B Giraudeau

Summary

Country: France

Publications

  1. pmc Mixing nulliparous and multiparous women in randomised controlled trials of preeclampsia prevention is debatable: evidence from a systematic review
    Emmanuel Simon
    INSERM, UMR S 738, Paris, France
    PLoS ONE 8:e66677. 2013
  2. pmc Participant informed consent in cluster randomized trials: review
    Bruno Giraudeau
    INSERM, U738, Paris, France
    PLoS ONE 7:e40436. 2012
  3. pmc Peer review of grant applications: a simple method to identify proposals with discordant reviews
    Bruno Giraudeau
    Institut National de la Sante et de la Recherche Medicale, Tours, France
    PLoS ONE 6:e27557. 2011
  4. pmc A multicentre case-control study of nonsteroidal anti-inflammatory drugs as a risk factor for severe sepsis and septic shock
    Annick Legras
    Department of Intensive Care Unit, University Hospital of Tours, boulevard Tonnelle, 37044 Tours, France
    Crit Care 13:R43. 2009
  5. pmc A priori postulated and real power in cluster randomized trials: mind the gap
    Lydia Guittet
    Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard AP HP Université Paris 7, Paris, France
    BMC Med Res Methodol 5:25. 2005
  6. pmc Planning a cluster randomized trial with unequal cluster sizes: practical issues involving continuous outcomes
    Lydia Guittet
    Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard AP HP, Université Xavier Bichat, Paris, France
    BMC Med Res Methodol 6:17. 2006
  7. pmc Design effect in multicenter studies: gain or loss of power?
    Emilie Vierron
    INSERM, CIC 202, Tours, France
    BMC Med Res Methodol 9:39. 2009
  8. ncbi request reprint [Critical analysis of a parallel group randomized trial]
    B Giraudeau
    centre d investigation clinique, Faculte de Medecine, 2 bis, boulevard Tonnelle, 37032 Tours Cedex
    Rev Pneumol Clin 58:261-7. 2002
  9. ncbi request reprint Planning a reproducibility study: how many subjects and how many replicates per subject for an expected width of the 95 per cent confidence interval of the intraclass correlation coefficient
    B Giraudeau
    Centre de Recherche Clinique, Faculte de Medecine, Tours, France
    Stat Med 20:3205-14. 2001
  10. ncbi request reprint Power calculation for the likelihood ratio-test when comparing two dependent intraclass correlation coefficients
    B Giraudeau
    INSERM CIC 202, Faculte de Medecine, 10 Bd Tonnellé, BP 3223, 37032 Tours Cedex 1, France
    Comput Methods Programs Biomed 77:165-73. 2005

Detail Information

Publications75

  1. pmc Mixing nulliparous and multiparous women in randomised controlled trials of preeclampsia prevention is debatable: evidence from a systematic review
    Emmanuel Simon
    INSERM, UMR S 738, Paris, France
    PLoS ONE 8:e66677. 2013
    ..Nulliparity is a major risk factor of preeclampsia investigated in numerous trials of its prevention...
  2. pmc Participant informed consent in cluster randomized trials: review
    Bruno Giraudeau
    INSERM, U738, Paris, France
    PLoS ONE 7:e40436. 2012
    ..We assessed whether participant informed consent was required in such trials, which type of consent was required, and whether the trial was at risk of selection bias because of the very nature of participant information...
  3. pmc Peer review of grant applications: a simple method to identify proposals with discordant reviews
    Bruno Giraudeau
    Institut National de la Sante et de la Recherche Medicale, Tours, France
    PLoS ONE 6:e27557. 2011
    ..We propose a simple method to identify such proposals. Our approach is based on the intraclass correlation coefficient, which is usually used in assessing agreement in studies with continuous ratings...
  4. pmc A multicentre case-control study of nonsteroidal anti-inflammatory drugs as a risk factor for severe sepsis and septic shock
    Annick Legras
    Department of Intensive Care Unit, University Hospital of Tours, boulevard Tonnelle, 37044 Tours, France
    Crit Care 13:R43. 2009
    ..We aimed to establish whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during evolving bacterial community-acquired infection in adults is associated with severe sepsis or septic shock...
  5. pmc A priori postulated and real power in cluster randomized trials: mind the gap
    Lydia Guittet
    Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard AP HP Université Paris 7, Paris, France
    BMC Med Res Methodol 5:25. 2005
    ..The intraclass correlation coefficient (ICC) defines the clustering effect and be specified during planning. The aim of this work is to study the influence of the ICC on power in cluster randomized trials...
  6. pmc Planning a cluster randomized trial with unequal cluster sizes: practical issues involving continuous outcomes
    Lydia Guittet
    Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard AP HP, Université Xavier Bichat, Paris, France
    BMC Med Res Methodol 6:17. 2006
    ..At the planning stage, sample size calculations usually consider an average cluster size without taking into account any potential imbalance in cluster size. However, there may exist high discrepancies in cluster sizes...
  7. pmc Design effect in multicenter studies: gain or loss of power?
    Emilie Vierron
    INSERM, CIC 202, Tours, France
    BMC Med Res Methodol 9:39. 2009
    ..Such a clustering is usually assessed through the design effect, defined as a ratio of two variances. The aim of this work was to describe and understand situations where the design effect involves a gain or a loss of power...
  8. ncbi request reprint [Critical analysis of a parallel group randomized trial]
    B Giraudeau
    centre d investigation clinique, Faculte de Medecine, 2 bis, boulevard Tonnelle, 37032 Tours Cedex
    Rev Pneumol Clin 58:261-7. 2002
    ..Finally, the results should be interpreted in terms of their clinical relevance, which is not necessarily implied by statistical significance...
  9. ncbi request reprint Planning a reproducibility study: how many subjects and how many replicates per subject for an expected width of the 95 per cent confidence interval of the intraclass correlation coefficient
    B Giraudeau
    Centre de Recherche Clinique, Faculte de Medecine, Tours, France
    Stat Med 20:3205-14. 2001
    ..Optimal designs are also discussed such as the optimal distribution between the number of subjects and the number of replicates per subject for a fixed total number of measures...
  10. ncbi request reprint Power calculation for the likelihood ratio-test when comparing two dependent intraclass correlation coefficients
    B Giraudeau
    INSERM CIC 202, Faculte de Medecine, 10 Bd Tonnellé, BP 3223, 37032 Tours Cedex 1, France
    Comput Methods Programs Biomed 77:165-73. 2005
    ..We propose SAS and S-plus macros, which allow power calculations by implementing a simulation study where dependent ICCs are compared by means of a likelihood ratio-test...
  11. ncbi request reprint Does data rounding-off influence reproducibility index estimates?
    Bruno Giraudeau
    INSERM CIC 202, Faculte de Medecine, 2bis Bd Tonnelle, 37032 Tours Cedex, France
    J Appl Meas 6:100-8. 2005
    ..Therefore, in most practical situations the consequences of rounding-off data on the estimation of reproducibility levels can be ignored...
  12. doi request reprint Sample size calculation for cluster randomized cross-over trials
    B Giraudeau
    INSERM, CIC 202, France
    Stat Med 27:5578-85. 2008
    ..We derived a sample size formula for continuous outcomes that takes into account both the intraclass correlation coefficient (representing the clustering effect) and the interperiod correlation (induced by the cross-over design)...
  13. ncbi request reprint Is ultrasound lymph node examination superior to clinical examination in melanoma follow-up? A monocentre cohort study of 373 patients
    L Machet
    Service de Dermatologie, Centre Hospitalier Universitaire, Hopital Trousseau, 37044 Tours Cedex 1, France
    Br J Dermatol 152:66-70. 2005
    ..There is still lack of consensus regarding the most effective follow-up for stage I and II melanoma patients although some consensus conferences have provided guidelines stating that clinical examination should be the standard...
  14. ncbi request reprint Factors influencing laparoconversions during the learning curve of laparoscopic myomectomy
    H Marret
    Département de gynécologie, Obstétrique, Medecine Foetale et Reproduction Humaine, Centre Hospitalier Universitaire Hôpital Bretonneau, Tours, France
    Acta Obstet Gynecol Scand 85:324-9. 2006
    ..2001) based on four preoperative risk factors. Routinely this score is not appropriate, as realized by the most skilled laparoscopic surgeons...
  15. ncbi request reprint Power Doppler vascularity index for predicting malignancy of adnexal masses
    H Marret
    Department of Gynaecology, Obstetrics, Fetal Medicine and Human Reproduction, Tours, France
    Ultrasound Obstet Gynecol 25:508-13. 2005
    ..To assess the performance of a power Doppler vascularity index in the preoperative diagnosis of ovarian malignancy...
  16. ncbi request reprint SMN1 gene, but not SMN2, is a risk factor for sporadic ALS
    P Corcia
    INSERM U619, Faculte de Medecine, Tours, France
    Neurology 67:1147-50. 2006
    ..SMN1 gene deletions cause spinal muscular atrophy, and SMN2 gene deletions have been associated with sporadic lower motor neuron diseases...
  17. ncbi request reprint [Power Doppler Index for preoperative ovarian tumors discrimination]
    H Marret
    pôle de gynécologie, Obstétrique, Medecine Foetale et Reproduction Humaine, Hopital Bretonneau, Tours Cedex 01, France
    Gynecol Obstet Fertil 35:541-7. 2007
    ..To assess the performance of a power doppler vascularity index in the preoperative diagnosis of ovarian malignancy...
  18. ncbi request reprint Evaluation of left ventricular systolic function by 3D echocardiography: a comparative study with X-ray angiography and radionuclide angiography
    V Eder
    Service Médecine Nucléaire et Ultrasons, CHU Trousseau, 37044, Tours, France
    Eur J Ultrasound 11:105-15. 2000
    ..the aim of this study was to evaluate left ventricular systolic function by 3D ultrasound as compared to with radionuclide and X-ray angiographies...
  19. ncbi request reprint Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general population
    J M Halimi
    Center de Recherche Clinique, Faculte de Medecine, and Service de Néphrologie Immunologie Clinique, Hopital Bretonneau, Tours, France
    Kidney Int 58:1285-92. 2000
    ..Smoking may adversely affect the progression of renal diseases. However, it is unknown whether smoking affects renal function in subjects without nephropathy...
  20. pmc Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial
    P Bougnoux
    INSERM U921 Nutrition, Croissance et Cancer, Tours, France
    Br J Cancer 101:1978-85. 2009
    ....
  21. pmc Epidural corticosteroid injections for sciatica: a randomised, double blind, controlled clinical trial
    J P Valat
    Service de Rhumatologie, Hopital Trousseau, CHU, Tours, France
    Ann Rheum Dis 62:639-43. 2003
    ..To determine the efficacy of epidural corticosteroid injections for sciatica...
  22. ncbi request reprint [Real-time contrast-enhanced ultrasound in the evaluation of focal liver lesions: diagnostic efficacy and economical issues from a French multicentric study]
    F Tranquart
    Pole Imagerie, CIC IT Ultrasons Radiopharmaceutiques, Hopital Bretonneau, CHRU de Tours, UMR Inserm 930 CNRS 2448 Université François Rabelais, 37044 Tours cedex 9, France
    J Radiol 90:109-22. 2009
    ..This French multicentric study confirmed the high diagnostic value of CEUS for focal liver lesion characterization and demonstrated a lower economical impact compared to other imaging modalities such as CT and MRI...
  23. doi request reprint Center effect on ankle-brachial index measurement when using the reference method (Doppler and manometer): results from a large cohort study
    Emilie Vierron
    INSERM, CIC 202, Tours, France
    Am J Hypertens 22:718-22. 2009
    ..We aimed to assess, in a French multicenter cohort, the center effect associated with arterial pressure (AP) and ABI measurements using the reference method and using a semiautomatic device...
  24. ncbi request reprint Enalapril/amlodipine combination in cyclosporine-treated renal transplant recipients: a prospective randomized trial
    Jean Michel Halimi
    Department of Nephrology and Clinical Immunology, Francois Rabelais University, CHRU Bretonneau, Tours, France
    Clin Transplant 21:277-84. 2007
    ..Most hypertensive renal transplant recipients require two or more antihypertensive medications to achieve blood pressure control. However, which medications must be combined is still a matter of debate...
  25. doi request reprint Iatrogenic events contributing to ICU admission: a prospective study
    Emmanuelle Mercier
    Service de Reanimation Medicale, Universite Francois Rabelais, Hopital Bretonneau, CHRU, 37044, Tours Cedex 9, France
    Intensive Care Med 36:1033-7. 2010
    ..To determine the incidence, risk factors, severity, and preventability of iatrogenic events (IEs) as a cause of intensive care unit (ICU) admission...
  26. pmc Amoxicillin/clavulanic acid is ineffective at preventing otitis media in children with presumed viral upper respiratory infection: a randomized, double-blind equivalence, placebo-controlled trial
    Elisabeth Autret-Leca
    Department of Clinical Pharmacology, Hospital Bretonneau and University François Rabelais, Tours, France
    Br J Clin Pharmacol 54:652-6. 2002
    ..To assess the equivalence of amoxicillin/clavulanic acid and placebo in the prevention of acute otitis media in children at high risk of acute otitis media who develop upper respiratory tract infection...
  27. pmc Diet, cancer, and the lipidome
    Philippe Bougnoux
    INSERM E 0211, University Hospital of Tours, 2 boulevard Tonnelle, 37044 Tours Cedex, France
    Cancer Epidemiol Biomarkers Prev 15:416-21. 2006
    ....
  28. ncbi request reprint Absence of inferior labial and lingual frenula in Ehlers-Danlos syndrome: a minor diagnostic criterion in French patients
    Laurent Machet
    INSERM U930 CNRS ERL 3106, Universite Francois Rabelais, Tours, France
    Am J Clin Dermatol 11:269-73. 2010
    ..The absence of the lingual and inferior labial frenula was reported to be a useful diagnostic tool in a series of 12 patients with classical and hypermobile EDS. However, two further reports have contested the value of this sign...
  29. ncbi request reprint Sample size calculation for multicenter randomized trial: taking the center effect into account
    Emilie Vierron
    INSERM CIC 202, Universite Francois Rabelais, Tours, CHRU de Tours, France
    Contemp Clin Trials 28:451-8. 2007
    ..This work allows for adjusting and reducing the sample size according to the magnitude of the center effect and leads to a better consistency in the conduct of multicenter randomized trials...
  30. doi request reprint Preoperative measurement of thickness of cutaneous melanoma using high-resolution 20 MHz ultrasound imaging: A monocenter prospective study and systematic review of the literature
    Laurent Machet
    Universite Francois Rabelais de Tours, UMR INSERM U CNRS ERL, France
    Ultrasound Med Biol 35:1411-20. 2009
    ..Preoperative high-resolution ultrasound is a noninvasive examination that can help in choosing appropriate surgical margins and should reduce the need of partial or excisional biopsy before surgery, and the need for further re-excision...
  31. ncbi request reprint Model mis-specification and overestimation of the intraclass correlation coefficient in cluster randomized trials
    Bruno Giraudeau
    INSERM CIC 202, Faculte de Medecine, Tours, France
    Stat Med 25:957-64. 2006
    ..This study demonstrates that estimating this parameter with one-way ANOVA and an underlying mixed-effects statistical model leads to biased estimates. The bias depends on the effect size of the studied treatment...
  32. ncbi request reprint [The cluster-randomized trial]
    Bruno Giraudeau
    INSERM CIC 202, Faculte de Medecine, 2bis, boulevard Tonnelle, 37032 Tours Cedex, France
    Med Sci (Paris) 20:363-6. 2004
    ..A cluster randomized trial is thus justified only if the context or the question of interest imposes it and biostatistical issues have then to be handled in a rigorous way...
  33. ncbi request reprint A retrospective multicentre study comparing myomectomy by laparoscopy and laparotomy in current surgical practice. What are the best patient selection criteria?
    Henri Marret
    Département de gynécologie, Obstétrique, Medecine Foetale et Reproduction Humaine, Centre Hospitalier Universitaire Hôpital Bretonneau, 2 Bd Tonnelle, 37044 Tours Cedex 1, France
    Eur J Obstet Gynecol Reprod Biol 117:82-6. 2004
    ..To determine the differences in myoma characteristics before laparoscopic myomectomy (LM) and abdominal myomectomy (AM) and to compare outcomes in current practice...
  34. ncbi request reprint Living with a functioning kidney transplant at 74 yr or older: a national epidemiological study
    Matthias Buchler
    Department of Nephrology and Clinical Immunology, CHU Bretonneau, Tours, France
    Clin Transplant 18:681-5. 2004
    ..Renal function in this group of patients was good and quality of life seemed excellent. Cardiovascular disease and malignancies were the main co-morbid conditions...
  35. ncbi request reprint Contrast-enhanced sonography helps in discrimination of benign from malignant adnexal masses
    Henri Marret
    Department of Gynecology and Obstetrics, Fetal Medicine, and Human Reproduction, Bretonneau University Hospital, Tours, France
    J Ultrasound Med 23:1629-39; quiz 1641-42. 2004
    ..To investigate the potential efficacy of real-time contrast-enhanced power Doppler sonography in the differentiation of benign and malignant adnexal masses in a pilot study...
  36. ncbi request reprint Routine ultrasonography in melanoma follow-up?
    Laurent Machet
    Department of Dermatology, University Hospital, Hopital Trousseau, 37044 Tours Cedex 1, France
    Lancet Oncol 6:2; discussion 3. 2005
  37. ncbi request reprint Simultaneous estimation of cyclosporin and mycophenolic acid areas under the curve in stable renal transplant patients using a limited sampling strategy
    Chantal Le Guellec
    Department of Pharmacology, Tours University Hospital, France
    Eur J Clin Pharmacol 57:805-11. 2002
    ..It is the method of choice for mycophenolic acid (MPA). The objective of this study was to develop a limited sampling strategy for simultaneous estimation of CsA and MPA AUCs in long-term renal transplant patients...
  38. ncbi request reprint The risk of hypertension in men: direct and indirect effects of chronic smoking
    Jean Michel Halimi
    Centre de Recherche Clinique, Faculte de Medecine, Tours, France
    J Hypertens 20:187-93. 2002
    ..To assess the risk of hypertension associated with smoking status...
  39. doi request reprint Propensity scores used for analysis of cluster randomized trials with selection bias: a simulation study
    C Leyrat
    INSERM UMR S 738, Paris, France
    Stat Med 32:3357-72. 2013
    ..However, they showed poorer statistical efficiency than classical methods, with higher standard error for the treatment effect, and type I error much smaller than the 5% nominal level...
  40. ncbi request reprint Despite financial penalties, French physicians' knowledge of regulatory practice guidelines is poor
    P Durieux
    Santé Publique, Faculté de Médecine Broussais Hôtel Dieu, Paris, France
    Arch Fam Med 9:414-8. 2000
    ..To evaluate the level of awareness and knowledge of regulatory practice guidelines (references medicales opposables [RMOs] or regulatory medical references) implemented to control ambulatory care costs among French family physicians...
  41. pmc ARTIST (osteoarthritis intervention standardized) study of standardised consultation versus usual care for patients with osteoarthritis of the knee in primary care in France: pragmatic randomised controlled trial
    P Ravaud
    INSERM, U738, Paris, France
    BMJ 338:b421. 2009
    ..To evaluate the impact of standardised consultations on patients with osteoarthritis of the knee...
  42. ncbi request reprint Histologic multifocality is predictive of skin recurrences after conserving treatment of stage I and II breast cancers
    H Marret
    Department of Gynaecology and Obstetrics, Hopital Bretonneau, Tours, France
    Breast Cancer Res Treat 68:1-8. 2001
    ....
  43. ncbi request reprint Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis
    Veronique Chajes
    Inserm Emi U 0211, IFR 120, Tours Bretonneau, Tours, France
    Nutr Cancer 45:17-23. 2003
    ....
  44. ncbi request reprint Assessment of cyclic changes of microvessels in ovine ovaries using Sonovue contrast-enhanced ultrasound
    Henri Marret
    Department of Gynecology, Obstetrics, Fetal Medicine and Human Reproduction, Bretonneau University Hospital, Tours, France
    Ultrasound Med Biol 32:163-9. 2006
    ..Thus, using these parameters in premenopausal women will allow more accurate detection of vascular modifications that may be associated with ovarian cancer...
  45. ncbi request reprint Association of donor TNFRSF6 (FAS) gene polymorphism with acute rejection in renal transplant patients: a case-control study
    Sandrine Cappellesso
    UPRES EA 3249 Cellules Hématopoïétiques, Hémostase et Greffe, Universite de Tours, Faculte de Medecine, and Laboratoire d Immunologie and Service de Néphrologie et Immunologie Clinique, CHRU de Tours, Tours Cedex, France
    Nephrol Dial Transplant 19:439-43. 2004
    ....
  46. ncbi request reprint Nasal carriage of methicillin-resistant staphylococcus aureus in vascular surgery
    Virginie Morange-Saussier
    Department of Bacteriology and Hospital Hygiene, Trousseau University Hospital, Tours, France
    Ann Vasc Surg 20:767-72. 2006
    ..French recommendations issued for cardiac and orthopedic surgery by the consensus conference on preoperative management of infectious risk on March 5, 2004, should be extended to vascular surgery...
  47. ncbi request reprint Revascularization algorithm in acute STEMI should take into account age
    Axel de Labriolle
    Departement de Cardiologie, Centre Hospitalier Universitaire Tours, Tours, France
    Cardiovasc Revasc Med 8:90-3. 2007
    ..Moreover, there is a lack of data regarding the effect of time to treatment (TT) on prognosis of STEMI in elderly patients...
  48. ncbi request reprint [Epidemiology and management of stroke patients in emergency departments of the Centre region of France]
    I Bonnaud
    Service de Neurologie, Hopital Bretonneau, 2, boulevard Tonnelle, 37000 Tours, France
    Rev Neurol (Paris) 161:311-7. 2005
    ..Patients with suspected stroke are usually managed in emergency departments (ED). Stroke units must be created in our country, but only few French epidemiological data are available to define needs in stroke care...
  49. ncbi request reprint Color Doppler energy prediction of malignancy in adnexal masses using logistic regression models
    H Marret
    Department of Gynecology, Obstetrics, Fetal Medicine and Human Reproduction, Bretonneau University Hospital, Tours, France
    Ultrasound Obstet Gynecol 20:597-604. 2002
    ..The aim of this study was to assess the usefulness of color Doppler energy in the preoperative diagnosis of ovarian malignancy using multivariate logistic regression analysis...
  50. pmc Reporting of radiographic methods in randomised controlled trials assessing structural outcomes in rheumatoid arthritis
    Gabriel Baron
    Département d Epidémiologie Biostatistique et Recherche Clinique, INSERM, U738, Groupe Hospitalier Bichat Claude Bernard, 46 rue Henri Huchard, 75018 Paris, France
    Ann Rheum Dis 66:651-7. 2007
    ....
  51. pmc Reporting of sample size calculation in randomised controlled trials: review
    Pierre Charles
    INSERM, U738, Paris, France
    BMJ 338:b1732. 2009
    ..To assess quality of reporting of sample size calculation, ascertain accuracy of calculations, and determine the relevance of assumptions made when calculating sample size in randomised controlled trials...
  52. doi request reprint Avoidability of adverse drug reactions spontaneously reported to a French regional drug monitoring centre
    Annie Pierre Jonville-Bera
    Pharmacoepidemiology and Clinical Pharmacology Unit Regional Drug Monitoring Centre, CHRU de Tours, Tours, France
    Drug Saf 32:429-40. 2009
    ..Adverse drug reactions (ADRs) are now recognized as a major category of iatrogenic illness in terms of morbidity and mortality...
  53. doi request reprint Comparison of degree of stenosis and plaque volume for the assessment of carotid atherosclerosis using 2-D ultrasound
    Axel de Labriolle
    Departement de Cardiologie, Centre Hospitalier Universitaire, Tours, France
    Ultrasound Med Biol 35:1436-42. 2009
    ..The absence of correlation between the PVI and the %ST confirm that these two parameters describe two different processes of the atheromatous development...
  54. pmc Relationship between 5-fluorouracil exposure and outcome in patients receiving continuous venous infusion with or without concomitant radiotherapy
    Maud Beneton
    Department of Pharmacology, CHRU de Tours, Tours, France
    Br J Clin Pharmacol 64:613-21. 2007
    ..We investigated the plasma concentration-effect relationship for this regimen, with the aim of developing recommendations for dose adjustment...
  55. doi request reprint Missing data in randomized controlled trials of rheumatoid arthritis with radiographic outcomes: a simulation study
    Gabriel Baron
    AP HP, Hopital Bichat, Biostatistique et Recherche Clinique, INSERM, U738, and Université Paris, France
    Arthritis Rheum 59:25-31. 2008
    ..To assess the impact, in terms of statistical power and bias of treatment effect, of approaches to dealing with missing data in randomized controlled trials of rheumatoid arthritis with radiographic outcomes...
  56. ncbi request reprint [Correcting the critical reading test of the national ranking examination]
    Annabel Maruani
    Faculte de Medecine, Universite Francois Rabelais, Tours
    Presse Med 36:571-4. 2007
    ..The aim of our study was to assess the consistency of grading between this two-part test (critical analysis and summarizing, analyzed separately), and the more classic tests...
  57. ncbi request reprint The methods for handling missing data in clinical trials influence sample size requirements
    Guy Robert Auleley
    université Paris V René Descartes, Faculté de Médecine Cochin Port Royal and Clinique de Rhumatologie, Hopital Cochin, AP HP, Paris, France
    J Clin Epidemiol 57:447-53. 2004
    ..Results of studies estimating osteoarthritis progression may be affected by missing values. In clinical trials assessing disease-modifying osteoarthritis drugs, sample sizes should be calculated using close estimates of outcome variables...
  58. ncbi request reprint Antipyretic drug use in children in French office based medical practice
    Jean Deligne
    CANAM, Caisse Nationale d Assurance Maladie des Professions Indépendantes, France
    Pharmacoepidemiol Drug Saf 16:812-7. 2007
    ..To analyse antipyretics (APs) prescriptions profile in children, particularly the frequency of AP combinations...
  59. ncbi request reprint Ovine model to evaluate ovarian vascularization by using contrast-enhanced sonography
    Henri Marret
    Department of Gynecology, Obstetrics, Fetal Medicine and Human Reproduction, Bretonneau University Hospital, 2 boulevard Tonnelle, 37044 Tours cedex 1 France
    Comp Med 55:150-5. 2005
    ..001), but the enhancement time was the same. We concluded that the sheep is an excellent animal model to illustrate microcirculation enhancement by using Sonovue to demonstrate ovarian vascular changes...
  60. ncbi request reprint Renal arterial resistance index
    Bruno Giraudeau
    N Engl J Med 349:1573-4; author reply 1573-4. 2003
  61. ncbi request reprint Violation of the intent-to-treat principle and rate of missing data in superiority trials assessing structural outcomes in rheumatic diseases
    Gabriel Baron
    INSERM U 738, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 52:1858-65. 2005
    ..To evaluate the methodologic quality of and identify methodologic issues in superiority trials assessing structural outcomes in rheumatic diseases...
  62. ncbi request reprint Lack of association between rifampicin plasma concentration and treatment-related side effects in osteoarticular infections
    France Roblot
    CHRU de Tours, Service des Maladies Infectieuses, 2 boulevard Tonnelle, 37044 Tours Cedex, France
    Fundam Clin Pharmacol 21:363-9. 2007
    ..GSE occur frequently in patients receiving rifampicin for osteoarticular infection but without an association with rifampicin plasma concentrations. Thus, therapeutic drug monitoring of rifampicin is irrelevant in the management of GSE...
  63. ncbi request reprint Reporting of drug tolerance in randomized clinical trials: when data conflict with authors' conclusions
    Annie Pierre Jonville-Bera
    Ann Intern Med 144:306-7. 2006
  64. ncbi request reprint Reporting of harm in randomized, controlled trials of nonpharmacologic treatment for rheumatic disease
    Morgane Ethgen
    Centre Hospitalier Universitaire de Hautepierre, Strasbourg, France
    Ann Intern Med 143:20-5. 2005
    ..Reports of clinical trials usually emphasize benefits and give less attention to harms...
  65. ncbi request reprint Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study
    Xavier Chevalier
    Department of Rheumatology, Hospital Henri Mondor, University Paris XII, Paris, France
    J Rheumatol 32:1317-23. 2005
    ..In animal models of OA, IL-1 blockade by IL-1 receptor antagonist (IL-1Ra) can slow the progression of disease. We examined the safety of intraarticular (IA) injections of recombinant human IL-1Ra in patients with knee OA...
  66. ncbi request reprint Quality of reporting of noninferiority and equivalence randomized trials
    Anne Le Henanff
    Institut National de la Santé et de la Recherche Médicale INSERM U738, Paris, France
    JAMA 295:1147-51. 2006
    ..These study objectives imply particular planning and analysis...
  67. ncbi request reprint Predictive factors for fibroids recurrence after uterine artery embolisation
    Henri Marret
    Department of Gynaecology, Obstetrics, Fetal Medicine and Human Reproduction, Bretonneau University Hospital, 2 boulevard Tonnelle, 37044 Tours Cedex 1, France
    BJOG 112:461-5. 2005
    ..To assess clinical failure and symptom recurrence after uterine artery embolisation (UAE) and to define predictive factors...
  68. ncbi request reprint Anisotropy changes in post-menopausal osteoporosis: characterization by a new index applied to trabecular bone radiographic images
    Christine Chappard
    INSERM ERIT M0101, CHR Orleans, 1 rue Porte Madeleine, 45032 Orleans Cedex 1, France
    Osteoporos Int 16:1193-202. 2005
    ..These data suggest that we can improve the fracture risk evaluation by adding information related to the directional organization of trabecular bone derived from the FFT spectrum on conventional radiographic images...
  69. ncbi request reprint A checklist to evaluate a report of a nonpharmacological trial (CLEAR NPT) was developed using consensus
    Isabelle Boutron
    INSERM U738, Paris, France
    J Clin Epidemiol 58:1233-40. 2005
    ..To develop a checklist of items measuring the quality of reports of randomized clinical trials (RCTs) assessing nonpharmacological treatments (NPTs)...
  70. ncbi request reprint [Impact of a recall campaign of the rules of the elimination of the injection equipment used for the treatment of hepatitis C in the centre region of France]
    Louis d'Alteroche
    Gastroenterol Clin Biol 30:492-3. 2006
  71. ncbi request reprint Treatment of chronic hepatitis C in patients unresponsive to interferon. Interest of re-treatment combining interferon induction therapy and ribavirin (a multicenter pilot study)
    Xavier Causse
    Service d Hepato Gastroenterologie, CHR La Source, BP 6709, 45067 Orleans Cedex 2
    Gastroenterol Clin Biol 29:117-21. 2005
    ....
  72. ncbi request reprint Methodological differences in clinical trials evaluating nonpharmacological and pharmacological treatments of hip and knee osteoarthritis
    Isabelle Boutron
    Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique des Hopitaux de Paris, Faculte Xavier Bichat, Universite Paris VII, Paris, France
    JAMA 290:1062-70. 2003
    ....
  73. ncbi request reprint Blinding was judged more difficult to achieve and maintain in nonpharmacologic than pharmacologic trials
    Isabelle Boutron
    INSERM EMI 03 57, Département d Epidémiologie, Biostatistique et Recherche Clinique, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Faculte Xavier Bichat, Universite Paris 7, France
    J Clin Epidemiol 57:543-50. 2004
    ..To compare the feasibility of blinding and the perceived risk of unblinding in trials evaluating pharmacologic (PT) and nonpharmacologic treatments (NPT) of hip or knee osteoarthritis...
  74. pmc Frequency of adverse drug reactions in children: a prospective study
    Annie Pierre Jonville-Bera
    Department of Clinical Pharmacology and Regional Drug Monitoring Centre, University Hospital of Tours, 2 Boulevard Tonellé, 37044 Tours Cedex, France
    Br J Clin Pharmacol 53:207-10. 2002
    ..To assess the frequency of adverse drug reactions (ADRs) in children in France...