Patricia Gaspar

Summary

Country: France

Publications

  1. ncbi The developmental role of serotonin: news from mouse molecular genetics
    Patricia Gaspar
    INSERM U 106, Hopital Salpetriere, 47, Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Nat Rev Neurosci 4:1002-12. 2003
  2. ncbi Role of the calcium modulated cyclases in the development of the retinal projections
    Xavier Nicol
    INSERM, U616, IFR Neurosciences, Hopital Salpetriere, Paris, France
    Eur J Neurosci 24:3401-14. 2006
  3. ncbi [Genetic models to understand how serotonin acts during development]
    Patricia Gaspar
    INSERM Unité 106, Bâtiment Pédiatrie, Hopital de la Salpetriere, 47, Boulevard de l Hopital, 75651 Paris 13
    J Soc Biol 198:18-21. 2004
  4. doi Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve
    Elli Chatzopoulou
    Institut National de la Sante et de la Recherche Medicale, Unité 711, Universite Pierre et Marie Curie, Faculte de Medecine, Hopital de la Salpetriere, Institut Fédératif de Recherche 70, F 75013 Paris, France
    J Neurosci 28:7624-36. 2008
  5. ncbi cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map
    Xavier Nicol
    INSERM, U616, Hopital Salpetriere, 47 Blvd de l Hopital, 75013 Paris, France
    Nat Neurosci 10:340-7. 2007
  6. ncbi Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter
    Catherine Verney
    INSERM E9935, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Anat Rec 267:87-93. 2002
  7. ncbi Spatiotemporal localization of the calcium-stimulated adenylate cyclases, AC1 and AC8, during mouse brain development
    Xavier Nicol
    Institut National de la Santé et de la Recherche Médicale U616, Universite Pierre et Marie Curie Paris VI, Hopital Salpetriere, 75651 Paris, France
    J Comp Neurol 486:281-94. 2005
  8. pmc Cross talk between tetanus neurotoxin-insensitive vesicle-associated membrane protein-mediated transport and L1-mediated adhesion
    Philipp Alberts
    Membrane Traffic and Neuronal Plasticity, Institut National de la Santé et de la Recherche Médicale U536, F 75005 Paris, France
    Mol Biol Cell 14:4207-20. 2003
  9. ncbi Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter
    Lea Stankovski
    Institut National de la Sante et de la Recherche Medicale, Unité 616, Institut Fédératif de Recherche Neurosciences, Hopital de la Pitie Salpetriere, 75651 Paris, France
    J Neurosci 27:1315-24. 2007
  10. ncbi Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice
    Alban Laurent
    Laboratoire de Neurophysiologie et Nouvelles Microscopies, Institut National de la Santé et de la Recherche Médicale INSERM EPI 0002, Ecole Supérieure de Physique et de Chimie Industrielle, 75231 Paris Cedex 5, France
    J Neurosci 22:886-900. 2002

Collaborators

  • Xavier Nicol
  • Yoshihiro Ishikawa
  • Richard Miles
  • Isabelle Bachy
  • Thomas C Sudhof
  • Tania Vitalis
  • Antonio Baldini
  • David J Price
  • Jean Shih
  • C Verney
  • Alexandra Rebsam
  • Jean Pierre Baudoin
  • Chantal Alvarez
  • Olivier Cases
  • Elli Chatzopoulou
  • Luigi Michele Pavone
  • Christine Metin
  • Lea Stankovski
  • Arnaud Ferrere
  • Caroline Kappeler
  • Aude Muzerelle
  • Isabelle Seif
  • Philipp Alberts
  • Alban Laurent
  • Marie Paule Muriel
  • Bernard Zalc
  • Grégoire Levasseur
  • Olivier Goureau
  • Kazutada Watanabe
  • Andres Miguez
  • Jean Leon Thomas
  • Laurence Goutebroze
  • Domna Karagogeos
  • Maria Savvaki
  • Evan Deneris
  • Tanja Ouimet
  • Pratibha Mithbaokar
  • Veeramani Maharajan
  • Vincenzo Mastellone
  • Luigi Avallone
  • Khalid H El-Hachimi
  • Françoise Phan Dinh Tuy
  • Jamel Chelly
  • Ghislaine Hamard
  • Fiona Francis
  • Christophe Houbron
  • Yoann Saillour
  • Helene Gingras
  • Sonia Martinez-Arca
  • Thierry Galli
  • Ina Hinners
  • Fritz Rathjen
  • Theano Irinopoulou
  • Sharon Tooze
  • Veronique Marthiens
  • Rachel Rudge
  • Jean Marc Goaillard
  • Nicole Ropert
  • Cecile Lebrand

Detail Information

Publications21

  1. ncbi The developmental role of serotonin: news from mouse molecular genetics
    Patricia Gaspar
    INSERM U 106, Hopital Salpetriere, 47, Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Nat Rev Neurosci 4:1002-12. 2003
    ..In addition, studies have revealed that serotonergic traits are dissociable, as there are populations of neurons that contain serotonin but do not synthesize it...
  2. ncbi Role of the calcium modulated cyclases in the development of the retinal projections
    Xavier Nicol
    INSERM, U616, IFR Neurosciences, Hopital Salpetriere, Paris, France
    Eur J Neurosci 24:3401-14. 2006
    ..The specificity of AC1's action is linked to its cellular localization in the RGCs and to its distinctive functional profile, compared with the other cyclases expressed in the same cells...
  3. ncbi [Genetic models to understand how serotonin acts during development]
    Patricia Gaspar
    INSERM Unité 106, Bâtiment Pédiatrie, Hopital de la Salpetriere, 47, Boulevard de l Hopital, 75651 Paris 13
    J Soc Biol 198:18-21. 2004
    ..Each of these effects could be mediated by a different 5-HT receptor. Abnormalities have been best characterized in the somatosensory and visual system but are likely to occur throughout the central nervous system...
  4. doi Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve
    Elli Chatzopoulou
    Institut National de la Sante et de la Recherche Medicale, Unité 711, Universite Pierre et Marie Curie, Faculte de Medecine, Hopital de la Salpetriere, Institut Fédératif de Recherche 70, F 75013 Paris, France
    J Neurosci 28:7624-36. 2008
    ..Therefore, TAG-1 is an essential regulator of the structure of RGC axons and their surrounding glial cells in the optic nerve...
  5. ncbi cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map
    Xavier Nicol
    INSERM, U616, Hopital Salpetriere, 47 Blvd de l Hopital, 75013 Paris, France
    Nat Neurosci 10:340-7. 2007
    ..These results provide a direct molecular link between spontaneous neural activity and axon guidance mechanisms during the refinement of neural maps...
  6. ncbi Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporter
    Catherine Verney
    INSERM E9935, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Anat Rec 267:87-93. 2002
    ....
  7. ncbi Spatiotemporal localization of the calcium-stimulated adenylate cyclases, AC1 and AC8, during mouse brain development
    Xavier Nicol
    Institut National de la Santé et de la Recherche Médicale U616, Universite Pierre et Marie Curie Paris VI, Hopital Salpetriere, 75651 Paris, France
    J Comp Neurol 486:281-94. 2005
    ..Transient expression of these genes designate areas that may be particularly sensitive to neural activity/calcium-modulated cAMP responses during development...
  8. pmc Cross talk between tetanus neurotoxin-insensitive vesicle-associated membrane protein-mediated transport and L1-mediated adhesion
    Philipp Alberts
    Membrane Traffic and Neuronal Plasticity, Institut National de la Santé et de la Recherche Médicale U536, F 75005 Paris, France
    Mol Biol Cell 14:4207-20. 2003
    ..We conclude that TI-VAMP mediates the intracellular transport of L1 and that L1-mediated adhesion controls this membrane trafficking, thereby suggesting an important cross talk between membrane trafficking and cell-cell adhesion...
  9. ncbi Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter
    Lea Stankovski
    Institut National de la Sante et de la Recherche Medicale, Unité 616, Institut Fédératif de Recherche Neurosciences, Hopital de la Pitie Salpetriere, 75651 Paris, France
    J Neurosci 27:1315-24. 2007
    ..Altogether, these results suggest that high levels of serotonin, acting through 5-HT2 receptors, have neuroprotective action on cortical neurons by controlling Bcl-X(L) mRNA levels and that this action is independent of trkB signaling...
  10. ncbi Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice
    Alban Laurent
    Laboratoire de Neurophysiologie et Nouvelles Microscopies, Institut National de la Santé et de la Recherche Médicale INSERM EPI 0002, Ecole Supérieure de Physique et de Chimie Industrielle, 75231 Paris Cedex 5, France
    J Neurosci 22:886-900. 2002
    ..Our results show that in the developing barrel field of the neonatal mice, 5-HT1B receptors mediate an activity-dependent regulation of the TC EPSC that could favor the propagation of high-frequency TC activity...
  11. ncbi Interactions between TrkB signaling and serotonin excess in the developing murine somatosensory cortex: a role in tangential and radial organization of thalamocortical axons
    Tania Vitalis
    Department of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 22:4987-5000. 2002
    ....
  12. ncbi Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective mice
    Arnaud Ferrere
    INSERM U616, Hopital de la Pitie Salpetriere, Paris, France
    Anat Rec A Discov Mol Cell Evol Biol 288:158-65. 2006
    ..Our results indicate that Cux-1 is a useful marker of the layer IV neurons in S1, and that Cux-1 and Cux-2 are differently regulated in the upper layers of the cerebral cortex...
  13. ncbi Refinement of thalamocortical arbors and emergence of barrel domains in the primary somatosensory cortex: a study of normal and monoamine oxidase a knock-out mice
    Alexandra Rebsam
    Institut National de la Santé et de la Recherche Médicale U106, Hopital Pitie Salpetriere, 75013 Paris, France
    J Neurosci 22:8541-52. 2002
    ..Our results indicate that the barrel-deficient phenotype of MAOA-KO mice results from an altered refinement of the TCA arbors in their target layer IV, involving branch elaboration and collateral retraction during early postnatal life...
  14. ncbi Dissociating barrel development and lesion-induced plasticity in the mouse somatosensory cortex
    Alexandra Rebsam
    Institut National de la Santé et de la Recherche Médicale U616, Université Paris VI Hôpital Salpêtrière, 75651 Paris Cedex 13, France
    J Neurosci 25:706-10. 2005
    ..We conclude that the closure of the lesion-induced plasticity period in the barrelfield is probably not determined at the cortical level...
  15. ncbi Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives
    Tania Vitalis
    Department of Anatomy and Developmental Biology, University College London, WC1E6BT London, United Kingdom
    J Comp Neurol 464:392-403. 2003
    ....
  16. ncbi Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse
    Tania Vitalis
    Department of Biomedical Sciences, Edinburgh EH8 9XD, Scotland, United Kingdom
    J Comp Neurol 442:331-47. 2002
    ..These localizations are of importance for understanding the effects of monoaminergic transmission during development...
  17. ncbi Requirement of adenylate cyclase 1 for the ephrin-A5-dependent retraction of exuberant retinal axons
    Xavier Nicol
    Institut National de la Sante et de la Recherche Medicale, U616, University Paris 06, Hopital Pitie Salpetriere, Institut Féderatif Neurosciences, F 75013 Paris, France
    J Neurosci 26:862-72. 2006
    ..Our results demonstrate a presynaptic, cell autonomous role of AC1 in the retina and further indicate that AC1 is necessary to enact a retraction response of the retinal axons to ephrin-A5 during the refinement of the retinotopic map...
  18. ncbi Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout mice
    Caroline Kappeler
    Département de Génétique et Développement, Institut Cochin, F 75014 Paris, France
    Hum Mol Genet 15:1387-400. 2006
    ..These novel data thus highlight a role for Dcx, a microtubule-associated protein enriched at the leading edge in the branching and nucleokinesis of migrating interneurons...
  19. ncbi Fate map of serotonin transporter-expressing cells in developing mouse heart
    Luigi Michele Pavone
    Department of Biological Structures, Functions, and Technologies, University of Naples Federico II, Naples, Italy
    Genesis 45:689-95. 2007
    ..Overall, our data reveal specific and regionally restricted distribution of SERT-expressing cells in the developing heart of mouse...
  20. ncbi Nocodazole-induced changes in microtubule dynamics impair the morphology and directionality of migrating medial ganglionic eminence cells
    Jean Pierre Baudoin
    INSERM, U839, Hopital Pitie Salpetriere, Paris, France
    Dev Neurosci 30:132-43. 2008
    ..These results suggest that microtubule stability is crucial for maintaining polarity and controlling the directional migration of MGE cells, whereas additional mechanisms are required to control cell motility...
  21. doi [Interaction between neuronal activity and ephrin signalling during the refinement of neuronal connections]
    Xavier Nicol
    Med Sci (Paris) 24:144-6. 2008