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Genomes and Genes | Nelly FrossardSummaryCountry: France Publications
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Publications
Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCFCarla Alexandra Da Silva
INSERM U425, Université Louis Pasteur Strasbourg I, 67401 Illkirch Cedex, France
Br J Pharmacol 135:1634-40. 2002..The reduced number and activation of mast cells observed in the bronchi of asthmatic patients treated by glucocorticoids may be due in part to this effect...
Nerve growth factor and its receptors in asthma and inflammationNelly Frossard
EA 3771 Inflammation and Environment in Asthma Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
Eur J Pharmacol 500:453-65. 2004....- Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrateCarine Delayre-Orthez
EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
Eur J Pharmacol 581:177-84. 2008.... - Regulation of peroxisome proliferator-activated receptor-alpha expression during lung inflammationJulien Becker
EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 60024, 67401 Illkirch, France
Pulm Pharmacol Ther 21:324-30. 2008..Taken together, our data show that PPARalpha expression is inversely regulated with lung inflammation... - A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthmaLaurent L Reber
Laboratoire d Innovation Therapeutique, Unité Mixte de Recherche 7200, Centre National de la Recherche Scientifique Université de Strasbourg, Faculte de Pharmacie, F 67400 Illkirch, France
J Immunol 188:3478-87. 2012..In conclusion, we clearly show in this study the anti-inflammatory effect of CpdA in a Th2-driven asthma model in the absence of transactivation, suggesting a potential therapeutic benefit of this strategy... - Regulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?Julien Becker
EA 3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
Fundam Clin Pharmacol 20:429-47. 2006.... - Exposure to endotoxins during sensitization prevents further endotoxin-induced exacerbation of airway inflammation in a mouse model of allergic asthmaCarine Delayre-Orthez
EA 3771, Inflammation et environnement dans l'asthme, , , Illkirch, France
Int Arch Allergy Immunol 138:298-304. 2005.... - Inflammatory conditions increase expression of protease-activated receptor-2 by human airway smooth muscle cells in cultureVéronique Freund-Michel
EA 3771 Inflammation and Environment in Asthma, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
Fundam Clin Pharmacol 20:351-7. 2006..This increased expression of PAR-2 in inflammatory conditions may have functional consequences in the bronchial dysfunction of asthmatic airways... - Overexpression of functional TrkA receptors after internalisation in human airway smooth muscle cellsVéronique Freund-Michel
EA 3771 Inflammation and Environment in Asthma, University Louis Pasteur Strasbourg I, Faculty of Pharmacy, Illkirch, France
Biochim Biophys Acta 1783:1964-71. 2008..This may have pathophysiological consequences in airway inflammatory diseases... - Regulation of stem cell factor expression in inflammation and asthmaCarla A Da Silva
, , 67401 Illkirch Cedex, France
Mem Inst Oswaldo Cruz 100:145-51. 2005..In conclusion, this review concerns new mechanisms of regulation of SCF expression in inflammation that could lead to potential therapeutic strategy allowing to control mast cell number in the asthmatic airways... - Stem cell factor expression, mast cells and inflammation in asthmaCarla A Da Silva
EA3771, Inflammation and Environment in Asthma, , BP 24, 67401 Illkirch Cedex, France
Fundam Clin Pharmacol 20:21-39. 2006..We here report the main pathways of SCF synthesis and signalling, and its potential role on airway function and asthma... - Expression of nerve growth factor in the airways and its possible role in asthmaVéronique Freund
Institut National de la Sante et de la Recherche Medicale, Unité 425, Neuroimmunopharmacologie Pulmonaire, Universite Louis Pasteur, Strasburg I, Faculte de Pharmacie, France
Prog Brain Res 146:335-46. 2004..Taken together, these results suggest that NGF is an important mediator in both inflammation and asthma... 
Marked stem cell factor expression in the airways of lung transplant recipientsCarla A Da Silva
1EA 3771 Inflammation and environment in asthma, Faculte de Pharmacie, BP 60024, 67401 Illkirch Cedex, France
Respir Res 7:90. 2006..Airways repair is critical to lung function following transplantation. We hypothesised that the stem cell factor (SCF) could play a role in this setting...- Stem cell factor and its receptor c-Kit as targets for inflammatory diseasesLaurent Reber
EA 3771 Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
Eur J Pharmacol 533:327-40. 2006..Taken together, these data suggest that SCF/c-Kit may be a potential therapeutic target for the control of mast cell and eosinophil number and activation in inflammatory diseases... - Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammationLaurent Reber
EA3771, Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
PLoS ONE 4:e4393. 2009..Our study provides therefore a direct link between MSK1-mediated phosphorylation of Ser276 p65 of NF-kappaB, allowing its binding to the SCF intronic enhancer, and pathophysiological SCF expression in inflammation... - Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadineNelly Frossard
Faculty of Pharmacy, University Louis Pasteur Strasbourg I, Strasbourg, France
Br J Clin Pharmacol 65:172-9. 2008..This study clearly shows the potential anti-inflammatory properties of desloratadine and levocetirizine in their skin activity when allergen is the challenging agent as occurs in the clinical situation... - Transcription of stem cell factor (SCF) is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response elementCarla Alexandra Da Silva
INSERM U425, Université Louis Pasteur Strasbourg I, France
FASEB J 17:2334-6. 2003.... - Paradoxical early glucocorticoid induction of stem cell factor (SCF) expression in inflammatory conditionsCarla Alexandra Da Silva
INSERM U425, Université Louis Pasteur Strasbourg I, France
Br J Pharmacol 141:75-84. 2004.... - The peroxisome proliferator-activated receptor alpha agonist fenofibrate decreases airway reactivity to methacholine and increases endothelial nitric oxide synthase phosphorylation in mouse lungJulien Becker
EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 60024, 67401 Illkirch, France
Fundam Clin Pharmacol 26:340-6. 2012..05). Taken together, our data demonstrate that fenofibrate downregulates airway reactivity to methacholine in the mouse and suggest that this effect could involve an increase in NO generation through an enhanced eNOS phosphorylation... - Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16alpha-carbonitrileMuriel Haag
INSERM U425, Neuroimmunopharmacologie Pulmonaire, , , 74 route du Rhin, BP 2467401, Illkirch Cedex, France
Arch Toxicol 77:145-9. 2003..This potentiation may involve PXR, expression of which is induced in the lung of glucocorticoid-treated mice... - The AGC Kinase Inhibitor H89 Attenuates Airway Inflammation in Mouse Models of AsthmaLaurent L Reber
Laboratoire d Innovation Therapeutique, UMR 7200 CNRS Universite de Strasbourg, Faculte de Pharmacie, Illkirch, France
PLoS ONE 7:e49512. 2012..H89 has been extensively used in vitro but its anti-inflammatory potential in vivo has not been reported to date. To assess the anti-inflammatory properties of H89 in mouse models of asthma... - TrkA signalling pathways in human airway smooth muscle cell proliferationVéronique Freund-Michel
EA 3771 Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, 74 route du Rhin, BP 60024, 67401 Illkirch Cedex, France
Cell Signal 18:621-7. 2006..In conclusion, NGF activation of the TrkA receptor involves two distinct signalling pathways: PKC selectively activates p38, and the ras/raf pathway selectively activates ERK1/2. Both are necessary to induce HASMC proliferation... - Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1betaRenaud Le Bouquin
EA Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, BP 60024, 67401 Illkirch, France
Fundam Clin Pharmacol 18:181-6. 2004..Since IL-1beta has been largely associated with asthma, our data suggest that CYP4A expression could be altered in asthmatic conditions and may thus contribute to changes in airway reactivity... - Similar rapid onset of action and magnitude of effect of fexofenadine and cetirizine as assessed by inhibition of histamine-induced wheal-and-flare reactionAshok Purohit
INSERM U425/EA3771, Faculte de Pharmacie, Illkirch, and Service de Pneumologie, , Strasbourg, France
Ann Allergy Asthma Immunol 93:562-7. 2004..12 by exact permutation test). CONCLUSIONS: Fexofenadine and cetirizine have comparable onset of action times and similar frequencies of inhibition, as evaluated by the occurrence of 95% inhibition of histamine-induced wheal and flare... - PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouseCarine Delayre-Orthez
EA 3771, Inflammation et Environnement dans l Asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
Respir Res 6:91. 2005.... - Potential role of stem cell factor in the asthma control by glucocorticoidsCarla Alexandra Da Silva
EA 3771, Inflammation and Environment in Asthma, Faculte de Pharmacie, Illkirch, France carla da
Chem Immunol Allergy 87:154-62. 2005..Thus, SCF could be involved in mast cell-associated diseases such as asthma. We here review the main effects of glucocorticoids in asthma and on mast cells, with a special interest on SCF, as a potential therapeutic target in asthma... - Nerve growth factor and asthmaCaroline Olgart Hoglund
Institut National de la Santé et de la Recherche Médicale Unité 425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, B P 24, 67 401 Illkirch Cedex, France
Pulm Pharmacol Ther 15:51-60. 2002 - Transforming growth factor-beta and its role in asthmaCatherine Duvernelle
, , Neuroimmunopharmacologie Pulmonaire, , , 74, route du Rhin, B P 24, 67401 Illkirch Cedex, France
Pulm Pharmacol Ther 16:181-96. 2003..However, as its role is dual in the modulation of inflammation, further studies are needed to elucidate the precise role of TGF-beta in the airways... - Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthmaMuriel Haag
INSERM U425, Neuroimmunopharmacologie Pulmonaire, , , BP 24, 67401 Illkirch Cedex, France
Arch Toxicol 76:621-7. 2002..However, this effect is associated with a decreased enzyme activity, which might limit the toxicological consequences of increased Cyp1a1 expression... - Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skinAshok Purohit
INSERM U425, Service de Pneumologie, , Strasbourg, France
Br J Clin Pharmacol 56:388-94. 2003..In addition, its activity was more consistent and lasted longer... - Allergen-induced lung inflammation in actively sensitized mice assessed with MR imagingFrançois Xavier Blé
Respiratory Diseases Department, Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, WSJ 386 2 09, CH 4002 Basel, Switzerland
Radiology 248:834-43. 2008..To demonstrate the feasibility of using proton magnetic resonance (MR) imaging to noninvasively detect extravascular and luminal fluid in a murine model of allergen-induced airway inflammation... - Role of tachykinin NK3 receptors in the release and effects of nerve growth factor in human isolated bronchiEmmanuel Naline
Research Unit EA220, Universite de Versailles, Faculte de Medecine, Pharmacology, Hopital Foch, 40 rue Worth, 92150 Suresnes, France
Eur J Pharmacol 560:206-11. 2007..05). SR142801 also inhibited the NGF-induced airway hyperresponsiveness (P<0.01). This study suggests tachykininergic sensory nerves to be involved in the interleukin-1beta-induced NGF release and airway hyperresponsiveness... - Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hoursAshok Purohit
INSERM U425 and EA3771, Service de Pneumologie, , Strasbourg, France
Ann Allergy Asthma Immunol 92:635-40. 2004.... - Small neutralizing molecules to inhibit actions of the chemokine CXCL12Muriel Hachet-Haas
Institut Gilbert Laustriat Biomolécules, Biotechnologie, Innovation Therapeutique, Universite Louis Pasteur, 67401 Illkirch, France
J Biol Chem 283:23189-99. 2008..By analogy to the effect of neutralizing antibodies, this molecule behaves as a small organic neutralizing compound that may prove to have valuable pharmacological and therapeutic potential... - Expression of substance P and nitric oxide synthase in vagal sensory neurons innervating the mouse airwaysQ Thai Dinh
Department of Internal Medicine, Charite School of Medicine, Humboldt University, Berlin, Germany
Regul Pept 126:189-94. 2005..The aim of the present study was to investigate substance P and neuronal nitric oxide synthase (NOS-1) expression in airway-specific sensory neurons... - Acid-induced modulation of airway basal tone and contractility: role of acid-sensing ion channels (ASICs) and TRPV1 receptorChristophe Faisy
Research Unit UPRES EA220, Université Versailles Saint Quentin, Hopital Foch, 40 rue Worth, 92150 Suresnes, France
Life Sci 81:1094-102. 2007..Conversely, the pH-induced hyperresponsiveness involves sensory nerves-dependent ASICs and TRPV1, and an unknown epithelial component in response to acidosis...