Jerome Galon

Summary

Country: France

Publications

  1. ncbi Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
    Jerome Galon
    Lymphocyte Cell Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 16:61-71. 2002
  2. ncbi Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Jerome Galon
    INSERM U 255, Paris, 75006 France Université Paris Descartes Paris 5, Faculte de Medecine, Paris, 75006 France
    Science 313:1960-4. 2006
  3. ncbi The adaptive immunologic microenvironment in colorectal cancer: a novel perspective
    Jerome Galon
    Institut National de la Sante et de la Recherche Medicale, UMRS872, Team 13 and Avenir team, Cordeliers Research Center, F 75006 Paris, France
    Cancer Res 67:1883-6. 2007
  4. ncbi Effector memory T cells, early metastasis, and survival in colorectal cancer
    Franck Pages
    INSERM UNITE 255, René Descartes Faculté de Médecine, Assistance Publique Hopitaux de Paris, Cordeliers Biomedical Research Center, University Paris 6, Paris, France
    N Engl J Med 353:2654-66. 2005
  5. doi Coordination of intratumoral immune reaction and human colorectal cancer recurrence
    Matthieu Camus
    Integrative Cancer Immunology INSERM AVENIR Team 15, Inserm U872, Paris, France
    Cancer Res 69:2685-93. 2009
  6. doi Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer
    Marie Tosolini
    INSERM, Integrative Cancer Immunology Team, Inserm U872, Paris, France
    Cancer Res 71:1263-71. 2011
  7. ncbi Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer
    Bernhard Mlecnik
    INSERM, Integrative Cancer Immunology Team, Inserm U872, Paris, France
    Gastroenterology 138:1429-40. 2010
  8. doi In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer
    Franck Pages
    INSERM Avenir, U872, Paris, France
    J Clin Oncol 27:5944-51. 2009
  9. pmc Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, France Université Paris Descartes, Paris, France Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, France
    J Pathol 232:199-209. 2014
  10. ncbi Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
    Denis Franchimont
    Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:2212-8. 2002

Collaborators

Detail Information

Publications22

  1. ncbi Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
    Jerome Galon
    Lymphocyte Cell Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 16:61-71. 2002
    ..Considering the broad and continuously renewed interest in glucocorticoid therapy, the profiles we describe here will be useful in designing more specific and efficient treatment strategies...
  2. ncbi Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Jerome Galon
    INSERM U 255, Paris, 75006 France Université Paris Descartes Paris 5, Faculte de Medecine, Paris, 75006 France
    Science 313:1960-4. 2006
    ..In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies...
  3. ncbi The adaptive immunologic microenvironment in colorectal cancer: a novel perspective
    Jerome Galon
    Institut National de la Sante et de la Recherche Medicale, UMRS872, Team 13 and Avenir team, Cordeliers Research Center, F 75006 Paris, France
    Cancer Res 67:1883-6. 2007
    ..Here, we discuss the meaning and potential implications of this novel finding...
  4. ncbi Effector memory T cells, early metastasis, and survival in colorectal cancer
    Franck Pages
    INSERM UNITE 255, René Descartes Faculté de Médecine, Assistance Publique Hopitaux de Paris, Cordeliers Biomedical Research Center, University Paris 6, Paris, France
    N Engl J Med 353:2654-66. 2005
    ..The role of tumor-infiltrating immune cells in the early metastatic invasion of colorectal cancer is unknown...
  5. doi Coordination of intratumoral immune reaction and human colorectal cancer recurrence
    Matthieu Camus
    Integrative Cancer Immunology INSERM AVENIR Team 15, Inserm U872, Paris, France
    Cancer Res 69:2685-93. 2009
    ..Investigation of the colorectal cancer primary tumor microenvironment allowed us to uncover the association of favorable outcomes with efficient coordination of the intratumoral immune response...
  6. doi Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer
    Marie Tosolini
    INSERM, Integrative Cancer Immunology Team, Inserm U872, Paris, France
    Cancer Res 71:1263-71. 2011
    ..Our findings argue that functional Th1 and Th17 clusters yield opposite effects on patient survival in colorectal cancer, and they provide complementary information that may improve prognosis...
  7. ncbi Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer
    Bernhard Mlecnik
    INSERM, Integrative Cancer Immunology Team, Inserm U872, Paris, France
    Gastroenterology 138:1429-40. 2010
    ..Herein, we used data integration and biomolecular network reconstruction to generate hypotheses about the mechanisms underlying immune responses in colorectal cancer that are relevant to tumor recurrence...
  8. doi In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer
    Franck Pages
    INSERM Avenir, U872, Paris, France
    J Clin Oncol 27:5944-51. 2009
    ..We hypothesized that intratumoral immune reaction could influence their prognosis...
  9. pmc Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, France Université Paris Descartes, Paris, France Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, France
    J Pathol 232:199-209. 2014
    ..The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  10. ncbi Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
    Denis Franchimont
    Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:2212-8. 2002
    ..These observations provide a mechanism by which glucocorticoids may have a positive influence on T cell survival and function...
  11. ncbi [Immunology and personalized medicine in oncology]
    Franck Zinzindohoue
    Service de Chirurgie Generale et Digestive, Hopital Europeen Georges Pompidou, AP HP, Paris, France
    Bull Cancer 101:S12-7. 2014
    ..Taking account of parameters derived from the reaction of the host against his tumor is an additional step towards a so-called Personalized Medicine in patients with cancer. ..
  12. ncbi [Intratumoral immune microenvironment and survival: the immunoscore]
    Jerome Galon
    Inserm U872, laboratoire d immunologie et de cancérologie intégratives, 15, rue de l Ecole de Medecine, 75006 Paris, France Université Paris Descartes, Paris, France Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, 15, rue de l Ecole de Medecine, Paris, France
    Med Sci (Paris) 30:439-44. 2014
    ..This could result in the implementation of the immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-immune). ..
  13. doi The essential role of the in situ immune reaction in human colorectal cancer
    Franck Pages
    Centre de Recherche des Cordeliers, Universite Paris Descartes, Paris, France
    J Leukoc Biol 84:981-7. 2008
    ..The strength of the immune reaction identified in our studies could advance our understanding of cancer evolution and have important consequences for clinical practice...
  14. ncbi Natural immunity to cancer in humans
    Gabriela Bindea
    Inserm U872, Integrative Cancer Immunology Team, Paris, France
    Curr Opin Immunol 22:215-22. 2010
    ..Recent advances support the existence of immunosurveillance in human cancer. The major role of the intratumoral immune reaction could advance our understanding of tumor evolution and have important consequences in clinical practice...
  15. pmc The prognostic impact of anti-cancer immune response: a novel classification of cancer patients
    Gabriela Bindea
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Cordeliers Research Center, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Semin Immunopathol 33:335-40. 2011
    ..Thus, the strength of the immune reaction could advance our understanding of cancer evolution and have important consequences in clinical practice...
  16. pmc ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
    Gabriela Bindea
    INSERM, Avenir Team, Integrative Cancer Immunology, U872, Paris, France
    Bioinformatics 25:1091-3. 2009
    ..ClueGO provides an intuitive representation of the analysis results and can be optionally used in conjunction with the GOlorize plug-in...
  17. doi Immunosurveillance in human non-viral cancers
    Wolf Herman Fridman
    Inserm U872, Paris, France
    Curr Opin Immunol 23:272-8. 2011
    ..Systems biology predicted markers shaping an efficient immune reaction can serve as tools and targets for novel therapeutic approaches...
  18. doi Immune infiltration in human cancer: prognostic significance and disease control
    Wolf H Fridman
    Inserm U872, Centre de Recherche des Cordeliers, Paris, 75006, France
    Curr Top Microbiol Immunol 344:1-24. 2011
    ....
  19. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
    ..The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  20. ncbi Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells
    Franck Pages
    Institut National de la Santé et de la Recherche Médicale INSERM U255, Centre de Recherche Biomédicale des Cordeliers, Paris, France
    Blood 105:1632-9. 2005
    ..We report that EBNA2 expression is associated with IL-18R expression in vivo in EBV-positive B-lymphomas from AIDS patients...
  21. ncbi Glucocorticoids and inflammation revisited: the state of the art. NIH clinical staff conference
    Denis Franchimont
    Pediatric and Reproductive Endocrinology Branch, NICHD, NIH, Bethesda, MD 20892 1583, USA
    Neuroimmunomodulation 10:247-60. 2002
    ..Designer' glucocorticoids promise to be a great new advance in the therapy of inflammatory diseases...
  22. ncbi From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer
    Helen Angell
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, France
    Curr Opin Immunol 25:261-7. 2013
    ..Finally we introduce the concept that the host-immune reaction could be the critical element in determining response to therapy. The effect on the immune response could be the underlying factor behind many of the predictive markers...