C Francois

Summary

Country: France

Publications

  1. ncbi Dopaminergic cell group A8 in the monkey: anatomical organization and projections to the striatum
    C Francois
    INSERM U289, Mécanismes et Conséquences de la Mort Neuronale, Hopital de la Salpetriere, 75013, Paris, France
    J Comp Neurol 414:334-47. 1999
  2. ncbi Dopaminergic innervation of the subthalamic nucleus in the normal state, in MPTP-treated monkeys, and in Parkinson's disease patients
    C Francois
    INSERM U289, Mécanismes et Conséquences de la Mort Neuronale, Hopital de la Salpetriere, 75013 Paris, France
    J Comp Neurol 425:121-9. 2000
  3. ncbi Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
    Chantal Francois
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 127:2055-70. 2004
  4. ncbi Distribution and morphology of nigral axons projecting to the thalamus in primates
    Chantal Francois
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75013, Paris, France
    J Comp Neurol 447:249-60. 2002
  5. ncbi Behavioural disorders induced by external globus pallidus dysfunction in primates: I. Behavioural study
    David Grabli
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 127:2039-54. 2004
  6. ncbi Parkinson's disease is a neuropsychiatric disorder
    Y Agid
    centre d investigation clinique, INSERM U289, Hopital de la Salpetriere, France
    Adv Neurol 91:365-70. 2003
  7. ncbi Tremor-related activity of neurons in the 'motor' thalamus: changes in firing rate and pattern in the MPTP vervet model of parkinsonism
    D Guehl
    INSERM U 289 Experimental Neurology and Therapeutics, Hopital de la Salpetriere, 47 bd de l Hopital, 75651 Paris Cedex 13, France
    Eur J Neurosci 17:2388-400. 2003
  8. ncbi Localization of D1a dopamine receptors on cell bodies and axonal endings in the substantia nigra pars reticulata of the rat
    C Jan
    INSERM UMR 679, Neurology and Experimental Therapeutics, Paris, France
    J Neural Transm 114:1509-17. 2007
  9. ncbi Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys
    Carine Karachi
    INSERM, UMR_S679, Neurology and Experimental Therapeutics, Paris, France
    Mov Disord 24:1183-92. 2009
  10. ncbi Nondopaminergic neurons in Parkinson's disease
    E C Hirsch
    INSERM U289, Department of Experimental Neurology and Therapeutics, Hopital de la Salpetriere, Paris, France
    Adv Neurol 91:29-37. 2003

Collaborators

Detail Information

Publications26

  1. ncbi Dopaminergic cell group A8 in the monkey: anatomical organization and projections to the striatum
    C Francois
    INSERM U289, Mécanismes et Conséquences de la Mort Neuronale, Hopital de la Salpetriere, 75013, Paris, France
    J Comp Neurol 414:334-47. 1999
    ..In conclusion, each mesencephalic cell group projects primarily to one specific striatal region but also participates, albeit to a lesser extent, in the innervation of all the remaining striatal parts...
  2. ncbi Dopaminergic innervation of the subthalamic nucleus in the normal state, in MPTP-treated monkeys, and in Parkinson's disease patients
    C Francois
    INSERM U289, Mécanismes et Conséquences de la Mort Neuronale, Hopital de la Salpetriere, 75013 Paris, France
    J Comp Neurol 425:121-9. 2000
    ..The loss of dopaminergic innervation in MPTP-intoxicated monkeys and in Parkinson's disease patients may directly affect the activity of STN neurons and could participate in the hyperactivity of the structure...
  3. ncbi Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
    Chantal Francois
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 127:2055-70. 2004
    ..This study provides the basis for further researches with a therapeutical viewpoint...
  4. ncbi Distribution and morphology of nigral axons projecting to the thalamus in primates
    Chantal Francois
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75013, Paris, France
    J Comp Neurol 447:249-60. 2002
    ..These findings demonstrate that the overall morphological organization of individual nigral axons is complex and allows single axons to influence thalamic neurons via a combination of divergent, convergent, and amplification processes...
  5. ncbi Behavioural disorders induced by external globus pallidus dysfunction in primates: I. Behavioural study
    David Grabli
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 127:2039-54. 2004
    ..Thus, our study provides experimental evidence for the involvement of the associative and limbic parts of the basal ganglia in these pathologies. These results may provide the basis for a primate model of these disorders...
  6. ncbi Parkinson's disease is a neuropsychiatric disorder
    Y Agid
    centre d investigation clinique, INSERM U289, Hopital de la Salpetriere, France
    Adv Neurol 91:365-70. 2003
  7. ncbi Tremor-related activity of neurons in the 'motor' thalamus: changes in firing rate and pattern in the MPTP vervet model of parkinsonism
    D Guehl
    INSERM U 289 Experimental Neurology and Therapeutics, Hopital de la Salpetriere, 47 bd de l Hopital, 75651 Paris Cedex 13, France
    Eur J Neurosci 17:2388-400. 2003
    ....
  8. ncbi Localization of D1a dopamine receptors on cell bodies and axonal endings in the substantia nigra pars reticulata of the rat
    C Jan
    INSERM UMR 679, Neurology and Experimental Therapeutics, Paris, France
    J Neural Transm 114:1509-17. 2007
    ....
  9. ncbi Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys
    Carine Karachi
    INSERM, UMR_S679, Neurology and Experimental Therapeutics, Paris, France
    Mov Disord 24:1183-92. 2009
    ..Our study supports the hypothesis that the anteromedial part of the STN is involved in behavioral control...
  10. ncbi Nondopaminergic neurons in Parkinson's disease
    E C Hirsch
    INSERM U289, Department of Experimental Neurology and Therapeutics, Hopital de la Salpetriere, Paris, France
    Adv Neurol 91:29-37. 2003
  11. ncbi Functional mapping of the human globus pallidus: contrasting effect of stimulation in the internal and external pallidum in Parkinson's disease
    J Yelnik
    INSERM U289, Hopital de la Salpetriere, 47 Boulevard de l H opital, F 75013 Paris, France
    Neuroscience 101:77-87. 2000
    ..The effect on akinesia and dyskinesias suggests that stimulation activates pallidal neurons, a result which challenges the generally accepted concept that high-frequency stimulation inactivates neurons in the region stimulated...
  12. ncbi Metabolic activity of cerebellar and basal ganglia-thalamic neurons is reduced in parkinsonism
    Anne Sophie Rolland
    INSERM, UMR679, Neurology and Experimental Therapeutics, Paris, France
    Brain 130:265-75. 2007
    ..Hypoactivity of both the basal ganglia-thalamic and cerebellar-thalamic pathways might therefore be implicated in the development of parkinsonian symptoms...
  13. ncbi Consequences of dopaminergic denervation on the metabolic activity of the cortical neurons projecting to the subthalamic nucleus in the rat
    Gaël Orieux
    Institut National de la Santé et de la Recherche Médicale U 289 Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
    J Neurosci 22:8762-70. 2002
    ....
  14. ncbi Three-dimensional cartography of functional territories in the human striatopallidal complex by using calbindin immunoreactivity
    Carine Karachi
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75013 Paris, France
    J Comp Neurol 450:122-34. 2002
    ..This three-dimensional partitioning of the human striatopallidal complex could help to define functional targets for high-frequency stimulation with greater accuracy and help to identify new stimulation sites...
  15. ncbi A direct prefrontotectal tract against distractibility in the human brain
    Bertrand Gaymard
    INSERM U289 and Service d Explorations Fonctionnelles du Système Nerveux, Hopital de la Salpetriere, Paris, France
    Ann Neurol 53:542-5. 2003
    ....
  16. ncbi Parafascicular nucleus projection to the extrastriatal basal ganglia in monkeys
    Dominique Tande
    INSERM U679, Neurology and Experimental Therapeutics, Pierre and Marie Curie University, Paris, France
    Neuroreport 17:277-80. 2006
    ..Our study provides evidence that the parafascicular nucleus, and especially its medial part, can relay emotional and motivational information back to all basal ganglia components in primates...
  17. ncbi Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method
    Jerome Yelnik
    Institut National de la Santé et de la Recherche Médicale U289, Hopital de la Salpetriere, Paris, France
    J Neurosurg 99:89-99. 2003
    ....
  18. ncbi The pallidosubthalamic projection: an anatomical substrate for nonmotor functions of the subthalamic nucleus in primates
    Carine Karachi
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, Paris, France
    Mov Disord 20:172-80. 2005
    ..These data provide a functional cartography of this structure in primates and suggest that behavioral disorders observed in stimulated parkinsonian patients could result from a dysfunction of the limbic part of the STN...
  19. ncbi Parkin immunoreactivity in the brain of human and non-human primates: an immunohistochemical analysis in normal conditions and in Parkinsonian syndromes
    M Zarate-Lagunes
    INSERM U 289, Hopital de la Salpetriere, 47 bd de l Hopital, 75013 Paris, France
    J Comp Neurol 432:184-96. 2001
    ..Thus, the degeneration of dopaminergic neurons in familial cases of Parkinson's disease with autosomal recessive transmission cannot be explained solely in terms of an alteration of this protein...
  20. ncbi Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuits
    Mathias Pessiglione
    Laboratoire de neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale Unité 679, Hopital de la Salpetriere, 75651 Paris, France
    J Neurosci 25:1523-31. 2005
    ..Thus the major dysfunction after dopamine depletion appeared to be the loss of functional segregation within cortico-BG circuits, which could also be at the heart of parkinsonian pathophysiology...
  21. ncbi Effect of intrastriatal 6-OHDA lesion on dopaminergic innervation of the rat cortex and globus pallidus
    Thomas Debeir
    INSERM U679, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013, Paris, France
    Exp Neurol 193:444-54. 2005
    ....
  22. doi Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxication
    Anne Sophie Rolland
    INSERM, UMR_S975, Experimental Therapeutics of Neurodegeneration, Paris, France
    J Neurochem 110:1321-9. 2009
    ....
  23. ncbi Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys
    Caroline Jan
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013, Paris, France
    Eur J Neurosci 18:2082-6. 2003
    ..The preservation of dopaminergic innervation of the limbic part of cerebral structures may explain the preservation of motivational processes mediated by these limbic regions in MPTP-treated monkeys...
  24. ncbi New striatal dopamine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogenesis
    Dominique Tande
    INSERM U679, Neurology and Experimental Therapeutics, Salpetriere Hospital, Paris, France
    Brain 129:1194-200. 2006
    ..Understanding of the molecular signals mediating this phenotypic shift might help in developing novel and elegant strategies for a cell-based therapy for Parkinson's disease that would avoid many of the drawbacks of cell transplantation...
  25. ncbi Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism: II. Effects of reward preference
    Mathias Pessiglione
    Neurologie et Thérapeutique expérimentale INSERM U289, Hopital de la Salpetriere, Paris, France
    Eur J Neurosci 19:437-46. 2004
    ..Thus, the preserved motivational processes may help to overcome executive dysfunction in the early stages of human PD...
  26. pmc Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease
    Carine Karachi
    Universite Pierre et Marie Curie Paris 6, CR Icm, UMR S975, Paris, France
    J Clin Invest 120:2745-54. 2010
    ..Our data therefore reveal that the cholinergic neurons of the PPN play a central role in controlling gait and posture and represent a possible target for pharmacological treatment of gait disorders in PD...