J N Freund

Summary

Country: France

Publications

  1. ncbi request reprint The rudimentary gene of Drosophila melanogaster encodes four enzymic functions
    J N Freund
    J Mol Biol 193:1-13. 1987
  2. ncbi request reprint The Cdx-1 and Cdx-2 homeobox genes in the intestine
    J N Freund
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    Biochem Cell Biol 76:957-69. 1998
  3. pmc Cellular and molecular partners involved in gut morphogenesis and differentiation
    M Kedinger
    INSERM Unit 381, Development and Pathology of the Digestive Tract, Strasbourg, France
    Philos Trans R Soc Lond B Biol Sci 353:847-56. 1998
  4. pmc Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation
    O Lorentz
    Institut National de la Sante et de la Recherche Medicale, Unité 381, 67200 Strasbourg, France
    J Cell Biol 139:1553-65. 1997
  5. ncbi request reprint Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells
    I Duluc
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    J Cell Sci 110:1317-24. 1997
  6. ncbi request reprint The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells
    I Gross
    INSERM, U682, Strasbourg, France
    Oncogene 27:107-15. 2008
  7. ncbi request reprint Intestinal epithelial-mesenchymal cell interactions
    M Kedinger
    INSERM, Unit 381 Ontogenesis and Pathology of the Gut, Strasbourg, France
    Ann N Y Acad Sci 859:1-17. 1998
  8. ncbi request reprint Differentially expressed endoderm and mesenchyme genes along the fetal rat intestine
    I Duluc
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    Genesis 29:55-9. 2001
  9. doi request reprint Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer
    C Bonhomme
    INSERM, U682, Strasbourg, France
    Oncogene 27:4497-502. 2008
  10. pmc Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells
    C Domon-Dell
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    Gut 50:525-9. 2002

Collaborators

  • I Duluc
  • M Kedinger
  • Patricia Simon-Assmann
  • Francis Raul
  • S Kim
  • Q Wang
  • T Brabletz
  • O Lefebvre
  • O Chassande
  • C Gaiddon
  • E Martin
  • C Domon-Dell
  • I Gross
  • T Saandi
  • L Derbal-Wolfrom
  • M Plateroti
  • C Bonhomme
  • A Calon
  • E Pencreach
  • P Cardot
  • A L Cattin
  • R Greferath
  • F Benahmed
  • J M Lehn
  • E Tufa
  • P Choquet
  • M Aprahamian
  • A Ribeiro
  • B Duclos
  • F Baraille
  • C Nicolau
  • J Samarut
  • K Gauthier
  • S Robine
  • T Benameur
  • A Neuville
  • O Armant
  • J L G de Aguilar
  • J D Licht
  • J P Loeffler
  • S Benosman
  • O Lorentz
  • B M Evers
  • A Fraichard
  • A D Arcangelis
  • M Galluser
  • J M Rawls
  • M Danielsen
  • R Belkhou
  • C Louis
  • W A Segraves
  • B P Jarry
  • P Schedl
  • N Torp

Detail Information

Publications21

  1. ncbi request reprint The rudimentary gene of Drosophila melanogaster encodes four enzymic functions
    J N Freund
    J Mol Biol 193:1-13. 1987
    ..We have found that the corresponding mammalian gene, the CAD gene, exhibits a similar functional organization, and we propose schemes for the evolution of the corresponding coding sequences...
  2. ncbi request reprint The Cdx-1 and Cdx-2 homeobox genes in the intestine
    J N Freund
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    Biochem Cell Biol 76:957-69. 1998
    ..The participation of these genes in colon tumorigenesis and their identification as important actors of the oncogenic process are also discussed...
  3. pmc Cellular and molecular partners involved in gut morphogenesis and differentiation
    M Kedinger
    INSERM Unit 381, Development and Pathology of the Digestive Tract, Strasbourg, France
    Philos Trans R Soc Lond B Biol Sci 353:847-56. 1998
    ....
  4. pmc Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation
    O Lorentz
    Institut National de la Sante et de la Recherche Medicale, Unité 381, 67200 Strasbourg, France
    J Cell Biol 139:1553-65. 1997
    ..Hence, we conclude that Cdx2 plays a key role in the extracellular matrix-mediated intestinal cell differentiation...
  5. ncbi request reprint Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells
    I Duluc
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    J Cell Sci 110:1317-24. 1997
    ..They also indicate that the level of Cdx-1 and Cdx-2 homeobox gene expression is influenced by epithelial-mesenchymal cell interactions in the intestinal mucosa...
  6. ncbi request reprint The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells
    I Gross
    INSERM, U682, Strasbourg, France
    Oncogene 27:107-15. 2008
    ..These data provide evidence that Cdx2 antagonizes the process of tumor cell dissemination, and they suggest that this homeobox gene might represent a new therapeutic target against metastatic spreading of colon cancer...
  7. ncbi request reprint Intestinal epithelial-mesenchymal cell interactions
    M Kedinger
    INSERM, Unit 381 Ontogenesis and Pathology of the Gut, Strasbourg, France
    Ann N Y Acad Sci 859:1-17. 1998
    ..Finally the epithelial-mesenchymal unit is controlled by hormonal and exogenous factors...
  8. ncbi request reprint Differentially expressed endoderm and mesenchyme genes along the fetal rat intestine
    I Duluc
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    Genesis 29:55-9. 2001
    ..The selected genes are involved in several aspects of cell physiology, including metabolic pathways, cytoskeleton organization, signal transduction, protein biosynthesis, and regulation of gene transcription...
  9. doi request reprint Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer
    C Bonhomme
    INSERM, U682, Strasbourg, France
    Oncogene 27:4497-502. 2008
    ..We conclude that Cdx1 is dispensable for intestinal development and that its overexpression could increase malignancy in early stages of tumourigenesis...
  10. pmc Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells
    C Domon-Dell
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    Gut 50:525-9. 2002
    ....
  11. doi request reprint Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer
    T Saandi
    INSERM, Unité 682, Strasbourg, France
    Oncogene 32:3782-8. 2013
    ..Consistently, similar to Cdx2, HNF4α exerts a tumor suppressor function in the colon in that its loss of function facilitates tumor progression. ..
  12. doi request reprint Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2
    L Derbal-Wolfrom
    INSERM U682, Strasbourg, France
    Oncogene 32:4313-8. 2013
    ..The present study provides evidence that a chemical compound that increases oxygen pressure can antagonize the hypoxic setting and reduce the growth of human colon tumors implanted in nu/nu mice...
  13. pmc Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs)
    J N Freund
    INSERM Unite 381, Strasbourg, France
    Biochem J 322:491-8. 1997
    ..These data provide evidence that proteins phylogenetically related to the mammalian-specific lactase are widespread in the animal kingdom, and that these proteins are expressed in the intestinal tract...
  14. ncbi request reprint Adaptation of intestinal hydrolases to starvation in rats: effect of thyroid function
    M Galluser
    , INSERM U 61, Strasbourg, France
    J Comp Physiol B 161:357-61. 1991
    ..These adaptive processes seemed to be partly controlled at a post-transcriptional level...
  15. ncbi request reprint Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival
    I Gross
    U682 INSERM, 3 avenue Moliere, Strasbourg 67200, France
    Cell Death Differ 14:1802-12. 2007
    ..Together, our results imply that Spry2 is involved in the development of the CNS by inhibiting both neuronal differentiation and survival through a negative-feedback loop that downregulates neurotrophic factors-driven signaling pathways...
  16. ncbi request reprint Involvement of T3Ralpha- and beta-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development
    M Plateroti
    INSERM Unite 381, Strasbourg, France
    Gastroenterology 116:1367-78. 1999
    ..Their effects are mediated by nuclear receptors, which are transcriptional regulators activated upon binding of triiodothyronine. The aim of this study was to define the involvement of the receptor subtypes during intestinal development...
  17. ncbi request reprint Sequence of the precursor of intestinal lactase-phlorizin hydrolase from fetal rat
    I Duluc
    INSERM U61, Strasbourg, France
    Gene 103:275-6. 1991
    ..The precursor consists of four tandemly organized homologous domains flanked by a signal peptide in the N-terminal region and by a transmembrane peptide in the C-terminal region...
  18. ncbi request reprint Gradient expression of Cdx along the rat intestine throughout postnatal development
    J N Freund
    INSERM U61, Strasbourg, France
    FEBS Lett 314:163-6. 1992
    ..No obvious correlation could be established with the patterns of expression of transcripts corresponding to markers of cell proliferation and cell differentiation during postnatal development...
  19. pmc Functional interference between thyroid hormone receptor alpha (TRalpha) and natural truncated TRDeltaalpha isoforms in the control of intestine development
    M Plateroti
    Laboratoire de Biologie Moléculaire et Cellulaire de l ENS de Lyon, UMR 5665 CNRS, LA 913 INRA, 69364 Lyon Cedex 07, France
    Mol Cell Biol 21:4761-72. 2001
    ....
  20. ncbi request reprint Organization of transcription units around the Drosophila melanogaster rudimentary locus and temporal pattern of expression
    J M Rawls
    Mol Gen Genet 202:493-9. 1986
    ..The accumulation of the r product correlates well with the enzymatic activity determined for the protein product of the gene, being highest in very early embryos and adult females...
  21. ncbi request reprint Molecular organization of the rudimentary gene of Drosophila melanogaster
    J N Freund
    J Mol Biol 189:25-36. 1986
    ..This is in good agreement with the genetic map of the locus, which indicates that the enzymic activities encoded by the gene are organized linearly along the DNA...