Nelly Frossard

Summary

Country: France

Publications

  1. pmc Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCF
    Carla Alexandra Da Silva
    INSERM U425, Université Louis Pasteur Strasbourg I, 67401 Illkirch Cedex, France
    Br J Pharmacol 135:1634-40. 2002
  2. ncbi request reprint Nerve growth factor and its receptors in asthma and inflammation
    Nelly Frossard
    EA 3771 Inflammation and Environment in Asthma Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    Eur J Pharmacol 500:453-65. 2004
  3. ncbi request reprint Regulation of peroxisome proliferator-activated receptor-alpha expression during lung inflammation
    Julien Becker
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 60024, 67401 Illkirch, France
    Pulm Pharmacol Ther 21:324-30. 2008
  4. pmc The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma
    Laurent L Reber
    Laboratoire d Innovation Therapeutique, UMR 7200 CNRS Universite de Strasbourg, Faculte de Pharmacie, Illkirch, France
    PLoS ONE 7:e49512. 2012
  5. ncbi request reprint Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate
    Carine Delayre-Orthez
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Eur J Pharmacol 581:177-84. 2008
  6. doi request reprint A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma
    Laurent L Reber
    Laboratoire d Innovation Therapeutique, Unité Mixte de Recherche 7200, Centre National de la Recherche Scientifique Université de Strasbourg, Faculte de Pharmacie, F 67400 Illkirch, France
    J Immunol 188:3478-87. 2012
  7. ncbi request reprint Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
    Laurent Reber
    EA 3771 Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    Eur J Pharmacol 533:327-40. 2006
  8. ncbi request reprint Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta
    Renaud Le Bouquin
    EA Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, BP 60024, 67401 Illkirch, France
    Fundam Clin Pharmacol 18:181-6. 2004
  9. pmc Marked stem cell factor expression in the airways of lung transplant recipients
    Carla A Da Silva
    1EA 3771 Inflammation and environment in asthma, Faculte de Pharmacie, BP 60024, 67401 Illkirch Cedex, France
    Respir Res 7:90. 2006
  10. ncbi request reprint Stem cell factor expression, mast cells and inflammation in asthma
    Carla A Da Silva
    EA3771, Inflammation and Environment in Asthma, Faculte de Pharmacie, BP 24, 67401 Illkirch Cedex, France
    Fundam Clin Pharmacol 20:21-39. 2006

Collaborators

Detail Information

Publications38

  1. pmc Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCF
    Carla Alexandra Da Silva
    INSERM U425, Université Louis Pasteur Strasbourg I, 67401 Illkirch Cedex, France
    Br J Pharmacol 135:1634-40. 2002
    ..The reduced number and activation of mast cells observed in the bronchi of asthmatic patients treated by glucocorticoids may be due in part to this effect...
  2. ncbi request reprint Nerve growth factor and its receptors in asthma and inflammation
    Nelly Frossard
    EA 3771 Inflammation and Environment in Asthma Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    Eur J Pharmacol 500:453-65. 2004
    ....
  3. ncbi request reprint Regulation of peroxisome proliferator-activated receptor-alpha expression during lung inflammation
    Julien Becker
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 60024, 67401 Illkirch, France
    Pulm Pharmacol Ther 21:324-30. 2008
    ..Taken together, our data show that PPARalpha expression is inversely regulated with lung inflammation...
  4. pmc The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma
    Laurent L Reber
    Laboratoire d Innovation Therapeutique, UMR 7200 CNRS Universite de Strasbourg, Faculte de Pharmacie, Illkirch, France
    PLoS ONE 7:e49512. 2012
    ..H89 has been extensively used in vitro but its anti-inflammatory potential in vivo has not been reported to date. To assess the anti-inflammatory properties of H89 in mouse models of asthma...
  5. ncbi request reprint Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate
    Carine Delayre-Orthez
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Eur J Pharmacol 581:177-84. 2008
    ....
  6. doi request reprint A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma
    Laurent L Reber
    Laboratoire d Innovation Therapeutique, Unité Mixte de Recherche 7200, Centre National de la Recherche Scientifique Université de Strasbourg, Faculte de Pharmacie, F 67400 Illkirch, France
    J Immunol 188:3478-87. 2012
    ..In conclusion, we clearly show in this study the anti-inflammatory effect of CpdA in a Th2-driven asthma model in the absence of transactivation, suggesting a potential therapeutic benefit of this strategy...
  7. ncbi request reprint Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
    Laurent Reber
    EA 3771 Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    Eur J Pharmacol 533:327-40. 2006
    ..Taken together, these data suggest that SCF/c-Kit may be a potential therapeutic target for the control of mast cell and eosinophil number and activation in inflammatory diseases...
  8. ncbi request reprint Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta
    Renaud Le Bouquin
    EA Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, BP 60024, 67401 Illkirch, France
    Fundam Clin Pharmacol 18:181-6. 2004
    ..Since IL-1beta has been largely associated with asthma, our data suggest that CYP4A expression could be altered in asthmatic conditions and may thus contribute to changes in airway reactivity...
  9. pmc Marked stem cell factor expression in the airways of lung transplant recipients
    Carla A Da Silva
    1EA 3771 Inflammation and environment in asthma, Faculte de Pharmacie, BP 60024, 67401 Illkirch Cedex, France
    Respir Res 7:90. 2006
    ..Airways repair is critical to lung function following transplantation. We hypothesised that the stem cell factor (SCF) could play a role in this setting...
  10. ncbi request reprint Stem cell factor expression, mast cells and inflammation in asthma
    Carla A Da Silva
    EA3771, Inflammation and Environment in Asthma, Faculte de Pharmacie, BP 24, 67401 Illkirch Cedex, France
    Fundam Clin Pharmacol 20:21-39. 2006
    ..We here report the main pathways of SCF synthesis and signalling, and its potential role on airway function and asthma...
  11. ncbi request reprint Exposure to endotoxins during sensitization prevents further endotoxin-induced exacerbation of airway inflammation in a mouse model of allergic asthma
    Carine Delayre-Orthez
    EA 3771, Inflammation et Environnement dans l Asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Int Arch Allergy Immunol 138:298-304. 2005
    ..We have here investigated the effect of LPS administered during both sensitization and challenge on airway inflammation, as well as on the profile of the T-helper (Th) response to allergen...
  12. ncbi request reprint Mast Cells Contribute to Bleomycin-Induced Lung Inflammation and Injury in Mice through a Chymase/Mast Cell Protease 4-Dependent Mechanism
    Laurent L Reber
    Laboratoire d Innovation Therapeutique, Unité Mixte de Recherche 7200, Centre National de la Recherche Scientifique Université de Strasbourg, Laboratoire d Excellence Medalis, Faculte de Pharmacie, 67401 Illkirch, France
    J Immunol 192:1847-54. 2014
    ..Our results support the conclusion that MCs can contribute to the initial lung injury induced by BLM through release of the MCPT4 chymase. ..
  13. ncbi request reprint Inflammatory conditions increase expression of protease-activated receptor-2 by human airway smooth muscle cells in culture
    Véronique Freund-Michel
    EA 3771 Inflammation and Environment in Asthma, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Fundam Clin Pharmacol 20:351-7. 2006
    ..This increased expression of PAR-2 in inflammatory conditions may have functional consequences in the bronchial dysfunction of asthmatic airways...
  14. doi request reprint Overexpression of functional TrkA receptors after internalisation in human airway smooth muscle cells
    Véronique Freund-Michel
    EA 3771 Inflammation and Environment in Asthma, University Louis Pasteur Strasbourg I, Faculty of Pharmacy, Illkirch, France
    Biochim Biophys Acta 1783:1964-71. 2008
    ..This may have pathophysiological consequences in airway inflammatory diseases...
  15. ncbi request reprint Regulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?
    Julien Becker
    EA 3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Fundam Clin Pharmacol 20:429-47. 2006
    ....
  16. ncbi request reprint Expression of nerve growth factor in the airways and its possible role in asthma
    Véronique Freund
    Institut National de la Sante et de la Recherche Medicale, Unité 425, Neuroimmunopharmacologie Pulmonaire, Universite Louis Pasteur, Strasburg I, Faculte de Pharmacie, France
    Prog Brain Res 146:335-46. 2004
    ..Taken together, these results suggest that NGF is an important mediator in both inflammation and asthma...
  17. doi request reprint The peroxisome proliferator-activated receptor α agonist fenofibrate decreases airway reactivity to methacholine and increases endothelial nitric oxide synthase phosphorylation in mouse lung
    Julien Becker
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 60024, 67401 Illkirch, France
    Fundam Clin Pharmacol 26:340-6. 2012
    ..05). Taken together, our data demonstrate that fenofibrate downregulates airway reactivity to methacholine in the mouse and suggest that this effect could involve an increase in NO generation through an enhanced eNOS phosphorylation...
  18. pmc Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation
    Laurent Reber
    EA3771, Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    PLoS ONE 4:e4393. 2009
    ..Our study provides therefore a direct link between MSK1-mediated phosphorylation of Ser276 p65 of NF-kappaB, allowing its binding to the SCF intronic enhancer, and pathophysiological SCF expression in inflammation...
  19. pmc Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine
    Nelly Frossard
    Faculty of Pharmacy, University Louis Pasteur Strasbourg I, Strasbourg, France
    Br J Clin Pharmacol 65:172-9. 2008
    ..This study clearly shows the potential anti-inflammatory properties of desloratadine and levocetirizine in their skin activity when allergen is the challenging agent as occurs in the clinical situation...
  20. ncbi request reprint Transcription of stem cell factor (SCF) is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element
    Carla Alexandra Da Silva
    INSERM U425, Université Louis Pasteur Strasbourg I, France
    FASEB J 17:2334-6. 2003
    ....
  21. pmc Paradoxical early glucocorticoid induction of stem cell factor (SCF) expression in inflammatory conditions
    Carla Alexandra Da Silva
    INSERM U425, Université Louis Pasteur Strasbourg I, France
    Br J Pharmacol 141:75-84. 2004
    ....
  22. ncbi request reprint Regulation of stem cell factor expression in inflammation and asthma
    Carla A Da Silva
    Faculte de Pharmacie, Universite Louis Pasteur, 67401 Illkirch Cedex, France
    Mem Inst Oswaldo Cruz 100:145-51. 2005
    ..In conclusion, this review concerns new mechanisms of regulation of SCF expression in inflammation that could lead to potential therapeutic strategy allowing to control mast cell number in the asthmatic airways...
  23. ncbi request reprint Potential role of stem cell factor in the asthma control by glucocorticoids
    Carla Alexandra Da Silva
    EA 3771, Inflammation and Environment in Asthma, Faculte de Pharmacie, Illkirch, France carla da
    Chem Immunol Allergy 87:154-62. 2005
    ..Thus, SCF could be involved in mast cell-associated diseases such as asthma. We here review the main effects of glucocorticoids in asthma and on mast cells, with a special interest on SCF, as a potential therapeutic target in asthma...
  24. pmc An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in mice
    Francois Daubeuf
    Laboratoire d Innovation Therapeutique, UMR 7200 CNRS Universite de Strasbourg, Faculte de Pharmacie, 74 route du Rhin, 67401 Illkirch, France
    J Biol Chem 288:11865-76. 2013
    ..This approach allows selective action of the CXCL12 neutraligands although the target protein is widely distributed in the organism...
  25. ncbi request reprint Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16alpha-carbonitrile
    Muriel Haag
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 2467401, Illkirch Cedex, France
    Arch Toxicol 77:145-9. 2003
    ..This potentiation may involve PXR, expression of which is induced in the lung of glucocorticoid-treated mice...
  26. ncbi request reprint Transforming growth factor-beta and its role in asthma
    Catherine Duvernelle
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74, route du Rhin, B P 24, 67401 Illkirch Cedex, France
    Pulm Pharmacol Ther 16:181-96. 2003
    ..However, as its role is dual in the modulation of inflammation, further studies are needed to elucidate the precise role of TGF-beta in the airways...
  27. ncbi request reprint TrkA signalling pathways in human airway smooth muscle cell proliferation
    Véronique Freund-Michel
    EA 3771 Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, 74 route du Rhin, BP 60024, 67401 Illkirch Cedex, France
    Cell Signal 18:621-7. 2006
    ..In conclusion, NGF activation of the TrkA receptor involves two distinct signalling pathways: PKC selectively activates p38, and the ras/raf pathway selectively activates ERK1/2. Both are necessary to induce HASMC proliferation...
  28. ncbi request reprint Similar rapid onset of action and magnitude of effect of fexofenadine and cetirizine as assessed by inhibition of histamine-induced wheal-and-flare reaction
    Ashok Purohit
    INSERM U425 EA3771, Faculte de Pharmacie, Illkirch, and Service de Pneumologie, Hopitaux Universitaires, Strasbourg, France
    Ann Allergy Asthma Immunol 93:562-7. 2004
    ..Histamine-induced wheal-and-flare studies are useful, objective tests for determining differences in the peripheral H1-receptor blockade activities of antihistamines...
  29. ncbi request reprint Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma
    Muriel Haag
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, BP 24, 67401 Illkirch Cedex, France
    Arch Toxicol 76:621-7. 2002
    ..However, this effect is associated with a decreased enzyme activity, which might limit the toxicological consequences of increased Cyp1a1 expression...
  30. pmc PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse
    Carine Delayre-Orthez
    EA 3771, Inflammation et Environnement dans l Asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Respir Res 6:91. 2005
    ....
  31. ncbi request reprint Nerve growth factor and asthma
    Caroline Olgart Hoglund
    Institut National de la Santé et de la Recherche Médicale Unité 425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, B P 24, 67 401 Illkirch Cedex, France
    Pulm Pharmacol Ther 15:51-60. 2002
  32. ncbi request reprint Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging
    François Xavier Blé
    Respiratory Diseases Department, Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, WSJ 386 2 09, CH 4002 Basel, Switzerland
    Radiology 248:834-43. 2008
    ..To demonstrate the feasibility of using proton magnetic resonance (MR) imaging to noninvasively detect extravascular and luminal fluid in a murine model of allergen-induced airway inflammation...
  33. ncbi request reprint Role of tachykinin NK3 receptors in the release and effects of nerve growth factor in human isolated bronchi
    Emmanuel Naline
    Research Unit EA220, Universite de Versailles, Faculte de Medecine, Pharmacology, Hopital Foch, 40 rue Worth, 92150 Suresnes, France
    Eur J Pharmacol 560:206-11. 2007
    ..05). SR142801 also inhibited the NGF-induced airway hyperresponsiveness (P<0.01). This study suggests tachykininergic sensory nerves to be involved in the interleukin-1beta-induced NGF release and airway hyperresponsiveness...
  34. pmc Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin
    Ashok Purohit
    INSERM U425, Service de Pneumologie, Hopitaux Universitaires, Strasbourg, France
    Br J Clin Pharmacol 56:388-94. 2003
    ..We set out to compare their antihistaminic activity in the skin for 24 h in a double-blind, randomized cross-over trial...
  35. ncbi request reprint Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours
    Ashok Purohit
    INSERM U425 and EA3771, Service de Pneumologie, Hopitaux Universitaires, Strasbourg, France
    Ann Allergy Asthma Immunol 92:635-40. 2004
    ..Cetirizine and desloratadine are antihistamines active in the treatment of symptoms associated with seasonal allergic rhinitis and chronic urticaria...
  36. ncbi request reprint Small neutralizing molecules to inhibit actions of the chemokine CXCL12
    Muriel Hachet-Haas
    Institut Gilbert Laustriat Biomolécules, Biotechnologie, Innovation Therapeutique, Universite Louis Pasteur, 67401 Illkirch, France
    J Biol Chem 283:23189-99. 2008
    ..By analogy to the effect of neutralizing antibodies, this molecule behaves as a small organic neutralizing compound that may prove to have valuable pharmacological and therapeutic potential...
  37. ncbi request reprint Acid-induced modulation of airway basal tone and contractility: role of acid-sensing ion channels (ASICs) and TRPV1 receptor
    Christophe Faisy
    Research Unit UPRES EA220, Université Versailles Saint Quentin, Hopital Foch, 40 rue Worth, 92150 Suresnes, France
    Life Sci 81:1094-102. 2007
    ..Conversely, the pH-induced hyperresponsiveness involves sensory nerves-dependent ASICs and TRPV1, and an unknown epithelial component in response to acidosis...
  38. ncbi request reprint Expression of substance P and nitric oxide synthase in vagal sensory neurons innervating the mouse airways
    Q Thai Dinh
    Department of Internal Medicine, Charite School of Medicine, Humboldt University, Berlin, Germany
    Regul Pept 126:189-94. 2005
    ..The aim of the present study was to investigate substance P and neuronal nitric oxide synthase (NOS-1) expression in airway-specific sensory neurons...