Research Topics
Genomes and Genes | J N FreundSummaryCountry: France Publications
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Publications
The rudimentary gene of Drosophila melanogaster encodes four enzymic functionsJ N Freund
J Mol Biol 193:1-13. 1987..We have found that the corresponding mammalian gene, the CAD gene, exhibits a similar functional organization, and we propose schemes for the evolution of the corresponding coding sequences...- The Cdx-1 and Cdx-2 homeobox genes in the intestineJ N Freund
Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
Biochem Cell Biol 76:957-69. 1998..The participation of these genes in colon tumorigenesis and their identification as important actors of the oncogenic process are also discussed... 
Cellular and molecular partners involved in gut morphogenesis and differentiationM Kedinger
INSERM Unit 381, Development and Pathology of the Digestive Tract, Strasbourg, France
Philos Trans R Soc Lond B Biol Sci 353:847-56. 1998....- Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cellsI Duluc
Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
J Cell Sci 110:1317-24. 1997..They also indicate that the level of Cdx-1 and Cdx-2 homeobox gene expression is influenced by epithelial-mesenchymal cell interactions in the intestinal mucosa... - Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiationO Lorentz
Institut National de la Sante et de la Recherche Medicale, Unité 381, 67200 Strasbourg, France
J Cell Biol 139:1553-65. 1997..Hence, we conclude that Cdx2 plays a key role in the extracellular matrix-mediated intestinal cell differentiation... - Intestinal epithelial-mesenchymal cell interactionsM Kedinger
INSERM, Unit 381 Ontogenesis and Pathology of the Gut, Strasbourg, France
Ann N Y Acad Sci 859:1-17. 1998..Finally the epithelial-mesenchymal unit is controlled by hormonal and exogenous factors... - The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cellsI Gross
INSERM, U682, Strasbourg, France
Oncogene 27:107-15. 2008..These data provide evidence that Cdx2 antagonizes the process of tumor cell dissemination, and they suggest that this homeobox gene might represent a new therapeutic target against metastatic spreading of colon cancer... 
Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancerC Bonhomme
INSERM, U682, Strasbourg, France
Oncogene 27:4497-502. 2008..We conclude that Cdx1 is dispensable for intestinal development and that its overexpression could increase malignancy in early stages of tumourigenesis...- Differentially expressed endoderm and mesenchyme genes along the fetal rat intestineI Duluc
Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
Genesis 29:55-9. 2001..The selected genes are involved in several aspects of cell physiology, including metabolic pathways, cytoskeleton organization, signal transduction, protein biosynthesis, and regulation of gene transcription... - Adaptation of intestinal hydrolases to starvation in rats: effect of thyroid functionM Galluser
, INSERM U 61, Strasbourg, France
J Comp Physiol B 161:357-61. 1991..These adaptive processes seemed to be partly controlled at a post-transcriptional level... - Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs)J N Freund
INSERM Unite 381, Strasbourg, France
Biochem J 322:491-8. 1997..These data provide evidence that proteins phylogenetically related to the mammalian-specific lactase are widespread in the animal kingdom, and that these proteins are expressed in the intestinal tract... - Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survivalI Gross
U682 INSERM, 3 avenue Moliere, Strasbourg 67200, France
Cell Death Differ 14:1802-12. 2007..Together, our results imply that Spry2 is involved in the development of the CNS by inhibiting both neuronal differentiation and survival through a negative-feedback loop that downregulates neurotrophic factors-driven signaling pathways... - Sequence of the precursor of intestinal lactase-phlorizin hydrolase from fetal ratI Duluc
INSERM U61, Strasbourg, France
Gene 103:275-6. 1991..The precursor consists of four tandemly organized homologous domains flanked by a signal peptide in the N-terminal region and by a transmembrane peptide in the C-terminal region... - Involvement of T3Ralpha- and beta-receptor subtypes in mediation of T3 functions during postnatal murine intestinal developmentM Plateroti
INSERM Unite 381, Strasbourg, France
Gastroenterology 116:1367-78. 1999..Their effects are mediated by nuclear receptors, which are transcriptional regulators activated upon binding of triiodothyronine. The aim of this study was to define the involvement of the receptor subtypes during intestinal development... - Gradient expression of Cdx along the rat intestine throughout postnatal developmentJ N Freund
INSERM U61, Strasbourg, France
FEBS Lett 314:163-6. 1992..No obvious correlation could be established with the patterns of expression of transcripts corresponding to markers of cell proliferation and cell differentiation during postnatal development... - Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancerT Saandi
1 INSERM, Unit 682, Strasbourg, France 2 Facult de M decine, Universit de Strasbourg, Strasbourg, France
Oncogene . 2012..Consistently, similar to Cdx2, HNF4α exerts a tumor suppressor function in the colon in that its loss of function facilitates tumor progression.Oncogene advance online publication, 17 September 2012; doi:10.1038/onc.2012.401... - Functional interference between thyroid hormone receptor alpha (TRalpha) and natural truncated TRDeltaalpha isoforms in the control of intestine developmentM Plateroti
Laboratoire de Biologie Moléculaire et Cellulaire de l ENS de Lyon, UMR 5665 CNRS, LA 913 INRA, 69364 Lyon Cedex 07, France
Mol Cell Biol 21:4761-72. 2001.... - Molecular organization of the rudimentary gene of Drosophila melanogasterJ N Freund
J Mol Biol 189:25-36. 1986..This is in good agreement with the genetic map of the locus, which indicates that the enzymic activities encoded by the gene are organized linearly along the DNA... - Organization of transcription units around the Drosophila melanogaster rudimentary locus and temporal pattern of expressionJ M Rawls
Mol Gen Genet 202:493-9. 1986..The accumulation of the r product correlates well with the enzymatic activity determined for the protein product of the gene, being highest in very early embryos and adult females...