- Taurine: the comeback of a neutraceutical in the prevention of retinal degenerationsNicolas Froger
INSERM, U968, Institut de la Vision, Paris, France Sorbonne Universités, Universite Pierre et Marie Curie Paris 6, UMR S 968, Institut de la Vision, Paris, France CNRS, UMR 7210, Institut de la Vision, Paris, France Electronic address
Prog Retin Eye Res 41:44-63. 2014..Along with other antioxidant molecules, taurine should therefore be seriously reconsidered as a potential treatment for such retinal diseases. ..
- Taurine provides neuroprotection against retinal ganglion cell degenerationNicolas Froger
Institut National de la Santé et de la Recherche Médicale UMR 968, Institut de la Vision, Paris, France
PLoS ONE 7:e42017. 2012..This study indicates that enriched taurine nutrition can directly promote RGC survival through RGC intracellular pathways. It provides evidence that taurine can positively interfere with retinal degenerative diseases...
- Taurine is a crucial factor to preserve retinal ganglion cell survivalNicolas Froger
INSERM, U968, Institut de la Vision, Paris, France
Adv Exp Med Biol 775:69-83. 2013..These data suggest that the retinal taurine level is a crucial marker to prevent RGC damage in major retinal diseases...
- Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotectiveNicolas Froger
Inserm U840, College de France, 11 place Marcelin Berthelot, 75231 Paris, Cedex 05, France
Mol Cell Neurosci 45:37-46. 2010..Altogether, these data demonstrate that inflammation-induced astroglial hemichannel activation plays a critical role in neuronal death and suggest a neuroprotective role of connexin43 hemichannel blockade...
- Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatmentsNicolas Froger
Institut National de la Sante et de la Recherche Medicale, U840, Paris, France
J Neurochem 111:1383-97. 2009....
- Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloidWilliam Meme
INSERM U587, College de France, Paris, France
FASEB J 20:494-6. 2006..Thus, the suppression of communication between astrocytes, induced by activated MG could contribute to the proposed role of reactive gliosis in this neurodegenerative disease...
- Taurine deficiency damages retinal neurones: cone photoreceptors and retinal ganglion cellsDavid Gaucher
INSERM, U 968, Insitut de la Vision Retinal Information Processing Pharmacology and Pathologies, 17, rue Moreau, 75012 Paris, France
Amino Acids 43:1979-93. 2012..Cone photoreceptors and retinal ganglion cells appear as the most sensitive cells to taurine deficiency. These results may explain the recent therapeutic interest of taurine in retinal degenerative pathologies...