E Georges-Labouesse

Summary

Country: France

Publications

  1. ncbi alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development
    C M DiPersio
    Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Sci 113:3051-62. 2000
  2. ncbi Essential role of alpha 6 integrins in cortical and retinal lamination
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, C U de Strasbourg, France
    Curr Biol 8:983-6. 1998
  3. ncbi Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse
    A De Arcangelis
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
    Development 126:3957-68. 1999
  4. ncbi Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, C U de Strasbourg, France
    Nat Genet 13:370-3. 1996
  5. ncbi Integrin and ECM functions: roles in vertebrate development
    A De Arcangelis
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch, C U de Strasbourg, France
    Trends Genet 16:389-95. 2000
  6. ncbi Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits
    T C Klinowska
    School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
    Dev Biol 233:449-67. 2001
  7. pmc Regulation of laminin 1-induced pancreatic beta-cell differentiation by alpha6 integrin and alpha-dystroglycan
    F X Jiang
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    Mol Med 7:107-14. 2001
  8. ncbi Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads
    R Anderson
    Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Development 126:1655-64. 1999
  9. pmc Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent
    B J Miller
    Department of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    J Cell Biol 149:1289-96. 2000

Collaborators

Detail Information

Publications9

  1. ncbi alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development
    C M DiPersio
    Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Cell Sci 113:3051-62. 2000
    ..These findings show that while alpha3beta1 and alpha6beta4 are both required for integrity of the dermo-epidermal junction, neither one is essential for epidermal morphogenesis during skin development...
  2. ncbi Essential role of alpha 6 integrins in cortical and retinal lamination
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, C U de Strasbourg, France
    Curr Biol 8:983-6. 1998
    ..These observations are particularly significant given the recent report that human patients suffering from epidermolysis bullosa can carry mutations in ITGA6, the gene encoding the alpha 6 integrin chain [8,9]...
  3. ncbi Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse
    A De Arcangelis
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
    Development 126:3957-68. 1999
    ..The presence of novel phenotypes in double mutant embryos demonstrates the synergism between alpha3 and alpha6 integrins and their essential roles in multiple processes during embryogenesis...
  4. ncbi Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice
    E Georges-Labouesse
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, C U de Strasbourg, France
    Nat Genet 13:370-3. 1996
    ..Our study provides evidence that some forms of epidermolysis bullosa may originate from defects of the alpha 6 gene...
  5. ncbi Integrin and ECM functions: roles in vertebrate development
    A De Arcangelis
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch, C U de Strasbourg, France
    Trends Genet 16:389-95. 2000
    ..Their role in tissue integrity has also been highlighted. Models have been produced that should prove very useful in defining the cellular mechanisms and the functions of integrins and ECM signaling cascades in vivo...
  6. ncbi Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits
    T C Klinowska
    School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom
    Dev Biol 233:449-67. 2001
    ..This work demonstrates that mammary tissue genetically lacking major laminin-binding integrin receptors is still able to develop and function...
  7. pmc Regulation of laminin 1-induced pancreatic beta-cell differentiation by alpha6 integrin and alpha-dystroglycan
    F X Jiang
    Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    Mol Med 7:107-14. 2001
    ..Laminin-I had a dominant effect via alpha-DG to promote cell survival and beta-cell differentiation, which was modestly inhibited by alpha6 signaling...
  8. ncbi Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads
    R Anderson
    Department of Cell Biology and Neuroanatomy and Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Development 126:1655-64. 1999
    ..These results demonstrate a role for beta1-containing integrins in the development of the germline, although an equivalent role for * integrin subunit(s) has yet to be established...
  9. pmc Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent
    B J Miller
    Department of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    J Cell Biol 149:1289-96. 2000
    ....