L Garcia-Larrea

Summary

Country: France

Publications

  1. doi request reprint The posterior insular-opercular region and the search of a primary cortex for pain
    L Garcia-Larrea
    Central Integration of Pain Laboratory NeuroPain, Centre for Neuroscience of Lyon, Hopital Neurologique, boulevard Pinel, Lyon, France
    Neurophysiol Clin 42:299-313. 2012
  2. doi request reprint Objective pain diagnostics: clinical neurophysiology
    L Garcia-Larrea
    INSERM U1028, Central Integration of Pain Unit, Centre for Neuroscience of Lyon, University Claude Bernard Lyon, University Hospital Pain Center, Neurological Hospital, 69003 Lyon, France
    Neurophysiol Clin 42:187-97. 2012
  3. ncbi request reprint Brain generators of laser-evoked potentials: from dipoles to functional significance
    L Garcia-Larrea
    Inserm EMI 0342, Human Neuro Laboratory at CERMEP, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    Neurophysiol Clin 33:279-92. 2003
  4. ncbi request reprint Role of operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials
    R Peyron
    Clinical Neurophysiology and Epileptology Department, Lyon, France
    Neuroimage 17:1336-46. 2002
  5. ncbi request reprint Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study
    L Garcia-Larrea
    Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, and Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
    Pain 83:259-73. 1999
  6. ncbi request reprint Functional imaging and neurophysiological assessment of spinal and brain therapeutic modulation in humans
    L Garcia-Larrea
    Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, Affiliated with the Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
    Arch Med Res 31:248-57. 2000
  7. ncbi request reprint Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part II: The focal hypometabolism is reactive to GABAA agonist administration in TL
    R Peyron
    Centre d Exploration et de Recherches Médicales par Emission de Positions, Lyon, France
    Epilepsy Res 19:55-62. 1994
  8. ncbi request reprint Positron emission tomography during motor cortex stimulation for pain control
    L Garcia-Larrea
    CERMEP Positron Emission Tomography Center, Lyon, France
    Stereotact Funct Neurosurg 68:141-8. 1997
  9. doi request reprint How the pain of others enhances our pain: searching the cerebral correlates of 'compassional hyperalgesia'
    F Godinho
    Central Integration of Pain Unit INSERM U1028, University of Lyon, Lyon, France
    Eur J Pain 16:748-59. 2012
  10. ncbi request reprint Responses of the supra-sylvian (SII) cortex in humans to painful and innocuous stimuli. A study using intra-cerebral recordings
    M Frot
    EA 1880, Functional Neurology and Epileptology Department, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    Pain 94:65-73. 2001

Collaborators

Detail Information

Publications42

  1. doi request reprint The posterior insular-opercular region and the search of a primary cortex for pain
    L Garcia-Larrea
    Central Integration of Pain Laboratory NeuroPain, Centre for Neuroscience of Lyon, Hopital Neurologique, boulevard Pinel, Lyon, France
    Neurophysiol Clin 42:299-313. 2012
    ....
  2. doi request reprint Objective pain diagnostics: clinical neurophysiology
    L Garcia-Larrea
    INSERM U1028, Central Integration of Pain Unit, Centre for Neuroscience of Lyon, University Claude Bernard Lyon, University Hospital Pain Center, Neurological Hospital, 69003 Lyon, France
    Neurophysiol Clin 42:187-97. 2012
    ....
  3. ncbi request reprint Brain generators of laser-evoked potentials: from dipoles to functional significance
    L Garcia-Larrea
    Inserm EMI 0342, Human Neuro Laboratory at CERMEP, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    Neurophysiol Clin 33:279-92. 2003
    ..This would make sense as the insular region has been shown to respond to thermal pain stimuli in both functional imaging and intracranial EEG studies...
  4. ncbi request reprint Role of operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials
    R Peyron
    Clinical Neurophysiology and Epileptology Department, Lyon, France
    Neuroimage 17:1336-46. 2002
    ....
  5. ncbi request reprint Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study
    L Garcia-Larrea
    Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, and Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
    Pain 83:259-73. 1999
    ..In contrast, the hypothesis of somatosensory cortex activation by MCS could not be confirmed by our results...
  6. ncbi request reprint Functional imaging and neurophysiological assessment of spinal and brain therapeutic modulation in humans
    L Garcia-Larrea
    Functional Neurology Unit, UPRES EA 1880, Claude Bernard University, Affiliated with the Institut Fédératif de Neurosciences of Lyon IFNL, Lyon, France
    Arch Med Res 31:248-57. 2000
    ..The combination of clinical electrophysiology and functional neuroimaging provides insight into the mechanisms of action of neuromodulation procedures, guides clinical decision, and contributes to optimize patient selection...
  7. ncbi request reprint Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part II: The focal hypometabolism is reactive to GABAA agonist administration in TL
    R Peyron
    Centre d Exploration et de Recherches Médicales par Emission de Positions, Lyon, France
    Epilepsy Res 19:55-62. 1994
    ..This metabolic response in the hypometabolic focus, observed in the absence of any epileptic discharge during FDG accumulation and PET data acquisition, suggests that GABAA receptors are up-regulated or, at least, preserved in TLE...
  8. ncbi request reprint Positron emission tomography during motor cortex stimulation for pain control
    L Garcia-Larrea
    CERMEP Positron Emission Tomography Center, Lyon, France
    Stereotact Funct Neurosurg 68:141-8. 1997
    ..Such effects may be obtained only if thalamic activation reaches a 'threshold' level, below which the analgesic cascade would not be successfully triggered...
  9. doi request reprint How the pain of others enhances our pain: searching the cerebral correlates of 'compassional hyperalgesia'
    F Godinho
    Central Integration of Pain Unit INSERM U1028, University of Lyon, Lyon, France
    Eur J Pain 16:748-59. 2012
    ..The Pain Matrix cannot be considered as an 'objective' correlate of the pain experience in all situations...
  10. ncbi request reprint Responses of the supra-sylvian (SII) cortex in humans to painful and innocuous stimuli. A study using intra-cerebral recordings
    M Frot
    EA 1880, Functional Neurology and Epileptology Department, Hopital Neurologique, 59 Boulevard Pinel, 69003 Lyon, France
    Pain 94:65-73. 2001
    ....
  11. doi request reprint Discriminating neurological from psychiatric hypersomnia using the forced awakening test
    L Peter-Derex
    Unité d Hypnologie, Service de Neurologie Fonctionnelle et d Epileptologie, Hopital Neurologique, Centre Hospitalier Est, 59, boulevard Pinel, 69677 Bron, France
    Neurophysiol Clin 43:171-9. 2013
    ..Their modifications during forced awakening (FA) context have been shown to reflect sleep inertia...
  12. ncbi request reprint Mechanical allodynia in neuropathic pain. Where are the brain representations located? A positron emission tomography (PET) study
    R Peyron
    Department of Neurology, Pain Center, CHU de Saint Etienne, France
    Eur J Pain 17:1327-37. 2013
    ..The same is not true for allodynic pain in patients with neuropathic pain since the cortical reorganizations that are involved in the conversion of non-noxious stimuli into painful sensations still remain unknown...
  13. ncbi request reprint The role of parietal opercular and insular cortex in pain sensation in humans: data from PET activation studies and intracortical recordings of CO2 laser evoked potentials (LEPs)
    F Mauguiere
    Functional Neurology and Epileptology Department, Neurological Hospital, Lyon, France
    Electroencephalogr Clin Neurophysiol Suppl 49:255-60. 1999
  14. ncbi request reprint Clinical use of polysynaptic flexion reflexes in the management of spasticity with intrathecal baclofen
    M Parise
    Department of Functional Neurology and Epileptology, Pierre Wertheimer Neurological Hospital, Lyon, France
    Electroencephalogr Clin Neurophysiol 105:141-8. 1997
    ..In our experience, FR recordings appeared to be a useful tool for quantifying the benefit of antispastic treatment and might be used as an ancillary indicator to determine the minimal effective dose of intrathecal baclofen...
  15. ncbi request reprint P3, positive slow wave and working memory load: a study on the functional correlates of slow wave activity
    L Garcia-Larrea
    Human Neurophysiology Lab, CERMEP, EA1880, Université Claude Besnard, Lyon, France
    Electroencephalogr Clin Neurophysiol 108:260-73. 1998
    ..The present paradigm proved to be easy to implement and suitable to study the 'executive' functions governing attentional and working-memory control during the performance of multiple tasks...
  16. ncbi request reprint Brain-stem monitoring. I. A system for high-rate sequential BAEP recording and feature extraction
    O Bertrand
    INSERM, Unite 280, Lyon, France
    Electroencephalogr Clin Neurophysiol 68:433-45. 1987
    ..Some clinical examples of comatose patient monitoring are briefly presented to illustrate the performance and the reliability of the system...
  17. ncbi request reprint The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's disease
    E Broussolle
    Department of Neurology, Hopital Neurologique Pierre Wertheimer, Lyon, France
    J Neurol Sci 166:141-51. 1999
    ....
  18. ncbi request reprint Brain-stem monitoring. II. Preterminal BAEP changes observed until brain death in deeply comatose patients
    L Garcia-Larrea
    Laboratorie de Neurophysiologie Sensorielle, Faculté de Médecine Lyon Nord, Hopital Neurologique, France
    Electroencephalogr Clin Neurophysiol 68:446-57. 1987
    ..Our results suggest that continuous brain-stem monitoring could be helpful for management of comatose head-injured patients...
  19. ncbi request reprint Transient drug-induced abolition of BAEPs in coma
    L Garcia-Larrea
    EEG Department, Hopital Neurologique, Lyon, France
    Neurology 38:1487-9. 1988
    ..BAEPs are resistant to hypothermia and barbiturates, but must be interpreted cautiously in patients treated with a combination of anesthetic drugs that includes lidocaine...
  20. doi request reprint Autonomic pain responses during sleep: a study of heart rate variability
    F Chouchou
    Unité INSERM U879, Central Integration of Pain, Universite Lyon 1, Lyon, France
    Eur J Pain 15:554-60. 2011
    ....
  21. ncbi request reprint Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study. Part I: Brain glucose metabolism is increased after GABAA receptors activation
    R Peyron
    Centre d Exploration et de Recherches Médicales par Emission de Positons, Lyon, France
    Epilepsy Res 19:45-54. 1994
    ....
  22. ncbi request reprint Hyperalgesia with reduced laser evoked potentials in neuropathic pain
    Q Wu
    UPRES Neurologi e fonctionnelle EA1880, UCB Lyon CERMEP, Hopital Neurologique, France
    Pain 80:209-14. 1999
    ..The dissociation between pain sensation and cortical EPs deserve to be added to the current semiology of LEPs, as the presence of abnormal pain to laser on the background of reduced LEPs substantiates the neuropathic nature of the pain...
  23. ncbi request reprint Attention shifts and anticipatory mechanisms in hyperactive children: an ERP study using the Posner paradigm
    C Perchet
    Clinical Neurophysiology Laboratory, Research Unit EA1880, University Claude Bernard, Lyon, France
    Biol Psychiatry 50:44-57. 2001
    ..These deficits may be partly attributed to dysmaturation of executive frontal functions. In addition, a minor deficit in early attentional priming was also observed in ERPs, with no apparent behavioral counterparts...
  24. ncbi request reprint Cognitive effects of precentral cortical stimulation for pain control: an ERP study
    C Montes
    Equipe d Accueil, EA1880 UCB, Lyon, France
    Neurophysiol Clin 32:313-25. 2002
    ....
  25. ncbi request reprint High signal intensity on T2-weighted MRI correlates with hypoperfusion in temporal lobe epilepsy
    P Ryvlin
    EEG Department, Neurological Hospital, Lyon, France
    Epilepsia 33:28-35. 1992
    ..The degree of temporal perfusion asymmetry measured in each individual was higher in patients whose MRI was abnormal...
  26. ncbi request reprint Nociceptive flexion reflexes during analgesic neurostimulation in man
    L Garcia-Larrea
    Evoked Potentials Unit EEG Department, Hopital Neurologique, Lyon, France
    Pain 39:145-56. 1989
    ..In addition, RIII behavior in patients could be relevant to the understanding of some of the mechanisms involved in AN-induced pain relief...
  27. ncbi request reprint Long-term clinical, electrophysiological and urodynamic effects of chronic intrathecal baclofen infusion for treatment of spinal spasticity
    P Mertens
    Department of Neurosurgery, Hopital Neurologique, Lyon, France
    Acta Neurochir Suppl 64:17-25. 1995
    ..In patients with spastic bladder, intrathecal baclofen produced a decrease of detrusor hypertonia and hyperactivity in 50% of cases, with reduction of leakage and increase in functional bladder capacity...
  28. ncbi request reprint Clinical use of nociceptive flexion reflex recording in the evaluation of functional neurosurgical procedures
    L Garcia-Larrea
    EEG Department Clin Hôpital Neurologique, Lyon, France
    Acta Neurochir Suppl (Wien) 46:53-7. 1989
    ..Routine recording of nociceptive reflexes in man proved to be a useful tool for the objective evaluation of anatomo-physiological effects of functional neurosurgical procedures...
  29. ncbi request reprint Functional dissociation of the early and late portions of human K-complexes
    F Perrin
    UPRES EA 1880, University Claude Bernard, Functional Neurology Department, Neurological Hospital, Lyon, France
    Neuroreport 11:1637-40. 2000
    ..This latter may appear either within a full KC or in isolation, and in this case it is reminiscent of the N200-P300 complex observed in wakefulness...
  30. ncbi request reprint Brain processing of stimulus deviance during slow-wave and paradoxical sleep: a study of human auditory evoked responses using the oddball paradigm
    H Bastuji
    Service de Neurologie Fonctionelle et Epileptologie, Hopital Neurologique, Lyon, France
    J Clin Neurophysiol 12:155-67. 1995
    ....
  31. ncbi request reprint Mapping study of somatosensory evoked potentials during selective spatial attention
    L Garcia-Larrea
    CERMEP Clinical Neurophysiology Laboratory, Hopital Neurologique, Lyon, France
    Electroencephalogr Clin Neurophysiol 80:201-14. 1991
    ..The late negative component (N140) shares several features with the 'processing negativity' described in auditory paradigms and could represent the equivalent of this effect in the somatosensory system...
  32. ncbi request reprint Flexion reflexes following anterolateral cordotomy in man: dissociation between pain sensation and nociceptive reflex RIII
    L Garcia-Larrea
    Department of Clinical Neurophysiology, Hopital Neurologique, Lyon, France
    Pain 55:139-49. 1993
    ....
  33. ncbi request reprint [Effect of anesthetics on sensory evoked potentials]
    L Garcia-Larrea
    Service de neurologie fonctionnelle, Hopital Neurologique, Lyon, France
    Neurophysiol Clin 23:141-62. 1993
    ..Amplitude changes of middle-latency auditory responses (Pa/Nb) seem to be a good marker for estimating depth of anaesthesia with the aid of EPs...
  34. ncbi request reprint Subthalamic nucleus stimulation in Parkinson's disease : anatomical and electrophysiological localization of active contacts
    F Godinho
    Department of Functional Neurosurgery, Hopital Neurologique et Neurochirurgical, Pierre Wertheimer, 9 Bd Pinel, 69003, Lyon, France
    J Neurol 253:1347-55. 2006
    ..2 - To analyze the stereotactic spatial distribution of the active contacts in relation to the dorsal and the ventral electrophysiologically-defined borders of the STN and the stereotactic theoretical target...
  35. ncbi request reprint Brain responses to detection of right or left somatic targets are symmetrical in unilateral Parkinson's disease: a case against the concept of "parkinsonian neglect'
    L Garcia-Larrea
    Clinical Neurophysiology Lab, CERMEP, UPR 1880, VCB, Lyon, France
    Cortex 32:679-91. 1996
    ....
  36. ncbi request reprint Sleep/wake abnormalities in patients with periodic leg movements during sleep: factor analysis on data from 24-h ambulatory polygraphy
    H Bastuji
    Sleep Disorders Unit, Functional Neurology Department, Hopital Neurologique, Lyon, France
    J Sleep Res 8:217-23. 1999
    ..On the other hand, our analysis suggests that in PLM patients the concomitant existence of a RLS is not related to the frequency of occurrence of PLMs, at least when these latter are quantified independently of their arousal index...
  37. ncbi request reprint Timing and characteristics of perceptual attenuation by transcranial stimulation: a study using magnetic cortical stimulation and somatosensory-evoked potentials
    N Andre-Obadia
    Service de Neurologie Fonctionnelle et d Epileptologie, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France
    Psychophysiology 36:476-83. 1999
    ..The results also suggest that the cortical processes active during the N20 and N120 potentials may be essential for the conscious perception of somatosensory stimuli delivered to the hand...
  38. ncbi request reprint Visuospatial attention and motor reaction in children: an electrophysiological study of the "Posner" paradigm
    C Perchet
    Research Unit UPRES EA1880 University Claude Bernard, CERMEP, Lyon, France
    Psychophysiology 37:231-41. 2000
    ..This method may be applied in clinical settings to disentangle selective processing deficits in target detection, response selection, or motor preparation stages...
  39. ncbi request reprint Somatosensory responses during selective spatial attention: The N120-to-N140 transition
    L Garcia-Larrea
    JE133 Université Claude Bernard, CERMEP, Hopital Neurologique, Lyon, France
    Psychophysiology 32:526-37. 1995
    ....
  40. ncbi request reprint Evoked potentials as a tool for the investigation of human sleep
    H Bastuji
    Sleep Disorders Unit, Functional Neurology Dept, Hopital Neurologique, Lyon, France
    Sleep Med Rev 3:23-45. 1999
    ..A promising approach is the utilization of late responses to the study of sleep inertia with the use of "forced awakening" recording paradigms...
  41. ncbi request reprint Electrophysiological assessment of nociception in normals and patients: the use of nociceptive reflexes
    L Garcia-Larrea
    EEG and EP Department, Hopital Neurologique, Lyon, France
    Electroencephalogr Clin Neurophysiol Suppl 41:102-18. 1990
  42. pmc The combined monitoring of brain stem auditory evoked potentials and intracranial pressure in coma. A study of 57 patients
    L Garcia-Larrea
    EEG Department, Hopital Neurologique, Lyon, France
    J Neurol Neurosurg Psychiatry 55:792-8. 1992
    ..Serial recording of cortical EPs should be added to BAEP monitoring to permit the early detection of rostrocaudal deterioration...