Genomes and Genes
- alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin developmentC M DiPersio
Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Cell Sci 113:3051-62. 2000..These findings show that while alpha3beta1 and alpha6beta4 are both required for integrity of the dermo-epidermal junction, neither one is essential for epidermal morphogenesis during skin development...
- Essential role of alpha 6 integrins in cortical and retinal laminationE Georges-Labouesse
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, C U de Strasbourg, France
Curr Biol 8:983-6. 1998..These observations are particularly significant given the recent report that human patients suffering from epidermolysis bullosa can carry mutations in ITGA6, the gene encoding the alpha 6 integrin chain [8,9]...
- Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouseA De Arcangelis
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
Development 126:3957-68. 1999..The presence of novel phenotypes in double mutant embryos demonstrates the synergism between alpha3 and alpha6 integrins and their essential roles in multiple processes during embryogenesis...
- Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in miceE Georges-Labouesse
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, C U de Strasbourg, France
Nat Genet 13:370-3. 1996..Our study provides evidence that some forms of epidermolysis bullosa may originate from defects of the alpha 6 gene...
- Integrin and ECM functions: roles in vertebrate developmentA De Arcangelis
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch, C U de Strasbourg, France
Trends Genet 16:389-95. 2000..Their role in tissue integrity has also been highlighted. Models have been produced that should prove very useful in defining the cellular mechanisms and the functions of integrins and ECM signaling cascades in vivo...
- Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunitsT C Klinowska
School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
Dev Biol 233:449-67. 2001..This work demonstrates that mammary tissue genetically lacking major laminin-binding integrin receptors is still able to develop and function...
- Regulation of laminin 1-induced pancreatic beta-cell differentiation by alpha6 integrin and alpha-dystroglycanF X Jiang
Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
Mol Med 7:107-14. 2001..Laminin-I had a dominant effect via alpha-DG to promote cell survival and beta-cell differentiation, which was modestly inhibited by alpha6 signaling...
- Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonadsR Anderson
Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
Development 126:1655-64. 1999..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established...
- Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependentB J Miller
Department of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
J Cell Biol 149:1289-96. 2000....