Genomes and Genes
- The developmental role of serotonin: news from mouse molecular geneticsPatricia Gaspar
INSERM U 106, Hopital Salpetriere, 47, Boulevard de l Hopital, 75651, Paris Cedex 13, France
Nat Rev Neurosci 4:1002-12. 2003..In addition, studies have revealed that serotonergic traits are dissociable, as there are populations of neurons that contain serotonin but do not synthesize it...
- Role of the calcium modulated cyclases in the development of the retinal projectionsXavier Nicol
INSERM, U616, IFR Neurosciences, Hopital Salpetriere, Paris, France
Eur J Neurosci 24:3401-14. 2006..The specificity of AC1's action is linked to its cellular localization in the RGCs and to its distinctive functional profile, compared with the other cyclases expressed in the same cells...
- [Genetic models to understand how serotonin acts during development]Patricia Gaspar
INSERM Unité 106, Bâtiment Pédiatrie, Hopital de la Salpetriere, 47, Boulevard de l Hopital, 75651 Paris 13
J Soc Biol 198:18-21. 2004..Each of these effects could be mediated by a different 5-HT receptor. Abnormalities have been best characterized in the somatosensory and visual system but are likely to occur throughout the central nervous system...
- Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerveElli Chatzopoulou
Institut National de la Sante et de la Recherche Medicale, Unité 711, Universite Pierre et Marie Curie, Faculte de Medecine, Hopital de la Salpetriere, Institut Fédératif de Recherche 70, F 75013 Paris, France
J Neurosci 28:7624-36. 2008..Therefore, TAG-1 is an essential regulator of the structure of RGC axons and their surrounding glial cells in the optic nerve...
- cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic mapXavier Nicol
INSERM, U616, Hopital Salpetriere, 47 Blvd de l Hopital, 75013 Paris, France
Nat Neurosci 10:340-7. 2007..These results provide a direct molecular link between spontaneous neural activity and axon guidance mechanisms during the refinement of neural maps...
- Changing distribution of monoaminergic markers in the developing human cerebral cortex with special emphasis on the serotonin transporterCatherine Verney
INSERM E9935, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
Anat Rec 267:87-93. 2002....
- Spatiotemporal localization of the calcium-stimulated adenylate cyclases, AC1 and AC8, during mouse brain developmentXavier Nicol
Institut National de la Santé et de la Recherche Médicale U616, Universite Pierre et Marie Curie Paris VI, Hopital Salpetriere, 75651 Paris, France
J Comp Neurol 486:281-94. 2005..Transient expression of these genes designate areas that may be particularly sensitive to neural activity/calcium-modulated cAMP responses during development...
- Cross talk between tetanus neurotoxin-insensitive vesicle-associated membrane protein-mediated transport and L1-mediated adhesionPhilipp Alberts
Membrane Traffic and Neuronal Plasticity, Institut National de la Santé et de la Recherche Médicale U536, F 75005 Paris, France
Mol Biol Cell 14:4207-20. 2003..We conclude that TI-VAMP mediates the intracellular transport of L1 and that L1-mediated adhesion controls this membrane trafficking, thereby suggesting an important cross talk between membrane trafficking and cell-cell adhesion...
- Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporterLea Stankovski
Institut National de la Sante et de la Recherche Medicale, Unité 616, Institut Fédératif de Recherche Neurosciences, Hopital de la Pitie Salpetriere, 75651 Paris, France
J Neurosci 27:1315-24. 2007..Altogether, these results suggest that high levels of serotonin, acting through 5-HT2 receptors, have neuroprotective action on cortical neurons by controlling Bcl-X(L) mRNA levels and that this action is independent of trkB signaling...
- Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal miceAlban Laurent
Laboratoire de Neurophysiologie et Nouvelles Microscopies, Institut National de la Santé et de la Recherche Médicale INSERM EPI 0002, Ecole Supérieure de Physique et de Chimie Industrielle, 75231 Paris Cedex 5, France
J Neurosci 22:886-900. 2002..Our results show that in the developing barrel field of the neonatal mice, 5-HT1B receptors mediate an activity-dependent regulation of the TC EPSC that could favor the propagation of high-frequency TC activity...
- Interactions between TrkB signaling and serotonin excess in the developing murine somatosensory cortex: a role in tangential and radial organization of thalamocortical axonsTania Vitalis
Department of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 22:4987-5000. 2002....
- Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective miceArnaud Ferrere
INSERM U616, Hopital de la Pitie Salpetriere, Paris, France
Anat Rec A Discov Mol Cell Evol Biol 288:158-65. 2006..Our results indicate that Cux-1 is a useful marker of the layer IV neurons in S1, and that Cux-1 and Cux-2 are differently regulated in the upper layers of the cerebral cortex...
- Refinement of thalamocortical arbors and emergence of barrel domains in the primary somatosensory cortex: a study of normal and monoamine oxidase a knock-out miceAlexandra Rebsam
Institut National de la Santé et de la Recherche Médicale U106, Hopital Pitie Salpetriere, 75013 Paris, France
J Neurosci 22:8541-52. 2002..Our results indicate that the barrel-deficient phenotype of MAOA-KO mice results from an altered refinement of the TCA arbors in their target layer IV, involving branch elaboration and collateral retraction during early postnatal life...
- Dissociating barrel development and lesion-induced plasticity in the mouse somatosensory cortexAlexandra Rebsam
Institut National de la Santé et de la Recherche Médicale U616, Université Paris VI Hôpital Salpêtrière, 75651 Paris Cedex 13, France
J Neurosci 25:706-10. 2005..We conclude that the closure of the lesion-induced plasticity period in the barrelfield is probably not determined at the cortical level...
- Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivativesTania Vitalis
Department of Anatomy and Developmental Biology, University College London, WC1E6BT London, United Kingdom
J Comp Neurol 464:392-403. 2003....
- Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouseTania Vitalis
Department of Biomedical Sciences, Edinburgh EH8 9XD, Scotland, United Kingdom
J Comp Neurol 442:331-47. 2002..These localizations are of importance for understanding the effects of monoaminergic transmission during development...
- Requirement of adenylate cyclase 1 for the ephrin-A5-dependent retraction of exuberant retinal axonsXavier Nicol
Institut National de la Sante et de la Recherche Medicale, U616, University Paris 06, Hopital Pitie Salpetriere, Institut Féderatif Neurosciences, F 75013 Paris, France
J Neurosci 26:862-72. 2006..Our results demonstrate a presynaptic, cell autonomous role of AC1 in the retina and further indicate that AC1 is necessary to enact a retraction response of the retinal axons to ephrin-A5 during the refinement of the retinotopic map...
- Branching and nucleokinesis defects in migrating interneurons derived from doublecortin knockout miceCaroline Kappeler
Département de Génétique et Développement, Institut Cochin, F 75014 Paris, France
Hum Mol Genet 15:1387-400. 2006..These novel data thus highlight a role for Dcx, a microtubule-associated protein enriched at the leading edge in the branching and nucleokinesis of migrating interneurons...
- Fate map of serotonin transporter-expressing cells in developing mouse heartLuigi Michele Pavone
Department of Biological Structures, Functions, and Technologies, University of Naples Federico II, Naples, Italy
Genesis 45:689-95. 2007..Overall, our data reveal specific and regionally restricted distribution of SERT-expressing cells in the developing heart of mouse...
- Nocodazole-induced changes in microtubule dynamics impair the morphology and directionality of migrating medial ganglionic eminence cellsJean Pierre Baudoin
INSERM, U839, Hopital Pitie Salpetriere, Paris, France
Dev Neurosci 30:132-43. 2008..These results suggest that microtubule stability is crucial for maintaining polarity and controlling the directional migration of MGE cells, whereas additional mechanisms are required to control cell motility...
- [Interaction between neuronal activity and ephrin signalling during the refinement of neuronal connections]Xavier Nicol
Med Sci (Paris) 24:144-6. 2008