Affiliation: Centre for Neurosciences of Lyon
Location: Lyon, France
Clinical and physiological research in diagnosis and therapy of neuropathic pain. Cortial neurostimulation. Clinical neurophysiology.
- On the relation between sensory deafferentation, pain and thalamic activity in Wallenberg's syndrome: a PET-scan study before and after motor cortex stimulationLuis Garcia-Larrea
INSERM E342, Central Integration of Human Pain, Hopital Neurologique, 59 Bd Pinel, 69003 Lyon, France Université Claude Bernard Lyon1, France
Eur J Pain 10:677-88. 2006..Restoration of thalamic activity in neuropathic pain might represent one important condition to obtain successful relief by analgesic procedures, including cortical neurostimulation...
- Clinical neurophysiology for neurologists: the importance of being trainedLuis Garcia-Larrea
Insitut National de la Santé et de la Recherche Médicale EMI 342, and Central Integration of Pain Unit, Neurological Hospital, Lyon, France
Nat Clin Pract Neurol 3:116-7. 2007
- On insular responses and laser-evoked potentialsLuis Garcia-Larrea
Int J Psychophysiol 43:197-8. 2002
- Motor cortex stimulation in neuropathic pain. Correlations between analgesic effect and hemodynamic changes in the brain. A PET studyRoland Peyron
Department of Neurology, CHU Saint Etienne, France
Neuroimage 34:310-21. 2007..These hemodynamic changes are lengthened and might therefore underlie the long-lasting clinical effects that largely outlast the actual stimulation periods...
- Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked painLuis Garcia-Larrea
INSERM and Laboratoire de neurophysiologie humaine du CERMEP, Lyon, France
Brain 125:2766-81. 2002..In selected contexts (pain sine materia, non-organic anaesthesia), normal or enhanced LEPs may support a psychogenic participation in the syndrome...
- Predictive value of somatosensory evoked potentials for long-lasting pain relief after spinal cord stimulation: practical use for patient selectionMarc P Sindou
Department of Neurosurgery and UPRES EA 1880, University of Lyon, Hôpital Neurologique P Wertheimer, 59 Boulevard Pinel, F 69003 Lyon, France
Neurosurgery 52:1374-83; discussion 1383-4. 2003..Thus, we examined the value of preoperative central conduction time (CCT) of SSEPs to stimulation at the level of the painful area as a possible predictor of patient outcome after SCS...
- Parallel processing of nociceptive A-delta inputs in SII and midcingulate cortex in humansMaud Frot
INSERM, U879, Bron, F 69677 France
J Neurosci 28:944-52. 2008..These functions are, not surprisingly, conducted in parallel with pain intensity coding and stimulus localization specifically subserved by the sensory-discriminative "lateral" pain system...
- Motor cortex stimulation for neuropathic pain: From phenomenology to mechanismsLuis Garcia-Larrea
Central Integration of Pain Inserm U 879, F 69677, France
Neuroimage 37:S71-9. 2007..This, along with the delayed and long-lasting activation of several brain structures, is consistent with the clinical effects of MCS, which may also last for hours or days after MCS discontinuation...
- Human SII and posterior insula differently encode thermal laser stimuliMaud Frot
Institut National de la Santé et de la recherche médicale 342, Bron F 69677, France
Cereb Cortex 17:610-20. 2007....
- Association and dissociation between laser-evoked potentials and pain perceptionL Garcia-Larrea
UPR EA 1880 Neurologie fonctionnelle, Universite Claude Bernard, Lyon I, France
Neuroreport 8:3785-9. 1997....
- Apparent asynchrony between interictal electric and magnetic spikesI Merlet
UPR, Claude Bernard University, Lyon I, France
Neuroreport 8:1071-6. 1997..We conclude that non-identical neurone currents underlie the MEG and EEG signals, and emphasize the importance of modelling early phases of EEG spikes when localizing interictal epileptic zones...
- Relief of dyspnea involves a characteristic brain activation and a specific quality of sensationClaudine Peiffer
Laboratoire de Physiologie EFR, Hôpital Saint Vincent de Paul 82, avenue Denfert Rochereau, 75014 Paris, France
Am J Respir Crit Care Med 177:440-9. 2008..Central processing of dyspnea relief remains largely unknown...
- Transcranial magnetic stimulation for pain control. Double-blind study of different frequencies against placebo, and correlation with motor cortex stimulation efficacyNathalie Andre-Obadia
University Hospital Lyon Sud, Lyon, France
Clin Neurophysiol 117:1536-44. 2006..To assess, using a double-blind procedure, the pain-relieving effects of rTMS against placebo, and their predictive value regarding the efficacy of implanted motor cortex stimulation (MCS)...
- Auditory event-related potentials and clinical scores in unmedicated schizophrenic patientsA Laurent
Institut de Psychopathologie, Cognitive et Neurobiologique, Hôpital du Vinatier, Bron, France
Psychiatry Res 86:229-38. 1999..The P200 latency was negatively correlated with the PANSS positive syndrome score. The ERP abnormalities shown in this study appear to be enduring traits of the disorder as they persist in stabilized patients even after drug withdrawal...
- Evoked potentials as a tool for the investigation of human sleepH Bastuji
Sleep Disorders Unit, Functional Neurology Dept, Hopital Neurologique, Lyon, France
Sleep Med Rev 3:23-45. 1999..A promising approach is the utilization of late responses to the study of sleep inertia with the use of "forced awakening" recording paradigms...
- Visuospatial attention and motor reaction in children: an electrophysiological study of the "Posner" paradigmC Perchet
Research Unit UPRES EA1880 University Claude Bernard, CERMEP, Lyon, France
Psychophysiology 37:231-41. 2000..This method may be applied in clinical settings to disentangle selective processing deficits in target detection, response selection, or motor preparation stages...
- Contribution of attentional and cognitive factors to laser evoked brain potentialsJürgen Lorenz
Institute of Neurophysiology and Pathophysiology, University Clinic Hamburg Eppendorf, Hamburg, Germany
Neurophysiol Clin 33:293-301. 2003..This composite entity needs to be considered when LEP are experimentally or clinically used in the assessment of sensory and cognitive phenomena and abnormalities of pain sensation...
- Functional imaging and neurophysiological assessment of spinal and brain therapeutic modulation in humansL Garcia-Larrea
Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, Affiliated with the Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
Arch Med Res 31:248-57. 2000..The combination of clinical electrophysiology and functional neuroimaging provides insight into the mechanisms of action of neuromodulation procedures, guides clinical decision, and contributes to optimize patient selection...
- [Make your own interpretation. Cataract or retinal disease?]L Garcia-Larrea
Neurophysiol Clin 30:327-8. 2000
- Somatosensory volleys and cortical evoked potentials: 'first come, first served'?Luis Garcia-Larrea
Pain 112:5-7. 2004
- Semantic analysis of auditory input during sleep: studies with event related potentialsHélène Bastuji
Institut Fédératif des Neurosciences de Lyon IFNL, Lyon, France 1 fr
Int J Psychophysiol 46:243-55. 2002..All these data support the view that some semantic analysis of auditory stimuli remains possible in the human sleeping brain, and warrant further studies to elucidate the extent and limits of these capabilities...
- Capillary electrophoresis combined with microdialysis in the human spinal cord: a new tool for monitoring rapid peroperative changes in amino acid neurotransmitters within the dorsal hornSandrine Parrot
IFR 19, Institut Federatif des Neurosciences de Lyon, Hopital Neurologique, and Université Claude Bernard, 8 avenue Rockefeller, F 69373 Lyon Cedex 08, France
Electrophoresis 25:1511-7. 2004..The results obtained illustrate the advantages of combining microdialysis with CE-LIFD for studying neurotransmitters with such a high sampling rate...
- Long-term clinical, electrophysiological and urodynamic effects of chronic intrathecal baclofen infusion for treatment of spinal spasticityP Mertens
Department of Neurosurgery, Hopital Neurologique, Lyon, France
Acta Neurochir Suppl 64:17-25. 1995..In patients with spastic bladder, intrathecal baclofen produced a decrease of detrusor hypertonia and hyperactivity in 50% of cases, with reduction of leakage and increase in functional bladder capacity...
- Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET studyR Peyron
Department of Neurology, Bellevue Hospital, Etienne, France
Pain 62:275-86. 1995..Painful dysesthesiae during stimulation have to be distinguished from other innocuous sensory side effects, since they may compromise PGS efficacy...
- [Pathophysiology of neuropathic pain: review of experimental models and proposed mechanisms]Luis Garcia-Larrea
INSERM U879, Intégration centrale de la douleur, F 69677 Lyon, France
Presse Med 37:315-40. 2008..This suggests that their role in experimental allodynia would likely be reactive and protective, and that inability to generate their activation may contribute to the clinical expression of neuropathic pain...
- Nociceptive flexion reflexes during analgesic neurostimulation in manL Garcia-Larrea
Evoked Potentials Unit EEG Department, Hopital Neurologique, Lyon, France
Pain 39:145-56. 1989..In addition, RIII behavior in patients could be relevant to the understanding of some of the mechanisms involved in AN-induced pain relief...
- Thalamic deactivation at sleep onset precedes that of the cerebral cortex in humansMichel Magnin
Institut National de la Santé et de la Recherche Médicle U879, Bron, F 69677, France
Proc Natl Acad Sci U S A 107:3829-33. 2010..Thus, asynchronous thalamo-cortical deactivation while falling asleep probably explains the production of hypnagogic hallucinations by a still-activated cortex and the common self-overestimation of the time needed to fall asleep...
- Electrophysiological assessment of nociception in normals and patients: the use of nociceptive reflexesL Garcia-Larrea
EEG and EP Department, Hopital Neurologique, Lyon, France
Electroencephalogr Clin Neurophysiol Suppl 41:102-18. 1990
- Evoked potential studies in Friedreich's ataxia and progressive early onset cerebellar ataxiaM Vanasse
Laboratoire de Neurophysiologie Sensorielle, Faculté de Médecine Lyon Nord, France
Can J Neurol Sci 15:292-8. 1988..In FA, BAEP were abnormal in all patients with a disease duration of four years or more but were normal in four of the five PEOCA patients. Systematic evoked potential recording is useful in the investigation of hereditary ataxias...
- Clinical use of polysynaptic flexion reflexes in the management of spasticity with intrathecal baclofenM Parise
Department of Functional Neurology and Epileptology, Pierre Wertheimer Neurological Hospital, Lyon, France
Electroencephalogr Clin Neurophysiol 105:141-8. 1997..In our experience, FR recordings appeared to be a useful tool for quantifying the benefit of antispastic treatment and might be used as an ancillary indicator to determine the minimal effective dose of intrathecal baclofen...
- Involuntary orienting of attention to nociceptive events: neural and behavioral signaturesValery Legrain
Unité de Réadaptation et de Médecine physique READ, Universite Catholique de Louvain, Louvain la Neuve and Brussels, Belgium
J Neurophysiol 102:2423-34. 2009..We conclude that the laser-evoked potentials index the activity of a neural system involved in the detection of novel salient stimuli in order to focus attention and prioritize action to potentially damaging dangers...
- Pain relief by rTMS: differential effect of current flow but no specific action on pain subtypesN Andre-Obadia
INSERM U879, University Claude Bernard Lyon 1, France
Neurology 71:833-40. 2008..To assess, against placebo, the pain-relieving effects of high-rate repetitive transcranial magnetic stimulation (rTMS) on neuropathic pain...
- [Central post-stroke pain]S Demasles
Centre stéphanois de la douleur et service de neurologie, Hopital de Bellevue, 42055 Saint Etienne Cedex 02, France
Rev Neurol (Paris) 164:825-31. 2008..The thalamus plays a prominent role in this disorder of central control of pain...
- Unmasking of cortical SEP components by changes in stimulus rate: a topographic studyL Garcia Larrea
CERMEP, Hopital Neurologique, Lyon, France
Electroencephalogr Clin Neurophysiol 84:71-83. 1992..On the contrary, combination of different frequencies of stimulation should enhance the diagnostic utility of this technique by allowing a more selective assessment of overlapping activities...
- Recommendations for the clinical use of somatosensory-evoked potentialsG Cruccu
Department of Neurological Sciences, La Sapienza University, Viale Università 30, 00185 Rome, Italy
Clin Neurophysiol 119:1705-19. 2008..However, to prove clinically useful each of them requires a dedicated knowledge, both technical and pathophysiological. In this article we give technical advice, report normative values, and discuss clinical applications...
- Autonomic pain responses during sleep: a study of heart rate variabilityF Chouchou
Unité INSERM U879, Central Integration of Pain, Universite Lyon 1, Lyon, France
Eur J Pain 15:554-60. 2011....
- [The P 300 potential in schizophrenia]A Laurent
Service de Psychiatrie, C H R U de Grenoble
Encephale 19:221-7. 1993..In the present study, we attempted to explore the P 3 component in a group of schizophrenic patients with a precisely defined clinical symptomatology...
- Human thalamic medial pulvinar nucleus is not activated during paradoxical sleepMichel Magnin
Inserm EMI 342, Federative Institut of Neurosciences INSERM IFR 19, Unité d Hypnologie, Hopital Neurologique, 59 Bd Pinel, 69003 Lyon, France
Cereb Cortex 14:858-62. 2004..This discrepancy between activities in a thalamic nucleus and its related cortical areas may compromise the spatio-temporal binding of the high-frequency activities, resulting in altered perceptual experiences during dream periods...
- Cognitive modulation of pain-related brain responses. Comments on Seminowicz et al. (Pain 2004;112:48-58)Valery Legrain
Pain 114:524-6; author reply 526-7. 2005
- Thalamic thermo-algesic transmission: ventral posterior (VP) complex versus VMpo in the light of a thalamic infarct with central painCarmen Montes
Dept Fisiologia, Universidad de Malaga, Campus de Teatinos s n, 29080 Malaga, Spain
Pain 113:223-32. 2005....
- An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic painR Peyron
Departement de Neurologie, Hopital de Bellevue, Bd Pasteur, 42055 Saint Etienne, France
Neurology 63:1838-46. 2004..To investigate cerebral activity associated with allodynia in patients with neuropathic pain...
- Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological studyL Garcia-Larrea
Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, and Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
Pain 83:259-73. 1999..In contrast, the hypothesis of somatosensory cortex activation by MCS could not be confirmed by our results...
- EFNS guidelines on neuropathic pain assessment: revised 2009G Cruccu
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Eur J Neurol 17:1010-8. 2010....
- Does the insula tell our brain that we are in pain?Jean Isnard
Central Integration of Pain Unit INSERM U879, Lyon, France
Pain 152:946-51. 2011....
- Operculo-insular pain (parasylvian pain): a distinct central pain syndromeLuis Garcia-Larrea
Central Integration of Pain Unit, U879 INSERM and University Claude Bernard, Lyon 1, Neurological Hospital, Lyon, France
Brain 133:2528-39. 2010..Parasylvian pain may be extremely difficult to treat; the magnitude of pain-temperature sensory disturbances may be prognostic for its development, hence the importance of early sensory assessment with quantitative methods...
- Effect of sensory stimulus on striatal dopamine release in humans and cats: a [(11)C]raclopride PET studyStephane Thobois
Service de Neurologie D and INSERM U 534, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
Neurosci Lett 368:46-51. 2004..Sensory stimulation of the forelimb extremities constitutes a well-established experimental model that has consistently shown to activate dopamine (DA) neurotransmission in the mammals' forebrain...
- Clinical utility of pain--laser evoked potentialsG Cruccu
Department of Neurological Sciences, La Sapienza University, Viale Università 20, 00185 Rome, Italy
Suppl Clin Neurophysiol 57:101-10. 2004
- Laser evoked responses to painful stimulation persist during sleep and predict subsequent arousalsH Bastuji
INSERM, U 879 Central Integration of Pain, Bron F 69677, France
Pain 137:589-99. 2008..This response appeared functionally related to the P3 wave, which in waking subjects has been associated to conscious perception and memory encoding...
- Central representation of the RIII flexion reflex associated with overt motor reaction: an fMRI studyR Peyron
Departement de Neurologie, CHU de St Etienne, 42055 St Etienne, France
Neurophysiol Clin 37:249-59. 2007..They should be considered as a motor component of pain-related processes activated in case of intense pain...
- Emotional modulation of pain: is it the sensation or what we recall?Fabio Godinho
Equipe Mixte INSERM 342, Central Integration of Pain, Hopital Neurologique Pierre Wertheimer, 69003 Lyon, France
J Neurosci 26:11454-61. 2006..Memory encoding and recall, rather than sensory processing, appear to be modulated by empathy with others' physical suffering...
- Pain influences hedonic assessment of visual inputsFabio Godinho
INSERM U879, Central Integration of Pain, Hopital Neurologique Pierre Wertheimer, 59 Boulevard Pinel 69003, Rez de jardin, Lyon, France
Eur J Neurosci 27:2219-28. 2008..The latter correlated with changes in the subjective appraisal of visual stimuli, and may underlie not only the change in their subjective assessment but also reactive processes aimed at coping with unpleasant contexts...
- Motor cortex stimulation for pain control induces changes in the endogenous opioid systemJ Maarrawi
INSERM U879, Bron, France
Neurology 69:827-34. 2007..We studied the possible contribution of the endogenous opioid system to MCS-related pain relief...
- Right frontal event related EEG coherence (ERCoh) differentiates good from bad performers of the Wisconsin Card Sorting Test (WCST)M T Carrillo-de-la-Peña
Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain
Neurophysiol Clin 37:63-75. 2007..To investigate changes in Event-Related Coherence (ERCoh) associated to good and bad resolution of the Wisconsin Card Sorting Test (WCST)...
- Differential brain opioid receptor availability in central and peripheral neuropathic painJoseph Maarrawi
INSERM EMI 342 Central Integration of pain, 59 Bd Pinel, 69394 Lyon and St Etienne, France
Pain 127:183-94. 2007..Central and peripheral forms of NP may differ in distribution of brain opioid system changes and this in turn might underlie their different sensitivity to opiates...
- EFNS guidelines on neurostimulation therapy for neuropathic painG Cruccu
EFNS Panel on Neuropathic Pain, Vienna, Austria
Eur J Neurol 14:952-70. 2007..These chronically implanted techniques provide satisfactory pain relief in many patients, including those resistant to medication or other means...
- Chapter 30 Evoked potentials in the assessment of painLuis Garcia-Larrea
Handb Clin Neurol 81:439-XI. 2006
- Evoked potentials to nociceptive stimuli delivered by CO2 or Nd:YAP lasersCaroline Perchet
INSERM U879 Central integration of pain unit, Lyon F 69677, France
Clin Neurophysiol 119:2615-22. 2008..This study compares the amplitude, latency, morphology, scalp topography and intracranial generators of laser-evoked potentials (LEPs) to CO(2) and Nd:YAP laser stimuli...
- Motor cortex stimulation for refractory neuropathic pain: four year outcome and predictors of efficacyChristophe Nuti
Department of Neurosurgery, CHU Saint Etienne, Bd Pasteur, 42055 Saint Etienne Cedex 2, France
Pain 118:43-52. 2005..744; p<0.0001). These results confirm that MCS can be a satisfactory and durable alternative to medical treatments in patients with refractory pain, and suggest that the efficacy of MCS may be predicted in the first month of therapy...
- Striatal dopamine during sensorial stimulations: a [18F]FDOPA PET study in human and catsWadad Hassoun
Physiologie Intégrative Cellulaire et Moléculaire, CNRS UMR5123, Villeurbanne, France
Neurosci Lett 383:63-7. 2005..These results support the hypothesis that sensory stimulations activate a non-synaptic mode of dopamine release...
- Event-related potentials during forced awakening: a tool for the study of acute sleep inertiaHélène Bastuji
INSERM E0342, Lyon, France
J Sleep Res 12:189-206. 2003..In the present series, it proved to be much more discriminative than waking ERPs alone to demonstrate specific abnormalities in patients complaining of excessive daytime sleepiness...
- The combined monitoring of brain stem auditory evoked potentials and intracranial pressure in coma. A study of 57 patientsL Garcia-Larrea
EEG Department, Hopital Neurologique, Lyon, France
J Neurol Neurosurg Psychiatry 55:792-8. 1992..Serial recording of cortical EPs should be added to BAEP monitoring to permit the early detection of rostrocaudal deterioration...
- P3, positive slow wave and working memory load: a study on the functional correlates of slow wave activityL Garcia-Larrea
Human Neurophysiology Lab, CERMEP, EA1880, Université Claude Besnard, Lyon, France
Electroencephalogr Clin Neurophysiol 108:260-73. 1998..The present paradigm proved to be easy to implement and suitable to study the 'executive' functions governing attentional and working-memory control during the performance of multiple tasks...
- Allodynia after lateral-medullary (Wallenberg) infarct. A PET studyR Peyron
Neurological Department, Bellevue Hospital, Saint Etienne, France
Brain 121:345-56. 1998....
- [Monitoring of auditory evoked potentials of the brain stem in acute changes in intracranial pressure]L Garcia-Larrea
Agressologie 29:329-32. 1988
- Source propagation of interictal spikes in temporal lobe epilepsy. Correlations between spike dipole modelling and [18F]fluorodeoxyglucose PET dataI Merlet
Claude Bernard University Lyon I, Department of Functional Neurology and Epileptology, France
Brain 119:377-92. 1996....
- Flexion reflexes following anterolateral cordotomy in man: dissociation between pain sensation and nociceptive reflex RIIIL Garcia-Larrea
Department of Clinical Neurophysiology, Hopital Neurologique, Lyon, France
Pain 55:139-49. 1993....
- Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part II: The focal hypometabolism is reactive to GABAA agonist administration in TLR Peyron
Centre d Exploration et de Recherches Médicales par Emission de Positions, Lyon, France
Epilepsy Res 19:55-62. 1994..This metabolic response in the hypometabolic focus, observed in the absence of any epileptic discharge during FDG accumulation and PET data acquisition, suggests that GABAA receptors are up-regulated or, at least, preserved in TLE...
- Brain processing of stimulus deviance during slow-wave and paradoxical sleep: a study of human auditory evoked responses using the oddball paradigmH Bastuji
Service de Neurologie Fonctionelle et Epileptologie, Hopital Neurologique, Lyon, France
J Clin Neurophysiol 12:155-67. 1995....
- Target side and scalp topography of the somatosensory P300P Bruyant
Clinical Neurophysiology Unit, University Lyon I, France
Electroencephalogr Clin Neurophysiol 88:468-77. 1993....
- Transient drug-induced abolition of BAEPs in comaL Garcia-Larrea
EEG Department, Hopital Neurologique, Lyon, France
Neurology 38:1487-9. 1988..BAEPs are resistant to hypothermia and barbiturates, but must be interpreted cautiously in patients treated with a combination of anesthetic drugs that includes lidocaine...
- [Monitoring of evoked potentials in traumatic coma]F Mauguiere
Agressologie 29:351-7. 1988
- Clinical use of nociceptive flexion reflex recording in the evaluation of functional neurosurgical proceduresL Garcia-Larrea
EEG Department Clin Hôpital Neurologique, Lyon, France
Acta Neurochir Suppl (Wien) 46:53-7. 1989..Routine recording of nociceptive reflexes in man proved to be a useful tool for the objective evaluation of anatomo-physiological effects of functional neurosurgical procedures...
- [Anomalies in early somatosensory evoked potentials in brain stem lesions (study of 64 cases)]P Convers
Service de neurologie CHRU 15, Saint Etienne, France
Neurophysiol Clin 19:443-68. 1989....
- Latency and amplitude abnormalities of the scalp far-field P14 to median nerve stimulation in multiple sclerosis. A SEP study of 122 patients recorded with a non-cephalic reference montageL Garcia Larrea
Laboratoire de Neurophysiologie Sensorielle Appliquée, Faculté de Médecine Lyon Nord, Hopital Neurologique, France
Electroencephalogr Clin Neurophysiol 71:180-6. 1988..Also IPLs were increased in 12 patients with normal P14 amplitudes. These results suggest that adding the P9/P14 amplitude criterion to standard IPL data might be useful to detect conduction troubles in MS patients...
- Brain-stem monitoring. II. Preterminal BAEP changes observed until brain death in deeply comatose patientsL Garcia-Larrea
Laboratorie de Neurophysiologie Sensorielle, Faculté de Médecine Lyon Nord, Hopital Neurologique, France
Electroencephalogr Clin Neurophysiol 68:446-57. 1987..Our results suggest that continuous brain-stem monitoring could be helpful for management of comatose head-injured patients...
- High signal intensity on T2-weighted MRI correlates with hypoperfusion in temporal lobe epilepsyP Ryvlin
EEG Department, Neurological Hospital, Lyon, France
Epilepsia 33:28-35. 1992..The degree of temporal perfusion asymmetry measured in each individual was higher in patients whose MRI was abnormal...
- Mapping study of somatosensory evoked potentials during selective spatial attentionL Garcia-Larrea
CERMEP Clinical Neurophysiology Laboratory, Hopital Neurologique, Lyon, France
Electroencephalogr Clin Neurophysiol 80:201-14. 1991..The late negative component (N140) shares several features with the 'processing negativity' described in auditory paradigms and could represent the equivalent of this effect in the somatosensory system...
- Revisiting the oddball paradigm. Non-target vs neutral stimuli and the evaluation of ERP attentional effectsL Garcia-Larrea
CERMEP, Clinical Neurophysiology Lab, Université Lyon Nord, France
Neuropsychologia 30:723-41. 1992..Notably, non-target responses may help to decide whether an abnormal target-P300 is related or not to a deficit in the mobilization of attentional resources...
- Positron emission tomography during motor cortex stimulation for pain controlL Garcia-Larrea
CERMEP Positron Emission Tomography Center, Lyon, France
Stereotact Funct Neurosurg 68:141-8. 1997..Such effects may be obtained only if thalamic activation reaches a 'threshold' level, below which the analgesic cascade would not be successfully triggered...
- Topographical reliability of mesio-temporal sources of interictal spikes in temporal lobe epilepsyI Merlet
UPR, Equipe d Accueil 1880, Claude Bernard University Lyon I, Functional Neurology and Epileptology, France
Electroencephalogr Clin Neurophysiol 107:206-12. 1998..This study aimed at assessing the relevance of mesio-temporal dipoles, as identified by modeling of scalp recorded spikes in TLE...
- Simplified projection of EEG dipole sources onto human brain anatomyI Merlet
Département d EEG, Universite Claude Bernard Lyon I, France
Neurophysiol Clin 29:39-52. 1999....
- [Positron emission tomography to study central pain integration]B Laurent
Service de Neurologie de Saint Etienne et Centre stéphanois de la douleur, Lyon, France
Rev Neurol (Paris) 156:341-51. 2000..To advance our knowledge of the mechanisms generating both abnormal pain and analgesia (drugs and surgical techniques) in patients is the main motivation of such anexciting challenge...
- Precentral cortex stimulation for the treatment of central neuropathic pain: results of a prospective study in a 20-patient seriesP Mertens
Department of Neurosurgery, University of Lyon I, France
Stereotact Funct Neurosurg 73:122-5. 1999..In 25% the method failed. On the basis of these findings and the literature data (127 reported cases), the authors advocate PCS in patients with severe and medically refractory poststroke pain...
- Functional imaging of brain responses to pain. A review and meta-analysis (2000)R Peyron
Departement de Neurologie, Hopital de Bellevue, boulevard Pasteur, 42055 Saint Etienne, France
Neurophysiol Clin 30:263-88. 2000..The precise biochemical nature of these mechanisms remains to be investigated...
- Responses of the supra-sylvian (SII) cortex in humans to painful and innocuous stimuli. A study using intra-cerebral recordingsM Frot
EA 1880, Functional Neurology and Epileptology Department, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
Pain 94:65-73. 2001....
- Detection of verbal discordances during sleepFabien Perrin
EA 1880, University Claude Bernard, Lyon, France
Neuroreport 13:1345-9. 2002..Linguistic absurdity appears to be accepted in a different manner during paradoxical sleep than during waking, and this might explain why absurd contents are so naturally incorporated into otherwise plausible dream stories...
- Cognitive effects of precentral cortical stimulation for pain control: an ERP studyC Montes
Equipe d Accueil, EA1880 UCB, Lyon, France
Neurophysiol Clin 32:313-25. 2002....
- Modulation of the N400 potential during auditory phonological/semantic interactionFabien Perrin
EA 1880, University Claude Bernard, Lyon, France
Brain Res Cogn Brain Res 17:36-47. 2003..Our data also provide new elements supporting the persistence of the semantic N400 during 'shallow' word processing tasks, i.e. tasks that discourage analysis of semantic aspects of the words...
- Dissociable ERP profiles for processing rules vs instances in a cognitive sequencing taskT Lelekov
Institut de Sciences Cognitives, CNRS UPR 9075, Bron, France
Neuroreport 11:1129-32. 2000..We discuss implications for the rule vs instance debate, and similarities between this late positivity and the P600 observed in previous studies of syntactic processing...
- A differential brain response to the subject's own name persists during sleepF Perrin
UPRES EA 1880, University Claude Bernard, Lyons, France
Clin Neurophysiol 110:2153-64. 1999..All stimuli were disyllabic, equiprobable and presented in random order...
- Parietal and cingulate processes in central pain. A combined positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) study of an unusual caseR Peyron
Neurological Department, Bellevue Hospital, 42055, Saint Etienne, France
Pain 84:77-87. 2000..This response is likely to be responsible for the strange and very unpleasant allodynic sensation elicited on the left side by a non-noxious stimulation...
- Timing and characteristics of perceptual attenuation by transcranial stimulation: a study using magnetic cortical stimulation and somatosensory-evoked potentialsN Andre-Obadia
Service de Neurologie Fonctionnelle et d Epileptologie, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
Psychophysiology 36:476-83. 1999..The results also suggest that the cortical processes active during the N20 and N120 potentials may be essential for the conscious perception of somatosensory stimuli delivered to the hand...
- Haemodynamic brain responses to acute pain in humans: sensory and attentional networksR Peyron
Departement de Neurologie and Centre de la douleur, Hopital de Bellevue, Saint Etienne, France
Brain 122:1765-80. 1999..Attentional processes could possibly explain part of the variability observed in previous PET reports and should therefore be considered in further studies on pain in both normal subjects and patients with chronic pain...
- Brain responses to detection of right or left somatic targets are symmetrical in unilateral Parkinson's disease: a case against the concept of "parkinsonian neglect'L Garcia-Larrea
Clinical Neurophysiology Lab, CERMEP, UPR 1880, VCB, Lyon, France
Cortex 32:679-91. 1996....
- The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's diseaseE Broussolle
Department of Neurology, Hopital Neurologique Pierre Wertheimer, Lyon, France
J Neurol Sci 166:141-51. 1999....
- Sleep/wake abnormalities in patients with periodic leg movements during sleep: factor analysis on data from 24-h ambulatory polygraphyH Bastuji
Sleep Disorders Unit, Functional Neurology Department, Hopital Neurologique, Lyon, France
J Sleep Res 8:217-23. 1999..On the other hand, our analysis suggests that in PLM patients the concomitant existence of a RLS is not related to the frequency of occurrence of PLMs, at least when these latter are quantified independently of their arousal index...
- On the validity of interblock averaging of P300 in clinical settingsM T Carrillo-de-la-Peña
Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Santiago de Compostela, Spain
Int J Psychophysiol 34:103-12. 1999....
- Human thalamic and cortical activities assessed by dimension of activation and spectral edge frequency during sleep wake cyclesMarc Rey
Service de Neurophysiologie Clinique Hôpital Timone, Marseille, France
Sleep 30:907-12. 2007..Using spectral edge frequency (SEF95) and dimension of activation (DA), a new tool derived from the dimension of correlation, we assessed the activation of thalamus and cortex in the different vigilance states...
- Painful sensory neuropathyAndrea Truini
N Engl J Med 349:306-7; author reply 306-7. 2003