Research Topics
| C FrancoisSummaryCountry: France Publications
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Detail Information
Publications
Dopaminergic cell group A8 in the monkey: anatomical organization and projections to the striatumC Francois
INSERM U289, Mécanismes et Conséquences de la Mort Neuronale, Hopital de la Salpetriere, 75013, Paris, France
J Comp Neurol 414:334-47. 1999..In conclusion, each mesencephalic cell group projects primarily to one specific striatal region but also participates, albeit to a lesser extent, in the innervation of all the remaining striatal parts...- Dopaminergic innervation of the subthalamic nucleus in the normal state, in MPTP-treated monkeys, and in Parkinson's disease patientsC Francois
INSERM U289, Mécanismes et Conséquences de la Mort Neuronale, Hopital de la Salpetriere, 75013 Paris, France
J Comp Neurol 425:121-9. 2000..The loss of dopaminergic innervation in MPTP-intoxicated monkeys and in Parkinson's disease patients may directly affect the activity of STN neurons and could participate in the hyperactivity of the structure... - Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical studyChantal Francois
Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
Brain 127:2055-70. 2004..This study provides the basis for further researches with a therapeutical viewpoint... - Distribution and morphology of nigral axons projecting to the thalamus in primatesChantal Francois
INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75013, Paris, France
J Comp Neurol 447:249-60. 2002..These findings demonstrate that the overall morphological organization of individual nigral axons is complex and allows single axons to influence thalamic neurons via a combination of divergent, convergent, and amplification processes... - Behavioural disorders induced by external globus pallidus dysfunction in primates: I. Behavioural studyDavid Grabli
, INSERM U289, , Paris, France
Brain 127:2039-54. 2004..Thus, our study provides experimental evidence for the involvement of the associative and limbic parts of the basal ganglia in these pathologies. These results may provide the basis for a primate model of these disorders... - Tremor-related activity of neurons in the 'motor' thalamus: changes in firing rate and pattern in the MPTP vervet model of parkinsonismD Guehl
INSERM U 289 Experimental Neurology and Therapeutics, Hopital de la Salpetriere, 47 bd de l Hopital, 75651 Paris Cedex 13, France
Eur J Neurosci 17:2388-400. 2003.... - Localization of D1a dopamine receptors on cell bodies and axonal endings in the substantia nigra pars reticulata of the ratC Jan
INSERM UMR 679, Neurology and Experimental Therapeutics, Paris, France
J Neural Transm 114:1509-17. 2007.... 
Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeysCarine Karachi
INSERM, UMR_S679, Neurology and Experimental Therapeutics, Paris, France
Mov Disord 24:1183-92. 2009..Our study supports the hypothesis that the anteromedial part of the STN is involved in behavioral control...- Functional mapping of the human globus pallidus: contrasting effect of stimulation in the internal and external pallidum in Parkinson's diseaseJ Yelnik
INSERM U289, Hopital de la Salpetriere, 47 Boulevard de l H opital, F 75013 Paris, France
Neuroscience 101:77-87. 2000..The effect on akinesia and dyskinesias suggests that stimulation activates pallidal neurons, a result which challenges the generally accepted concept that high-frequency stimulation inactivates neurons in the region stimulated... - Metabolic activity of cerebellar and basal ganglia-thalamic neurons is reduced in parkinsonismAnne Sophie Rolland
INSERM, UMR679, Neurology and Experimental Therapeutics, Paris, France
Brain 130:265-75. 2007..Hypoactivity of both the basal ganglia-thalamic and cerebellar-thalamic pathways might therefore be implicated in the development of parkinsonian symptoms... - Consequences of dopaminergic denervation on the metabolic activity of the cortical neurons projecting to the subthalamic nucleus in the ratGaël Orieux
Institut National de la Santé et de la Recherche Médicale U 289 Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
J Neurosci 22:8762-70. 2002.... - Nondopaminergic neurons in Parkinson's diseaseE C Hirsch
INSERM U289, Department of Experimental Neurology and Therapeutics, , Paris, France
Adv Neurol 91:29-37. 2003 - Three-dimensional cartography of functional territories in the human striatopallidal complex by using calbindin immunoreactivityCarine Karachi
INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75013 Paris, France
J Comp Neurol 450:122-34. 2002..This three-dimensional partitioning of the human striatopallidal complex could help to define functional targets for high-frequency stimulation with greater accuracy and help to identify new stimulation sites... - The pallidosubthalamic projection: an anatomical substrate for nonmotor functions of the subthalamic nucleus in primatesCarine Karachi
INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, Paris, France
Mov Disord 20:172-80. 2005..These data provide a functional cartography of this structure in primates and suggest that behavioral disorders observed in stimulated parkinsonian patients could result from a dysfunction of the limbic part of the STN... - A direct prefrontotectal tract against distractibility in the human brainBertrand Gaymard
INSERM U289 and Service d Explorations Fonctionnelles du Système Nerveux, Hopital de la Salpetriere, Paris, France
Ann Neurol 53:542-5. 2003.... - Parafascicular nucleus projection to the extrastriatal basal ganglia in monkeysDominique Tande
INSERM U679, Neurology and Experimental Therapeutics, Pierre and Marie Curie University, Paris, France
Neuroreport 17:277-80. 2006..Our study provides evidence that the parafascicular nucleus, and especially its medial part, can relay emotional and motivational information back to all basal ganglia components in primates... - Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration methodJerome Yelnik
Institut National de la Santé et de la Recherche Médicale U289, Hopital de la Salpetriere, Paris, France
J Neurosurg 99:89-99. 2003.... - Parkin immunoreactivity in the brain of human and non-human primates: an immunohistochemical analysis in normal conditions and in Parkinsonian syndromesM Zarate-Lagunes
INSERM U 289, Hopital de la Salpetriere, 47 bd de l Hopital, 75013 Paris, France
J Comp Neurol 432:184-96. 2001..Thus, the degeneration of dopaminergic neurons in familial cases of Parkinson's disease with autosomal recessive transmission cannot be explained solely in terms of an alteration of this protein... - Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuitsMathias Pessiglione
, , , 75651 Paris, France
J Neurosci 25:1523-31. 2005..Thus the major dysfunction after dopamine depletion appeared to be the loss of functional segregation within cortico-BG circuits, which could also be at the heart of parkinsonian pathophysiology... - Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxicationAnne Sophie Rolland
INSERM, UMR_S975, Experimental Therapeutics of Neurodegeneration, Paris, France
J Neurochem 110:1321-9. 2009.... - Effect of intrastriatal 6-OHDA lesion on dopaminergic innervation of the rat cortex and globus pallidusThomas Debeir
INSERM U679, , , , 75013, Paris, France
Exp Neurol 193:444-54. 2005.... - Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeysCaroline Jan
INSERM U289, , , , 75013, Paris, France
Eur J Neurosci 18:2082-6. 2003..The preservation of dopaminergic innervation of the limbic part of cerebral structures may explain the preservation of motivational processes mediated by these limbic regions in MPTP-treated monkeys... - New striatal dopamine neurons in MPTP-treated macaques result from a phenotypic shift and not neurogenesisDominique Tande
INSERM U679, Neurology and Experimental Therapeutics, Salpetriere Hospital, Paris, France
Brain 129:1194-200. 2006..Understanding of the molecular signals mediating this phenotypic shift might help in developing novel and elegant strategies for a cell-based therapy for Parkinson's disease that would avoid many of the drawbacks of cell transplantation... - Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism: II. Effects of reward preferenceMathias Pessiglione
, , Paris, France
Eur J Neurosci 19:437-46. 2004..Thus, the preserved motivational processes may help to overcome executive dysfunction in the early stages of human PD... 
Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson diseaseCarine Karachi
Universite Pierre et Marie Curie Paris 6, CR Icm, UMR S975, Paris, France
J Clin Invest 120:2745-54. 2010..Our data therefore reveal that the cholinergic neurons of the PPN play a central role in controlling gait and posture and represent a possible target for pharmacological treatment of gait disorders in PD...