N Frossard

Summary

Country: France

Publications

  1. pmc Marked stem cell factor expression in the airways of lung transplant recipients
    Carla A Da Silva
    1EA 3771 Inflammation and environment in asthma, Faculte de Pharmacie, BP 60024, 67401 Illkirch Cedex, France
    Respir Res 7:90. 2006
  2. ncbi request reprint Nerve growth factor is released by IL-1beta and induces hyperresponsiveness of the human isolated bronchus
    N Frossard
    EA 3771, Inflammation and Environment in Asthma, Faculte de Pharmacie, Universite Louis Pasteur, BP 60024, 67401 Illkirch Cedex, France
    Eur Respir J 26:15-20. 2005
  3. ncbi request reprint [Role of bronchial smooth muscle in inflammation]
    N Frossard
    INSERM U425, Faculte de Pharmacie, Illkirch
    Rev Mal Respir 17:559-63. 2000
  4. ncbi request reprint Activity of ebastine (10 and 20 mg) and cetirizine at 24 hours of a steady state treatment in the skin of healthy volunteers
    N Frossard
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Illkirch, France
    Fundam Clin Pharmacol 14:409-13. 2000
  5. pmc Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine
    Nelly Frossard
    Faculty of Pharmacy, University Louis Pasteur Strasbourg I, Strasbourg, France
    Br J Clin Pharmacol 65:172-9. 2008
  6. ncbi request reprint Local increase in the number of mast cells and expression of nerve growth factor in the bronchus of asthmatic patients after repeated inhalation of allergen at low-dose
    O Kassel
    INSERM U 425, , , BP 24, 67401 Illkirch Cedex, France
    Clin Exp Allergy 31:1432-40. 2001
  7. ncbi request reprint Repeated inhalation of low doses of cat allergen that do not induce clinical symptoms increases bronchial hyperresponsiveness and eosinophil cationic protein levels
    F de Blay
    Institut National de la Santé et de la Recherche Médicale Unité 425, Hôpital Lyautey, Strasbourg, France
    Int Arch Allergy Immunol 120:158-65. 1999
  8. ncbi request reprint Twenty-four hours of activity of cetirizine and fexofenadine in the skin
    A Purohit
    , H pitaux Universitaires, Strasbourg, France
    Ann Allergy Asthma Immunol 86:387-92. 2001
  9. ncbi request reprint Regulation of peroxisome proliferator-activated receptor-alpha expression during lung inflammation
    Julien Becker
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 60024, 67401 Illkirch, France
    Pulm Pharmacol Ther 21:324-30. 2008
  10. ncbi request reprint Inhalation of toluene diisocyanate affects cytochrome P450 2B1 expression in rat lung
    F Pons
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Illkirch, France
    Arch Toxicol 74:397-403. 2000

Collaborators

Detail Information

Publications55

  1. pmc Marked stem cell factor expression in the airways of lung transplant recipients
    Carla A Da Silva
    1EA 3771 Inflammation and environment in asthma, Faculte de Pharmacie, BP 60024, 67401 Illkirch Cedex, France
    Respir Res 7:90. 2006
    ..Airways repair is critical to lung function following transplantation. We hypothesised that the stem cell factor (SCF) could play a role in this setting...
  2. ncbi request reprint Nerve growth factor is released by IL-1beta and induces hyperresponsiveness of the human isolated bronchus
    N Frossard
    EA 3771, Inflammation and Environment in Asthma, Faculte de Pharmacie, Universite Louis Pasteur, BP 60024, 67401 Illkirch Cedex, France
    Eur Respir J 26:15-20. 2005
    ....
  3. ncbi request reprint [Role of bronchial smooth muscle in inflammation]
    N Frossard
    INSERM U425, Faculte de Pharmacie, Illkirch
    Rev Mal Respir 17:559-63. 2000
    ..The demonstration of the occurrence and/or coexistence of such differentiation states in vivo will help understand the exact role of the bronchial smooth muscle in the airway inflammation in asthma...
  4. ncbi request reprint Activity of ebastine (10 and 20 mg) and cetirizine at 24 hours of a steady state treatment in the skin of healthy volunteers
    N Frossard
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Illkirch, France
    Fundam Clin Pharmacol 14:409-13. 2000
    ..This study clearly proves ebastine to be an effective, truly once-daily antihistamine...
  5. pmc Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine
    Nelly Frossard
    Faculty of Pharmacy, University Louis Pasteur Strasbourg I, Strasbourg, France
    Br J Clin Pharmacol 65:172-9. 2008
    ..This study clearly shows the potential anti-inflammatory properties of desloratadine and levocetirizine in their skin activity when allergen is the challenging agent as occurs in the clinical situation...
  6. ncbi request reprint Local increase in the number of mast cells and expression of nerve growth factor in the bronchus of asthmatic patients after repeated inhalation of allergen at low-dose
    O Kassel
    INSERM U 425, , , BP 24, 67401 Illkirch Cedex, France
    Clin Exp Allergy 31:1432-40. 2001
    ..In addition, our finding of the presence of the TrkA receptor on the membrane of the infiltrated mast cell in situ brings evidence of the mast cell as a target cell for the growth factor activity of NGF in the airways in asthma...
  7. ncbi request reprint Repeated inhalation of low doses of cat allergen that do not induce clinical symptoms increases bronchial hyperresponsiveness and eosinophil cationic protein levels
    F de Blay
    Institut National de la Santé et de la Recherche Médicale Unité 425, Hôpital Lyautey, Strasbourg, France
    Int Arch Allergy Immunol 120:158-65. 1999
    ....
  8. ncbi request reprint Twenty-four hours of activity of cetirizine and fexofenadine in the skin
    A Purohit
    , H pitaux Universitaires, Strasbourg, France
    Ann Allergy Asthma Immunol 86:387-92. 2001
    ..CONCLUSIONS: Our study clearly shows better duration of action and consistency of the antihistaminic activity of cetirizine compared with fexofenadine (120 and 180 mg) in the histamine-induced skin reaction during a 24-hour period...
  9. ncbi request reprint Regulation of peroxisome proliferator-activated receptor-alpha expression during lung inflammation
    Julien Becker
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 60024, 67401 Illkirch, France
    Pulm Pharmacol Ther 21:324-30. 2008
    ..Taken together, our data show that PPARalpha expression is inversely regulated with lung inflammation...
  10. ncbi request reprint Inhalation of toluene diisocyanate affects cytochrome P450 2B1 expression in rat lung
    F Pons
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Illkirch, France
    Arch Toxicol 74:397-403. 2000
    ..In conclusion, this study clearly shows a selective decrease in CYP 2B1 expression by TDI vapors in rat lung. The contribution of CYP 2B1 to metabolize further xenobiotics is therefore altered...
  11. ncbi request reprint Effect of toluene diisocyanate and its corresponding amines on viability and growth of human lung fibroblasts in culture
    F Pons
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Illkirch, France
    Cell Biol Toxicol 15:333-40. 1999
    ....
  12. pmc Comparative activity of cetirizine and mizolastine on histamine-induced skin wheal and flare responses at 24 h
    A Purohit
    INSERM U425, Service de Pneumologie, Hopitaux Universitaires, BP 426, 67091 Strasbourg, France
    Br J Clin Pharmacol 53:250-4. 2002
    ..The aim of our study was to compare the activity of cetirizine 10 mg with that of mizolastine 10 mg vs placebo at 24 h after intake in healthy volunteers...
  13. ncbi request reprint Nerve growth factor secretion by human lung epithelial A549 cells in pro- and anti-inflammatory conditions
    F Pons
    , , Neuroimmunopharmacologie Pulmonaire, , , B.P. 24, 67401 Cedex, Illkirch, France
    Eur J Pharmacol 428:365-9. 2001
    ..001). In conclusion, we here report that human airway A549 epithelial cells are capable of producing NGF. This production is positively regulated by the pro-inflammatory interleukin-1beta, and negatively regulated by dexamethasone...
  14. ncbi request reprint Regulation of stem cell factor expression in inflammation and asthma
    Carla A Da Silva
    Faculte de Pharmacie, Universite Louis Pasteur, 67401 Illkirch Cedex, France
    Mem Inst Oswaldo Cruz 100:145-51. 2005
    ..In conclusion, this review concerns new mechanisms of regulation of SCF expression in inflammation that could lead to potential therapeutic strategy allowing to control mast cell number in the asthmatic airways...
  15. ncbi request reprint Stem cell factor expression, mast cells and inflammation in asthma
    Carla A Da Silva
    EA3771, Inflammation and Environment in Asthma, Faculte de Pharmacie, BP 24, 67401 Illkirch Cedex, France
    Fundam Clin Pharmacol 20:21-39. 2006
    ..We here report the main pathways of SCF synthesis and signalling, and its potential role on airway function and asthma...
  16. ncbi request reprint Dose-dependent effects of endotoxins on allergen sensitization and challenge in the mouse
    C Delayre-Orthez
    Inflammation et Environnement dans l Asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Clin Exp Allergy 34:1789-95. 2004
    ..Levels of endotoxins greatly differ according to environmental settings...
  17. ncbi request reprint In vivo evaluation of a reverse water-in-fluorocarbon emulsion stabilized with a semifluorinated amphiphile as a drug delivery system through the pulmonary route
    H M Courrier
    UMR 7514, Laboratoire de Chimie Bioorganique, Faculte de Pharmacie, Universite Louis Pasteur, 74 route du Rhin, B P 60024, 67401 Illkirch Cedex, France
    Int J Pharm 282:131-40. 2004
    ....
  18. ncbi request reprint [Nerve growth factor (NGF) in inflammation and asthma]
    V Freund
    EA 3771 Inflammation et environnement dans l asthme, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    Rev Mal Respir 21:328-42. 2004
    ..The nerve growth factor (NGF) is known as a factor involved in neuronal growth and survival. From recent studies it may also be considered as a mediator of inflammation, in particular in the airways...
  19. ncbi request reprint The nerve growth factor and its receptors in airway inflammatory diseases
    V Freund-Michel
    EA 3771 Inflammation and Environment in Asthma, University Louis Pasteur Strasbourg I, Faculty of Pharmacy, Illkirch, France
    Pharmacol Ther 117:52-76. 2008
    ....
  20. ncbi request reprint Human lung fibroblasts secrete nerve growth factor: effect of inflammatory cytokines and glucocorticoids
    C Olgart
    , Neuroimmunopharmacologie Pulmonaire, , , Illkirch, France
    Eur Respir J 18:115-21. 2001
    ....
  21. ncbi request reprint Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate
    Carine Delayre-Orthez
    EA3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Eur J Pharmacol 581:177-84. 2008
    ....
  22. ncbi request reprint Effect of glucocorticoids on stem cell factor expression in human asthmatic bronchi
    C A da Silva
    EA 3771, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, Cedex, France
    Clin Exp Allergy 36:317-24. 2006
    ..Regulation of SCF expression by glucocorticoids has not yet been reported in human asthmatic bronchi...
  23. ncbi request reprint Duration of the antihistaminic effect after discontinuation of ebastine
    N Frossard
    INSRM U425, BP 24, 67401 Illkirch Cedex, France
    Allergy 56:553-7. 2001
    ..Therefore, patients using ebastine need to be antihistamine-free for 4 days before the skin prick test. This is valuable information for the allergologist seeking to diagnose allergen sensitivity...
  24. ncbi request reprint Difference in exposure to airborne major rat allergen (Rat n 1) and to endotoxin in rat quarters according to tasks
    F Lieutier-Colas
    , Service de Pneumologie, , Strasbourg, France
    Clin Exp Allergy 31:1449-56. 2001
    ..CONCLUSIONS: Exposure to airborne Rat n 1 and endotoxin is higher during cleaning and feeding tasks than during any other task, we feel that a major source of both is contaminated bedding that becomes airborne during disturbance...
  25. ncbi request reprint Altered expression of lung cytochrome P450 3A1 in rat after exposure to sulfur mustard
    F Pons
    INSERM U425, Faculty of Pharmacy, lllkirch, France
    Pharmacol Toxicol 88:40-4. 2001
    ..Taking into account the major role of CYP of the 3A family in the metabolism of drugs, up-regulation of CYP 3A1 by sulfur mustard might have important therapeutic consequences...
  26. ncbi request reprint Upregulation of nerve growth factor expression by human airway smooth muscle cells in inflammatory conditions
    V Freund
    National Institute of Health and Medical Research INSERM, Unit 425, Neuroimmunopharmacologie Pulmonaire, Faculty of Pharmacy, University Louis Pasteur Strasbourg I, Illkirch, France
    Eur Respir J 20:458-63. 2002
    ....
  27. pmc PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse
    Carine Delayre-Orthez
    EA 3771, Inflammation et Environnement dans l Asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Respir Res 6:91. 2005
    ....
  28. ncbi request reprint Transcription of stem cell factor (SCF) is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element
    Carla Alexandra Da Silva
    INSERM U425, Université Louis Pasteur Strasbourg I, France
    FASEB J 17:2334-6. 2003
    ....
  29. ncbi request reprint TrkA signalling pathways in human airway smooth muscle cell proliferation
    Véronique Freund-Michel
    EA 3771 Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, 74 route du Rhin, BP 60024, 67401 Illkirch Cedex, France
    Cell Signal 18:621-7. 2006
    ..In conclusion, NGF activation of the TrkA receptor involves two distinct signalling pathways: PKC selectively activates p38, and the ras/raf pathway selectively activates ERK1/2. Both are necessary to induce HASMC proliferation...
  30. ncbi request reprint Potential role of stem cell factor in the asthma control by glucocorticoids
    Carla Alexandra Da Silva
    EA 3771, Inflammation and Environment in Asthma, Faculte de Pharmacie, Illkirch, France carla da
    Chem Immunol Allergy 87:154-62. 2005
    ..Thus, SCF could be involved in mast cell-associated diseases such as asthma. We here review the main effects of glucocorticoids in asthma and on mast cells, with a special interest on SCF, as a potential therapeutic target in asthma...
  31. ncbi request reprint Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
    Laurent Reber
    EA 3771 Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    Eur J Pharmacol 533:327-40. 2006
    ..Taken together, these data suggest that SCF/c-Kit may be a potential therapeutic target for the control of mast cell and eosinophil number and activation in inflammatory diseases...
  32. ncbi request reprint Exposure to endotoxins during sensitization prevents further endotoxin-induced exacerbation of airway inflammation in a mouse model of allergic asthma
    Carine Delayre-Orthez
    EA 3771, Inflammation et Environnement dans l Asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Int Arch Allergy Immunol 138:298-304. 2005
    ..We have here investigated the effect of LPS administered during both sensitization and challenge on airway inflammation, as well as on the profile of the T-helper (Th) response to allergen...
  33. ncbi request reprint Nerve growth factor and its receptors in asthma and inflammation
    Nelly Frossard
    EA 3771 Inflammation and Environment in Asthma Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    Eur J Pharmacol 500:453-65. 2004
    ....
  34. ncbi request reprint Inflammatory conditions increase expression of protease-activated receptor-2 by human airway smooth muscle cells in culture
    Véronique Freund-Michel
    EA 3771 Inflammation and Environment in Asthma, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Fundam Clin Pharmacol 20:351-7. 2006
    ..This increased expression of PAR-2 in inflammatory conditions may have functional consequences in the bronchial dysfunction of asthmatic airways...
  35. ncbi request reprint Expression of nerve growth factor in the airways and its possible role in asthma
    Véronique Freund
    Institut National de la Sante et de la Recherche Medicale, Unité 425, Neuroimmunopharmacologie Pulmonaire, Universite Louis Pasteur, Strasburg I, Faculte de Pharmacie, France
    Prog Brain Res 146:335-46. 2004
    ..Taken together, these results suggest that NGF is an important mediator in both inflammation and asthma...
  36. pmc Paradoxical early glucocorticoid induction of stem cell factor (SCF) expression in inflammatory conditions
    Carla Alexandra Da Silva
    INSERM U425, Université Louis Pasteur Strasbourg I, France
    Br J Pharmacol 141:75-84. 2004
    ....
  37. pmc Twenty-four-hour activity and consistency of activity of levocetirizine and desloratadine in the skin
    Ashok Purohit
    INSERM U425, Service de Pneumologie, Hopitaux Universitaires, Strasbourg, France
    Br J Clin Pharmacol 56:388-94. 2003
    ..We set out to compare their antihistaminic activity in the skin for 24 h in a double-blind, randomized cross-over trial...
  38. pmc Inhibition by glucocorticoids of the interleukin-1beta-enhanced expression of the mast cell growth factor SCF
    Carla Alexandra Da Silva
    INSERM U425, Université Louis Pasteur Strasbourg I, 67401 Illkirch Cedex, France
    Br J Pharmacol 135:1634-40. 2002
    ..The reduced number and activation of mast cells observed in the bronchi of asthmatic patients treated by glucocorticoids may be due in part to this effect...
  39. doi request reprint Overexpression of functional TrkA receptors after internalisation in human airway smooth muscle cells
    Véronique Freund-Michel
    EA 3771 Inflammation and Environment in Asthma, University Louis Pasteur Strasbourg I, Faculty of Pharmacy, Illkirch, France
    Biochim Biophys Acta 1783:1964-71. 2008
    ..This may have pathophysiological consequences in airway inflammatory diseases...
  40. pmc Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation
    Laurent Reber
    EA3771, Inflammation and Environment in Asthma, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, Illkirch, France
    PLoS ONE 4:e4393. 2009
    ..Our study provides therefore a direct link between MSK1-mediated phosphorylation of Ser276 p65 of NF-kappaB, allowing its binding to the SCF intronic enhancer, and pathophysiological SCF expression in inflammation...
  41. ncbi request reprint Expression of cytochromes P450 3A in mouse lung: effects of dexamethasone and pregnenolone 16alpha-carbonitrile
    Muriel Haag
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74 route du Rhin, BP 2467401, Illkirch Cedex, France
    Arch Toxicol 77:145-9. 2003
    ..This potentiation may involve PXR, expression of which is induced in the lung of glucocorticoid-treated mice...
  42. ncbi request reprint Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta
    Renaud Le Bouquin
    EA Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, BP 60024, 67401 Illkirch, France
    Fundam Clin Pharmacol 18:181-6. 2004
    ..Since IL-1beta has been largely associated with asthma, our data suggest that CYP4A expression could be altered in asthmatic conditions and may thus contribute to changes in airway reactivity...
  43. ncbi request reprint Comparative activity of cetirizine and desloratadine on histamine-induced wheal-and-flare responses during 24 hours
    Ashok Purohit
    INSERM U425 and EA3771, Service de Pneumologie, Hopitaux Universitaires, Strasbourg, France
    Ann Allergy Asthma Immunol 92:635-40. 2004
    ..Cetirizine and desloratadine are antihistamines active in the treatment of symptoms associated with seasonal allergic rhinitis and chronic urticaria...
  44. ncbi request reprint Anti-proliferative effect of Euphorbia stenoclada in human airway smooth muscle cells in culture
    M Chaabi
    UMR CNRS 7175 Pharmacognosie et Molécules Naturelles Bioactives, Faculte de Pharmacie, Universite Louis Pasteur, Strasbourg I, Illkirch, France
    J Ethnopharmacol 109:134-9. 2007
    ..The present study shows that the anti-proliferative properties of Euphorbia stenoclada are mediated through the presence of quercetin that may explain the traditional use of this plant as a remedy against asthma...
  45. ncbi request reprint Similar rapid onset of action and magnitude of effect of fexofenadine and cetirizine as assessed by inhibition of histamine-induced wheal-and-flare reaction
    Ashok Purohit
    INSERM U425 EA3771, Faculte de Pharmacie, Illkirch, and Service de Pneumologie, Hopitaux Universitaires, Strasbourg, France
    Ann Allergy Asthma Immunol 93:562-7. 2004
    ..Histamine-induced wheal-and-flare studies are useful, objective tests for determining differences in the peripheral H1-receptor blockade activities of antihistamines...
  46. ncbi request reprint Regulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?
    Julien Becker
    EA 3771 Inflammation et environnement dans l asthme, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, Illkirch, France
    Fundam Clin Pharmacol 20:429-47. 2006
    ....
  47. ncbi request reprint Evaluation of cytotoxicity of new semi-fluorinated amphiphiles derived from dimorpholinophosphate
    H M Courrier
    Laboratoire de Chimie Thérapeutique et Nutritionnelle Biodisponibilité Tissulaire et Cellulaire, Faculte de Pharmacie, Universite Louis Pasteur, 67401 Illkirch Cedex, France
    Biomaterials 24:689-96. 2003
    ..Furthermore, water-in-fluorocarbon emulsions stabilized with F8H11DMP and F10H11DMP appeared to be non-cytotoxic towards HLEC in culture...
  48. doi request reprint Small neutralizing molecules to inhibit actions of the chemokine CXCL12
    Muriel Hachet-Haas
    Institut Gilbert Laustriat Biomolécules, Biotechnologie, Innovation Therapeutique, Universite Louis Pasteur, 67401 Illkirch, France
    J Biol Chem 283:23189-99. 2008
    ..By analogy to the effect of neutralizing antibodies, this molecule behaves as a small organic neutralizing compound that may prove to have valuable pharmacological and therapeutic potential...
  49. ncbi request reprint Transforming growth factor-beta and its role in asthma
    Catherine Duvernelle
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, 74, route du Rhin, B P 24, 67401 Illkirch Cedex, France
    Pulm Pharmacol Ther 16:181-96. 2003
    ..However, as its role is dual in the modulation of inflammation, further studies are needed to elucidate the precise role of TGF-beta in the airways...
  50. ncbi request reprint Nerve growth factor and asthma
    Caroline Olgart Hoglund
    Institut National de la Santé et de la Recherche Médicale Unité 425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, B P 24, 67 401 Illkirch Cedex, France
    Pulm Pharmacol Ther 15:51-60. 2002
  51. ncbi request reprint Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma
    Muriel Haag
    INSERM U425, Neuroimmunopharmacologie Pulmonaire, Faculte de Pharmacie, Université Louis Pasteur Strasbourg I, BP 24, 67401 Illkirch Cedex, France
    Arch Toxicol 76:621-7. 2002
    ..However, this effect is associated with a decreased enzyme activity, which might limit the toxicological consequences of increased Cyp1a1 expression...
  52. ncbi request reprint Role of tachykinin NK3 receptors in the release and effects of nerve growth factor in human isolated bronchi
    Emmanuel Naline
    Research Unit EA220, Universite de Versailles, Faculte de Medecine, Pharmacology, Hopital Foch, 40 rue Worth, 92150 Suresnes, France
    Eur J Pharmacol 560:206-11. 2007
    ..05). SR142801 also inhibited the NGF-induced airway hyperresponsiveness (P<0.01). This study suggests tachykininergic sensory nerves to be involved in the interleukin-1beta-induced NGF release and airway hyperresponsiveness...
  53. doi request reprint Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging
    François Xavier Blé
    Respiratory Diseases Department, Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, WSJ 386 2 09, CH 4002 Basel, Switzerland
    Radiology 248:834-43. 2008
    ..To demonstrate the feasibility of using proton magnetic resonance (MR) imaging to noninvasively detect extravascular and luminal fluid in a murine model of allergen-induced airway inflammation...
  54. ncbi request reprint Acid-induced modulation of airway basal tone and contractility: role of acid-sensing ion channels (ASICs) and TRPV1 receptor
    Christophe Faisy
    Research Unit UPRES EA220, Université Versailles Saint Quentin, Hopital Foch, 40 rue Worth, 92150 Suresnes, France
    Life Sci 81:1094-102. 2007
    ..Conversely, the pH-induced hyperresponsiveness involves sensory nerves-dependent ASICs and TRPV1, and an unknown epithelial component in response to acidosis...
  55. ncbi request reprint Expression of substance P and nitric oxide synthase in vagal sensory neurons innervating the mouse airways
    Q Thai Dinh
    Department of Internal Medicine, Charite School of Medicine, Humboldt University, Berlin, Germany
    Regul Pept 126:189-94. 2005
    ..The aim of the present study was to investigate substance P and neuronal nitric oxide synthase (NOS-1) expression in airway-specific sensory neurons...