Karim Bordji

Summary

Affiliation: GIP Cyceron
Country: France

Publications

  1. doi request reprint Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production
    Karim Bordji
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique, Caen, France
    J Neurosci 30:15927-42. 2010
  2. doi request reprint Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease
    Karim Bordji
    Groupement d Intérêt Public Cyceron, Centre National de la Recherche Scientifique, UMR 6232 Centre d Imagerie Neurosciences et d Applications aux Pathologies, Bd Becquerel, F 14074 Caen, France
    Rev Neurosci 22:285-94. 2011

Detail Information

Publications2

  1. doi request reprint Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production
    Karim Bordji
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique, Caen, France
    J Neurosci 30:15927-42. 2010
    ..Altogether, these data suggest that a chronic activation of extrasynaptic NMDAR promotes amyloidogenic KPI-APP expression leading to neuronal Aβ release, representing a causal risk factor for developing AD...
  2. doi request reprint Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease
    Karim Bordji
    Groupement d Intérêt Public Cyceron, Centre National de la Recherche Scientifique, UMR 6232 Centre d Imagerie Neurosciences et d Applications aux Pathologies, Bd Becquerel, F 14074 Caen, France
    Rev Neurosci 22:285-94. 2011
    ..This molecular mechanism could therefore explain why memantine is, to date, the only clinically approved NMDA receptor antagonist for the treatment of dementia...