Luis Garcia-Larrea

Summary

Affiliation: Centre for Neurosciences of Lyon
Location: Lyon, France
URL: http://ifnl.univ-lyon1.fr/u879/
Summary:
Clinical and physiological research in diagnosis and therapy of neuropathic pain. Cortial neurostimulation. Clinical neurophysiology.

Publications

  1. ncbi request reprint On the relation between sensory deafferentation, pain and thalamic activity in Wallenberg's syndrome: a PET-scan study before and after motor cortex stimulation
    Luis Garcia-Larrea
    INSERM E342, Central Integration of Human Pain, Hopital Neurologique, 59 Bd Pinel, 69003 Lyon, France Université Claude Bernard Lyon1, France
    Eur J Pain 10:677-88. 2006
  2. ncbi request reprint Clinical neurophysiology for neurologists: the importance of being trained
    Luis Garcia-Larrea
    Insitut National de la Santé et de la Recherche Médicale EMI 342, and Central Integration of Pain Unit, Neurological Hospital, Lyon, France
    Nat Clin Pract Neurol 3:116-7. 2007
  3. ncbi request reprint On insular responses and laser-evoked potentials
    Luis Garcia-Larrea
    Int J Psychophysiol 43:197-8. 2002
  4. ncbi request reprint Motor cortex stimulation in neuropathic pain. Correlations between analgesic effect and hemodynamic changes in the brain. A PET study
    Roland Peyron
    Department of Neurology, CHU Saint Etienne, France
    Neuroimage 34:310-21. 2007
  5. ncbi request reprint Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain
    Luis Garcia-Larrea
    INSERM and Laboratoire de neurophysiologie humaine du CERMEP, Lyon, France
    Brain 125:2766-81. 2002
  6. ncbi request reprint Predictive value of somatosensory evoked potentials for long-lasting pain relief after spinal cord stimulation: practical use for patient selection
    Marc P Sindou
    Department of Neurosurgery and UPRES EA 1880, University of Lyon, Hôpital Neurologique P Wertheimer, 59 Boulevard Pinel, F 69003 Lyon, France
    Neurosurgery 52:1374-83; discussion 1383-4. 2003
  7. ncbi request reprint Parallel processing of nociceptive A-delta inputs in SII and midcingulate cortex in humans
    Maud Frot
    INSERM, U879, Bron, F 69677 France
    J Neurosci 28:944-52. 2008
  8. ncbi request reprint Motor cortex stimulation for neuropathic pain: From phenomenology to mechanisms
    Luis Garcia-Larrea
    Central Integration of Pain Inserm U 879, F 69677, France
    Neuroimage 37:S71-9. 2007
  9. ncbi request reprint Human SII and posterior insula differently encode thermal laser stimuli
    Maud Frot
    Institut National de la Santé et de la recherche médicale 342, Bron F 69677, France
    Cereb Cortex 17:610-20. 2007
  10. ncbi request reprint Association and dissociation between laser-evoked potentials and pain perception
    L Garcia-Larrea
    UPR EA 1880 Neurologie fonctionnelle, Universite Claude Bernard, Lyon I, France
    Neuroreport 8:3785-9. 1997

Detail Information

Publications99

  1. ncbi request reprint On the relation between sensory deafferentation, pain and thalamic activity in Wallenberg's syndrome: a PET-scan study before and after motor cortex stimulation
    Luis Garcia-Larrea
    INSERM E342, Central Integration of Human Pain, Hopital Neurologique, 59 Bd Pinel, 69003 Lyon, France Université Claude Bernard Lyon1, France
    Eur J Pain 10:677-88. 2006
    ..Restoration of thalamic activity in neuropathic pain might represent one important condition to obtain successful relief by analgesic procedures, including cortical neurostimulation...
  2. ncbi request reprint Clinical neurophysiology for neurologists: the importance of being trained
    Luis Garcia-Larrea
    Insitut National de la Santé et de la Recherche Médicale EMI 342, and Central Integration of Pain Unit, Neurological Hospital, Lyon, France
    Nat Clin Pract Neurol 3:116-7. 2007
  3. ncbi request reprint On insular responses and laser-evoked potentials
    Luis Garcia-Larrea
    Int J Psychophysiol 43:197-8. 2002
  4. ncbi request reprint Motor cortex stimulation in neuropathic pain. Correlations between analgesic effect and hemodynamic changes in the brain. A PET study
    Roland Peyron
    Department of Neurology, CHU Saint Etienne, France
    Neuroimage 34:310-21. 2007
    ..These hemodynamic changes are lengthened and might therefore underlie the long-lasting clinical effects that largely outlast the actual stimulation periods...
  5. ncbi request reprint Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain
    Luis Garcia-Larrea
    INSERM and Laboratoire de neurophysiologie humaine du CERMEP, Lyon, France
    Brain 125:2766-81. 2002
    ..In selected contexts (pain sine materia, non-organic anaesthesia), normal or enhanced LEPs may support a psychogenic participation in the syndrome...
  6. ncbi request reprint Predictive value of somatosensory evoked potentials for long-lasting pain relief after spinal cord stimulation: practical use for patient selection
    Marc P Sindou
    Department of Neurosurgery and UPRES EA 1880, University of Lyon, Hôpital Neurologique P Wertheimer, 59 Boulevard Pinel, F 69003 Lyon, France
    Neurosurgery 52:1374-83; discussion 1383-4. 2003
    ..Thus, we examined the value of preoperative central conduction time (CCT) of SSEPs to stimulation at the level of the painful area as a possible predictor of patient outcome after SCS...
  7. ncbi request reprint Parallel processing of nociceptive A-delta inputs in SII and midcingulate cortex in humans
    Maud Frot
    INSERM, U879, Bron, F 69677 France
    J Neurosci 28:944-52. 2008
    ..These functions are, not surprisingly, conducted in parallel with pain intensity coding and stimulus localization specifically subserved by the sensory-discriminative "lateral" pain system...
  8. ncbi request reprint Motor cortex stimulation for neuropathic pain: From phenomenology to mechanisms
    Luis Garcia-Larrea
    Central Integration of Pain Inserm U 879, F 69677, France
    Neuroimage 37:S71-9. 2007
    ..This, along with the delayed and long-lasting activation of several brain structures, is consistent with the clinical effects of MCS, which may also last for hours or days after MCS discontinuation...
  9. ncbi request reprint Human SII and posterior insula differently encode thermal laser stimuli
    Maud Frot
    Institut National de la Santé et de la recherche médicale 342, Bron F 69677, France
    Cereb Cortex 17:610-20. 2007
    ....
  10. ncbi request reprint Association and dissociation between laser-evoked potentials and pain perception
    L Garcia-Larrea
    UPR EA 1880 Neurologie fonctionnelle, Universite Claude Bernard, Lyon I, France
    Neuroreport 8:3785-9. 1997
    ....
  11. ncbi request reprint Apparent asynchrony between interictal electric and magnetic spikes
    I Merlet
    UPR, Claude Bernard University, Lyon I, France
    Neuroreport 8:1071-6. 1997
    ..We conclude that non-identical neurone currents underlie the MEG and EEG signals, and emphasize the importance of modelling early phases of EEG spikes when localizing interictal epileptic zones...
  12. ncbi request reprint Relief of dyspnea involves a characteristic brain activation and a specific quality of sensation
    Claudine Peiffer
    Laboratoire de Physiologie EFR, Hôpital Saint Vincent de Paul 82, avenue Denfert Rochereau, 75014 Paris, France
    Am J Respir Crit Care Med 177:440-9. 2008
    ..Central processing of dyspnea relief remains largely unknown...
  13. ncbi request reprint Transcranial magnetic stimulation for pain control. Double-blind study of different frequencies against placebo, and correlation with motor cortex stimulation efficacy
    Nathalie Andre-Obadia
    University Hospital Lyon Sud, Lyon, France
    Clin Neurophysiol 117:1536-44. 2006
    ..To assess, using a double-blind procedure, the pain-relieving effects of rTMS against placebo, and their predictive value regarding the efficacy of implanted motor cortex stimulation (MCS)...
  14. ncbi request reprint Auditory event-related potentials and clinical scores in unmedicated schizophrenic patients
    A Laurent
    Institut de Psychopathologie, Cognitive et Neurobiologique, Hôpital du Vinatier, Bron, France
    Psychiatry Res 86:229-38. 1999
    ..The P200 latency was negatively correlated with the PANSS positive syndrome score. The ERP abnormalities shown in this study appear to be enduring traits of the disorder as they persist in stabilized patients even after drug withdrawal...
  15. ncbi request reprint Evoked potentials as a tool for the investigation of human sleep
    H Bastuji
    Sleep Disorders Unit, Functional Neurology Dept, Hopital Neurologique, Lyon, France
    Sleep Med Rev 3:23-45. 1999
    ..A promising approach is the utilization of late responses to the study of sleep inertia with the use of "forced awakening" recording paradigms...
  16. ncbi request reprint Visuospatial attention and motor reaction in children: an electrophysiological study of the "Posner" paradigm
    C Perchet
    Research Unit UPRES EA1880 University Claude Bernard, CERMEP, Lyon, France
    Psychophysiology 37:231-41. 2000
    ..This method may be applied in clinical settings to disentangle selective processing deficits in target detection, response selection, or motor preparation stages...
  17. ncbi request reprint Contribution of attentional and cognitive factors to laser evoked brain potentials
    Jürgen Lorenz
    Institute of Neurophysiology and Pathophysiology, University Clinic Hamburg Eppendorf, Hamburg, Germany
    Neurophysiol Clin 33:293-301. 2003
    ..This composite entity needs to be considered when LEP are experimentally or clinically used in the assessment of sensory and cognitive phenomena and abnormalities of pain sensation...
  18. ncbi request reprint Functional imaging and neurophysiological assessment of spinal and brain therapeutic modulation in humans
    L Garcia-Larrea
    Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, Affiliated with the Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
    Arch Med Res 31:248-57. 2000
    ..The combination of clinical electrophysiology and functional neuroimaging provides insight into the mechanisms of action of neuromodulation procedures, guides clinical decision, and contributes to optimize patient selection...
  19. ncbi request reprint [Make your own interpretation. Cataract or retinal disease?]
    L Garcia-Larrea
    Neurophysiol Clin 30:327-8. 2000
  20. ncbi request reprint Somatosensory volleys and cortical evoked potentials: 'first come, first served'?
    Luis Garcia-Larrea
    Pain 112:5-7. 2004
  21. ncbi request reprint Semantic analysis of auditory input during sleep: studies with event related potentials
    Hélène Bastuji
    Institut Fédératif des Neurosciences de Lyon IFNL, Lyon, France 1 fr
    Int J Psychophysiol 46:243-55. 2002
    ..All these data support the view that some semantic analysis of auditory stimuli remains possible in the human sleeping brain, and warrant further studies to elucidate the extent and limits of these capabilities...
  22. ncbi request reprint Capillary electrophoresis combined with microdialysis in the human spinal cord: a new tool for monitoring rapid peroperative changes in amino acid neurotransmitters within the dorsal horn
    Sandrine Parrot
    IFR 19, Institut Federatif des Neurosciences de Lyon, Hopital Neurologique, and Université Claude Bernard, 8 avenue Rockefeller, F 69373 Lyon Cedex 08, France
    Electrophoresis 25:1511-7. 2004
    ..The results obtained illustrate the advantages of combining microdialysis with CE-LIFD for studying neurotransmitters with such a high sampling rate...
  23. ncbi request reprint Long-term clinical, electrophysiological and urodynamic effects of chronic intrathecal baclofen infusion for treatment of spinal spasticity
    P Mertens
    Department of Neurosurgery, Hopital Neurologique, Lyon, France
    Acta Neurochir Suppl 64:17-25. 1995
    ..In patients with spastic bladder, intrathecal baclofen produced a decrease of detrusor hypertonia and hyperactivity in 50% of cases, with reduction of leakage and increase in functional bladder capacity...
  24. ncbi request reprint Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET study
    R Peyron
    Department of Neurology, Bellevue Hospital, Etienne, France
    Pain 62:275-86. 1995
    ..Painful dysesthesiae during stimulation have to be distinguished from other innocuous sensory side effects, since they may compromise PGS efficacy...
  25. doi request reprint [Pathophysiology of neuropathic pain: review of experimental models and proposed mechanisms]
    Luis Garcia-Larrea
    INSERM U879, Intégration centrale de la douleur, F 69677 Lyon, France
    Presse Med 37:315-40. 2008
    ..This suggests that their role in experimental allodynia would likely be reactive and protective, and that inability to generate their activation may contribute to the clinical expression of neuropathic pain...
  26. ncbi request reprint Nociceptive flexion reflexes during analgesic neurostimulation in man
    L Garcia-Larrea
    Evoked Potentials Unit EEG Department, Hopital Neurologique, Lyon, France
    Pain 39:145-56. 1989
    ..In addition, RIII behavior in patients could be relevant to the understanding of some of the mechanisms involved in AN-induced pain relief...
  27. pmc Thalamic deactivation at sleep onset precedes that of the cerebral cortex in humans
    Michel Magnin
    Institut National de la Santé et de la Recherche Médicle U879, Bron, F 69677, France
    Proc Natl Acad Sci U S A 107:3829-33. 2010
    ..Thus, asynchronous thalamo-cortical deactivation while falling asleep probably explains the production of hypnagogic hallucinations by a still-activated cortex and the common self-overestimation of the time needed to fall asleep...
  28. ncbi request reprint Electrophysiological assessment of nociception in normals and patients: the use of nociceptive reflexes
    L Garcia-Larrea
    EEG and EP Department, Hopital Neurologique, Lyon, France
    Electroencephalogr Clin Neurophysiol Suppl 41:102-18. 1990
  29. ncbi request reprint Evoked potential studies in Friedreich's ataxia and progressive early onset cerebellar ataxia
    M Vanasse
    Laboratoire de Neurophysiologie Sensorielle, Faculté de Médecine Lyon Nord, France
    Can J Neurol Sci 15:292-8. 1988
    ..In FA, BAEP were abnormal in all patients with a disease duration of four years or more but were normal in four of the five PEOCA patients. Systematic evoked potential recording is useful in the investigation of hereditary ataxias...
  30. ncbi request reprint Clinical use of polysynaptic flexion reflexes in the management of spasticity with intrathecal baclofen
    M Parise
    Department of Functional Neurology and Epileptology, Pierre Wertheimer Neurological Hospital, Lyon, France
    Electroencephalogr Clin Neurophysiol 105:141-8. 1997
    ..In our experience, FR recordings appeared to be a useful tool for quantifying the benefit of antispastic treatment and might be used as an ancillary indicator to determine the minimal effective dose of intrathecal baclofen...
  31. ncbi request reprint Involuntary orienting of attention to nociceptive events: neural and behavioral signatures
    Valery Legrain
    Unité de Réadaptation et de Médecine physique READ, Universite Catholique de Louvain, Louvain la Neuve and Brussels, Belgium
    J Neurophysiol 102:2423-34. 2009
    ..We conclude that the laser-evoked potentials index the activity of a neural system involved in the detection of novel salient stimuli in order to focus attention and prioritize action to potentially damaging dangers...
  32. ncbi request reprint Pain relief by rTMS: differential effect of current flow but no specific action on pain subtypes
    N Andre-Obadia
    INSERM U879, University Claude Bernard Lyon 1, France
    Neurology 71:833-40. 2008
    ..To assess, against placebo, the pain-relieving effects of high-rate repetitive transcranial magnetic stimulation (rTMS) on neuropathic pain...
  33. ncbi request reprint [Central post-stroke pain]
    S Demasles
    Centre stéphanois de la douleur et service de neurologie, Hopital de Bellevue, 42055 Saint Etienne Cedex 02, France
    Rev Neurol (Paris) 164:825-31. 2008
    ..The thalamus plays a prominent role in this disorder of central control of pain...
  34. ncbi request reprint Unmasking of cortical SEP components by changes in stimulus rate: a topographic study
    L Garcia Larrea
    CERMEP, Hopital Neurologique, Lyon, France
    Electroencephalogr Clin Neurophysiol 84:71-83. 1992
    ..On the contrary, combination of different frequencies of stimulation should enhance the diagnostic utility of this technique by allowing a more selective assessment of overlapping activities...
  35. doi request reprint Recommendations for the clinical use of somatosensory-evoked potentials
    G Cruccu
    Department of Neurological Sciences, La Sapienza University, Viale Università 30, 00185 Rome, Italy
    Clin Neurophysiol 119:1705-19. 2008
    ..However, to prove clinically useful each of them requires a dedicated knowledge, both technical and pathophysiological. In this article we give technical advice, report normative values, and discuss clinical applications...
  36. doi request reprint Autonomic pain responses during sleep: a study of heart rate variability
    F Chouchou
    Unité INSERM U879, Central Integration of Pain, Universite Lyon 1, Lyon, France
    Eur J Pain 15:554-60. 2011
    ....
  37. ncbi request reprint [The P 300 potential in schizophrenia]
    A Laurent
    Service de Psychiatrie, C H R U de Grenoble
    Encephale 19:221-7. 1993
    ..In the present study, we attempted to explore the P 3 component in a group of schizophrenic patients with a precisely defined clinical symptomatology...
  38. ncbi request reprint Human thalamic medial pulvinar nucleus is not activated during paradoxical sleep
    Michel Magnin
    Inserm EMI 342, Federative Institut of Neurosciences INSERM IFR 19, Unité d Hypnologie, Hopital Neurologique, 59 Bd Pinel, 69003 Lyon, France
    Cereb Cortex 14:858-62. 2004
    ..This discrepancy between activities in a thalamic nucleus and its related cortical areas may compromise the spatio-temporal binding of the high-frequency activities, resulting in altered perceptual experiences during dream periods...
  39. ncbi request reprint Cognitive modulation of pain-related brain responses. Comments on Seminowicz et al. (Pain 2004;112:48-58)
    Valery Legrain
    Pain 114:524-6; author reply 526-7. 2005
  40. ncbi request reprint Thalamic thermo-algesic transmission: ventral posterior (VP) complex versus VMpo in the light of a thalamic infarct with central pain
    Carmen Montes
    Dept Fisiologia, Universidad de Malaga, Campus de Teatinos s n, 29080 Malaga, Spain
    Pain 113:223-32. 2005
    ....
  41. ncbi request reprint An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain
    R Peyron
    Departement de Neurologie, Hopital de Bellevue, Bd Pasteur, 42055 Saint Etienne, France
    Neurology 63:1838-46. 2004
    ..To investigate cerebral activity associated with allodynia in patients with neuropathic pain...
  42. ncbi request reprint Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study
    L Garcia-Larrea
    Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, and Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
    Pain 83:259-73. 1999
    ..In contrast, the hypothesis of somatosensory cortex activation by MCS could not be confirmed by our results...
  43. ncbi request reprint EFNS guidelines on neuropathic pain assessment: revised 2009
    G Cruccu
    Department of Neurological Sciences, La Sapienza University, Rome, Italy
    Eur J Neurol 17:1010-8. 2010
    ....
  44. doi request reprint Does the insula tell our brain that we are in pain?
    Jean Isnard
    Central Integration of Pain Unit INSERM U879, Lyon, France
    Pain 152:946-51. 2011
    ....
  45. ncbi request reprint Operculo-insular pain (parasylvian pain): a distinct central pain syndrome
    Luis Garcia-Larrea
    Central Integration of Pain Unit, U879 INSERM and University Claude Bernard, Lyon 1, Neurological Hospital, Lyon, France
    Brain 133:2528-39. 2010
    ..Parasylvian pain may be extremely difficult to treat; the magnitude of pain-temperature sensory disturbances may be prognostic for its development, hence the importance of early sensory assessment with quantitative methods...
  46. ncbi request reprint Effect of sensory stimulus on striatal dopamine release in humans and cats: a [(11)C]raclopride PET study
    Stephane Thobois
    Service de Neurologie D and INSERM U 534, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    Neurosci Lett 368:46-51. 2004
    ..Sensory stimulation of the forelimb extremities constitutes a well-established experimental model that has consistently shown to activate dopamine (DA) neurotransmission in the mammals' forebrain...
  47. ncbi request reprint Clinical utility of pain--laser evoked potentials
    G Cruccu
    Department of Neurological Sciences, La Sapienza University, Viale Università 20, 00185 Rome, Italy
    Suppl Clin Neurophysiol 57:101-10. 2004
  48. ncbi request reprint Laser evoked responses to painful stimulation persist during sleep and predict subsequent arousals
    H Bastuji
    INSERM, U 879 Central Integration of Pain, Bron F 69677, France
    Pain 137:589-99. 2008
    ..This response appeared functionally related to the P3 wave, which in waking subjects has been associated to conscious perception and memory encoding...
  49. ncbi request reprint Central representation of the RIII flexion reflex associated with overt motor reaction: an fMRI study
    R Peyron
    Departement de Neurologie, CHU de St Etienne, 42055 St Etienne, France
    Neurophysiol Clin 37:249-59. 2007
    ..They should be considered as a motor component of pain-related processes activated in case of intense pain...
  50. ncbi request reprint Emotional modulation of pain: is it the sensation or what we recall?
    Fabio Godinho
    Equipe Mixte INSERM 342, Central Integration of Pain, Hopital Neurologique Pierre Wertheimer, 69003 Lyon, France
    J Neurosci 26:11454-61. 2006
    ..Memory encoding and recall, rather than sensory processing, appear to be modulated by empathy with others' physical suffering...
  51. ncbi request reprint Pain influences hedonic assessment of visual inputs
    Fabio Godinho
    INSERM U879, Central Integration of Pain, Hopital Neurologique Pierre Wertheimer, 59 Boulevard Pinel 69003, Rez de jardin, Lyon, France
    Eur J Neurosci 27:2219-28. 2008
    ..The latter correlated with changes in the subjective appraisal of visual stimuli, and may underlie not only the change in their subjective assessment but also reactive processes aimed at coping with unpleasant contexts...
  52. ncbi request reprint Motor cortex stimulation for pain control induces changes in the endogenous opioid system
    J Maarrawi
    INSERM U879, Bron, France
    Neurology 69:827-34. 2007
    ..We studied the possible contribution of the endogenous opioid system to MCS-related pain relief...
  53. ncbi request reprint Right frontal event related EEG coherence (ERCoh) differentiates good from bad performers of the Wisconsin Card Sorting Test (WCST)
    M T Carrillo-de-la-Peña
    Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain
    Neurophysiol Clin 37:63-75. 2007
    ..To investigate changes in Event-Related Coherence (ERCoh) associated to good and bad resolution of the Wisconsin Card Sorting Test (WCST)...
  54. ncbi request reprint Differential brain opioid receptor availability in central and peripheral neuropathic pain
    Joseph Maarrawi
    INSERM EMI 342 Central Integration of pain, 59 Bd Pinel, 69394 Lyon and St Etienne, France
    Pain 127:183-94. 2007
    ..Central and peripheral forms of NP may differ in distribution of brain opioid system changes and this in turn might underlie their different sensitivity to opiates...
  55. ncbi request reprint EFNS guidelines on neurostimulation therapy for neuropathic pain
    G Cruccu
    EFNS Panel on Neuropathic Pain, Vienna, Austria
    Eur J Neurol 14:952-70. 2007
    ..These chronically implanted techniques provide satisfactory pain relief in many patients, including those resistant to medication or other means...
  56. ncbi request reprint Chapter 30 Evoked potentials in the assessment of pain
    Luis Garcia-Larrea
    Handb Clin Neurol 81:439-XI. 2006
  57. ncbi request reprint Evoked potentials to nociceptive stimuli delivered by CO2 or Nd:YAP lasers
    Caroline Perchet
    INSERM U879 Central integration of pain unit, Lyon F 69677, France
    Clin Neurophysiol 119:2615-22. 2008
    ..This study compares the amplitude, latency, morphology, scalp topography and intracranial generators of laser-evoked potentials (LEPs) to CO(2) and Nd:YAP laser stimuli...
  58. ncbi request reprint Motor cortex stimulation for refractory neuropathic pain: four year outcome and predictors of efficacy
    Christophe Nuti
    Department of Neurosurgery, CHU Saint Etienne, Bd Pasteur, 42055 Saint Etienne Cedex 2, France
    Pain 118:43-52. 2005
    ..744; p<0.0001). These results confirm that MCS can be a satisfactory and durable alternative to medical treatments in patients with refractory pain, and suggest that the efficacy of MCS may be predicted in the first month of therapy...
  59. ncbi request reprint Striatal dopamine during sensorial stimulations: a [18F]FDOPA PET study in human and cats
    Wadad Hassoun
    Physiologie Intégrative Cellulaire et Moléculaire, CNRS UMR5123, Villeurbanne, France
    Neurosci Lett 383:63-7. 2005
    ..These results support the hypothesis that sensory stimulations activate a non-synaptic mode of dopamine release...
  60. ncbi request reprint Event-related potentials during forced awakening: a tool for the study of acute sleep inertia
    Hélène Bastuji
    INSERM E0342, Lyon, France
    J Sleep Res 12:189-206. 2003
    ..In the present series, it proved to be much more discriminative than waking ERPs alone to demonstrate specific abnormalities in patients complaining of excessive daytime sleepiness...
  61. pmc The combined monitoring of brain stem auditory evoked potentials and intracranial pressure in coma. A study of 57 patients
    L Garcia-Larrea
    EEG Department, Hopital Neurologique, Lyon, France
    J Neurol Neurosurg Psychiatry 55:792-8. 1992
    ..Serial recording of cortical EPs should be added to BAEP monitoring to permit the early detection of rostrocaudal deterioration...
  62. ncbi request reprint P3, positive slow wave and working memory load: a study on the functional correlates of slow wave activity
    L Garcia-Larrea
    Human Neurophysiology Lab, CERMEP, EA1880, Université Claude Besnard, Lyon, France
    Electroencephalogr Clin Neurophysiol 108:260-73. 1998
    ..The present paradigm proved to be easy to implement and suitable to study the 'executive' functions governing attentional and working-memory control during the performance of multiple tasks...
  63. ncbi request reprint Allodynia after lateral-medullary (Wallenberg) infarct. A PET study
    R Peyron
    Neurological Department, Bellevue Hospital, Saint Etienne, France
    Brain 121:345-56. 1998
    ....
  64. ncbi request reprint [Monitoring of auditory evoked potentials of the brain stem in acute changes in intracranial pressure]
    L Garcia-Larrea
    Agressologie 29:329-32. 1988
  65. ncbi request reprint Source propagation of interictal spikes in temporal lobe epilepsy. Correlations between spike dipole modelling and [18F]fluorodeoxyglucose PET data
    I Merlet
    Claude Bernard University Lyon I, Department of Functional Neurology and Epileptology, France
    Brain 119:377-92. 1996
    ....
  66. ncbi request reprint Flexion reflexes following anterolateral cordotomy in man: dissociation between pain sensation and nociceptive reflex RIII
    L Garcia-Larrea
    Department of Clinical Neurophysiology, Hopital Neurologique, Lyon, France
    Pain 55:139-49. 1993
    ....
  67. ncbi request reprint Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part II: The focal hypometabolism is reactive to GABAA agonist administration in TL
    R Peyron
    Centre d Exploration et de Recherches Médicales par Emission de Positions, Lyon, France
    Epilepsy Res 19:55-62. 1994
    ..This metabolic response in the hypometabolic focus, observed in the absence of any epileptic discharge during FDG accumulation and PET data acquisition, suggests that GABAA receptors are up-regulated or, at least, preserved in TLE...
  68. ncbi request reprint Brain processing of stimulus deviance during slow-wave and paradoxical sleep: a study of human auditory evoked responses using the oddball paradigm
    H Bastuji
    Service de Neurologie Fonctionelle et Epileptologie, Hopital Neurologique, Lyon, France
    J Clin Neurophysiol 12:155-67. 1995
    ....
  69. ncbi request reprint Target side and scalp topography of the somatosensory P300
    P Bruyant
    Clinical Neurophysiology Unit, University Lyon I, France
    Electroencephalogr Clin Neurophysiol 88:468-77. 1993
    ....
  70. ncbi request reprint Transient drug-induced abolition of BAEPs in coma
    L Garcia-Larrea
    EEG Department, Hopital Neurologique, Lyon, France
    Neurology 38:1487-9. 1988
    ..BAEPs are resistant to hypothermia and barbiturates, but must be interpreted cautiously in patients treated with a combination of anesthetic drugs that includes lidocaine...
  71. ncbi request reprint [Monitoring of evoked potentials in traumatic coma]
    F Mauguiere
    Agressologie 29:351-7. 1988
  72. ncbi request reprint Clinical use of nociceptive flexion reflex recording in the evaluation of functional neurosurgical procedures
    L Garcia-Larrea
    EEG Department Clin Hôpital Neurologique, Lyon, France
    Acta Neurochir Suppl (Wien) 46:53-7. 1989
    ..Routine recording of nociceptive reflexes in man proved to be a useful tool for the objective evaluation of anatomo-physiological effects of functional neurosurgical procedures...
  73. ncbi request reprint [Anomalies in early somatosensory evoked potentials in brain stem lesions (study of 64 cases)]
    P Convers
    Service de neurologie CHRU 15, Saint Etienne, France
    Neurophysiol Clin 19:443-68. 1989
    ....
  74. ncbi request reprint Latency and amplitude abnormalities of the scalp far-field P14 to median nerve stimulation in multiple sclerosis. A SEP study of 122 patients recorded with a non-cephalic reference montage
    L Garcia Larrea
    Laboratoire de Neurophysiologie Sensorielle Appliquée, Faculté de Médecine Lyon Nord, Hopital Neurologique, France
    Electroencephalogr Clin Neurophysiol 71:180-6. 1988
    ..Also IPLs were increased in 12 patients with normal P14 amplitudes. These results suggest that adding the P9/P14 amplitude criterion to standard IPL data might be useful to detect conduction troubles in MS patients...
  75. ncbi request reprint Brain-stem monitoring. II. Preterminal BAEP changes observed until brain death in deeply comatose patients
    L Garcia-Larrea
    Laboratorie de Neurophysiologie Sensorielle, Faculté de Médecine Lyon Nord, Hopital Neurologique, France
    Electroencephalogr Clin Neurophysiol 68:446-57. 1987
    ..Our results suggest that continuous brain-stem monitoring could be helpful for management of comatose head-injured patients...
  76. ncbi request reprint High signal intensity on T2-weighted MRI correlates with hypoperfusion in temporal lobe epilepsy
    P Ryvlin
    EEG Department, Neurological Hospital, Lyon, France
    Epilepsia 33:28-35. 1992
    ..The degree of temporal perfusion asymmetry measured in each individual was higher in patients whose MRI was abnormal...
  77. ncbi request reprint Mapping study of somatosensory evoked potentials during selective spatial attention
    L Garcia-Larrea
    CERMEP Clinical Neurophysiology Laboratory, Hopital Neurologique, Lyon, France
    Electroencephalogr Clin Neurophysiol 80:201-14. 1991
    ..The late negative component (N140) shares several features with the 'processing negativity' described in auditory paradigms and could represent the equivalent of this effect in the somatosensory system...
  78. ncbi request reprint Revisiting the oddball paradigm. Non-target vs neutral stimuli and the evaluation of ERP attentional effects
    L Garcia-Larrea
    CERMEP, Clinical Neurophysiology Lab, Université Lyon Nord, France
    Neuropsychologia 30:723-41. 1992
    ..Notably, non-target responses may help to decide whether an abnormal target-P300 is related or not to a deficit in the mobilization of attentional resources...
  79. ncbi request reprint Positron emission tomography during motor cortex stimulation for pain control
    L Garcia-Larrea
    CERMEP Positron Emission Tomography Center, Lyon, France
    Stereotact Funct Neurosurg 68:141-8. 1997
    ..Such effects may be obtained only if thalamic activation reaches a 'threshold' level, below which the analgesic cascade would not be successfully triggered...
  80. ncbi request reprint Topographical reliability of mesio-temporal sources of interictal spikes in temporal lobe epilepsy
    I Merlet
    UPR, Equipe d Accueil 1880, Claude Bernard University Lyon I, Functional Neurology and Epileptology, France
    Electroencephalogr Clin Neurophysiol 107:206-12. 1998
    ..This study aimed at assessing the relevance of mesio-temporal dipoles, as identified by modeling of scalp recorded spikes in TLE...
  81. ncbi request reprint Simplified projection of EEG dipole sources onto human brain anatomy
    I Merlet
    Département d EEG, Universite Claude Bernard Lyon I, France
    Neurophysiol Clin 29:39-52. 1999
    ....
  82. ncbi request reprint [Positron emission tomography to study central pain integration]
    B Laurent
    Service de Neurologie de Saint Etienne et Centre stéphanois de la douleur, Lyon, France
    Rev Neurol (Paris) 156:341-51. 2000
    ..To advance our knowledge of the mechanisms generating both abnormal pain and analgesia (drugs and surgical techniques) in patients is the main motivation of such anexciting challenge...
  83. ncbi request reprint Precentral cortex stimulation for the treatment of central neuropathic pain: results of a prospective study in a 20-patient series
    P Mertens
    Department of Neurosurgery, University of Lyon I, France
    Stereotact Funct Neurosurg 73:122-5. 1999
    ..In 25% the method failed. On the basis of these findings and the literature data (127 reported cases), the authors advocate PCS in patients with severe and medically refractory poststroke pain...
  84. ncbi request reprint Functional imaging of brain responses to pain. A review and meta-analysis (2000)
    R Peyron
    Departement de Neurologie, Hopital de Bellevue, boulevard Pasteur, 42055 Saint Etienne, France
    Neurophysiol Clin 30:263-88. 2000
    ..The precise biochemical nature of these mechanisms remains to be investigated...
  85. ncbi request reprint Responses of the supra-sylvian (SII) cortex in humans to painful and innocuous stimuli. A study using intra-cerebral recordings
    M Frot
    EA 1880, Functional Neurology and Epileptology Department, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    Pain 94:65-73. 2001
    ....
  86. ncbi request reprint Detection of verbal discordances during sleep
    Fabien Perrin
    EA 1880, University Claude Bernard, Lyon, France
    Neuroreport 13:1345-9. 2002
    ..Linguistic absurdity appears to be accepted in a different manner during paradoxical sleep than during waking, and this might explain why absurd contents are so naturally incorporated into otherwise plausible dream stories...
  87. ncbi request reprint Cognitive effects of precentral cortical stimulation for pain control: an ERP study
    C Montes
    Equipe d Accueil, EA1880 UCB, Lyon, France
    Neurophysiol Clin 32:313-25. 2002
    ....
  88. ncbi request reprint Modulation of the N400 potential during auditory phonological/semantic interaction
    Fabien Perrin
    EA 1880, University Claude Bernard, Lyon, France
    Brain Res Cogn Brain Res 17:36-47. 2003
    ..Our data also provide new elements supporting the persistence of the semantic N400 during 'shallow' word processing tasks, i.e. tasks that discourage analysis of semantic aspects of the words...
  89. ncbi request reprint Dissociable ERP profiles for processing rules vs instances in a cognitive sequencing task
    T Lelekov
    Institut de Sciences Cognitives, CNRS UPR 9075, Bron, France
    Neuroreport 11:1129-32. 2000
    ..We discuss implications for the rule vs instance debate, and similarities between this late positivity and the P600 observed in previous studies of syntactic processing...
  90. ncbi request reprint A differential brain response to the subject's own name persists during sleep
    F Perrin
    UPRES EA 1880, University Claude Bernard, Lyons, France
    Clin Neurophysiol 110:2153-64. 1999
    ..All stimuli were disyllabic, equiprobable and presented in random order...
  91. ncbi request reprint Parietal and cingulate processes in central pain. A combined positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) study of an unusual case
    R Peyron
    Neurological Department, Bellevue Hospital, 42055, Saint Etienne, France
    Pain 84:77-87. 2000
    ..This response is likely to be responsible for the strange and very unpleasant allodynic sensation elicited on the left side by a non-noxious stimulation...
  92. ncbi request reprint Timing and characteristics of perceptual attenuation by transcranial stimulation: a study using magnetic cortical stimulation and somatosensory-evoked potentials
    N Andre-Obadia
    Service de Neurologie Fonctionnelle et d Epileptologie, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    Psychophysiology 36:476-83. 1999
    ..The results also suggest that the cortical processes active during the N20 and N120 potentials may be essential for the conscious perception of somatosensory stimuli delivered to the hand...
  93. ncbi request reprint Haemodynamic brain responses to acute pain in humans: sensory and attentional networks
    R Peyron
    Departement de Neurologie and Centre de la douleur, Hopital de Bellevue, Saint Etienne, France
    Brain 122:1765-80. 1999
    ..Attentional processes could possibly explain part of the variability observed in previous PET reports and should therefore be considered in further studies on pain in both normal subjects and patients with chronic pain...
  94. ncbi request reprint Brain responses to detection of right or left somatic targets are symmetrical in unilateral Parkinson's disease: a case against the concept of "parkinsonian neglect'
    L Garcia-Larrea
    Clinical Neurophysiology Lab, CERMEP, UPR 1880, VCB, Lyon, France
    Cortex 32:679-91. 1996
    ....
  95. ncbi request reprint The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's disease
    E Broussolle
    Department of Neurology, Hopital Neurologique Pierre Wertheimer, Lyon, France
    J Neurol Sci 166:141-51. 1999
    ....
  96. ncbi request reprint Sleep/wake abnormalities in patients with periodic leg movements during sleep: factor analysis on data from 24-h ambulatory polygraphy
    H Bastuji
    Sleep Disorders Unit, Functional Neurology Department, Hopital Neurologique, Lyon, France
    J Sleep Res 8:217-23. 1999
    ..On the other hand, our analysis suggests that in PLM patients the concomitant existence of a RLS is not related to the frequency of occurrence of PLMs, at least when these latter are quantified independently of their arousal index...
  97. ncbi request reprint On the validity of interblock averaging of P300 in clinical settings
    M T Carrillo-de-la-Peña
    Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Santiago de Compostela, Spain
    Int J Psychophysiol 34:103-12. 1999
    ....
  98. pmc Human thalamic and cortical activities assessed by dimension of activation and spectral edge frequency during sleep wake cycles
    Marc Rey
    Service de Neurophysiologie Clinique Hôpital Timone, Marseille, France
    Sleep 30:907-12. 2007
    ..Using spectral edge frequency (SEF95) and dimension of activation (DA), a new tool derived from the dimension of correlation, we assessed the activation of thalamus and cortex in the different vigilance states...
  99. ncbi request reprint Painful sensory neuropathy
    Andrea Truini
    N Engl J Med 349:306-7; author reply 306-7. 2003