Dalet A, ArgÃ¼ello R, Combes A, Spinelli L, Jaeger S, Fallet M, et al
. Protein synthesis inhibition and GADD34 control IFN-Î² heterogeneous expression in response toÂ dsRNA. EMBO J. 2017;36:761-782 pubmed publisher
Perego J, Mendes A, Bourbon C, Camosseto V, Combes A, Liu H, et al
. Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2? dephosphorylation by the GADD34/PP1c complex. Sci Signal. 2018;11: pubmed publisher
..Our results therefore suggest that guanabenz and similar compounds could be used to treat type I IFN-dependent pathologies and that CH25H could be a therapeutic target to control these diseases. ..
Valečka J, Almeida C, Su B, Pierre P, Gatti E. Autophagy and MHC-restricted antigen presentation. Mol Immunol. 2018;99:163-170 pubmed publisher
..A better understanding of Type 2 cross-presentation may guide future efforts to control the immune system through autophagy manipulation. ..
Dalet A, Gatti E, Pierre P. Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response. FEBS Lett. 2015;589:1539-45 pubmed publisher
ArgÃ¼ello R, Rodríguez Rodrígues C, Gatti E, Pierre P. Protein synthesis regulation, a pillar of strength for innate immunity?. Curr Opin Immunol. 2015;32:28-35 pubmed publisher
..Here, we report on the rising matter that metabolism sensing and gene expression control at the level of mRNA translation, allow swift responses that mobilize host defenses and coordinate innate responses to infection. ..
Combes A, Camosseto V, N Guessan P, Argüello R, Mussard J, Caux C, et al
. BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells. Nat Commun. 2017;8:913 pubmed publisher
..Here the authors show that BAD-LAMP limits type 1 interferon responses by sorting TLR9 to late endosomal compartments. ..