Jerome Galon

Summary

Country: France

Publications

  1. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012"
    Paolo A Ascierto
    Istituto Nazionale Tumori, Fondazione G, Pascale, Naples, Italy
    J Transl Med 11:137. 2013
  2. pmc The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment
    Paolo A Ascierto
    Melanoma, Cancer Immunotherapy and Innovative Therapy Unit, Istituto Nazionale Tumori Fondazione G, Pascale, Napoli, Italy
    J Transl Med 11:54. 2013
  3. doi request reprint The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
    Jerome Galon
    Laboratory of Integrative Cancer Immunology, Inserm U872, 75006 Paris, France
    Immunity 39:11-26. 2013
  4. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
  5. pmc Toward integrative cancer immunotherapy: targeting the tumor microenvironment
    Leisha A Emens
    Tumor Immunology and Breast Cancer Research Programs, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Transl Med 10:70. 2012
  6. pmc Defining the critical hurdles in cancer immunotherapy
    Bernard A Fox
    Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA
    J Transl Med 9:214. 2011
  7. pmc The immune score as a new possible approach for the classification of cancer
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, 15 Rue de l Ecole de Medecine F 75006 Paris, France
    J Transl Med 10:1. 2012
  8. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010"
    Paolo A Ascierto
    Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy
    J Transl Med 9:32. 2011
  9. pmc Data integration and exploration for the identification of molecular mechanisms in tumor-immune cells interaction
    Bernhard Mlecnik
    Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Austria
    BMC Genomics 11:S7. 2010
  10. ncbi request reprint Effector memory T cells, early metastasis, and survival in colorectal cancer
    Franck Pages
    INSERM UNITE 255, René Descartes Faculté de Médecine, Assistance Publique Hopitaux de Paris, Cordeliers Biomedical Research Center, University Paris 6, Paris, France
    N Engl J Med 353:2654-66. 2005

Collaborators

Detail Information

Publications30

  1. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012"
    Paolo A Ascierto
    Istituto Nazionale Tumori, Fondazione G, Pascale, Naples, Italy
    J Transl Med 11:137. 2013
    ....
  2. pmc The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment
    Paolo A Ascierto
    Melanoma, Cancer Immunotherapy and Innovative Therapy Unit, Istituto Nazionale Tumori Fondazione G, Pascale, Napoli, Italy
    J Transl Med 11:54. 2013
    ..The challenge will be to identify the individual immunoprofile of each patient and the consequent choice of optimal therapy or combination of therapies to be used...
  3. doi request reprint The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
    Jerome Galon
    Laboratory of Integrative Cancer Immunology, Inserm U872, 75006 Paris, France
    Immunity 39:11-26. 2013
    ..Here, we propose a broader immunological interpretation of these three concepts--immune contexture, Immunoscore, and immunologic constant of rejection--that segregates oncogenic processes independently of their tissue origin...
  4. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
    ..The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  5. pmc Toward integrative cancer immunotherapy: targeting the tumor microenvironment
    Leisha A Emens
    Tumor Immunology and Breast Cancer Research Programs, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Transl Med 10:70. 2012
    ....
  6. pmc Defining the critical hurdles in cancer immunotherapy
    Bernard A Fox
    Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA
    J Transl Med 9:214. 2011
    ..Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet if overcome, have the potential to improve outcomes of patients with cancer...
  7. pmc The immune score as a new possible approach for the classification of cancer
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, 15 Rue de l Ecole de Medecine F 75006 Paris, France
    J Transl Med 10:1. 2012
    ....
  8. pmc Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010"
    Paolo A Ascierto
    Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy
    J Transl Med 9:32. 2011
    ..Four topics of discussion were identified: New pathways in Melanoma, Biomarkers, Clinical Trials and New Molecules and Strategies...
  9. pmc Data integration and exploration for the identification of molecular mechanisms in tumor-immune cells interaction
    Bernhard Mlecnik
    Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Austria
    BMC Genomics 11:S7. 2010
    ..Additionally, we discuss generic issues relevant to the integration of clinical and biomolecular data, as well as recent developments in integrative data analyses including biomolecular network reconstruction and mathematical modeling...
  10. ncbi request reprint Effector memory T cells, early metastasis, and survival in colorectal cancer
    Franck Pages
    INSERM UNITE 255, René Descartes Faculté de Médecine, Assistance Publique Hopitaux de Paris, Cordeliers Biomedical Research Center, University Paris 6, Paris, France
    N Engl J Med 353:2654-66. 2005
    ..The role of tumor-infiltrating immune cells in the early metastatic invasion of colorectal cancer is unknown...
  11. doi request reprint Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction
    Bernhard Mlecnik
    Inserm U872, Integrative Cancer Immunology Team, 15 rue de l Ecole de Medecine, Centre de Recherche des Cordeliers, 75006 Paris, France
    J Clin Oncol 29:610-8. 2011
    ....
  12. doi request reprint Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, France Université Paris Descartes, Paris, France Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, France
    J Pathol 232:199-209. 2014
    ..The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  13. doi request reprint Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer
    Bernhard Mlecnik
    INSERM, Integrative Cancer Immunology Team, Inserm U872, Paris, France
    Gastroenterology 138:1429-40. 2010
    ..Herein, we used data integration and biomolecular network reconstruction to generate hypotheses about the mechanisms underlying immune responses in colorectal cancer that are relevant to tumor recurrence...
  14. doi request reprint Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    Gabriela Bindea
    Inserm U872, Laboratory of Integrative Cancer Immunology, Paris 75006, France Université Paris Descartes, Paris 75006, France Cordeliers Research Centre, Universite Pierre et Marie Curie Paris 6, Paris 75006, France
    Immunity 39:782-95. 2013
    ..This integrative study reveals the immune landscape in human colorectal cancer and the major hallmarks of the microenvironment associated with tumor progression and recurrence. ..
  15. doi request reprint Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer
    Marie Tosolini
    INSERM, Integrative Cancer Immunology Team, Inserm U872, Paris, France
    Cancer Res 71:1263-71. 2011
    ..Our findings argue that functional Th1 and Th17 clusters yield opposite effects on patient survival in colorectal cancer, and they provide complementary information that may improve prognosis...
  16. pmc Tumor immunosurveillance in human cancers
    Bernhard Mlecnik
    Inserm U872, Integrative Cancer Immunology Team, 15 rue de l Ecole de Medecine, Paris 75006, France
    Cancer Metastasis Rev 30:5-12. 2011
    ..Thus, the strength of the immune reaction could advance our understanding of cancer evolution and have important consequences in clinical practice...
  17. doi request reprint In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer
    Franck Pages
    INSERM Avenir, U872, Paris, France
    J Clin Oncol 27:5944-51. 2009
    ..We hypothesized that intratumoral immune reaction could influence their prognosis...
  18. doi request reprint Prognostic and predictive impact of intra- and peritumoral immune infiltrates
    Wolf Herman Fridman
    Inserm U872, Centre de Recherche des Cordeliers, France
    Cancer Res 71:5601-5. 2011
    ....
  19. pmc The prognostic impact of anti-cancer immune response: a novel classification of cancer patients
    Gabriela Bindea
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Cordeliers Research Center, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Semin Immunopathol 33:335-40. 2011
    ..Thus, the strength of the immune reaction could advance our understanding of cancer evolution and have important consequences in clinical practice...
  20. doi request reprint The essential role of the in situ immune reaction in human colorectal cancer
    Franck Pages
    Centre de Recherche des Cordeliers, Universite Paris Descartes, Paris, France
    J Leukoc Biol 84:981-7. 2008
    ..The strength of the immune reaction identified in our studies could advance our understanding of cancer evolution and have important consequences for clinical practice...
  21. doi request reprint Natural immunity to cancer in humans
    Gabriela Bindea
    Inserm U872, Integrative Cancer Immunology Team, Paris, France
    Curr Opin Immunol 22:215-22. 2010
    ..Recent advances support the existence of immunosurveillance in human cancer. The major role of the intratumoral immune reaction could advance our understanding of tumor evolution and have important consequences in clinical practice...
  22. pmc ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
    Gabriela Bindea
    INSERM, Avenir Team, Integrative Cancer Immunology, U872, Paris, France
    Bioinformatics 25:1091-3. 2009
    ..ClueGO provides an intuitive representation of the analysis results and can be optionally used in conjunction with the GOlorize plug-in...
  23. ncbi request reprint Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Jerome Galon
    INSERM U 255, Paris, 75006 France Université Paris Descartes Paris 5, Faculte de Medecine, Paris, 75006 France
    Science 313:1960-4. 2006
    ..In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies...
  24. doi request reprint Immunosurveillance in human non-viral cancers
    Wolf Herman Fridman
    Inserm U872, Paris, France
    Curr Opin Immunol 23:272-8. 2011
    ..Systems biology predicted markers shaping an efficient immune reaction can serve as tools and targets for novel therapeutic approaches...
  25. ncbi request reprint Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
    Jerome Galon
    Lymphocyte Cell Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 16:61-71. 2002
    ..Considering the broad and continuously renewed interest in glucocorticoid therapy, the profiles we describe here will be useful in designing more specific and efficient treatment strategies...
  26. doi request reprint Immune infiltration in human cancer: prognostic significance and disease control
    Wolf H Fridman
    Inserm U872, Centre de Recherche des Cordeliers, Paris, 75006, France
    Curr Top Microbiol Immunol 344:1-24. 2011
    ....
  27. pmc CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data
    Gabriela Bindea
    INSERM, Laboratory of Integrative Cancer Immunology, 75006 Paris, France
    Bioinformatics 29:661-3. 2013
    ..Combining all these features is essential for data interpretation and the generation of new hypotheses. The CluePedia Cytoscape plugin is user-friendly and has an expressive and intuitive visualization...
  28. ncbi request reprint Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells
    Franck Pages
    Institut National de la Santé et de la Recherche Médicale INSERM U255, Centre de Recherche Biomédicale des Cordeliers, Paris, France
    Blood 105:1632-9. 2005
    ..We report that EBNA2 expression is associated with IL-18R expression in vivo in EBV-positive B-lymphomas from AIDS patients...
  29. doi request reprint Coordination of intratumoral immune reaction and human colorectal cancer recurrence
    Matthieu Camus
    Integrative Cancer Immunology INSERM AVENIR Team 15, Inserm U872, Paris, France
    Cancer Res 69:2685-93. 2009
    ..Investigation of the colorectal cancer primary tumor microenvironment allowed us to uncover the association of favorable outcomes with efficient coordination of the intratumoral immune response...
  30. ncbi request reprint The adaptive immunologic microenvironment in colorectal cancer: a novel perspective
    Jerome Galon
    Institut National de la Sante et de la Recherche Medicale, UMRS872, Team 13 and Avenir team, Cordeliers Research Center, F 75006 Paris, France
    Cancer Res 67:1883-6. 2007
    ..Here, we discuss the meaning and potential implications of this novel finding...