Research Topics
Genomes and Genes | Christian GiaumeSummaryCountry: France Publications
| Collaborators
|
Detail Information
Publications
The barrel cortex as a model to study dynamic neuroglial interactionChristian Giaume
Inserm U840, College de France, Paris, France
Neuroscientist 15:351-66. 2009..Finally, this review outlines how the use of the barrel cortex as a model might in the future help to address important questions related to dynamic neuroglia interaction...- From a glial syncytium to a more restricted and specific glial networkingChristian Giaume
CIRB, CNRS UMR UMR7241 INSERM U1050, MEMOLIFE Laboratory of Excellence and Paris Science Lettre, College de France, University Pierre et Marie Curie, ED, n 158, 11 place Marcelin Berthelot, 75005 Paris, France
J Physiol Paris 106:34-9. 2012.... - Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous systemChristian Giaume
Inserm U840, College de France, Paris, France
Brain Res Rev 63:160-76. 2010..We outline new avenues not only to study specific mechanisms by which connexins exert these functions but also to selectively investigate well-defined coupling compartments among glial networks... - Astroglial networks: a step further in neuroglial and gliovascular interactionsChristian Giaume
Inserm U840, College de France, 75005 Paris, France
Nat Rev Neurosci 11:87-99. 2010..This intercellular communication between glia has implications for neuroglial and gliovascular interactions and hence has added another level of complexity to our understanding of brain function... - Connexin-based channels in astrocytes: how to study their propertiesChristian Giaume
CIRB, CNRS UMR7241 INSERM U1050 Collège de France, Paris, France
Methods Mol Biol 814:283-303. 2012..These techniques are applied in astrocyte studies using in vitro models, mainly primary cultures and acute brain slices... 
Astroglial networks scale synaptic activity and plasticityUlrike Pannasch
Centre National de la Recherche Scientifique Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, College de France, 75005 Paris, France
Proc Natl Acad Sci U S A 108:8467-72. 2011..Altogether, these results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses...
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatmentsNicolas Froger
Institut National de la Sante et de la Recherche Medicale, U840, Paris, France
J Neurochem 111:1383-97. 2009....- Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotectiveNicolas Froger
Inserm U840, College de France, 11 place Marcelin Berthelot, 75231 Paris, Cedex 05, France
Mol Cell Neurosci 45:37-46. 2010..Altogether, these data demonstrate that inflammation-induced astroglial hemichannel activation plays a critical role in neuronal death and suggest a neuroprotective role of connexin43 hemichannel blockade... - Astroglial metabolic networks sustain hippocampal synaptic transmissionNathalie Rouach
Inserm U840, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
Science 322:1551-5. 2008..These results indicate that astroglial gap junctions provide an activity-dependent intercellular pathway for the delivery of energetic metabolites from blood vessels to distal neurons... - Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytesAnnette Koulakoff
INSERM, U840, College de France, 11 place Marcelin Berthelot, Paris, France
Glia 56:1299-311. 2008..Altogether these observations indicate that the expression of the two main astrocyte connexins is tightly regulated by neurons... - Gap junction-mediated astrocytic networks in the mouse barrel cortexVanessa Houades
INSERM, U840, 75005 Paris, France
J Neurosci 28:5207-17. 2008..Such properties confine intercellular communication in astrocytes within a defined barrel as previously reported for excitatory neuronal circuits... - Deletion of astroglial connexins weakens the blood-brain barrierPascal Ezan
Center for Interdisciplinary Research in Biology Centre National de la Recherche Scientifique, College de France, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, Paris, France
J Cereb Blood Flow Metab 32:1457-67. 2012..Furthermore, the absence of astroglial connexins weakens the BBB, which opens upon increased hydrostatic vascular pressure and shear stress. These results demonstrate that astroglial connexins are necessary to maintain BBB integrity... - Lysosomes are the major vesicular compartment undergoing Ca2+-regulated exocytosis from cortical astrocytesDongdong Li
Institut National de la Sante et de la Recherche Medicale, Unité 603, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8154, Laboratory of Neurophysiology and New Microscopies, Universite Paris Descartes, Paris, France
J Neurosci 28:7648-58. 2008..Our experiments suggest that astroglial Ca(2+)-regulated exocytosis is carried by lysosomes and operates on a timescale orders of magnitude slower than synaptic transmission... - Neurons and brain macrophages regulate connexin expression in cultured astrocytesAnnette Koulakoff
INSERM U114, , Paris, France
Cell Commun Adhes 10:407-11. 2003..Thus, in brain diseases and injuries, neuronal death associated with the BM activation may decrease GJC in astrocytes and therefore have a physiopathological relevance... - Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonistsMartine Tencé
College de France, Center for Interdisciplinary Research in Biology CIRB, CNRS UMR 7241, INSERM U1050, Paris, France
Cell Signal 24:86-98. 2012..As a whole, this study identifies a new mechanism of GJIC regulation in which two GPCR agonists dynamically alter interactions of Cx43 with its molecular partners... - Neurons set the tone of gap junctional communication in astrocytic networksNathalie Rouach
INSERM U114, , 11 place Marcelin Berthelot, 75005 Paris, France
Neurochem Int 45:265-72. 2004.... - Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloidWilliam Meme
INSERM U587, College de France, Paris, France
FASEB J 20:494-6. 2006..Thus, the suppression of communication between astrocytes, induced by activated MG could contribute to the proposed role of reactive gliosis in this neurodegenerative disease... - Plasticity of astroglial networks in olfactory glomeruliLisa Roux
College de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, 75231 Paris Cedex 05, France
Proc Natl Acad Sci U S A 108:18442-6. 2011.... - Systematic colocalization errors between acridine orange and EGFP in astrocyte vesicular organellesFabien Nadrigny
INSERM, U603, Paris, France
Biophys J 93:969-80. 2007..We finally introduce FM4-64/EGFP dual-color imaging as a remedy for imaging a distinct population of astroglial fusion-competent secretory vesicles... - A role of the (pro)renin receptor in neuronal cell differentiationAurelie Contrepas
Institut National de la Sante et de la Recherche Medicale, Unit 833 and Collège de France, Experimental Medicine Unit, Paris, France
Am J Physiol Regul Integr Comp Physiol 297:R250-7. 2009..In conclusion, our results show that (P)RR is expressed in mouse brain and suggest that the XLMR and epilepsy phenotype might result from a dominant-negative effect of the Delta4-(P)RR protein... - S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCKNathalie Rouach
INSERM U587, , 11, place Marcelin Berthelot, 75005 Paris, France
Eur J Neurosci 23:1453-64. 2006..This novel effect of S1P may have an important physiopathological significance when considering the proposed roles for astrocyte gap junctions on neuronal survival... - Bmcc1s interacts with the phosphate-activated glutaminase in the brainAnne Cécile Boulay
College de France, Center for Interdisciplinary Research in Biology CIRB Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France
Biochimie 95:799-807. 2013..Overexpression of Bmcc1s in mouse primary cortical neurons impaired proper mitochondrial targeting of KGA leading to its accumulation within the cytoplasm. Thus, Bmcc1s may control the trafficking of KGA to the mitochondria... - Hearing is normal without connexin30Anne Cécile Boulay
College de France, Centre Interdisciplinaire de Recherche en Biologie CIRB Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR 7241 Institut National de la Santé et de la Recherche Médicale Inserm, U1050, 75231 Paris Cedex 05, France
J Neurosci 33:430-4. 2013..Thus, in deaf patients with GJB6 deletion as well as in the previous Cx30 knock-out mouse model, defective Cx26 expression is the likely cause of deafness, and in contrast to current opinion, Cx30 is dispensable for cochlear functions... - Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functionsJessica Arama
College de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, Paris, France
PLoS ONE 7:e35488. 2012..This study identifies Bmcc1s as a new MAP6 interacting protein able to modulate MAP6-induced microtubule cold stability. Moreover, it illustrates a novel mechanism by which Bmcc1 regulates cell morphology... - Glial connexin expression and function in the context of Alzheimer's diseaseAnnette Koulakoff
Centre National de la Recherche Scientifique, Unite Mixte de Recherche, Paris Cedex 05, France
Biochim Biophys Acta 1818:2048-57. 2012..This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics... - Electrical and chemical transmission between striatal GABAergic output neurones in rat brain slicesLaurent Venance
Neurobiologie Pharmacologique, INSERM U 114, College de France, Paris, France
J Physiol 559:215-30. 2004..These results suggest that preferential networks of electrically and chemically connected SONs, might be involved in the channelling of cortico-basal ganglia information processing... - Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixingFabien Nadrigny
Molecular and Cellular Biophysics of Synaptic Transmission, Laboratory of Neurophysiology and New Microscopies, INSERM U603, CNRS FRE 2500, Universite Rene Descartes Paris 5, 45 Rue des Saints Peres, 75 006, Paris, France
Eur Biophys J 35:533-47. 2006..Our technique provides a robust alternative to error-prone dual- or triple colour co-localisation studies... - Hydrogen peroxide increases gap junctional communication and induces astrocyte toxicity: regulation by brain macrophagesNathalie Rouach
INSERM U114, , Paris, France
Glia 45:28-38. 2004..Finally, when astrocytes are cocultured with brain macrophages, the effects of H2O2 on both GJC and toxicity are not observed, revealing a new protective role of brain macrophages during oxidative stress...