P Garnero

Summary

Country: France

Publications

  1. ncbi The collagenolytic activity of cathepsin K is unique among mammalian proteinases
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Pav F, 69437 Lyon Cedex 03, France
    J Biol Chem 273:32347-52. 1998
  2. ncbi Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: assessment with serum type I collagen breakdown products
    P Garnero
    INSERM Unit 403, Department of Immunology, Hopital Edouard Herriot, Lyon, France
    Bone 24:381-5. 1999
  3. ncbi Do markers of bone resorption add to bone mineral density and ultrasonographic heel measurement for the prediction of hip fracture in elderly women? The EPIDOS prospective study
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Lyon, France
    Osteoporos Int 8:563-9. 1998
  4. pmc Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage
    P Garnero
    INSERM Research Unit 403, Lyon, France
    Ann Rheum Dis 60:619-26. 2001
  5. ncbi Cross-sectional evaluation of bone metabolism in men
    P Szulc
    INSERM Research Unit 403, Lyon, France
    J Bone Miner Res 16:1642-50. 2001
  6. ncbi Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study
    P Chavassieux
    , , Lyon, France
    J Bone Miner Res 16:89-96. 2001
  7. ncbi The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Lyon, France
    J Bone Miner Res 18:859-67. 2003
  8. ncbi Effects of intranasal 17beta-estradiol on bone turnover and serum insulin-like growth factor I in postmenopausal women
    P Garnero
    INSERM U 403, Hopital E Herriot, Lyon, France
    J Clin Endocrinol Metab 84:2390-7. 1999
  9. doi Nitrated type III collagen as a biological marker of nitric oxide-mediated synovial tissue metabolism in osteoarthritis
    P Richardot
    CCBR SYNARC, Lyon, France
    Osteoarthritis Cartilage 17:1362-7. 2009
  10. ncbi The bisphosphonate zoledronate decreases type II collagen breakdown in patients with Paget's disease of bone
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Pav F, 69003 Lyon, France
    Bone 28:461-4. 2001

Detail Information

Publications41

  1. ncbi The collagenolytic activity of cathepsin K is unique among mammalian proteinases
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Pav F, 69437 Lyon Cedex 03, France
    J Biol Chem 273:32347-52. 1998
    ..This property of cathepsin K is unique among mammalian proteinases and is reminiscent of bacterial collagenases. It is likely to be responsible for the key role of cathepsin K in bone resorption...
  2. ncbi Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: assessment with serum type I collagen breakdown products
    P Garnero
    INSERM Unit 403, Department of Immunology, Hopital Edouard Herriot, Lyon, France
    Bone 24:381-5. 1999
    ..Bone formation appears to be reduced both in patients with and without joint destruction, whereas resorption is increased only in patients with joint destruction in relation to disease activity...
  3. ncbi Do markers of bone resorption add to bone mineral density and ultrasonographic heel measurement for the prediction of hip fracture in elderly women? The EPIDOS prospective study
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Lyon, France
    Osteoporos Int 8:563-9. 1998
    ..If DXA is not available, the combination of history of fracture and urinary CTX performs as well as hip BMD to assess hip fracture risk in elderly women...
  4. pmc Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage
    P Garnero
    INSERM Research Unit 403, Lyon, France
    Ann Rheum Dis 60:619-26. 2001
    ..The clinical performance of these two new markers was compared with that of a panel of other established biochemical markers of connective tissue metabolism...
  5. ncbi Cross-sectional evaluation of bone metabolism in men
    P Szulc
    INSERM Research Unit 403, Lyon, France
    J Bone Miner Res 16:1642-50. 2001
    ..After the age of 60 years, bone resorption markers--but not bone formation markers--increase in some men and are associated with lower BMD, suggesting that this imbalance is responsible for increasing bone loss in elderly men...
  6. ncbi Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study
    P Chavassieux
    , , Lyon, France
    J Bone Miner Res 16:89-96. 2001
    ..These effects on cortical bone were reflected by changes in biochemical markers. MDL markedly reduces bone turnover and increases BMD suggesting that this new agent may prevent postmenopausal bone loss...
  7. ncbi The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Lyon, France
    J Bone Miner Res 18:859-67. 2003
    ..We conclude that the generation of ICTP and CTX depends on different collagenolytic pathways. This finding may explain why these two markers may discriminate between different bone pathologies...
  8. ncbi Effects of intranasal 17beta-estradiol on bone turnover and serum insulin-like growth factor I in postmenopausal women
    P Garnero
    INSERM U 403, Hopital E Herriot, Lyon, France
    J Clin Endocrinol Metab 84:2390-7. 1999
    ..The delayed decrease in bone formation observed with intranasal E2 compared to oral E2 may be related to different effects on serum IGF-I levels...
  9. doi Nitrated type III collagen as a biological marker of nitric oxide-mediated synovial tissue metabolism in osteoarthritis
    P Richardot
    CCBR SYNARC, Lyon, France
    Osteoarthritis Cartilage 17:1362-7. 2009
    ..We investigated the nitration of type III collagen, a major constituent of synovial membrane, in knee OA...
  10. ncbi The bisphosphonate zoledronate decreases type II collagen breakdown in patients with Paget's disease of bone
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Pav F, 69003 Lyon, France
    Bone 28:461-4. 2001
    ..Measurement of type II collagen breakdown by a new urinary biochemical marker may be useful for in vivo assessment of the effects of drugs that potentially inhibit cartilage destruction...
  11. ncbi Evaluation of a fully automated serum assay for C-terminal cross-linking telopeptide of type I collagen in osteoporosis
    P Garnero
    INSERM Research Unit 403, Hopital E Herriot, Pavillon F, 69437 Lyon Cedex 03, France
    Clin Chem 47:694-702. 2001
    ..Our aim was to evaluate the technical and clinical performances of a new, fully automated assay for serum C-terminal cross-linking telopeptide of type I collagen (CTX), a marker of bone resorption...
  12. doi Association of serum sclerostin with bone mineral density, bone turnover, steroid and parathyroid hormones, and fracture risk in postmenopausal women: the OFELY study
    P Garnero
    INSERM Research Unit 1033, Lyon, France
    Osteoporos Int 24:489-94. 2013
    ....
  13. ncbi Urinary excretion of glucosyl-galactosyl pyridinoline: a specific biochemical marker of synovium degradation
    E Gineyts
    INSERM Research Unit 403, , Lyon and. SYNARC, Lyon, France
    Rheumatology (Oxford) 40:315-23. 2001
    ..CONCLUSION: Glc-Gal-PYD may be useful for the clinical investigation of patients with joint disease...
  14. pmc Increased urinary type II collagen helical and C telopeptide levels are independently associated with a rapidly destructive hip osteoarthritis
    P Garnero
    Molecular Markers, Synarc, Lyon, France
    Ann Rheum Dis 65:1639-44. 2006
    ..Aim: To investigate the association of rapidly destructive hip osteoarthritis with urinary Helix-II and urinary CTX-II...
  15. ncbi Cross-sectional and longitudinal assessment of pre- and postmenopausal bone loss with a portable forearm X-ray device: the Ofely study
    F Duboeuf
    INSERM Research Unit 403, Hopital E Herriot, Lyon, France
    Bone 26:131-5. 2000
    ....
  16. ncbi Early effects of zoledronic acid and teriparatide on bone microarchitecture, remodeling and collagen crosslinks: comparison between iliac crest and lumbar vertebra in ewes
    N R Portero-Muzy
    INSERM UMR 1033 et Université de Lyon, Lyon, France
    Bone 51:714-9. 2012
    ..The distinction of bone sites to study the early effects of anti-osteoporotic therapies appears meaningful in order to approach their site-specific anti-fracture efficacy...
  17. doi The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation
    N Charni-Ben Tabassi
    Synarc, Molecular Markers, Lyon, France
    Osteoarthritis Cartilage 16:1183-91. 2008
    ..In this study we analyzed the release of Helix-II and CTX-II from human cartilage collagen by the proteinases reported to play a role in cartilage degradation...
  18. pmc Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis
    E Gineyts
    INSERM Research Unit 403, Hopital Edouard Herriot, Pavillon F, Place d Arsonval, 69003 Lyon, France
    Ann Rheum Dis 63:857-61. 2004
    ....
  19. ncbi Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis
    J C Rousseau
    INSERM Unit 403, Pavillon F, Hopital E Herriot, Lyon, France
    Osteoarthritis Cartilage 12:440-7. 2004
    ..In addition, we investigated circulating forms recognized by antiserum IIA in pools of serum from healthy adults, patients with OA and patients with RA...
  20. doi Quantification of immature and mature collagen crosslinks by liquid chromatography-electrospray ionization mass spectrometry in connective tissues
    E Gineyts
    INSERM Research Unit 831 and Université de Lyon, Lyon, France
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1449-54. 2010
    ..This novel technique should be useful to quantify simultaneously DHLNL, HLNL, PYD and DPD in connective tissues and to evaluate the maturation of collagen by determination of the ratio between immature and mature enzymatic crosslinks...
  21. pmc Racemization and isomerization of type I collagen C-telopeptides in human bone and soft tissues: assessment of tissue turnover
    E Gineyts
    INSERM U403, Hopital E Herriot, Pavillon F, Place d Arsonval, 69437 Lyon Cedex 03, France
    Biochem J 345:481-5. 2000
    ....
  22. ncbi A model to monitor the efficacy of alendronate treatment in women with osteoporosis using a biochemical marker of bone turnover
    P Garnero
    INSERM Unit 403, Hopital E Herriot, Lyon, France
    Bone 24:603-9. 1999
    ..Because this model is independent of the study design, it should be broadly applicable...
  23. ncbi An immunoassay for type I collagen alpha 1 helicoidal peptide 620-633, a new marker of bone resorption in osteoporosis
    P Garnero
    INSERM Research Unit 403, Hôpital E Herriot Pavillon F, 69437 Lyon Cedex 03, France
    Bone 32:20-6. 2003
    ..The test was a sensitive indicator of the antiresorptive effects of bisphosphonate and estrogens in postmenopausal women. This new bone resorption marker should be useful for the clinical investigation of patients with osteoporosis...
  24. ncbi Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study
    P Garnero
    Synarc 16 rue Montbrillant 69003, Lyon, France
    Bone 40:716-22. 2007
    ..The aim of this study was to investigate the associations between serum 25-hydroxyvitamin D (25-OH D), bone turnover markers, bone mineral density (BMD), radius bone loss and incidence of fracture in postmenopausal women...
  25. ncbi Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density
    P Garnero
    Institut National de la Santé et de la Recherche Médicale Research Unit 403, Hopital E Herriot, Pavillon F, 69437 Lyon Cedex 03, France
    J Clin Endocrinol Metab 90:4829-35. 2005
    ..Vitamin D receptor (VDR) gene polymorphisms explain only a small part of the genetic influence on the level of bone mineral density (BMD), whereas their effect on fracture remains uncertain...
  26. pmc Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis
    P Garnero
    INSERM Research Unit 403, Lyon, France
    Ann Rheum Dis 62:939-43. 2003
    ..To compare type II collagen degradation using a new urinary specific marker in patients with rapidly destructive and those with slowly progressive hip OA...
  27. ncbi Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trial
    P Garnero
    INSERM Research Unit 664, Lyon, France
    Osteoarthritis Cartilage 16:660-6. 2008
    ....
  28. ncbi Contribution of bone mineral density and bone turnover markers to the estimation of risk of osteoporotic fracture in postmenopausal women
    P Garnero
    INSERM Research Unit 403 and Synarc, Lyon, France
    J Musculoskelet Neuronal Interact 4:50-63. 2004
    ..Further studies in osteoporosis should explore the changes in these biochemical parameters of bone matrix as they may represent a key component of bone quality...
  29. ncbi Biochemical markers of bone formation reflect endosteal bone loss in elderly men--MINOS study
    P Szulc
    INSERM 403 Research Unit, Hopital Edouard Herriot, Claude Bernard University, Lyon, France
    Bone 36:13-21. 2005
    ..In contrast, they do not reflect the periosteal bone formation, probably because the periosteal surface is smaller and has a slower remodelling rate than the endosteal surface...
  30. pmc Markers of bone turnover for the management of patients with bone metastases from prostate cancer
    P Garnero
    INSERM Research Unit 403, , Lyon, France
    Br J Cancer 82:858-64. 2000
    ..These findings suggest that these new resorption markers may be useful for the management of these patients...
  31. ncbi Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis: a three-month longitudinal study
    P Garnero
    Synarc, Lyon, France
    Arthritis Rheum 52:2822-9. 2005
    ....
  32. ncbi The role of collagen in bone strength
    S Viguet-Carrin
    INSERM Research Unit 403 and Claude Bernard University, Lyon, France
    Osteoporos Int 17:319-36. 2006
    ..To illustrate the role of the crosslinking process of collagen in bone strength, clinical disorders associated with bone collagen abnormalities and bone fragility, such as osteogenesis imperfecta and osteoporosis, are described...
  33. ncbi Monitoring individual response to hormone replacement therapy with bone markers
    P D Delmas
    INSERM Research Unit 403, Hopital E Herriot, Lyon, France
    Bone 26:553-60. 2000
    ..Our data suggest that bone turnover markers can be used to monitor the BMD response to HRT at the individual level. Whether such monitoring could improve long-term compliance to HRT should be tested prospectively...
  34. ncbi Potential contribution of IL-17-producing Th(1)cells to defective repair activity in joint inflammation: partial correction with Th(2)-promoting conditions
    M Chabaud
    Departments of Immunology and Rheumatology, , 69437 Lyon Cedex 03, France
    Cytokine 13:113-8. 2001
    ..As rheumatoid synovium is infiltrated by Th(1)cells, local cell interactions result in a pro-inflammatory pattern with defective repair, which can be reversed at least in part, by a Th(2)pattern...
  35. pmc Addition of interleukin 1 (IL1) and IL17 soluble receptors to a tumour necrosis factor alpha soluble receptor more effectively reduces the production of IL6 and macrophage inhibitory protein-3alpha and increases that of collagen in an in vitro model of rh
    G Chevrel
    Department of Immunology, Hopital E Herriot, 69437 Lyon Cedex 03, France
    Ann Rheum Dis 61:730-3. 2002
    ..To evaluate the usefulness of combination treatment with cytokine inhibitors...
  36. ncbi Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the OFELY study
    P Garnero
    INSERM Research Unit 403, Hopital E Herriot, Lyon, France
    Bone 31:43-50. 2002
    ..Larger long-term studies are necessary to assess adequately the relationships between IL-6 genotype, rate of bone loss, and risk of fracture...
  37. ncbi Serum Periostin Is Associated With Fracture Risk in Postmenopausal Women: A 7-Year Prospective Analysis of the OFELY Study
    J C Rousseau
    INSERM Research Unit 1033 J C R, E S R, C B, R C, P G, Universite de Lyon, and Service de Rhumatologie et Pathologie Osseuse R C, Hopital E Herriot, Universite de Lyon, 69437 Lyon Cedex 03, France and Cisbio Bioassays P G, 30200 Codolet, France
    J Clin Endocrinol Metab 99:2533-9. 2014
    ..8) after adjustment for age. Conclusion: High serum POSTN levels are independently associated with increased fracture risk in postmenopausal women. These data suggest that serum POSTN could be useful to improve fracture risk assessment. ..
  38. ncbi Markers of bone turnover in prostate cancer
    P Garnero
    INSERM Research Unit 403 and Synarc, Lyon, France
    Cancer Treat Rev 27:187-92; discussion 193-6. 2001
    ..Thus, bone markers are likely to become a useful and objective tool to monitor bisphosphonate treatment and individual the therapy scheme...
  39. doi The multiple facets of periostin in bone metabolism
    B Merle
    INSERM Research Unit 1033, Pavillon F, Hopital E Herriot, Place d Arsonval, 69437, Lyon Cedex 03, France
    Osteoporos Int 23:1199-212. 2012
    ..The aim of this article is to provide an extensive review on the implications of periostin in bone biology and its potential use in benign and metabolic bone diseases...
  40. doi Biological markers in osteoarthritis
    J Ch Rousseau
    INSERM Unit 1033 Pathophysiology, Diagnosis and Treatments of bone diseases, Universite de Lyon, Lyon, France
    Bone 51:265-77. 2012
    ..In this review, we will use the BIPED classification that appeared in 2006 for OA markers to describe the potential usage of a given marker [5]. This article is part of a Special Issue entitled "Osteoarthritis"...
  41. ncbi Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study
    M C Chapuy
    Hopital Edouard Herriot, Lyon, France
    Osteoporos Int 13:257-64. 2002
    ....