Sophie Gillette

Summary

Country: France

Publications

  1. ncbi request reprint Body composition in French women 75+ years of age: the EPIDOS study
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire Purpan Casselardit, 170 avenue de Casselardit, F 31300 Toulouse, France
    Mech Ageing Dev 124:311-6. 2003
  2. pmc Nutrition and neurodegeneration: epidemiological evidence and challenges for future research
    Sophie Gillette-Guyonnet
    Gerontopole, Toulouse University Hospital, Department of Internal Medicine and Geriatrics, Purpan University Hospital, Toulouse F 31059, France
    Br J Clin Pharmacol 75:738-55. 2013
  3. doi request reprint Long-term progression of Alzheimer's disease in patients under antidementia drugs
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Geriatrics, Purpan University Hospital, Gerontopole Toulouse University Hospital, France
    Alzheimers Dement 7:579-92. 2011
  4. doi request reprint The Toulouse Gérontopôle Research Center: report of activities, 2007-2011
    Sophie Gillette-Guyonnet
    Gerontopole, Toulouse University Hospital, Department of Internal Medicine and Geriatrics, Purpan University Hospital, Toulouse, France
    J Alzheimers Dis 28:721-32. 2012
  5. ncbi request reprint The REAL.FR research program on Alzheimer's disease and its management: methods and preliminary results
    S Gillette-Guyonnet
    Service de médecine interne et gérontologie clinique, Pavillon Junod, 170 avenue de Casselardit, 31300 Toulouse France
    J Nutr Health Aging 7:91-6. 2003
  6. ncbi request reprint Long-term cholinergic treatment is not associated with greater risk of weight loss during Alzheimer's disease: data from the French REAL.FR cohort
    S Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerongology, Centre Hospitalier Universitaire Purpan Casselardit, F 31300 Toulouse, France
    J Nutr Health Aging 9:69-73. 2005
  7. ncbi request reprint The potential influence of silica present in drinking water on Alzheimer's disease and associated disorders
    S Gillette Guyonnet
    Service de Medecine Interne et de Gerontologie Clinique, Pavillon J P Junod, Centre Hospitalier Universitaire La Grave Casselardit, Toulouse Cedex 9, France
    J Nutr Health Aging 11:119-24. 2007
  8. ncbi request reprint [The French network multicenter study. Predictive factors of hospitalization and management of Alzheimer's disease patients (REAL.FR)]
    S Gillette-Guyonnet
    Service de médecine interne et gérontologie clinique, Unite INSERM 558, Toulouse, France
    Rev Med Interne 24:278s-282s. 2003
  9. doi request reprint Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease
    Sophie Gillette-Guyonnet
    Gérontopôle de Toulouse, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France
    Alzheimers Dement 5:114-21. 2009
  10. ncbi request reprint IANA task force on nutrition and cognitive decline with aging
    S Gillette Guyonnet
    Service de Medecine Interne et de Gerontologie Clinique, Pavillon J P Junod, Centre Hospitalier Universitaire La Grave Casselardit, Toulouse Cedex 9, France
    J Nutr Health Aging 11:132-52. 2007

Detail Information

Publications41

  1. ncbi request reprint Body composition in French women 75+ years of age: the EPIDOS study
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire Purpan Casselardit, 170 avenue de Casselardit, F 31300 Toulouse, France
    Mech Ageing Dev 124:311-6. 2003
    ..There are presently no published data on age-related changes in body composition in French individuals older than 65 or 80 years. This paper presents a cross-sectional study of 7518 community-residing French women older than 75 years...
  2. pmc Nutrition and neurodegeneration: epidemiological evidence and challenges for future research
    Sophie Gillette-Guyonnet
    Gerontopole, Toulouse University Hospital, Department of Internal Medicine and Geriatrics, Purpan University Hospital, Toulouse F 31059, France
    Br J Clin Pharmacol 75:738-55. 2013
    ..Limitations of the current data, divergence with results of interventional prevention studies and challenges for future research are discussed...
  3. doi request reprint Long-term progression of Alzheimer's disease in patients under antidementia drugs
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Geriatrics, Purpan University Hospital, Gerontopole Toulouse University Hospital, France
    Alzheimers Dement 7:579-92. 2011
    ..Data regarding the long-term disease progression outside of therapeutic trials are lacking. We examined the effects of standard of care for AD patients on the prognosis of the disease in a real-life study over a 4-year period...
  4. doi request reprint The Toulouse Gérontopôle Research Center: report of activities, 2007-2011
    Sophie Gillette-Guyonnet
    Gerontopole, Toulouse University Hospital, Department of Internal Medicine and Geriatrics, Purpan University Hospital, Toulouse, France
    J Alzheimers Dis 28:721-32. 2012
    ....
  5. ncbi request reprint The REAL.FR research program on Alzheimer's disease and its management: methods and preliminary results
    S Gillette-Guyonnet
    Service de médecine interne et gérontologie clinique, Pavillon Junod, 170 avenue de Casselardit, 31300 Toulouse France
    J Nutr Health Aging 7:91-6. 2003
    ..The satisfactory participation of patients and their families in the later evaluations which have already been carried out also seem promising for the continuation of follow-up...
  6. ncbi request reprint Long-term cholinergic treatment is not associated with greater risk of weight loss during Alzheimer's disease: data from the French REAL.FR cohort
    S Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerongology, Centre Hospitalier Universitaire Purpan Casselardit, F 31300 Toulouse, France
    J Nutr Health Aging 9:69-73. 2005
    ..The proportion of patients losing weight is extremely variable from one study to another and further analysis is necessary to reach a conclusion on the association of weight loss and AChEI...
  7. ncbi request reprint The potential influence of silica present in drinking water on Alzheimer's disease and associated disorders
    S Gillette Guyonnet
    Service de Medecine Interne et de Gerontologie Clinique, Pavillon J P Junod, Centre Hospitalier Universitaire La Grave Casselardit, Toulouse Cedex 9, France
    J Nutr Health Aging 11:119-24. 2007
    ..The aim of this paper is to review articles published on silica present in drinking water in relation with AD and associated disorders...
  8. ncbi request reprint [The French network multicenter study. Predictive factors of hospitalization and management of Alzheimer's disease patients (REAL.FR)]
    S Gillette-Guyonnet
    Service de médecine interne et gérontologie clinique, Unite INSERM 558, Toulouse, France
    Rev Med Interne 24:278s-282s. 2003
    ..The satisfactory participation of patients and their families in the later evaluations which have already been carried out also seem promising for the continuation of follow-up...
  9. doi request reprint Commentary on "A roadmap for the prevention of dementia II. Leon Thal Symposium 2008." The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease
    Sophie Gillette-Guyonnet
    Gérontopôle de Toulouse, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France
    Alzheimers Dement 5:114-21. 2009
    ..The study also collects imaging and biological data that could be used in future AD prevention and treatment trials...
  10. ncbi request reprint IANA task force on nutrition and cognitive decline with aging
    S Gillette Guyonnet
    Service de Medecine Interne et de Gerontologie Clinique, Pavillon J P Junod, Centre Hospitalier Universitaire La Grave Casselardit, Toulouse Cedex 9, France
    J Nutr Health Aging 11:132-52. 2007
    ..These studies must control for the greatest number of known confounding factors and take into account the impact of the standard social determinants of food habits, such as the regional cultures, social status, and educational level...
  11. doi request reprint Caloric restriction and brain function
    Sophie Gillette-Guyonnet
    Gérontopôle Toulouse, France
    Curr Opin Clin Nutr Metab Care 11:686-92. 2008
    ..caloric restriction on brain functioning? Could caloric restriction be proposed in the future to prevent or treat neurodegenerative disorders such as Alzheimer's disease? Is there a future for caloric restriction interventions in adults?..
  12. ncbi request reprint Outcome of Alzheimer's disease: potential impact of cholinesterase inhibitors
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire La Grave Casselardit, 170 avenue de Casselardit, TSA40031, 31059 Toulouse Cedex 9, France
    J Gerontol A Biol Sci Med Sci 61:516-20. 2006
    ..This study aims to investigate the effect of CEIs on three clinically relevant domains (rapid cognitive decline, institutionalization, and weight loss) in patients with Alzheimer's disease...
  13. doi request reprint Weight loss and rapid cognitive decline in community-dwelling patients with Alzheimer's disease
    Maria E Soto
    Alzheimer s Disease Research and Clinical Centre, Department of Geriatric Medicine, Gerontopole, Toulouse University Hospital, Toulouse, France
    J Alzheimers Dis 28:647-54. 2012
    ..50, 95% CI = 1.04-2.17). In conclusion, weight loss predicted RCD in this cohort. Whether the prevention of weight loss (by improving nutritional status) impacts cognitive decline remains an open question...
  14. ncbi request reprint Sarcopenia and cognitive impairment in elderly women: results from the EPIDOS cohort
    Gabor Abellan van Kan
    Gérontopôle de Toulouse, Department of Geriatric Medicine, Toulouse University Hospital, 170, avenue de Casselardit, Toulouse 31059, France
    Age Ageing 42:196-202. 2013
    ..common pathophysiological pathways are shared between age-related body composition changes and cognitive impairment...
  15. doi request reprint Predictive value of rapid decline in mini mental state examination in clinical practice for prognosis in Alzheimer's disease
    Maria E Soto
    Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    Dement Geriatr Cogn Disord 26:109-16. 2008
    ..Given the poorer prognosis of Alzheimer's disease (AD) patients with rapid cognitive decline (RCD), there is a need for a clinical assessment tool to detect these patients...
  16. ncbi request reprint Is there a relationship between fat-free soft tissue mass and low cognitive function? Results from a study of 7,105 women
    Fati Nourhashemi
    Department of Internal Medicine and Gerontology Clinic, CHU Purpan Casselardit, Toulouse, France
    J Am Geriatr Soc 50:1796-801. 2002
    ..To test the hypothesis that low fat-free soft tissue mass and cognitive impairment are independently associated...
  17. ncbi request reprint A 2-year follow-up of 233 very mild (CDR 0.5) Alzheimer's disease patients (REAL.FR cohort)
    Fati Nourhashemi
    CHU Toulouse, Hôpital Casselardit, Service de médecine interne et gérontologie clinique, Toulouse, France
    Int J Geriatr Psychiatry 23:460-5. 2008
    ..The primary objective of our study was to examine the evolution of AD in individuals with very mild AD (CDR 0.5) across a 2-year follow up...
  18. doi request reprint Characteristics of Alzheimer's disease patients with a rapid weight loss during a six-year follow-up
    Olivier Guerin
    INSERM U558, Department of Internal Medicine and Clinical Gerontology, CHU de Toulouse, Universite Paul Sabatier, France
    Clin Nutr 28:141-6. 2009
    ..Weight loss in Alzheimer's disease (AD) may be either progressive or rapid, with different consequences. The aim of this study was to characterize massive weight loss (>or= 5 kg over 6 months) during a 6.5-year follow-up...
  19. doi request reprint Alzheimer's disease progression in the oldest old compared to younger elderly patient: data from the REAL.FR study
    Fati Nourhashemi
    Gérontopôle Toulouse, France
    Int J Geriatr Psychiatry 24:149-55. 2009
    ..The aim of this study is to describe the progression of Alzheimer's disease (AD) in the oldest old (>or=85 years) and to compare it with the younger elderly...
  20. doi request reprint Prognosis of Alzheimer's disease today: a two-year prospective study in 686 patients from the REAL-FR Study
    Frederic Cortes
    Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire Purpan Casselardit, Toulouse, France
    Alzheimers Dement 4:22-9. 2008
    ..The aim of the present study was to describe the long-term evolution of Alzheimer's disease (AD) in a prospective cohort of patients under treatment with a close follow-up...
  21. ncbi request reprint Risk factors for functional decline and institutionalisation among community-dwelling older adults with mild to severe Alzheimer's disease: one year of follow-up
    Maria E Soto
    Médicine Interne et Gériatrie, CHU Purpan Casselardit, Toulouse, Midi Pirinées, France
    Age Ageing 35:308-10. 2006
  22. doi request reprint Gait speed, body composition, and dementia. The EPIDOS-Toulouse cohort
    Gabor Abellan van Kan
    Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    J Gerontol A Biol Sci Med Sci 67:425-32. 2012
    ..The aim of the study was to evaluate whether GS, TLM, and TFM were associated factors with an increased risk for subsequent dementia in community-dwelling older women...
  23. doi request reprint Predictive factors of attrition in a cohort of Alzheimer disease patients. The REAL.FR study
    Nicola Coley
    INSERM, U558, University of Toulouse III, Toulouse, France
    Neuroepidemiology 31:69-79. 2008
    ..Attrition, i.e. patient dropout, can threaten the validity of results in longitudinal studies. The aim of this study was to identify patient and caregiver factors predictive of attrition in a cohort of Alzheimer disease (AD) patients...
  24. pmc Effectiveness of a specific care plan in patients with Alzheimer's disease: cluster randomised trial (PLASA study)
    Fati Nourhashemi
    Gerontopole, CMRR, Toulouse, France
    BMJ 340:c2466. 2010
    ..To test the effectiveness of a comprehensive specific care plan in decreasing the rate of functional decline in patients with mild to moderate Alzheimer's disease compared with usual care in memory clinics...
  25. ncbi request reprint Association of Alzheimer's disease onset with ginkgo biloba and other symptomatic cognitive treatments in a population of women aged 75 years and older from the EPIDOS study
    Sandrine Andrieu
    Department of Internal Medicine and Clinical Gerontology, Acute Unit for Alzheimer s Patients, Toulouse, France
    J Gerontol A Biol Sci Med Sci 58:372-7. 2003
    ..The potential association between use of C4A treatments, in particular EGb 761 (standardized Ginkgo biloba extracts), and dementia of the Alzheimer type was investigated...
  26. ncbi request reprint Comparison of bone mineral density and body composition measurements in women obtained from two DXA instruments
    Sophie Gillette-Guyonnet
    Department of Internal Medicine and Clinical Gerontology Pr JL Albarède, Centre Hospitalier Universitaire Purpan Casselardit, 170 avenue de Casselardit, F 31300 Toulouse, France
    Mech Ageing Dev 124:317-21. 2003
    ..However, due to the bone mineral inter-machine differences, comparisons of DXA measurements from different machines should be interpreted with caution...
  27. ncbi request reprint Cognitive function and caregiver burden: predictive factors for eating behaviour disorders in Alzheimer's disease
    Stéphanie Rivière
    Department of Internal Medicine and Clinical Gerontology, Hopital La Grave Casselardit, Toulouse, France
    Int J Geriatr Psychiatry 17:950-5. 2002
    ..These behaviours lead to weight loss and frequently to physicians using tube feeding. Little is known about factors correlated with feeding difficulties during AD...
  28. ncbi request reprint Improvement of weight and fat-free mass with oral nutritional supplementation in patients with Alzheimer's disease at risk of malnutrition: a prospective randomized study
    Sylvie Lauque
    Alzheimer Research and Clinical Center, Toulouse University Hospital, Toulouse, France
    J Am Geriatr Soc 52:1702-7. 2004
    ..To study the effects of oral nutritional supplements (OS) on body weight, body composition, nutritional status, and cognition in elderly patients with Alzheimer's disease (AD)...
  29. ncbi request reprint Family history of dementia does not influence the progression of Alzheimer's disease at two years: results from the REAL.FR Study
    Frederic Cortes
    Service de médecine interne et gérontologie clinique, Toulouse, France
    Am J Alzheimers Dis Other Demen 21:131-6. 2006
    ....
  30. ncbi request reprint Cognitive impairment and composition of drinking water in women: findings of the EPIDOS Study
    Sophie Gillette-Guyonnet
    Service de médecine interne et gérontologie clinique, Hôpital Casselardit, Toulouse, France
    Am J Clin Nutr 81:897-902. 2005
    ..The concentration of aluminum or silica in drinking water may be a potential environmental risk factor for Alzheimer disease (AD)...
  31. doi request reprint Patterns of dementia treatment use in assisted living facilities: a cross-sectional study of 1975 demented residents
    Nadège Barro-Belaygues
    Gérontopôle de Toulouse, Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    J Am Med Dir Assoc 12:648-54. 2011
    ..To report the associated factors with the nonuse of cholinesterase-inhibitors and memantine in residents from assisted living (AL) facilities suffering from dementia...
  32. doi request reprint Dementia prevention: methodological explanations for inconsistent results
    Nicola Coley
    INSERM unit 558, Toulouse, France
    Epidemiol Rev 30:35-66. 2008
    ..Because of the multifactorial origin of dementia, it appears that multidomain interventions could be a suitable candidate for preventive interventions, but designing such trials remains very challenging for researchers...
  33. ncbi request reprint The assessment of frailty in older adults
    Gabor Abellan van Kan
    Gérontopôle de Toulouse, Department of Geriatric Medicine, Pavillon JP Junod, University Hospital Toulouse, CHU Toulouse, 170 avenue de Casselardit, TSA 40031, 31059 Toulouse Cedex 9, France
    Clin Geriatr Med 26:275-86. 2010
    ..The evaluation of gait speed over a short distance emerges from the literature as a tool with the capacity to identify frail older adults, and slow gait speed has been proven to be a strong predictor for frailty-adverse outcomes...
  34. ncbi request reprint [Nutrition and Alzheimer's disease]
    Sophie Gillette-Guyonnet
    centre mémoire de ressource et de recherche, Toulouse, France
    Psychol Neuropsychiatr Vieil 3:S35-41. 2005
    ..Patients' caregivers play a central role in prevention and management of nutritional disorders. Information programs for caregivers may reduce caregiver burden and improve patients' health status...
  35. doi request reprint Cachexia versus sarcopenia
    Yves Rolland
    INSERM U558, University of Toulouse III, France
    Curr Opin Clin Nutr Metab Care 14:15-21. 2011
    ..The review summarizes and discusses the proposed new definitions for sarcopenia and cachexia. It also highlights the overlapping of both conditions and the fact that these conditions frequently occur in elderly patients...
  36. doi request reprint Strontium ranelate and risk of vertebral fractures in frail osteoporotic women
    Yves Rolland
    INSERM U558, F 31073, Avenue Jules Guesdes, University of Toulouse III, F 31073, France
    Bone 48:332-8. 2011
    ..Our study determined and compared the risk of vertebral fractures in frail, intermediate and robust older patients being treated with strontium ranelate vs. placebo...
  37. ncbi request reprint Factors associated with undertreatment of atrial fibrillation in geriatric outpatients with Alzheimer disease
    Neda Tavassoli
    Gérontopôle de Toulouse, Departement de Medecine Interne et Gerontologie Clinique, Centre Hospitalier Universitaire de Toulouse, Pavillon Junod, 170 avenue de Casselardit, 31300, Toulouse, France
    Am J Cardiovasc Drugs 13:425-33. 2013
    ..These recommendations are not systematically observed in patients with Alzheimer disease (AD). The aim of our study was to determine the factors associated with undertreatment of AF in geriatric outpatients with AD...
  38. doi request reprint A follow-up intervention in severely demented patients after discharge from a special Alzheimer acute care unit: impact on early emergency room re-hospitalization rate
    Hélène Villars
    Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    Int J Geriatr Psychiatry 28:1131-40. 2013
    ..Emergency room (ER) re-hospitalizations are prevalent in severe Alzheimer's disease affected older patients...
  39. pmc Comparison of informal care time and costs in different age-related dementias: a review
    Nadège Costa
    UMR1027, INSERM, 31073 Toulouse, France
    Biomed Res Int 2013:852368. 2013
    ..Dementias cause a substantial burden on society and on families who provide informal care. This study aims to review the relevant papers to compare informal care time and costs in different dementias...
  40. doi request reprint Memory health clinics-a first step to prevention
    Bruno Vellas
    Department of Internal Medicine and Clinical Gerontology, Gerontopole, Toulouse Université Hospital, CHU La Grave Casselardit, Toulouse, France Inserm U 558, Toulouse, France
    Alzheimers Dement 4:S144-9. 2008
    ..Leon Thal suggested that this could have a much bigger impact than all the drugs we might ever hope to develop. The main objective of this article is to present the rationale for multi-domain preventive approaches...
  41. pmc Methodological considerations in cost of illness studies on Alzheimer disease
    Nagede Costa
    Department of Medical Information, University Hospital of Toulouse, Toulouse, F 31059, France
    Health Econ Rev 2:18. 2012
    ..To increase its credibility, closer agreement among researchers on the methodological principles of cost studies would be desirable...