kremlin Bicetre, France
    Neurology 66:210-6. 2006
    ..To assess the efficacy and tolerability of vardenafil in men with erectile dysfunction (ED) due to traumatic spinal cord injury (SCI)...
  11. ncbi L6-S1 spinal nerve stimulation reduces micturition frequency in anaesthetized rats with cyclophosphamide-induced cystitis
    Francois A Giuliano
    Pelvipharm Laboratories, CNRS, Gif sur Yvette, AP HP, Raymond Poincare Hospital, Garches, France
    BJU Int 97:386-92. 2006
    ....
  12. ncbi Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat
    F Giuliano
    Pelvipharm Laboratories, CNRS, Bat 5, Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Neuroscience 138:293-301. 2006
    ..These results lead to the conclusion that central and peripheral melanocortin pathways are recruited by melanotan-II, depending on its route of delivery, to exert both inducer and facilitator activities on erection...
  13. ncbi Neuroanatomy and physiology of ejaculation
    Francois Giuliano
    Pelvipharm Laboratories, Neuro urology unit, Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    Annu Rev Sex Res 16:190-216. 2005
    ....
  14. ncbi Physiology of ejaculation: emphasis on serotonergic control
    Francois Giuliano
    Pelvipharm, Domaine CNRS, Gif sur Yvette, France
    Eur Urol 48:408-17. 2005
    ..In this perspective, the use of selective serotonin reuptake inhibitors (SSRIs) which basically increase the amount of central 5-HT and delay ejaculation in humans seems promising...
  15. ncbi The use of telemetry technology to test the proerectile effect of melanotan-II (MT-II) in conscious rats
    F Giuliano
    Pelvipharm Laboratories, CNRS, Bat 5, 1 Avenue de la Terrasse, 91190, Gif sur Yvette, France
    Eur Urol 48:145-51; discussion 151-2. 2005
    ....
  16. ncbi Serotonin and premature ejaculation: from physiology to patient management
    Francois Giuliano
    Pelvipharm Laboratories, Gif sur Yvette, France
    Eur Urol 50:454-66. 2006
    ..The aims of this paper are to provide a scientific and pharmacologic rationale, and to discuss to what extent selective serotonin reuptake inhibitors (SSRIs) can help patients with PE...
  17. ncbi Comparison between tamsulosin and alfuzosin on the expulsion phase of ejaculation in rats
    Francois A Giuliano
    Pelvipharm Laboratories, CNRS, Gif sur Yvette, France
    BJU Int 98:876-9. 2006
    ....
  18. doi Vardenafil improves ejaculation success rates and self-confidence in men with erectile dysfunction due to spinal cord injury
    Francois Giuliano
    AP HP, Neuro Uro Andrology, Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    Spine (Phila Pa 1976) 33:709-15. 2008
    ..Multicenter, double-blind, placebo-controlled, parallel-group study...
  19. ncbi Efficacy and safety of tadalafil in men with erectile dysfunction following spinal cord injury
    Francois Giuliano
    Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Arch Neurol 64:1584-92. 2007
    ..To determine the efficacy and safety of tadalafil when taken on demand by men with erectile dysfunction (ED) secondary to traumatic spinal cord injury (SCI)...
  20. ncbi [Oral pharmacological treatments for sphincteric dysfunction in neurourology]
    F Giuliano
    Service de Medecine Physique et de Readaptation, Raymond Poincaré, Université Versailles Saint Quentin en Yvelines, Garches, France
    Prog Urol 17:510-1. 2007
    ..The few treatments that induce sphincter relaxation are not sufficient to justify a routine therapeutic indication...
  21. ncbi Premature ejaculation: results from a five-country European observational study
    Francois Giuliano
    Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    Eur Urol 53:1048-57. 2008
    ..To characterize premature ejaculation (PE) in five European countries using intravaginal ejaculatory latency time (IELT) and the Premature Ejaculation Profile (PEP)...
  22. ncbi Editorial comment on: Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use
    Francois Giuliano
    Neuro Urology Andrology Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    Eur Urol 52:563-4. 2007
  23. ncbi How urologists manage erectile dysfunction after radical prostatectomy: a national survey (REPAIR) by the French urological association
    Francois Giuliano
    AP HP, Raymond Poincare Hospital, Garches, France
    J Sex Med 5:448-57. 2008
    ..There is little sound information on how urologists manage erectile dysfunction (ED) arising after radical prostatectomy (RP) in a real-world situation...
  24. ncbi 5-Hydroxytryptamine in premature ejaculation: opportunities for therapeutic intervention
    Francois Giuliano
    AP HP, Neuro Uro Andrology Unit, Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, 104 Bd Raymond Poincaré, 92380 Garches, France
    Trends Neurosci 30:79-84. 2007
    ..However, a new short-acting SSRI is effective 'on demand' and might represent the first of a new generation of therapies targeted to premature ejaculation...
  25. ncbi Effect of acute dapoxetine administration on the pudendal motoneuron reflex in anesthetized rats: comparison with paroxetine
    F Giuliano
    Pelvipharm Laboratories, Gif sur Yvette, France
    J Urol 177:386-9. 2007
    ..Dapoxetine was compared with paroxetine, the selective serotonin reuptake inhibitor of reference...
  26. doi Lower urinary tract symptoms and sexual dysfunction: a common approach
    Francois Giuliano
    Neuro Uro Andrology, Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    BJU Int 101:22-6. 2008
    ..Further research is warranted to establish the value of this combination therapy in LUTS and ED...
  27. doi [Impact of the pharmacokinetic properties of PDE5 inhibitors on the dose/sexual intercourse interval]
    F Giuliano
    Neuro andro urologie, Service de médecine physique et de rééducation, Hopital Raymond Poincare, AP HP, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Prog Urol 18:536-42. 2008
    ....
  28. ncbi Vardenafil is effective and well-tolerated for treating erectile dysfunction in a broad population of men, irrespective of age
    Francois Giuliano
    Department of Urology, CHU de Bicetre, AP HP, 78 rue du General Leclerc, 94272 Le Kremlin Bicêtre Cedex, France
    BJU Int 95:110-6. 2005
    ..To assess the efficacy and safety of vardenafil in the treatment of erectile dysfunction (ED) in men of different age groups...
  29. ncbi Neurophysiology and pharmacology of female genital sexual response
    Francois Giuliano
    Groupe de Recherche en Urologie, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    J Sex Marital Ther 28:101-21. 2002
    ....
  30. ncbi Apomorphine SL (Uprima): preclinical and clinical experiences learned from the first central nervous system-acting ED drug
    F Giuliano
    Department of Urology, CHU de Bicetre, Assistance Publique Hopitaux de Paris, France
    Int J Impot Res 14:S53-6. 2002
    ..New centrally acting therapy for ED should concentrate on receptor targets more specific to erectile command. Clinical efficacy of new centrally-acting compounds will assess the well-founded purpose of this rationalization...
  31. ncbi Dopamine and male sexual function
    F Giuliano
    Groupe de Recherche en Urologie, UPRES, EA 1602, Medical University of Paris South, Le Kremlin Bicetre, France
    Eur Urol 40:601-8. 2001
    ..In conclusion, central dopamine is a key neurotransmitter in the control of sexual function...
  32. ncbi Efficacy results and quality-of-life measures in men receiving sildenafil citrate for the treatment of erectile dysfunction
    F Giuliano
    Department of Urology, CHU de Bicetre, AP HP, Le Kremlin Bicetre, France
    Qual Life Res 10:359-69. 2001
    ..05) following treatment with sildenafil. Thus, treatment of ED with sildenafil can significantly improve key QoL parameters related to sexual dysfunction and general mental health...
  33. ncbi Central noradrenergic control of penile erection
    F Giuliano
    Service d Urologie, CHU de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, France
    Int J Impot Res 12:S13-19. 2000
    ..Taken together, the data propose new directions in the physiological exploration of penile erection and the therapeutic approach of erectile dysfunction...
  34. ncbi Dopamine and sexual function
    F Giuliano
    Groupe de Recherche en Urologie, UPRES, Medical University of Paris South, France
    Int J Impot Res 13:S18-28. 2001
    ..The counterpart of such regulation of the genital arousal by dopamine has not yet been established in females. In conclusion, the central dopaminergic system is a key element of the control of sexual function...
  35. ncbi Spinal proerectile effect of apomorphine in the anesthetized rat
    F Giuliano
    Groupe de Recherche en Urologie, UPRES, 1602 EA, Medical University of Paris South, France
    Int J Impot Res 13:110-5. 2001
    ..v. apomorphine. These results suggest the existence of a spinal site of action for apomorphine which may (1) participate to generation of erection and (2) exerts a facilitator effect on erection of supraspinal origin...
  36. ncbi Spinal proerectile effect of oxytocin in anesthetized rats
    F Giuliano
    Groupe de Recherche en Urologie, UPRES EA1602, Faculte de Medecine Paris Sud, 94270 Le Kremlin Bicetre, France
    Am J Physiol Regul Integr Comp Physiol 280:R1870-7. 2001
    ..They suggest that OT, released on physiological activation of the PVN in a sexually relevant context, is a potent activator of spinal proerectile neurons...
  37. ncbi Central control of erection and its pharmacological modification
    F Giuliano
    Department of Urology, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, France
    Curr Opin Urol 10:629-33. 2000
    ..New strategies to treat erectile dysfunction employ oral agents, some of which target central brain nuclei. The future of such treatments largely depends on a better understanding of the central mechanisms of penile erection...
  38. ncbi Central nervous system agents in the treatment of erectile dysfunction: how do they work?
    J Allard
    Department of Urology, CHU de Bicetre, 78 rue du General Leclerc, 94270 Le Kremlin Bicêtre cedex, France
    Curr Urol Rep 2:488-94. 2001
    ..Our knowledge of the mode of action of CNS drugs comes mainly from experiments on rodents. Consequently, explanations regarding the way they work in humans are only speculative...
  39. doi Neurophysiology of erection and ejaculation
    Francois Giuliano
    Department of Physical Medicine and Rehabilitation, Raymond Poincaré Academic Hospital, Garches, Versailles Saint Quentin en Yvelines University, Garches, France
    J Sex Med 8:310-5. 2011
    ..Ejaculation represents the climax of the sexual cycle and comprises emission (secretion of semen) and expulsion (propulsion of semen) phases...
  40. ncbi Prevalence of erectile dysfunction in France: results of an epidemiological survey of a representative sample of 1004 men
    Francois Giuliano
    Service d Urologie, CHU de Bicetre, 78 rue du General Leclerc, 94270 Le Kremlin Bicetre, France
    Eur Urol 42:382-9. 2002
    ..Several recent studies have reported prevalence rates for erectile dysfunction (ED) displaying considerable variation from country to country. We report here the results of a survey carried out in France in 2001...
  41. doi New horizons in erectile and endothelial dysfunction research and therapies
    F Giuliano
    Neuro Urology Andrology, Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    Int J Impot Res 20:S2-8. 2008
    ..Furthermore, in the general population and in men with diabetes or obesity, ED may be a valuable early marker for serious subclinical CVD, coronary artery disease and atherosclerosis...
  42. pmc Safety of sildenafil citrate: review of 67 double-blind placebo-controlled trials and the postmarketing safety database
    F Giuliano
    AP HP, Neuro Uro Andrology, Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    Int J Clin Pract 64:240-55. 2010
    ..To review special safety topics associated with sildenafil and to document the tolerability of 50- and 100-mg doses, overall and by age, in men with erectile dysfunction (ED)...
  43. doi A placebo-controlled exploratory study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369,003 for the treatment of men with storage lower urinary tract symptoms associated with a clinical diagnosis of overactive bladder
    Francois A Giuliano
    Department of Physical Medicine and Rehabilitation, Raymond Poincare Hospital, Garches, France
    BJU Int 106:666-73. 2010
    ..To evaluate the efficacy and safety of the phosphodiesterase type 5 inhibitor, UK-369,003 modified release (MR), for the treatment of storage lower urinary tract symptoms (LUTS) in men with and without erectile dysfunction (ED)...
  44. ncbi Control of penile erection by the melanocortinergic system: experimental evidences and therapeutic perspectives
    Francois Giuliano
    Department of Urology, CHU de Bicetre, 78 rue du General Leclerc, 94270 Le Kremlin Bicêtre cedex, France
    J Androl 25:683-91. 2004
  45. ncbi A comparison of the effects of tamsulosin and alfuzosin on neurally evoked increases in bladder neck and seminal vesicle pressure in rats
    F Giuliano
    Pelvipharm Laboratories, CNRS, Gif sur Yvette, France
    BJU Int 93:605-8. 2004
    ....
  46. ncbi Pro-erectile effect of vardenafil: in vitro experiments in rabbits and in vivo comparison with sildenafil in rats
    F Giuliano
    Pelvipharm Laboratories, CNRS Bat 5, 1 Avenue de la Terrasse, 91140 Gif sur Yvette, France
    Eur Urol 44:731-6. 2003
    ..To assess pro-erectile responses to vardenafil, a new selective PDE5 inhibitor, in vitro in isolated rabbit corpora cavernosa, and in vivo in anaesthetized rats...
  47. doi Experimental models for the study of female and male sexual function
    Francois Giuliano
    Raymond Poincare Hospital, Department of Physical Medicine and Rehabilitation, Garches, France
    J Sex Med 7:2970-95. 2010
    ..Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models...
  48. ncbi Central neural regulation of penile erection
    F Giuliano
    Service d Urologie, CHU de Bicetre, Assistance Publique Hopitaux de Paris, F 94270 Cedex, Le Kremlin Bicetre, France
    Neurosci Biobehav Rev 24:517-33. 2000
    ..Finally, the central and spinal role of regulatory peptides (oxytocin, melanocortins, endorphins) has only recently been elucidated...
  49. ncbi Daily treatment with sildenafil reverses endothelial dysfunction and oxidative stress in an animal model of insulin resistance
    Delphine Behr-Roussel
    Pelvipharm, Domaine CNRS, 1 Avenue de la Terrasse, BAtiment 5, 91190 Gif sur Yvette, France
    Eur Urol 53:1272-80. 2008
    ..Patients with insulin resistance exhibit endothelial dysfunction with decreased nitric oxide (NO) production and increased oxidative stress. We postulated that daily sildenafil improved endothelial function in fructose-fed rats...
  50. doi Combination of doxazosin and sildenafil exerts an additive relaxing effect compared with each compound alone on human cavernosal and prostatic tissue
    Stephanie Oger
    Pelvipharm, Orsay Parc, Orsay, France
    J Sex Med 6:836-47. 2009
    ..ED and LUTS/BPH are conditions that are often associated. Accordingly, alpha1-adrenoceptor antagonists and PDE5 inhibitors will be often prescribed in real life setting together...
  51. ncbi Serotonin 5-HT2A and 5-HT5A receptors are expressed by different motoneuron populations in rat Onuf's nucleus
    Chen Xu
    Groupe de Recherche en Urologie, UPRESS EA 1602, Faculte de Medecine Paris Sud, 94270 Le Kremlin Bicetre, France
    J Comp Neurol 502:620-34. 2007
    ..This might have implications for pharmacological research targeting different pelvic functions e.g., micturition and ejaculation...
  52. doi How does chronic sildenafil prevent vascular oxidative stress in insulin-resistant rats?
    Alexandra Oudot
    Pelvipharm, Orsay, France
    J Sex Med 7:79-88. 2010
    ..Both disorders are targeted by a chronic treatment with sildenafil. However, the mechanism of action by which chronic sildenafil exerts its effects on reactive oxygen species sources is still largely unknown...
  53. ncbi Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension, or both
    Francois A Giuliano
    Department of Urology, CHU de Bicetre, AP HP, Hopital de Bicetre, Bicetre, France
    Urology 64:1196-201. 2004
    ..To survey the presence of, and attitudes toward, erectile dysfunction (ED) among patients with hypertension and/or diabetes mellitus who sought general medical care for any reason...
  54. doi Nitric oxide/cyclic guanosine monophosphate signalling mediates an inhibitory action on sensory pathways of the micturition reflex in the rat
    Romain Caremel
    Charles Nicolle Hospital, Department of Urology, Rouen, France
    Eur Urol 58:616-25. 2010
    ..Several studies have suggested that nitric oxide (NO) or its downstream signalling could modulate the micturition reflex (MR) by reducing the excitability of bladder afferents...
  55. ncbi Chronic sildenafil improves erectile function and endothelium-dependent cavernosal relaxations in rats: lack of tachyphylaxis
    Delphine Behr-Roussel
    Pelvipharm, Domaine CNRS, 1 Avenue de la Terrasse, BAtiment 5, 91190 Gif sur Yvette, France
    Eur Urol 47:87-91. 2005
    ..Sildenafil is a widely-prescribed effective on-demand treatment of erectile dysfunction (ED). Chronic treatment with sildenafil could help patients with ED...
  56. ncbi [Prevalence of erectile dysfunction in France: results of an epidemiological survey conducted on a representative sample of 1004 men]
    Francois Giuliano
    Service d Urologie, CHU de Bicetre, Le Kremlin Bicetre, France
    Prog Urol 12:260-7. 2002
    ..Several studies have recently reported the prevalence rates of erectile dysfunction (ED) that vary according to the country. The authors report the results of a survey conducted in France in 2001...
  57. doi Effect of a local delivery of triiodothyronine (T3) within neuroregenerative guide on recovery of erectile function in a rat-model of cavernous nerve injury
    Thomas Bessede
    UPRES EA 4122 University Paris Sud, Le Kremlin Bicetre, France
    J Sex Med 7:1798-806. 2010
    ..A promoting effect of thyroid hormones has been established on the maturation of central and peripheral nervous systems. However, effects on autonomic nerves have never been experimentally investigated...
  58. doi Differences in the spinal command of ejaculation in rapid ejaculating rats
    Aren J Borgdorff
    Pelvipharm Laboratories, Orsay, France
    J Sex Med 6:2197-205. 2009
    ..It has been hypothesized that lifelong premature ejaculation is part of a biological variation in the intravaginal ejaculation latency, but what causes this variation remains poorly understood...
  59. doi Does management of erectile dysfunction after radical prostatectomy meet patients' expectations? Results of a national survey (REPAIR) by the French Urological Association
    Emmanuel Chartier-Kastler
    AP HP, Department of Urology, La Pitie Salpetriere Hospital, Paris, France
    J Sex Med 5:693-704. 2008
    ..Little stress has been placed on patients' satisfaction with regard to management of erectile dysfunction (ED) after radical prostatectomy (RP) and on how physicians' and patients' views may differ in this respect...
  60. ncbi Ejaculation induced by i.c.v. injection of the preferential dopamine D(3) receptor agonist 7-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats
    P Clement
    Pelvipharm Laboratories, Centre National de la Recherche Scientifique, BAtiment 5, Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Neuroscience 145:605-10. 2007
    ..It is inferred that targeting brain D(3) receptors may provide a therapeutic approach for treating ejaculatory disorders in humans...
  61. ncbi Distinct mechanisms implicated in atherosclerosis-induced erectile dysfunction in rabbits
    Delphine Behr-Roussel
    Pelvipharm, Domaine INRA, Route de la Guyonnerie, 91440, Bures sur Yvette, France
    Atherosclerosis 162:355-62. 2002
    ....
  62. ncbi Erectile dysfunction: an early marker for hypertension? A longitudinal study in spontaneously hypertensive rats
    Delphine Behr-Roussel
    Pelvipharm, Domaine CNRS, 1 Avenue de la Terrasse, BAtiment 5, 91190 Gif sur Yvette, France
    Am J Physiol Regul Integr Comp Physiol 288:R276-83. 2005
    ..If confirmed in humans, ED could be an early warning sign for hypertension, and common therapeutic strategies targeting both ED and hypertension could be investigated...
  63. ncbi Pro-erectile effect of systemic apomorphine: existence of a spinal site of action
    Francois Giuliano
    Groupe de Recherche en Urologie, UPRES, Medical University of Paris South, Le Kremlin Bicetre, France
    J Urol 167:402-6. 2002
    ..In spinal cord injured rats we assessed whether apomorphine also directly activates the spinal autonomic and somatic neurons controlling penile erection..
  64. ncbi Erectile dysfunction in spontaneously hypertensive rats: pathophysiological mechanisms
    Delphine Behr-Roussel
    Pelvipharm, Domaine Centre National de Recherche Scientifique, 91190 Gif sur Yvette, France
    Am J Physiol Regul Integr Comp Physiol 284:R682-8. 2003
    ..Drugs targeting endothelial dysfunction may delay the occurrence of ED as a complication of hypertension...
  65. ncbi Central neurophysiology and dopaminergic control of ejaculation
    Magali Peeters
    Pelvipharm Laboratories, Gif sur Yvette, France
    Neurosci Biobehav Rev 32:438-53. 2008
    ....
  66. doi Impact of a long-term sildenafil treatment on pressor response in conscious rats with insulin resistance and hypertriglyceridemia
    Delphine Behr-Roussel
    Pelvipharm, Orsay, France
    Am J Hypertens 21:1258-63. 2008
    ..Endothelium-dependent vasomotor function is ultimately linked to blood pressure (BP) regulation. We postulated that sildenafil would ameliorate BP and biological markers of endothelial function in fructose-fed rats (FFRs)...
  67. ncbi Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine
    Pierre Clement
    Pelvipharm Laboratories, CNRS, Gif sur Yvette, France
    Eur Urol 51:825-32. 2007
    ..The aim of the study was to determine whether dapoxetine, a short-acting selective serotonin reuptake inhibitor, acts at the spinal or supraspinal level to inhibit the ejaculatory reflex...
  68. ncbi Erectile dysfunction in hypercholesterolemic atherosclerotic apolipoprotein E knockout mice
    Delphine Behr-Roussel
    Pelvipharm, Gif sur Yvette, France
    J Sex Med 3:596-603. 2006
    ....
  69. ncbi The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat
    Anne Sophie Rössler
    Pelvipharm Laboratories, CNRS, Bat 5, 1 Avenue de la Terrasse, 91190, Gif sur Yvette, France
    Pharmacol Biochem Behav 85:514-21. 2006
    ....
  70. ncbi [Ageing men's sexual functions decline and the erectile dysfunction (ED) increase]
    Edouard Amar
    Service d Urologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    Prog Urol 15:6-9. 2005
    ..With these patients, the prescription of testosterone replacement therapy may improve the response of PDE5 inhibitors...
  71. ncbi Identification of androgen receptors in the motoneurons of the external urethral sphincter in the spinal cord of female rats
    Pascal Blanchet
    Department of Urology, Bicêtre Hospital AP HP, Paris Sud University School of Medicine, Kremlin Bicetre, France
    Eur Urol 47:118-24. 2005
    ..The role of androgen changes on urinary continence in perimenopausal women has not been studied. We studied the presence of androgen receptors in pudendal motoneurons controlling the external urethral sphincter of female rats...
  72. ncbi D2-like receptors mediate the expulsion phase of ejaculation elicited by 8-hydroxy-2-(di-N-propylamino)tetralin in rats
    Pierre Clement
    Pelvipharm Laboratories, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    J Pharmacol Exp Ther 316:830-4. 2006
    ..c.v. delivery of D2-like receptor agonists to anesthetized rats represents a relevant experimental model to study the expulsion phase of ejaculation...
  73. ncbi Relaxation of phasic contractile activity of human detrusor strips by cyclic nucleotide phosphodiesterase type 4 inhibition
    Stephanie Oger
    Pelvipharm, Domaine CNRS, Gif sur Yvette, France
    Eur Urol 51:772-80; discussion 780-1. 2007
    ..Elevation of cAMP levels by phosphodiesterase type 4 (PDE4) inhibition relaxes smooth muscles of various origins. We aimed to determine the effect of a PDE4 inhibitor, rolipram, on human detrusor contractions...
  74. ncbi Seminal plug expulsion induced by electrical stimulation of the intermesenteric nerve in anesthetized rats
    Jacques Bernabe
    Pelvipharm Laboratories, CNRS, 91190 Gif sur Yvette, France
    Biol Reprod 77:717-22. 2007
    ..We propose that the IMN electrical stimulation paradigm can be used to investigate physiological and pharmacologic aspects of ejaculation...
  75. ncbi [Phyllodes tumour of the prostate in a 28-year-old man]
    Hadi Mawlawi
    Service d Urologie, CHU de Bicetre, Le Kremlin Bicetre, France
    Prog Urol 17:1379-81. 2007
    ..The authors stress the importance of nerve-sparing radical surgery and early sexual rehabilitation...