Gael Chetelat

Summary

Affiliation: GIP Cyceron
Country: France

Publications

  1. pmc Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease
    Marine Fouquet
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Brain 132:2058-67. 2009
  2. doi Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers
    G Chetelat
    INSERM, U1077, CHU de Caen, Avenue de la Cote de Nacre, CS 30001, 14033 Caen cedex 9, France UMR S1077, laboratoire de neuropsychologie campus, Universite de Caen Basse Normandie, 5, Avenue de la Cote de Nacre, 14033 Caen cedex 9, France UMR S1077, Ecole Pratique des Hautes Etudes, Avenue de la Cote de Nacre, CS 30001, 14033 Caen cedex 9, France Electronic address
    Rev Neurol (Paris) 169:729-36. 2013
  3. doi Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity
    Gael Chetelat
    INSERM, U1077, Caen, France
    Neuroimage 76:167-77. 2013
  4. doi Alzheimer disease: Aβ-independent processes-rethinking preclinical AD
    Gael Chetelat
    INSERM, U1077, CHU Avenue de la Cote de Nacre, CS 30001, 14033 Caen cedex 9, Caen, France
    Nat Rev Neurol 9:123-4. 2013
  5. doi Relationship between memory performance and β-amyloid deposition at different stages of Alzheimer's disease
    Gael Chetelat
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Vic, Australia
    Neurodegener Dis 10:141-4. 2012
  6. doi Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition
    G Chetelat
    Department of Nuclear Medicine, Austin Health, Melbourne, Australia
    Neurology 78:477-84. 2012
  7. ncbi Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease
    G Chetelat
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218 U923, Laboratoire de Neuropsychologie, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Brain 131:60-71. 2008
  8. doi Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry
    G Chetelat
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Neuropsychologia 46:1721-31. 2008
  9. doi Larger temporal volume in elderly with high versus low beta-amyloid deposition
    Gael Chetelat
    Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia
    Brain 133:3349-58. 2010
  10. ncbi [Brain profile of hypometabolism in early Alzheimer's disease: relationships with cognitive deficits and atrophy]
    G Chetelat
    INSERM, EPHE, Universite de Caen, Unité E0218, GIP Cyceron, Caen, France
    Rev Neurol (Paris) 162:945-51. 2006

Detail Information

Publications58

  1. pmc Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease
    Marine Fouquet
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Brain 132:2058-67. 2009
    ..Altogether, our findings emphasize the potential of 18FDG-positron emission tomography for monitoring early Alzheimer's disease progression...
  2. doi Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers
    G Chetelat
    INSERM, U1077, CHU de Caen, Avenue de la Cote de Nacre, CS 30001, 14033 Caen cedex 9, France UMR S1077, laboratoire de neuropsychologie campus, Universite de Caen Basse Normandie, 5, Avenue de la Cote de Nacre, 14033 Caen cedex 9, France UMR S1077, Ecole Pratique des Hautes Etudes, Avenue de la Cote de Nacre, CS 30001, 14033 Caen cedex 9, France Electronic address
    Rev Neurol (Paris) 169:729-36. 2013
    ..e. atrophy with structural MRI, hypometabolism with FDG-PET, and amyloid deposition with amyloid-PET imaging...
  3. doi Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity
    Gael Chetelat
    INSERM, U1077, Caen, France
    Neuroimage 76:167-77. 2013
    ..The findings offer new perspectives to understand normal aging processes and open avenues for future studies to explore causality between age-related metabolism and connectivity changes...
  4. doi Alzheimer disease: Aβ-independent processes-rethinking preclinical AD
    Gael Chetelat
    INSERM, U1077, CHU Avenue de la Cote de Nacre, CS 30001, 14033 Caen cedex 9, Caen, France
    Nat Rev Neurol 9:123-4. 2013
    ..Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies...
  5. doi Relationship between memory performance and β-amyloid deposition at different stages of Alzheimer's disease
    Gael Chetelat
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Vic, Australia
    Neurodegener Dis 10:141-4. 2012
    ..The development of Aβ ligands for in vivo PET imaging has greatly facilitated the assessment of this question...
  6. doi Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition
    G Chetelat
    Department of Nuclear Medicine, Austin Health, Melbourne, Australia
    Neurology 78:477-84. 2012
    ..The aim of the present study was to assess whether Aβ influences the rate of atrophy in cognitively normal elderly individuals...
  7. ncbi Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease
    G Chetelat
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218 U923, Laboratoire de Neuropsychologie, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Brain 131:60-71. 2008
    ..Conversely, in the hippocampus, where disconnection processes are also likely to occur, relative synaptic compensatory mechanisms may be taking place, maintaining neuronal activity in the face of structural alterations...
  8. doi Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry
    G Chetelat
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Neuropsychologia 46:1721-31. 2008
    ..Our findings also suggest that the degree of hippocampal atrophy, more than its spatial localization, predicts rapid conversion to AD in patients with MCI...
  9. doi Larger temporal volume in elderly with high versus low beta-amyloid deposition
    Gael Chetelat
    Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia
    Brain 133:3349-58. 2010
    ..Our complementary analyses tend to support the latter hypotheses. Overall, our findings suggest that the deleterious effects of β-amyloid on cognition may be delayed in those subjects with larger brain (temporal) volume...
  10. ncbi [Brain profile of hypometabolism in early Alzheimer's disease: relationships with cognitive deficits and atrophy]
    G Chetelat
    INSERM, EPHE, Universite de Caen, Unité E0218, GIP Cyceron, Caen, France
    Rev Neurol (Paris) 162:945-51. 2006
    ....
  11. doi Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease
    Gael Chetelat
    Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia
    Brain 134:798-807. 2011
    ....
  12. ncbi Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study
    G Chetelat
    Inserm E0218 Université de Caen, Laboratoire de Neuropsychologie, Centre Cyceron, Bd H Becquerel, BP 5229, 14074 Caen Cedex, France
    Neuroimage 27:934-46. 2005
    ..The ability to longitudinally assess GM changes in MCI offers new perspectives to better understand the pathological processes underlying AD and to monitor the effects of treatment on brain structure...
  13. ncbi FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment
    Gael Chetelat
    INSERM E0218, Universite de Caen, GIP Cyceron, CHU Côte de Nacre France
    Neurocase 11:14-25. 2005
    ..However, they suggest that only the latter predictor is specifically and accurately associated with subsequent cognitive decline in patients with MCI within 18 months of first assessment...
  14. ncbi [At the boundary between normal aging and Alzheimer disease]
    G Chetelat
    Equipe Mixte de Recherche Inserm Université de Caen Basse Normandie 0218, Caen, France
    Rev Neurol (Paris) 160:S55-63. 2004
    ..Whereas functional neuroimaging, and more specifically FDG-PET, seems particularly accurate to predict AD, the combination of multiple approaches is likely to be a promising avenue...
  15. doi [Neuroimaging Alzheimer's disease: early diagnosis, monitoring, and mechanism understanding]
    Gael Chetelat
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Boulevard Henri Becquerel, BP 5229, 14074 Caen, France
    Med Sci (Paris) 27:193-8. 2011
    ..e. beta-amyloid depositions) offers a unique opportunity to better understand the mechanisms underlying this multifaceted disease...
  16. doi Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study
    Nicolas Villain
    INSERM, U1077, Caen 14000, France
    Brain 135:2126-39. 2012
    ..Furthermore, this study identified the existence of Pittsburgh compound 'accumulators' and 'non-accumulators', notably within the Pittsburgh compound B-negative group, which may be a relevant concept for future studies...
  17. ncbi In search of autobiographical memories: A PET study in the frontal variant of frontotemporal dementia
    Pascale Piolino
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218, Caen, France
    Neuropsychologia 45:2730-43. 2007
    ..This study supports the view that fv-FTD patients undergo a breakdown of generative processes which relies regardless of the remoteness on the left orbitofrontal cortex and temporal neocortex to gain access to AM...
  18. doi Relationship between atrophy and beta-amyloid deposition in Alzheimer disease
    Gael Chetelat
    Department of Nuclear Medicine and Center for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia
    Ann Neurol 67:317-24. 2010
    ..The present study aims to assess this relationship...
  19. pmc Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease
    Victor L Villemagne
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia
    Ann Neurol 69:181-92. 2011
    ..Assess Aβ deposition longitudinally and explore its relationship with cognition and disease progression...
  20. pmc Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease
    Nicolas Villain
    Institut National de la Santé et de la Recherche Médicale Ecole Pratique des Hautes Etudes Université de Caen Basse Normandie, Unité U923, Groupement d Intérêt Public Cyceron, Centre Hospitalier Universitaire Côte de Nacre, 14074 Caen, France
    J Neurosci 28:6174-81. 2008
    ....
  21. pmc Age-related changes in the cerebral substrates of cognitive procedural learning
    Valérie Hubert
    Inserm EPHE Universite de Caen Basse Normandie, GIP Cyceron, France
    Hum Brain Mapp 30:1374-86. 2009
    ..We assume that this additional activation in the older group during the associative and autonomous phases reflected compensatory processes and the fact that some older subjects failed to fully automate the procedure...
  22. doi Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study
    Kerryn E Pike
    Department of Nuclear Medicine, Centre for PET, Austin Health, Heidelberg, Vic, Australia
    Neuropsychologia 49:2384-90. 2011
    ..The finding of gender differences deserves further research to answer definitively the important question of gender susceptibility to adverse cognitive effects from β-amyloid...
  23. doi Mental time travel into the past and the future in healthy aged adults: an fMRI study
    Armelle Viard
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Brain Cogn 75:1-9. 2011
    ..Within this network, differential recruitment of specific areas highlights the episodic distinction between past and future mental time travel...
  24. doi Differential diagnosis in Alzheimer's disease and dementia with Lewy bodies via VMAT2 and amyloid imaging
    Victor L Villemagne
    Mental Health Research Institute, University of Melbourne, Melbourne, Vic, Australia
    Neurodegener Dis 10:161-5. 2012
    ..The noninvasive evaluation of nigrostriatal dopaminergic integrity by PET can provide useful information for the differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD)...
  25. ncbi The neural basis of intrusions in free recall and cued recall: a PET study in Alzheimer's disease
    Beatrice Desgranges
    INSERM E0218, Universite de Caen, Centre Cyceron, CHU Cote de Nacre, 14033, Caen Cedex, France
    Neuroimage 17:1658-64. 2002
    ..Frontal dysfunction would be responsible for the former and rhinal dysfunction for the latter...
  26. pmc Patterns of hippocampal-neocortical interactions in the retrieval of episodic autobiographical memories across the entire life-span of aged adults
    Armelle Viard
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Hippocampus 20:153-65. 2010
    ..Overall, this paper emphasizes the role of a bilateral network of MTL and neocortical areas whose activation correlate during the recollection of rich phenomenological recent and remote EAMs...
  27. ncbi Detecting hippocampal hypometabolism in Mild Cognitive Impairment using automatic voxel-based approaches
    Katell Mevel
    Inserm E0218 EPHE Université de Caen Basse Normandie, Laboratoire de Neuropsychologie, GIP Cyceron, CHU Cote de Nacre, Bd H Becquerel, 14074 Caen Cedex, Caen, France
    Neuroimage 37:18-25. 2007
    ..These findings have clinical relevance since they support the validity of more automatic and time-saving approaches to assess hippocampal metabolism changes in aMCI and early AD...
  28. doi Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence
    Renaud La Joie
    Inserm EPHE, Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Neuroimage 53:506-14. 2010
    ....
  29. doi Age effect on the default mode network, inner thoughts, and cognitive abilities
    Katell Mevel
    INSERM, U1077 Caen, France
    Neurobiol Aging 34:1292-301. 2013
    ..These findings provide new information to fuel the debate on the role of the brain default mode and more specifically on the effect of age-related changes in resting-state activity as measured with fMRI...
  30. doi Structural and metabolic correlates of episodic memory in relation to the depth of encoding in normal aging
    Grégoria Kalpouzos
    Inserm EPHE Universite de Caen Basse Normandie, U 923, Caen, France
    J Cogn Neurosci 21:372-89. 2009
    ..By contrast, the impaired retrieval of deeply encoded words in the elderly group was mainly related to frontal and parietal regions, suggesting the adoption of inefficient strategic processes...
  31. pmc Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease
    Nicolas Villain
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, Bd H Becquerel, BP 5229, 14074 Caen Cedex, France
    Brain 133:3301-14. 2010
    ....
  32. ncbi Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment
    Gael Chetelat
    Inserm E0218 Université de Caen, Laboratoire de Neuropsychologie, CHU Cote de Nacre, 14033 Caen Cedex, France
    Brain 126:1955-67. 2003
    ....
  33. pmc Morphological and glucose metabolism abnormalities in alcoholic Korsakoff's syndrome: group comparisons and individual analyses
    Anne Lise Pitel
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    PLoS ONE 4:e7748. 2009
    ..Because of the lack of brain biomarkers, KS was found to be underdiagnosed in postmortem studies...
  34. doi Reliving lifelong episodic autobiographical memories via the hippocampus: a correlative resting PET study in healthy middle-aged subjects
    Pascale Piolino
    U923, Inserm EPHE Universite de Caen Basse Normandie, Unité 923, Caen, France
    Hippocampus 18:445-59. 2008
    ..These results highlight, in healthy subjects, the distinct role of these two structures in AM retrieval and support the view that the hippocampus is needed for reexperiencing detailed episodic memories no matter how old they are...
  35. doi Which SPM method should be used to extract hippocampal measures in early Alzheimer's disease?
    Katell Mevel
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    J Neuroimaging 21:310-6. 2011
    ..To provide guidance regarding the most appropriate voxel-based morphometry (VBM)-derived method for assessing hippocampal atrophy in early Alzheimer's disease (AD)...
  36. ncbi Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging
    Grégoria Kalpouzos
    Inserm EPHE Universite de Caen Basse Normandie, Unité de Recherche E0218, GIP Cyceron, Caen, France
    Neurobiol Aging 30:112-24. 2009
    ....
  37. doi Prediction of amyloid-β pathology in amnestic mild cognitive impairment with neuropsychological tests
    Alex Bahar-Fuchs
    Department of Nuclear Medicine, Centre for PET, Austin Health, Melbourne, Vic, Australia
    J Alzheimers Dis 33:451-62. 2013
    ..In conclusion, a measure of story recall may increase the confidence in making a diagnosis of MCI due to AD in clinical settings...
  38. ncbi Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients
    Grégoria Kalpouzos
    Inserm Université de Caen E0218, Laboratoire de Neuropsychologie, CHU Cote de Nacre, 14033 Caen Cedex, France
    J Neurol 252:548-58. 2005
    ....
  39. doi Role of hippocampal CA1 atrophy in memory encoding deficits in amnestic Mild Cognitive Impairment
    Marine Fouquet
    INSERM, U1077 Caen, France
    Neuroimage 59:3309-15. 2012
    ..In contrast, episodic retrieval deficits seem to be underlain by more distributed tissue losses, consistent with a disruption of a hippocampo-parieto-frontal network...
  40. doi Olfactory deficits and amyloid-β burden in Alzheimer's disease, mild cognitive impairment, and healthy aging: a PiB PET study
    Alex Bahar-Fuchs
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    J Alzheimers Dis 22:1081-7. 2010
    ..We conclude that AD-related olfactory identification deficits are not directly related to Aβ burden...
  41. pmc Is neocortical-hippocampal connectivity a better predictor of subsequent recollection than local increases in hippocampal activity? New insights on the role of priming
    Pierre Gagnepain
    Inserm EPHE Universite de Caen Basse Normandie, Caen, France
    J Cogn Neurosci 23:391-403. 2011
    ..We propose that one consequence of priming is to "free up" attentional resources from processing an item in a noisy context, thereby allowing greater attention to encoding of that context...
  42. doi Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease
    P A Yates
    Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australia
    Neurology 77:48-54. 2011
    ..We hypothesized that Aβ deposition in asymptomatic elderly individuals is associated with lobar MH (LMH)...
  43. ncbi Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging
    Gael Chetelat
    INSERM E0218, University of Caen, France
    Neuroimage 18:525-41. 2003
    ..Future research in this field should capitalize on thorough methodology for brain structure delineation, and combine atrophy measurements to cognitive and/or functional imaging data...
  44. ncbi Advances in structural and molecular neuroimaging in Alzheimer's disease
    Kathryn A Ellis
    Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 194:S20-3. 2011
    ....
  45. ncbi The dynamic network subserving the three phases of cognitive procedural learning
    Valérie Hubert
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218, GIP Cyceron, CHU de Caen, Caen, France
    Hum Brain Mapp 28:1415-29. 2007
    ..Lastly, the activation of the cerebellum during the autonomous phase is consistent with the fact that performance in this phase is determined by psychomotor abilities...
  46. pmc A simple way to improve anatomical mapping of functional brain imaging
    Nicolas Villain
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    J Neuroimaging 20:324-33. 2010
    ..The objective of this study is thus to provide a very simple alternative method for distortion correction and to demonstrate its efficiency...
  47. ncbi [Cerebral imaging and physiopathology of Alzheimer's disease]
    Marine Fouquet
    INSERM E0218, EPHE, Universite de Caen Basse Normandie, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Psychol Neuropsychiatr Vieil 5:269-79. 2007
    ..Furthermore, this synthesis emphasizes the relevance of neuroimaging for the early detection of AD...
  48. pmc Hippocampal activation for autobiographical memories over the entire lifetime in healthy aged subjects: an fMRI study
    Armelle Viard
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218, GIP Cyceron, CHU Cote de Nacre, 14033 Caen Cedex, France
    Cereb Cortex 17:2453-67. 2007
    ..The comparison with previous literature stresses the idea that a bilateral involvement of the hippocampus characterizes rich episodic autobiographical memory recollection...
  49. ncbi Anatomical and functional alterations in semantic dementia: a voxel-based MRI and PET study
    Beatrice Desgranges
    Inserm EPHE Université de Caen, Unité E0218, GIP Cyceron, CHU de Caen, Caen, France
    Neurobiol Aging 28:1904-13. 2007
    ..While PET is more sensitive than MRI, there is striking concordance between morphological and functional abnormalities, which contrasts with the discordance observed in Alzheimer's disease and might be a typical feature of SD...
  50. doi Morphological brain plasticity induced by musical expertise is accompanied by modulation of functional connectivity at rest
    Baptiste Fauvel
    INSERM, U1077, Caen, France Université de Caen Basse Normandie, UMR S1077, Caen, France École Pratique des Hautes Études, UMR S1077, Caen, France Caen University Hospital, U1077, Caen, France
    Neuroimage 90:179-88. 2014
    ..We interpreted these findings as the consequence of repeated collaborative use in general networks supporting some of the memory, perceptual-motor and emotional features of musical practice. ..
  51. doi Brain Activity and Functional Coupling Changes Associated with Self-Reference Effect during Both Encoding and Retrieval
    Nastassja Morel
    INSERM, U1077, Caen, France Université de Caen Basse Normandie, UMR S1077, Caen, France École Pratique des Hautes Études, UMR S1077, Caen, France CHU de Caen, U1077, Caen, France
    PLoS ONE 9:e90488. 2014
    ..This is consistent with the idea that SRE reflects a positive effect of the reactivation of self-related memories on the encoding of new information in episodic memory. ..
  52. doi Cross-sectional and longitudinal analysis of the relationship between Aβ deposition, cortical thickness, and memory in cognitively unimpaired individuals and in Alzheimer disease
    Vincent Dore
    CSIRO Preventative Health National Research Flagship ICTC, the Australian e Health Research Centre BioMedical, Royal Brisbane and Women s Hospital, Herston, Queensland, Australia
    JAMA Neurol 70:903-11. 2013
    ..We aimed to further characterize the cross-sectional and longitudinal relationship between Aβ deposition, gray matter atrophy, and cognitive impairment...
  53. doi In vivo assessment of vesicular monoamine transporter type 2 in dementia with lewy bodies and Alzheimer disease
    Victor L Villemagne
    Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health, Heidelber, Australia
    Arch Neurol 68:905-12. 2011
    ..Design, Setting, and..
  54. doi [Neuroimaging in Alzheimer's disease: a synthesis and a contribution to the understanding of physiopathological mechanisms]
    Nicolas Villain
    Universite de Caen, Caen, France
    Biol Aujourdhui 204:145-58. 2010
    ..It has underlined the relevance of distant over local mechanisms in the pathophysiology of Alzheimer's disease and offers new perspectives to the exploration of the neural bases of cognitive impairments in this disorder...
  55. pmc When Higher Activations Reflect Lower Deactivations: A PET Study in Alzheimer's Disease during Encoding and Retrieval in Episodic Memory
    Alexandre Bejanin
    U1077, Inserm Caen, France
    Front Hum Neurosci 6:107. 2012
    ..Although there has been evidence supporting the existence of genuine compensatory mechanisms, dysfunction within the DMN may be responsible for part of the apparent hyperactivations reported in the literature on AD...
  56. pmc Repetition enhancement and perceptual processing of visual word form
    Karine Lebreton
    INSERM, U1077 Caen, France
    Front Hum Neurosci 6:206. 2012
    ....
  57. pmc The default mode network in healthy aging and Alzheimer's disease
    Katell Mevel
    INSERM, EPHE, Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, 14074 Caen, France
    Int J Alzheimers Dis 2011:535816. 2011
    ..While perturbations of the DMN have been consistently reported, especially within the posterior cingulate, further studies are needed to understand their clinical implication...
  58. ncbi [Alzheimer's disease, hippocampus and neuroimaging]
    K Mevel
    Inserm EPHE Universite de Caen Basse Normandie, Unité E0218, Caen, France
    Encephale 32:S1149-54. 2006