Pierre Germain

Summary

Country: France

Publications

  1. ncbi request reprint International Union of Pharmacology. LXIII. Retinoid X receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:760-72. 2006
  2. ncbi request reprint International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
  3. ncbi request reprint Overview of nomenclature of nuclear receptors
    Pierre Germain
    Department of Cell Biology and Signal Transduction, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    Pharmacol Rev 58:685-704. 2006
  4. doi request reprint Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists
    Pierre Germain
    Department of Cancer Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Chem Biol 16:479-89. 2009
  5. ncbi request reprint Retinoids: potential in cancer prevention and therapy
    Nicole Clarke
    Department of Cell Biology and Signal Transduction, Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Expert Rev Mol Med 6:1-23. 2004
  6. pmc Rational design of RAR-selective ligands revealed by RARbeta crystal stucture
    Pierre Germain
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO Rep 5:877-82. 2004
  7. ncbi request reprint Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor
    Susana Alvarez
    Departamento de Quimica Organica, Facultad de Quimica, Universidade de Vigo, 36310 Vigo, Spain
    Int J Biochem Cell Biol 39:1406-15. 2007
  8. pmc Neofunctionalization in vertebrates: the example of retinoic acid receptors
    Hector Escriva
    Structure and Evolution of Nuclear Hormone Receptors, UMR 5161 du CNRS, INRA LA 1237, Laboratoire de Biologie Moleculaire de la Cellule, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS Genet 2:e102. 2006
  9. ncbi request reprint Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs
    Raquel Pereira
    Departamento de Quimica Organica, Universidade de Vigo, 36310 Vigo, Spain
    Bioorg Med Chem Lett 16:49-54. 2006
  10. ncbi request reprint 9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists
    Rosana Alvarez
    Departamento de Quimica Organica, Facultad de Quimica, Universidade de Vigo, 36200 Vigo, Spain
    Bioorg Med Chem Lett 14:6117-22. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint International Union of Pharmacology. LXIII. Retinoid X receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:760-72. 2006
    ..Indeed, multiple questions about the actual biological role of RXRs and the existence of an endogenous ligand have still to be answered...
  2. ncbi request reprint International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
    ..This review summarizes the considerable amount of knowledge generated on these receptors...
  3. ncbi request reprint Overview of nomenclature of nuclear receptors
    Pierre Germain
    Department of Cell Biology and Signal Transduction, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    Pharmacol Rev 58:685-704. 2006
    ..Thus, the characterization of nuclear receptors and their associated proteins and the ligands that interact with them will remain a challenge to pharmacologists...
  4. doi request reprint Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists
    Pierre Germain
    Department of Cancer Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Chem Biol 16:479-89. 2009
    ..These ligands will facilitate studies on the role of the constitutive activity of RARs, particularly of the tumor suppressor RARbeta, whose specific functions relative to other RARs have remained elusive...
  5. ncbi request reprint Retinoids: potential in cancer prevention and therapy
    Nicole Clarke
    Department of Cell Biology and Signal Transduction, Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Expert Rev Mol Med 6:1-23. 2004
    ..Extensive research efforts have been dedicated to elucidating the molecular and cellular networks that are induced by retinoids, and this has recently yielded novel insights into how retinoids can both prevent and combat cancer...
  6. pmc Rational design of RAR-selective ligands revealed by RARbeta crystal stucture
    Pierre Germain
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO Rep 5:877-82. 2004
    ....
  7. ncbi request reprint Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor
    Susana Alvarez
    Departamento de Quimica Organica, Facultad de Quimica, Universidade de Vigo, 36310 Vigo, Spain
    Int J Biochem Cell Biol 39:1406-15. 2007
    ..Herein we describe the structure, function and ligand-dependent transcription mechanism of retinoic acid receptor beta, and use rational drug design to understand the selectivity of these modulators...
  8. pmc Neofunctionalization in vertebrates: the example of retinoic acid receptors
    Hector Escriva
    Structure and Evolution of Nuclear Hormone Receptors, UMR 5161 du CNRS, INRA LA 1237, Laboratoire de Biologie Moleculaire de la Cellule, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
    PLoS Genet 2:e102. 2006
    ..We thus suggest that neofunctionalization occurred at both the expression and the functional levels to shape RAR roles during development in vertebrates...
  9. ncbi request reprint Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs
    Raquel Pereira
    Departamento de Quimica Organica, Universidade de Vigo, 36310 Vigo, Spain
    Bioorg Med Chem Lett 16:49-54. 2006
    ....
  10. ncbi request reprint 9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists
    Rosana Alvarez
    Departamento de Quimica Organica, Facultad de Quimica, Universidade de Vigo, 36200 Vigo, Spain
    Bioorg Med Chem Lett 14:6117-22. 2004
    ..In PLB985 leukemia cells that require RXR agonists for differentiation compounds 8 induced maturation in the presence of the RAR-selective pan-agonist TTNPB; this effect was blocked by an RXR-selective antagonist...
  11. ncbi request reprint Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies
    Vivian Pogenberg
    Centre de Biochimie Structurale, CNRS U5048 INSERM U554 UM1, Faculte de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier, France
    J Biol Chem 280:1625-33. 2005
    ..Together, our results reveal molecular and structural features that impact on the ligand-dependent interaction of the RAR/RXR heterodimer with nuclear receptor coactivators...
  12. ncbi request reprint RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis
    Sabrina Kammerer
    Department of Structural Biology and Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, France
    Acta Crystallogr D Biol Crystallogr 60:2048-50. 2004
    ..The unit-cell parameters are a = 47.81, b = 58.52, c = 92.83 A for the TTNPB-hRARbeta LBD crystal and a = 58.14, b = 84.07, c = 102.37 A when the SRC-1 peptide is also bound...
  13. ncbi request reprint Co-regulator recruitment and the mechanism of retinoic acid receptor synergy
    Pierre Germain
    Present addresses Monsanto Enterprises Limited, INBRI, 277 Chowdaiah Road, 18th cross Malleshwaram, Bangalore 560003, India
    Nature 415:187-92. 2002
    ....
  14. ncbi request reprint Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry
    Sarah Sanglier
    Laboratoire de Spectrometrie de Masse Bio Organique, CNRS UMR 7509, ECPM, Strasbourg, France
    Eur J Biochem 271:4958-67. 2004
    ....
  15. ncbi request reprint Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology
    Matthias W Büttner
    Universitat Wurzburg, Institut fur Anorganische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Chembiochem 8:1688-99. 2007
    ....
  16. pmc Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function
    Virginie Nahoum
    Institut National de la Sante et de la Recherche Medicale, U554, 34090 Montpellier, France
    Proc Natl Acad Sci U S A 104:17323-8. 2007
    ....