Christian Giaume

Summary

Country: France

Publications

  1. doi request reprint The barrel cortex as a model to study dynamic neuroglial interaction
    Christian Giaume
    Inserm U840, College de France, Paris, France
    Neuroscientist 15:351-66. 2009
  2. doi request reprint From a glial syncytium to a more restricted and specific glial networking
    Christian Giaume
    CIRB, CNRS UMR UMR7241 INSERM U1050, MEMOLIFE Laboratory of Excellence and Paris Science Lettre, College de France, University Pierre et Marie Curie, ED, n 158, 11 place Marcelin Berthelot, 75005 Paris, France
    J Physiol Paris 106:34-9. 2012
  3. doi request reprint Connexin-based channels in astrocytes: how to study their properties
    Christian Giaume
    CIRB, CNRS UMR7241 INSERM U1050 Collège de France, Paris, France
    Methods Mol Biol 814:283-303. 2012
  4. doi request reprint Astroglial networks: a step further in neuroglial and gliovascular interactions
    Christian Giaume
    Inserm U840, College de France, 75005 Paris, France
    Nat Rev Neurosci 11:87-99. 2010
  5. doi request reprint Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system
    Christian Giaume
    Inserm U840, College de France, Paris, France
    Brain Res Rev 63:160-76. 2010
  6. pmc Astroglial networks scale synaptic activity and plasticity
    Ulrike Pannasch
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, College de France, 75005 Paris, France
    Proc Natl Acad Sci U S A 108:8467-72. 2011
  7. ncbi request reprint Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments
    Nicolas Froger
    Institut National de la Sante et de la Recherche Medicale, U840, Paris, France
    J Neurochem 111:1383-97. 2009
  8. doi request reprint Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective
    Nicolas Froger
    Inserm U840, College de France, 11 place Marcelin Berthelot, 75231 Paris, Cedex 05, France
    Mol Cell Neurosci 45:37-46. 2010
  9. doi request reprint Astroglial metabolic networks sustain hippocampal synaptic transmission
    Nathalie Rouach
    Inserm U840, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    Science 322:1551-5. 2008
  10. doi request reprint Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes
    Annette Koulakoff
    INSERM, U840, College de France, 11 place Marcelin Berthelot, Paris, France
    Glia 56:1299-311. 2008

Collaborators

Detail Information

Publications30

  1. doi request reprint The barrel cortex as a model to study dynamic neuroglial interaction
    Christian Giaume
    Inserm U840, College de France, Paris, France
    Neuroscientist 15:351-66. 2009
    ..Finally, this review outlines how the use of the barrel cortex as a model might in the future help to address important questions related to dynamic neuroglia interaction...
  2. doi request reprint From a glial syncytium to a more restricted and specific glial networking
    Christian Giaume
    CIRB, CNRS UMR UMR7241 INSERM U1050, MEMOLIFE Laboratory of Excellence and Paris Science Lettre, College de France, University Pierre et Marie Curie, ED, n 158, 11 place Marcelin Berthelot, 75005 Paris, France
    J Physiol Paris 106:34-9. 2012
    ....
  3. doi request reprint Connexin-based channels in astrocytes: how to study their properties
    Christian Giaume
    CIRB, CNRS UMR7241 INSERM U1050 Collège de France, Paris, France
    Methods Mol Biol 814:283-303. 2012
    ..These techniques are applied in astrocyte studies using in vitro models, mainly primary cultures and acute brain slices...
  4. doi request reprint Astroglial networks: a step further in neuroglial and gliovascular interactions
    Christian Giaume
    Inserm U840, College de France, 75005 Paris, France
    Nat Rev Neurosci 11:87-99. 2010
    ..This intercellular communication between glia has implications for neuroglial and gliovascular interactions and hence has added another level of complexity to our understanding of brain function...
  5. doi request reprint Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system
    Christian Giaume
    Inserm U840, College de France, Paris, France
    Brain Res Rev 63:160-76. 2010
    ..We outline new avenues not only to study specific mechanisms by which connexins exert these functions but also to selectively investigate well-defined coupling compartments among glial networks...
  6. pmc Astroglial networks scale synaptic activity and plasticity
    Ulrike Pannasch
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, College de France, 75005 Paris, France
    Proc Natl Acad Sci U S A 108:8467-72. 2011
    ..Altogether, these results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses...
  7. ncbi request reprint Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments
    Nicolas Froger
    Institut National de la Sante et de la Recherche Medicale, U840, Paris, France
    J Neurochem 111:1383-97. 2009
    ....
  8. doi request reprint Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective
    Nicolas Froger
    Inserm U840, College de France, 11 place Marcelin Berthelot, 75231 Paris, Cedex 05, France
    Mol Cell Neurosci 45:37-46. 2010
    ..Altogether, these data demonstrate that inflammation-induced astroglial hemichannel activation plays a critical role in neuronal death and suggest a neuroprotective role of connexin43 hemichannel blockade...
  9. doi request reprint Astroglial metabolic networks sustain hippocampal synaptic transmission
    Nathalie Rouach
    Inserm U840, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    Science 322:1551-5. 2008
    ..These results indicate that astroglial gap junctions provide an activity-dependent intercellular pathway for the delivery of energetic metabolites from blood vessels to distal neurons...
  10. doi request reprint Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes
    Annette Koulakoff
    INSERM, U840, College de France, 11 place Marcelin Berthelot, Paris, France
    Glia 56:1299-311. 2008
    ..Altogether these observations indicate that the expression of the two main astrocyte connexins is tightly regulated by neurons...
  11. doi request reprint Gap junction-mediated astrocytic networks in the mouse barrel cortex
    Vanessa Houades
    INSERM, U840, 75005 Paris, France
    J Neurosci 28:5207-17. 2008
    ..Such properties confine intercellular communication in astrocytes within a defined barrel as previously reported for excitatory neuronal circuits...
  12. doi request reprint Increased interaction of connexin43 with zonula occludens-1 during inhibition of gap junctions by G protein-coupled receptor agonists
    Martine Tencé
    College de France, Center for Interdisciplinary Research in Biology CIRB, CNRS UMR 7241, INSERM U1050, Paris, France
    Cell Signal 24:86-98. 2012
    ..As a whole, this study identifies a new mechanism of GJIC regulation in which two GPCR agonists dynamically alter interactions of Cx43 with its molecular partners...
  13. doi request reprint Bmcc1s interacts with the phosphate-activated glutaminase in the brain
    Anne Cécile Boulay
    College de France, Center for Interdisciplinary Research in Biology CIRB Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France
    Biochimie 95:799-807. 2013
    ..Overexpression of Bmcc1s in mouse primary cortical neurons impaired proper mitochondrial targeting of KGA leading to its accumulation within the cytoplasm. Thus, Bmcc1s may control the trafficking of KGA to the mitochondria...
  14. doi request reprint Glial connexin expression and function in the context of Alzheimer's disease
    Annette Koulakoff
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche, Paris Cedex 05, France
    Biochim Biophys Acta 1818:2048-57. 2012
    ..This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics...
  15. pmc Deletion of astroglial connexins weakens the blood-brain barrier
    Pascal Ezan
    Center for Interdisciplinary Research in Biology Centre National de la Recherche Scientifique, College de France, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, Paris, France
    J Cereb Blood Flow Metab 32:1457-67. 2012
    ..Furthermore, the absence of astroglial connexins weakens the BBB, which opens upon increased hydrostatic vascular pressure and shear stress. These results demonstrate that astroglial connexins are necessary to maintain BBB integrity...
  16. doi request reprint Lysosomes are the major vesicular compartment undergoing Ca2+-regulated exocytosis from cortical astrocytes
    Dongdong Li
    Institut National de la Sante et de la Recherche Medicale, Unité 603, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8154, Laboratory of Neurophysiology and New Microscopies, Universite Paris Descartes, Paris, France
    J Neurosci 28:7648-58. 2008
    ..Our experiments suggest that astroglial Ca(2+)-regulated exocytosis is carried by lysosomes and operates on a timescale orders of magnitude slower than synaptic transmission...
  17. ncbi request reprint Neurons and brain macrophages regulate connexin expression in cultured astrocytes
    Annette Koulakoff
    INSERM U114, College de France, Paris, France
    Cell Commun Adhes 10:407-11. 2003
    ..Thus, in brain diseases and injuries, neuronal death associated with the BM activation may decrease GJC in astrocytes and therefore have a physiopathological relevance...
  18. ncbi request reprint Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloid
    William Meme
    INSERM U587, College de France, Paris, France
    FASEB J 20:494-6. 2006
    ..Thus, the suppression of communication between astrocytes, induced by activated MG could contribute to the proposed role of reactive gliosis in this neurodegenerative disease...
  19. ncbi request reprint Neurons set the tone of gap junctional communication in astrocytic networks
    Nathalie Rouach
    INSERM U114, College de France, 11 place Marcelin Berthelot, 75005 Paris, France
    Neurochem Int 45:265-72. 2004
    ....
  20. pmc Plasticity of astroglial networks in olfactory glomeruli
    Lisa Roux
    College de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, 75231 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 108:18442-6. 2011
    ....
  21. pmc Systematic colocalization errors between acridine orange and EGFP in astrocyte vesicular organelles
    Fabien Nadrigny
    INSERM, U603, Paris, France
    Biophys J 93:969-80. 2007
    ..We finally introduce FM4-64/EGFP dual-color imaging as a remedy for imaging a distinct population of astroglial fusion-competent secretory vesicles...
  22. ncbi request reprint S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK
    Nathalie Rouach
    INSERM U587, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Eur J Neurosci 23:1453-64. 2006
    ..This novel effect of S1P may have an important physiopathological significance when considering the proposed roles for astrocyte gap junctions on neuronal survival...
  23. pmc A role of the (pro)renin receptor in neuronal cell differentiation
    Aurelie Contrepas
    Institut National de la Sante et de la Recherche Medicale, Unit 833 and Collège de France, Experimental Medicine Unit, Paris, France
    Am J Physiol Regul Integr Comp Physiol 297:R250-7. 2009
    ..In conclusion, our results show that (P)RR is expressed in mouse brain and suggest that the XLMR and epilepsy phenotype might result from a dominant-negative effect of the Delta4-(P)RR protein...
  24. doi request reprint Hearing is normal without connexin30
    Anne Cécile Boulay
    College de France, Centre Interdisciplinaire de Recherche en Biologie CIRB Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR 7241 Institut National de la Santé et de la Recherche Médicale Inserm, U1050, 75231 Paris Cedex 05, France
    J Neurosci 33:430-4. 2013
    ..Thus, in deaf patients with GJB6 deletion as well as in the previous Cx30 knock-out mouse model, defective Cx26 expression is the likely cause of deafness, and in contrast to current opinion, Cx30 is dispensable for cochlear functions...
  25. pmc Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions
    Jessica Arama
    College de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241 Institut National de la Santé et de la Recherche Médicale U1050, Paris, France
    PLoS ONE 7:e35488. 2012
    ..This study identifies Bmcc1s as a new MAP6 interacting protein able to modulate MAP6-induced microtubule cold stability. Moreover, it illustrates a novel mechanism by which Bmcc1 regulates cell morphology...
  26. pmc Electrical and chemical transmission between striatal GABAergic output neurones in rat brain slices
    Laurent Venance
    Neurobiologie Pharmacologique, INSERM U 114, College de France, Paris, France
    J Physiol 559:215-30. 2004
    ..These results suggest that preferential networks of electrically and chemically connected SONs, might be involved in the channelling of cortico-basal ganglia information processing...
  27. ncbi request reprint Hydrogen peroxide increases gap junctional communication and induces astrocyte toxicity: regulation by brain macrophages
    Nathalie Rouach
    INSERM U114, College de France, Paris, France
    Glia 45:28-38. 2004
    ..Finally, when astrocytes are cocultured with brain macrophages, the effects of H2O2 on both GJC and toxicity are not observed, revealing a new protective role of brain macrophages during oxidative stress...
  28. ncbi request reprint Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing
    Fabien Nadrigny
    Molecular and Cellular Biophysics of Synaptic Transmission, Laboratory of Neurophysiology and New Microscopies, INSERM U603, CNRS FRE 2500, Universite Rene Descartes Paris 5, 45 Rue des Saints Peres, 75 006, Paris, France
    Eur Biophys J 35:533-47. 2006
    ..Our technique provides a robust alternative to error-prone dual- or triple colour co-localisation studies...
  29. doi request reprint The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes
    Xinhe Liu
    College de France, Center for Interdisciplinary Research in Biology CIRB, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7241, Institut National de la Santé et de la Recherche Médicale Unité 1050, 75231 Paris Cedex 05, France University Pierre et Marie Curie, ED, n 158, 75005 Paris, France MEMOLIFE Laboratory of Excellence and Paris Science Lettre Research University, 75005 Paris, France
    Neuropharmacology 75:533-8. 2013
    ..This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'. ..
  30. doi request reprint β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors
    Amulya Nidhi Shrivastava
    Biologie Cellulaire de la Synapse, Institut de Biologie de l Ecole Normale Supérieure, INSERM U1024 CNRS 8197, Paris 75005, France
    Glia 61:1673-86. 2013
    ..Thus, Aβ oligomer- and mGluR5-dependent ATP release by astrocytes may contribute to the overall deleterious effect of mGluR5s in Alzheimer's disease. GLIA 2013;61:1673-1686. ..