- The posterior insular-opercular region and the search of a primary cortex for painL Garcia-Larrea
Central Integration of Pain Laboratory NeuroPain, Centre for Neuroscience of Lyon, Hopital Neurologique, boulevard Pinel, Lyon, France
Neurophysiol Clin 42:299-313. 2012....
- Objective pain diagnostics: clinical neurophysiologyL Garcia-Larrea
INSERM U1028, Central Integration of Pain Unit, Centre for Neuroscience of Lyon, University Claude Bernard Lyon, University Hospital Pain Center, Neurological Hospital, 69003 Lyon, France
Neurophysiol Clin 42:187-97. 2012....
- Brain generators of laser-evoked potentials: from dipoles to functional significanceL Garcia-Larrea
Inserm EMI 0342, Human Neuro Laboratory at CERMEP, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
Neurophysiol Clin 33:279-92. 2003..This would make sense as the insular region has been shown to respond to thermal pain stimuli in both functional imaging and intracranial EEG studies...
- Role of operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentialsR Peyron
Clinical Neurophysiology and Epileptology Department, Lyon, France
Neuroimage 17:1336-46. 2002....
- Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological studyL Garcia-Larrea
Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, and Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
Pain 83:259-73. 1999..In contrast, the hypothesis of somatosensory cortex activation by MCS could not be confirmed by our results...
- Functional imaging and neurophysiological assessment of spinal and brain therapeutic modulation in humansL Garcia-Larrea
Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, Affiliated with the Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
Arch Med Res 31:248-57. 2000..The combination of clinical electrophysiology and functional neuroimaging provides insight into the mechanisms of action of neuromodulation procedures, guides clinical decision, and contributes to optimize patient selection...
- Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part II: The focal hypometabolism is reactive to GABAA agonist administration in TLR Peyron
Centre d Exploration et de Recherches Médicales par Emission de Positions, Lyon, France
Epilepsy Res 19:55-62. 1994..This metabolic response in the hypometabolic focus, observed in the absence of any epileptic discharge during FDG accumulation and PET data acquisition, suggests that GABAA receptors are up-regulated or, at least, preserved in TLE...
- Positron emission tomography during motor cortex stimulation for pain controlL Garcia-Larrea
CERMEP Positron Emission Tomography Center, Lyon, France
Stereotact Funct Neurosurg 68:141-8. 1997..Such effects may be obtained only if thalamic activation reaches a 'threshold' level, below which the analgesic cascade would not be successfully triggered...
- How the pain of others enhances our pain: searching the cerebral correlates of 'compassional hyperalgesia'F Godinho
Central Integration of Pain Unit INSERM U1028, University of Lyon, Lyon, France
Eur J Pain 16:748-59. 2012..The Pain Matrix cannot be considered as an 'objective' correlate of the pain experience in all situations...
- Responses of the supra-sylvian (SII) cortex in humans to painful and innocuous stimuli. A study using intra-cerebral recordingsM Frot
EA 1880, Functional Neurology and Epileptology Department, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
Pain 94:65-73. 2001....
- Discriminating neurological from psychiatric hypersomnia using the forced awakening testL Peter-Derex
Unité d Hypnologie, Service de Neurologie Fonctionnelle et d Epileptologie, Hopital Neurologique, Centre Hospitalier Est, 59, boulevard Pinel, 69677 Bron, France
Neurophysiol Clin 43:171-9. 2013..Their modifications during forced awakening (FA) context have been shown to reflect sleep inertia...
- Mechanical allodynia in neuropathic pain. Where are the brain representations located? A positron emission tomography (PET) studyR Peyron
Department of Neurology, Pain Center, CHU de Saint Etienne, France
Eur J Pain 17:1327-37. 2013..The same is not true for allodynic pain in patients with neuropathic pain since the cortical reorganizations that are involved in the conversion of non-noxious stimuli into painful sensations still remain unknown...
- The role of parietal opercular and insular cortex in pain sensation in humans: data from PET activation studies and intracortical recordings of CO2 laser evoked potentials (LEPs)F Mauguiere
Functional Neurology and Epileptology Department, Neurological Hospital, Lyon, France
Electroencephalogr Clin Neurophysiol Suppl 49:255-60. 1999
- Clinical use of polysynaptic flexion reflexes in the management of spasticity with intrathecal baclofenM Parise
Department of Functional Neurology and Epileptology, Pierre Wertheimer Neurological Hospital, Lyon, France
Electroencephalogr Clin Neurophysiol 105:141-8. 1997..In our experience, FR recordings appeared to be a useful tool for quantifying the benefit of antispastic treatment and might be used as an ancillary indicator to determine the minimal effective dose of intrathecal baclofen...
- P3, positive slow wave and working memory load: a study on the functional correlates of slow wave activityL Garcia-Larrea
Human Neurophysiology Lab, CERMEP, EA1880, Université Claude Besnard, Lyon, France
Electroencephalogr Clin Neurophysiol 108:260-73. 1998..The present paradigm proved to be easy to implement and suitable to study the 'executive' functions governing attentional and working-memory control during the performance of multiple tasks...
- Brain-stem monitoring. I. A system for high-rate sequential BAEP recording and feature extractionO Bertrand
INSERM, Unite 280, Lyon, France
Electroencephalogr Clin Neurophysiol 68:433-45. 1987..Some clinical examples of comatose patient monitoring are briefly presented to illustrate the performance and the reliability of the system...
- The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's diseaseE Broussolle
Department of Neurology, Hopital Neurologique Pierre Wertheimer, Lyon, France
J Neurol Sci 166:141-51. 1999....
- Brain-stem monitoring. II. Preterminal BAEP changes observed until brain death in deeply comatose patientsL Garcia-Larrea
Laboratorie de Neurophysiologie Sensorielle, Faculté de Médecine Lyon Nord, Hopital Neurologique, France
Electroencephalogr Clin Neurophysiol 68:446-57. 1987..Our results suggest that continuous brain-stem monitoring could be helpful for management of comatose head-injured patients...
- Transient drug-induced abolition of BAEPs in comaL Garcia-Larrea
EEG Department, Hopital Neurologique, Lyon, France
Neurology 38:1487-9. 1988..BAEPs are resistant to hypothermia and barbiturates, but must be interpreted cautiously in patients treated with a combination of anesthetic drugs that includes lidocaine...
- Autonomic pain responses during sleep: a study of heart rate variabilityF Chouchou
Unité INSERM U879, Central Integration of Pain, Universite Lyon 1, Lyon, France
Eur J Pain 15:554-60. 2011....
- Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part I: Brain glucose metabolism is increased after GABAA receptors activationR Peyron
Centre d Exploration et de Recherches Médicales par Emission de Positons, Lyon, France
Epilepsy Res 19:45-54. 1994....
- Hyperalgesia with reduced laser evoked potentials in neuropathic painQ Wu
UPRES Neurologi e fonctionnelle EA1880, UCB Lyon CERMEP, Hopital Neurologique, France
Pain 80:209-14. 1999..The dissociation between pain sensation and cortical EPs deserve to be added to the current semiology of LEPs, as the presence of abnormal pain to laser on the background of reduced LEPs substantiates the neuropathic nature of the pain...
- Attention shifts and anticipatory mechanisms in hyperactive children: an ERP study using the Posner paradigmC Perchet
Clinical Neurophysiology Laboratory, Research Unit EA1880, University Claude Bernard, Lyon, France
Biol Psychiatry 50:44-57. 2001..These deficits may be partly attributed to dysmaturation of executive frontal functions. In addition, a minor deficit in early attentional priming was also observed in ERPs, with no apparent behavioral counterparts...
- Cognitive effects of precentral cortical stimulation for pain control: an ERP studyC Montes
Equipe d Accueil, EA1880 UCB, Lyon, France
Neurophysiol Clin 32:313-25. 2002....
- High signal intensity on T2-weighted MRI correlates with hypoperfusion in temporal lobe epilepsyP Ryvlin
EEG Department, Neurological Hospital, Lyon, France
Epilepsia 33:28-35. 1992..The degree of temporal perfusion asymmetry measured in each individual was higher in patients whose MRI was abnormal...
- Nociceptive flexion reflexes during analgesic neurostimulation in manL Garcia-Larrea
Evoked Potentials Unit EEG Department, Hopital Neurologique, Lyon, France
Pain 39:145-56. 1989..In addition, RIII behavior in patients could be relevant to the understanding of some of the mechanisms involved in AN-induced pain relief...
- Long-term clinical, electrophysiological and urodynamic effects of chronic intrathecal baclofen infusion for treatment of spinal spasticityP Mertens
Department of Neurosurgery, Hopital Neurologique, Lyon, France
Acta Neurochir Suppl 64:17-25. 1995..In patients with spastic bladder, intrathecal baclofen produced a decrease of detrusor hypertonia and hyperactivity in 50% of cases, with reduction of leakage and increase in functional bladder capacity...
- Clinical use of nociceptive flexion reflex recording in the evaluation of functional neurosurgical proceduresL Garcia-Larrea
EEG Department Clin Hôpital Neurologique, Lyon, France
Acta Neurochir Suppl (Wien) 46:53-7. 1989..Routine recording of nociceptive reflexes in man proved to be a useful tool for the objective evaluation of anatomo-physiological effects of functional neurosurgical procedures...
- Functional dissociation of the early and late portions of human K-complexesF Perrin
UPRES EA 1880, University Claude Bernard, Functional Neurology Department, Neurological Hospital, Lyon, France
Neuroreport 11:1637-40. 2000..This latter may appear either within a full KC or in isolation, and in this case it is reminiscent of the N200-P300 complex observed in wakefulness...
- Brain processing of stimulus deviance during slow-wave and paradoxical sleep: a study of human auditory evoked responses using the oddball paradigmH Bastuji
Service de Neurologie Fonctionelle et Epileptologie, Hopital Neurologique, Lyon, France
J Clin Neurophysiol 12:155-67. 1995....
- Mapping study of somatosensory evoked potentials during selective spatial attentionL Garcia-Larrea
CERMEP Clinical Neurophysiology Laboratory, Hopital Neurologique, Lyon, France
Electroencephalogr Clin Neurophysiol 80:201-14. 1991..The late negative component (N140) shares several features with the 'processing negativity' described in auditory paradigms and could represent the equivalent of this effect in the somatosensory system...
- Flexion reflexes following anterolateral cordotomy in man: dissociation between pain sensation and nociceptive reflex RIIIL Garcia-Larrea
Department of Clinical Neurophysiology, Hopital Neurologique, Lyon, France
Pain 55:139-49. 1993....
- [Effect of anesthetics on sensory evoked potentials]L Garcia-Larrea
Service de neurologie fonctionnelle, Hopital Neurologique, Lyon, France
Neurophysiol Clin 23:141-62. 1993..Amplitude changes of middle-latency auditory responses (Pa/Nb) seem to be a good marker for estimating depth of anaesthesia with the aid of EPs...
- Subthalamic nucleus stimulation in Parkinson's disease : anatomical and electrophysiological localization of active contactsF Godinho
Department of Functional Neurosurgery, Hopital Neurologique et Neurochirurgical, Pierre Wertheimer, 9 Bd Pinel, 69003, Lyon, France
J Neurol 253:1347-55. 2006..2 - To analyze the stereotactic spatial distribution of the active contacts in relation to the dorsal and the ventral electrophysiologically-defined borders of the STN and the stereotactic theoretical target...
- Brain responses to detection of right or left somatic targets are symmetrical in unilateral Parkinson's disease: a case against the concept of "parkinsonian neglect'L Garcia-Larrea
Clinical Neurophysiology Lab, CERMEP, UPR 1880, VCB, Lyon, France
Cortex 32:679-91. 1996....
- Sleep/wake abnormalities in patients with periodic leg movements during sleep: factor analysis on data from 24-h ambulatory polygraphyH Bastuji
Sleep Disorders Unit, Functional Neurology Department, Hopital Neurologique, Lyon, France
J Sleep Res 8:217-23. 1999..On the other hand, our analysis suggests that in PLM patients the concomitant existence of a RLS is not related to the frequency of occurrence of PLMs, at least when these latter are quantified independently of their arousal index...
- Timing and characteristics of perceptual attenuation by transcranial stimulation: a study using magnetic cortical stimulation and somatosensory-evoked potentialsN Andre-Obadia
Service de Neurologie Fonctionnelle et d Epileptologie, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
Psychophysiology 36:476-83. 1999..The results also suggest that the cortical processes active during the N20 and N120 potentials may be essential for the conscious perception of somatosensory stimuli delivered to the hand...
- Visuospatial attention and motor reaction in children: an electrophysiological study of the "Posner" paradigmC Perchet
Research Unit UPRES EA1880 University Claude Bernard, CERMEP, Lyon, France
Psychophysiology 37:231-41. 2000..This method may be applied in clinical settings to disentangle selective processing deficits in target detection, response selection, or motor preparation stages...
- Somatosensory responses during selective spatial attention: The N120-to-N140 transitionL Garcia-Larrea
JE133 Université Claude Bernard, CERMEP, Hopital Neurologique, Lyon, France
Psychophysiology 32:526-37. 1995....
- Evoked potentials as a tool for the investigation of human sleepH Bastuji
Sleep Disorders Unit, Functional Neurology Dept, Hopital Neurologique, Lyon, France
Sleep Med Rev 3:23-45. 1999..A promising approach is the utilization of late responses to the study of sleep inertia with the use of "forced awakening" recording paradigms...
- Electrophysiological assessment of nociception in normals and patients: the use of nociceptive reflexesL Garcia-Larrea
EEG and EP Department, Hopital Neurologique, Lyon, France
Electroencephalogr Clin Neurophysiol Suppl 41:102-18. 1990
- The combined monitoring of brain stem auditory evoked potentials and intracranial pressure in coma. A study of 57 patientsL Garcia-Larrea
EEG Department, Hopital Neurologique, Lyon, France
J Neurol Neurosurg Psychiatry 55:792-8. 1992..Serial recording of cortical EPs should be added to BAEP monitoring to permit the early detection of rostrocaudal deterioration...