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Genomes and Genes | Pierre Edouard FournierSummaryCountry: France Publications
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Genomic comparison of Kingella kingae strainsPierre Edouard Fournier
Aix Marseille Universite, URMITE, UM63, CNRS 7278, IRD 198, INSERM 1095, Faculte de Medecine, Marseille, France
J Bacteriol 194:5972. 2012..We sequenced the genome from the septic arthritis strain 11220434. It is composed of a 1,990,794-bp chromosome but no plasmid, and it contains 2,042 protein-coding genes and 52 RNA genes, including 3 rRNA genes...
Actinomadura meyerae osteitis following wound contamination with hay in a woman in France: a case reportEmilie Bonnet
Fédération de Microbiologie, Hopital de la Timone, Marseille, France
J Med Case Reports 5:32. 2011..abstract:..
Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reductionPierre Edouard Fournier
Unite des Rickettsies, IFR 48 CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, Marseille Cedex 05, France
BMC Genomics 10:166. 2009..prowazekii, which causes epidemic typhus and kills its arthropod host, to the mild pathogen R. africae, the agent of African tick-bite fever, which does not affect the fitness of its tick vector...
Prospects for the future using genomics and proteomics in clinical microbiologyPierre Edouard Fournier
Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, Universite de la Mediterranee, Marseille Cedex 5, 13385 France
Annu Rev Microbiol 65:169-88. 2011..Herein, we review current achievements of genomics and proteomics and discuss potential developments for clinical microbiology laboratories...
Finegoldia magna, an early post-operative cause of infectious endocarditis: report of two cases and review of the literaturePierre Edouard Fournier
Fédération de Microbiologie, Hopital de la Timone, Marseille Hôpital de la Timone, rue Saint Pierre, 13385 Marseille Cedex 5, France
Anaerobe 14:310-2. 2008..Our report highlights the potential role of F. magna in early post-surgical endocarditis on prosthetic valves...
Current knowledge on phylogeny and taxonomy of Rickettsia sppPierre Edouard Fournier
Unite des Rickettsies, CNRS IRD UMR 6236, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
Ann N Y Acad Sci 1166:1-11. 2009..These data were incorporated into polyphasic consensus guidelines that provide clear recommendations for the taxonomic classification and nomenclature of rickettsiae and rickettsial diseases...
Mycoplasma hominis brain abscess following uterus curettage: a case reportMouhamad Al Masalma
Fédération de Microbiologie, Hopital de la Timone, Marseille, France
J Med Case Reports 5:278. 2011..abstract:..
Comparative genomics of multidrug resistance in Acinetobacter baumanniiPierre Edouard Fournier
Information Genomique et Structurale, Institute for Structural Biology and Microbiology, IBSM, Marseille, France
PLoS Genet 2:e7. 2006..Whole-genome sequencing appears to be a fast and efficient approach to the exhaustive identification of resistance genes in epidemic infectious agents of clinical significance...
The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasiteHiroyuki Ogata
Structural and Genomic Information Laboratory, UPR 2589, IBSM, CNRS, Marseille Cedex, France
PLoS Biol 3:e248. 2005..Our study demonstrates that complete genome sequencing is the fastest approach to reveal phenotypic characters of recently cultured obligate intracellular bacteria...
Isolation of a rickettsia related to Astrakhan fever rickettsia from a patient in ChadPierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseilles Cedex 05, France
Ann N Y Acad Sci 990:152-7. 2003..Although Astrakhan fever rickettsia is transmitted by Rhipicephalus ticks in Europe, further studies are indicated to identify its vector in Africa where these ticks are also prevalent...
Genetic identification of rickettsiae isolated from ticks in JapanPierre Edouard Fournier
Unite des Rickettsies, Faculte de Medecine, CNRS UMR 6020 27, Universite de la Mediterranee, 13385 Marseille, Cedex 05, France
J Clin Microbiol 40:2176-81. 2002..Finally, we identified a new genotype of unknown pathogenicity, genotype AT, that was isolated from Amblyomma testudinarium ticks and that is closely related to a Slovakian genotype obtained from Ixodes ricinus ticks...
Detection of a rickettsia closely related to Rickettsia aeschlimannii, "Rickettsia heilongjiangensis," Rickettsia sp. strain RpA4, and Ehrlichia muris in ticks collected in Russia and KazakhstanStanislav Shpynov
Unite des Rickettsies, IFR48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 5, France
J Clin Microbiol 42:2221-3. 2004..In Kazakhstan, we detected Rickettsia sp. strain RpA4 and a rickettsia closely related to Rickettsia aeschlimannii. These agents should be considered in a differential diagnosis of tick-borne infections in these areas...
Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogensHiroyuki Ogata
Structural and Genomic Information Laboratory, Centre National de la Recherche Scientifique UPR 2589, Institut de Biologie Structurale et Microbiologie, Parc Scientifique de Luminy, Marseille, France
PLoS Genet 2:e76. 2006....
Molecular evolution of rickettsia surface antigens: evidence of positive selectionGuillaume Blanc
Information Genomique et Structurale, UPR 2589, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
Mol Biol Evol 22:2073-83. 2005....
Molecular identification of a collection of spotted Fever group rickettsiae obtained from patients and ticks from RussiaStanislav N Shpynov
Unite des Rickettsies, Faculte de Medecine, Marseille, France
Am J Trop Med Hyg 74:440-3. 2006..Clinicians should be aware that several spotted fever rickettsioses with different prognoses coexist in Russia in areas where NATT was the only previously recognized rickettsiosis...
Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conoriiYong Zhu
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
BMC Microbiol 5:11. 2005..Then, we selected a representative of each MLST genotype and used multi-spacer typing (MST) and mouse serotyping to estimate their degree of taxonomic relatedness...
Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. novPierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
J Clin Microbiol 41:5456-65. 2003..3% for the ompA and ompB genes and gene D, respectively. By use of our classification scheme, "Rickettsia heilongjiangii" belongs to a new species for which we officially propose the name Rickettsia heilongjiangensis sp. nov...
Genotyping of human lice suggests multiple emergencies of body lice from local head louse populationsWenjun Li
URMITE, UMR CNRS 6236, IRD 198, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
PLoS Negl Trop Dis 4:e641. 2010..Recent studies suggest that body lice arose several times from head louse populations...
Rickettsia tamurae sp. nov., isolated from Amblyomma testudinarium ticksPierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Int J Syst Evol Microbiol 56:1673-5. 2006..Such genotypic and phenotypic characteristics warrant its classification as a representative of a novel species, for which the name Rickettsia tamurae sp. nov. is proposed, with the type strain AT-1(T) (=CSUR R1(T))...
Identification of rickettsial isolates at the species level using multi-spacer typingPierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille Cedex 05, France
BMC Microbiol 7:72. 2007....
Spotless rickettsiosis caused by Rickettsia slovaca and associated with Dermacentor ticksDidier Raoult
Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
Clin Infect Dis 34:1331-6. 2002..Immunofluorescence and/or Western blot analysis detected antibodies in 50% of tested patients. Three Dermacentor ticks obtained from patients revealed R. slovaca by PCR...
Insight into cross-talk between intra-amoebal pathogensGregory Gimenez
Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
BMC Genomics 12:542. 2011..This characteristic is proposed to be the result of frequent gene exchanges with other bacteria that share a sympatric lifestyle and contrasts with the genome reduction observed among strict human pathogens...
Sca1, a previously undescribed paralog from autotransporter protein-encoding genes in Rickettsia speciesMaxime Ngwamidiba
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
BMC Microbiol 6:12. 2006....
Phylogenetic study of Rickettsia species using sequences of the autotransporter protein-encoding gene sca2Maxime Ngwamidiba
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Ann N Y Acad Sci 1063:94-9. 2005..rickettsii, R. massiliae, R. akari, and typhus groups, which were supported by significant bootstrap values...
Detection of Astrakhan fever rickettsia from ticks in KosovoPierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseilles Cedex 05, France
Ann N Y Acad Sci 990:158-61. 2003..We suspect that the area of distribution of this rickettsia could be wider than initially suspected. Moreover, as R. sanguineus ticks bite humans, Astrakhan fever might be a cause of spotted fever in Kosovo...
MALDI-TOF-mass spectrometry applications in clinical microbiologyPiseth Seng
Pôle des Maladies Infectieuses, Assistance Publique Hôpitaux de Marseille et URMITE UMR CNRS IRD 6236, IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
Future Microbiol 5:1733-54. 2010..We will also discuss the application of MALDI-TOF-MS tools in the identification of Archaea, eukaryotes and viruses. Pathogenic identification from colony-cultured, blood-cultured, urine and environmental samples is also reviewed...
Genomic analysis of Rickettsia japonica strain YHTXin Dong
Faculte de Medecine, Aix Marseille Universite, URMITE, UM63, CNRS7278, IRD198, InsermU1095, Institut Hospitalo Universitaire Méditerranée Infection, Marseille, France
J Bacteriol 194:6992. 2012..Rickettsia japonica strain YH, isolated in 1984 in Japan, is the type strain of R. japonica, the tick-borne agent of Japanese spotted fever. Here, we report the 1.33-Mb genome of this rickettsial species...
Genome sequence of Rickettsia conorii subsp. caspia, the agent of Astrakhan feverErwin Sentausa
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 7278, IRD 190, IFR48, Institut Hospitalo Universitaire Méditerranée Infection, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:4763-4. 2012..Rickettsia conorii subsp. caspia is the agent of Astrakhan fever, a spotted fever group rickettsiosis endemic to Astrakhan, Russia. The present study reports the draft genome of Rickettsia conorii subsp. caspia strain A-167...
Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new casesPierre Edouard Fournier
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement, Unite Mixte de Recherche 6236, Faculte de Medecine, Universite de la Mediterranee, France
Clin Infect Dis 51:131-40. 2010..whipplei, Bartonella species, and fungi in blood. Broad-spectrum 16S and 18S ribosomal RNA PCR may be performed on valvular biopsies, when available...
Estimation of prokaryote genomic DNA G+C content by sequencing universally conserved genesPierre Edouard Fournier
Information Genomique et Structurale, CNRS UPR2589, Case 934, 163 Avenue de Luminy, 13288 Marseille Cedex 09, France
Int J Syst Evol Microbiol 56:1025-9. 2006..These data suggest that the genomic DNA G+C content of prokaryotes may be estimated easily and reliably from the ftsY gene sequence...
Investigation of blood culture-negative early prosthetic valve endocarditis reveals high prevalence of fungiFranck Thuny
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, CNRS IRD UMR 6236, Faculte de Medecine, Universite de la Mediterranee, 27 Blvd Jean Moulin, 13385 Marseille Cedex 05, France
Heart 96:743-7. 2010..Therefore, fungi should be investigated particularly by molecular methods on surgical specimens and an antifungal drug might be added to the empiric treatment...
Genotyping reveals a wide heterogeneity of Tropheryma whippleiWenjun Li
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille Cedex 05, France
Microbiology 154:521-7. 2008..whipplei strains that is apparently independent of geographical distribution and unrelated to bacterial pathogenicity. Genotyping in Whipple's disease may, however, be useful in epidemiological studies...
Phylogenetic classification of Bartonella species by comparing groEL sequencesZaher Zeaiter
Unite des Rickettsies, CNRS UPRES A 6020, Faculte de Medecine, Marseille, France
Int J Syst Evol Microbiol 52:165-71. 2002..In addition, the groEL gene was shown to be useful in subtyping six B. henselae isolates into three variants: Houston, Marseille and Fizz...
Genome sequence of Rickettsia australis, the agent of Queensland tick typhusXin Dong
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Institut Hospitalo Universitaire Méditerranée Infection, UMR CNRS 7278 IRD 198, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:5129. 2012..It is the tick-borne agent of Queensland tick typhus, a disease endemic in Australia. The 1.29-Mb genome sequence of this bacterium is highly similar to that of Rickettsia akari but contains two plasmids...
Genome sequence of Rickettsia conorii subsp. israelensis, the agent of Israeli spotted feverErwin Sentausa
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 7278 IRD 198, IFR48, Institut hospitalo universitaire, Méditerranée Infection, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:5130-1. 2012..israelensis is the agent of Israeli spotted fever. The present study reports the draft genome of Rickettsia conorii subsp. israelensis strain ISTT CDC1, isolated from a Rhipicephalus sanguineus tick collected in Israel...
Genome sequence of Diplorickettsia massiliensis, an emerging Ixodes ricinus-associated human pathogenMano J Mathew
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD 198, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:3287. 2012..We sequenced the genome from strain 20B, isolated from an Ixodes ricinus tick. The genome consists of a 1,727,973-bp chromosome but no plasmid and includes 2,269 protein-coding genes and 42 RNA genes, including 3 rRNA genes...
Genome sequence of Bartonella birtlesii, a bacterium isolated from small rodents of the genus ApodemusJean Marc Rolain
URMITE CNRS IRD, UMR 6236, Méditerranée Infection, Faculte de Medecine et de Pharmacie, Aix Marseille Universite, Marseille, France
J Bacteriol 194:4779. 2012..Bartonella birtlesii is a facultative intracellular bacterium isolated from the blood of small mammals of the genus Apodemus. The present study reports the draft genome of Bartonella birtlesii strain IBS 135(T) (CIP 106691(T))...
Prosthetic valve endocarditis caused by Pseudomonas luteolaJean Paul Casalta
Laboratoire de Microbiologie, IFR 48, Centre Hospitalier Universitaire de la Timone, 264 rue Saint Pierre, Marseille, France
BMC Infect Dis 5:82. 2005..Pseudomonas luteola has been recognized as an uncommon cause of bacteremia and of infections in patients with underlying medical disorders...
Endocarditis caused by Cardiobacterium valvarumElisabeth Bothelo
Laboratoire de Microbiologie, CNRS UMS 6020, IFR 48, Centre Hospitalier Universitaire de la Timone, 264 rue Saint Pierre, 13385 Marseille Cedex 5, France
J Clin Microbiol 44:657-8. 2006..Characterization of the organism through phenotypic and genotypic analyses revealed the causative role of Cardiobacterium valvarum. This is the third reported case of IE caused by C. valvarum...
Bacterial strain typing in the genomic eraWenjun Li
Unité des Rickettsies et pathogènes émergents, CNRS UMR 6236, IRD 198, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
FEMS Microbiol Rev 33:892-916. 2009....
Proposal to create subspecies of Rickettsia sibirica and an emended description of Rickettsia sibiricaPierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Ann N Y Acad Sci 1078:597-606. 2006..sibirica subsp. nov. (type strain = 2-4-6, ATCC VR-541(T)), and R. sibirica subsp. mongolitimonae subsp. nov. (type strain = HA-91, ATCC VR-1526(T)). The description of R. sibirica is emended to accommodate the two subspecies...
Genome sequence of Rickettsia conorii subsp. indica, the agent of Indian tick typhusErwin Sentausa
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD 198, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:3288-9. 2012..Rickettsia conorii subsp. indica is the agent of Indian tick typhus. The present study reports the draft genome of Rickettsia conorii subsp. indica strain ITTR (ATCC VR-597)...
Evidence for louse-transmitted diseases in soldiers of Napoleon's Grand Army in VilniusDidier Raoult
Unite des Rickettsies, Centre National de la Recherche Scientifique CNRS Unite Mixte de Recherche UMR 6020, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
J Infect Dis 193:112-20. 2006..Because soldiers were commonly infested with body lice, it has been speculated that louse-borne infectious diseases, such as epidemic typhus (caused by Rickettsia prowazekii), were common...
Mimivirus and the emerging concept of "giant" virusJean Michel Claverie
Information Genomique et Structurale, CNRS UPR 2589, IBSM, Parc Scientifique de Luminy, 163 Avenue de Luminy, Case 934, 13288 Marseille Cedex 9, France
Virus Res 117:133-44. 2006..We propose to introduce the word "girus" to recognize the intermediate status of these giant DNA viruses, the genome complexity of which makes them closer to small parasitic prokaryotes than to regular viruses...
Rickettsia raoultii sp. nov., a spotted fever group rickettsia associated with Dermacentor ticks in Europe and RussiaOleg Mediannikov
Unite des Rickettsies, CNRS UMR6020, IFR 48, Universite de la Mediterranee, Faculte de Medecine, 27 Blvd Jean Moulin, 13385 Marseille Cedex 5, France
Int J Syst Evol Microbiol 58:1635-9. 2008..This rickettsia also exhibited a serotype distinct from previously described Rickettsia species. The type strain of Rickettsia raoultii sp. nov. is strain Khabarovsk(T) (=CSUR R3(T) =ATCC VR-1596(T))...
Genetic diversity of Bartonella henselae in human infection detected with multispacer typingWenjun Li
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 13:1178-83. 2007..However, the diversity is not significantly different from that of cat strains. MST is thus a suitable genotyping tool for evaluating the genetic heterogeneity of B. henselae among isolates obtained from human patients...
Warmer weather linked to tick attack and emergence of severe rickettsiosesPhilippe Parola
Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes, CNRS IRD UMR 6236, WHO Collaborative Centre for Rickettsial and Other Arthropod Borne Bacterial Diseases, Faculte de Medecine, Marseille, France
PLoS Negl Trop Dis 2:e338. 2008..sanguineus, leading to increased human attacks. From a global perspective, we predict that as a result of globalisation and warming, more pathogens transmitted by the brown dog tick may emerge in the future...
Non-contiguous finished genome sequence and description of Brevibacterium senegalense sp. novSahare Kokcha
Aix Marseille Universite, Faculte de Medecine
Stand Genomic Sci 7:233-45. 2012..Here we describe the features of this organism, together with the complete genome sequence and annotation. The 3,425,960 bp long genome (1 chromosome but no plasmid) contains 3,064 protein-coding and 49 RNA genes...
Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometryPiseth Seng
Pôle des Maladies Infectieuses, Assistance Publique Hopitaux de Marseille, URMITE, Unite Mixte de Recherche, Centre National de la Recherche Scientifique Institut pour la Recherche et le Développement 6236, Universite de la Mediterranee, Marseille, France
Clin Infect Dis 49:543-51. 2009..Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry accurately identifies both selected bacteria and bacteria in select clinical situations. It has not been evaluated for routine use in the clinic...
DNA persistence and relapses questions on the treatment strategies of Enterococcus infections of prosthetic valvesJean Paul Casalta
URMITE, Aix Marseille Universite, UMR CNRS 7278, IRD 198, INSERM 1095, Faculte de Medecine, Marseille, France
PLoS ONE 7:e53335. 2012....
Genomic comparison of Rickettsia honei strain RBT and other Rickettsia SpeciesDong Xin
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236, IRD 198, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:4145. 2012..The comparison of this 1.27-Mb genome with other Rickettsia genomes provides additional insight into the mechanisms of evolution in Rickettsia species...
Genome sequence of "Rickettsia sibirica subsp. mongolitimonae"Erwin Sentausa
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236, IRD 190, IFR48, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:2389-90. 2012..The present study reports the draft genome of Rickettsia sibirica subsp. mongolitimonae strain HA-91...
Detection of rickettsioses and Q fever in Sri LankaEmmanouil Angelakis
Universite de la Mediterranee, URMITE UMR, CNRS IRD, Faculte de Medecine et de Pharmacie, Marseille, France
Am J Trop Med Hyg 86:711-2. 2012..6%) acute Q fever, 3 (1.6%) murine typhus, and 3 (1.6%) were infected by Rickettsia felis. In addition to already described scrub and murine typhus, we found that R. felis and C. burnetii infections should be considered in Sri Lanka...
Complete genome sequence of Rickettsia slovaca, the agent of tick-borne lymphadenitisPierre Edouard Fournier
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, CNRS UMR 6236, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
J Bacteriol 194:1612. 2012..The 1.27-Mb genome provides further insights into the acquisition of virulence related to genome reduction in Rickettsia species...
Metagenomic analysis of brain abscesses identifies specific bacterial associationsMouhamad Al Masalma
Fédération de Microbiologie Clinique, Hopital de la Timone, Marseille, France
Clin Infect Dis 54:202-10. 2012..In a previous study, using a metagenomic approach based on 16S ribosomal DNA (rDNA) amplification, we demonstrated that the diversity of the microbial flora involved in these infections was underestimated...
Bacterial genome sequencing and its use in infectious diseasesPierre Edouard Fournier
Rickettsies Unit, Faculty of Medicine, University of the Mediterranean, Marseille, France
Lancet Infect Dis 7:711-23. 2007..We review current achievements in these fields and potential developments in the future for the clinical microbiology laboratory...
Non-contiguous finished genome sequence and description of Paenibacillus senegalensis sp. novAjay Kumar Mishra
Aix Marseille Universite, URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo Universitaire Méditerranée Infection, Faculte de Medecine
Stand Genomic Sci 7:70-81. 2012..The 5,581,254 bp long genome (1 chromosome but no plasmid) exhibits a G+C content of 48.2% and contains 5,008 protein-coding and 51 RNA genes, including 9 rRNA genes...
Deciphering Genomic Virulence Traits of a Staphylococcus epidermidis Strain Causing Native-Valve EndocarditisPierre Edouard Fournier
Aix Marseille Universite, URMITE, UM63, CNRS 7278, IRD 198, INSERM U1095, Institut Hospitalo Universitaire Méditerranée Infection, Faculte de Medecine, Marseille, France
J Clin Microbiol 51:1617-21. 2013..The 2.5-Mb genome from strain CSUR P278 exhibited a unique sequence type among S. epidermidis strains and contained 32 genes previously considered virulence genes in this species...
Non-contiguous finished genome sequence and description of Alistipes timonensis sp. novJean Christophe Lagier
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR, Aix Marseille Universite, Marseille, France
Stand Genomic Sci 6:315-24. 2012..The 3,497,779 bp long genome (one chromosome but no plasmid) contains 2,742 protein-coding and 50 RNA genes, including three rRNA genes...
Non-contiguous finished genome sequence and description of Clostridium senegalense sp. novAjay Kumar Mishra
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS, Faculte de Medecine, Aix Marseille Universite
Stand Genomic Sci 6:386-95. 2012..The 3,893,008 bp long genome (1 chromosome but no plasmid) exhibits a G+C content of 26.8% and contains 3,704 protein-coding and 57 RNA genes, including 6 rRNA genes...
Variations of plasmid content in Rickettsia felisPierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS IRD UMR 6236, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
PLoS ONE 3:e2289. 2008..In a recent article, Gillespie et al. (PLoS One. 2007;2(3):e266.) used a bioinformatic approach to refute the presence of the second plasmid form, and proposed the creation of a specific phylogenetic group for R. felis...
Rapid identification of Legionella species by mass spectrometryClaire Moliner
URMITE CNRS IRD UMR 6236, Faculte de Medecine, 13385 Marseille Cedex 05, France
J Med Microbiol 59:273-84. 2010..2 and 89.9 % for the identification of Legionella strains at the genus and species level, respectively. This study demonstrated that MALDI-TOF-MS is a reliable tool for the rapid identification of Legionella strains at the species level...
Genomic comparison of Rickettsia helvetica and other Rickettsia speciesXin Dong
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236, IRD 198, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:2751. 2012..We report the complete and annotated genome sequence of Rickettsia helvetica strain C9P9, which was first isolated in 1979 from Ixodes ricinus ticks in Switzerland and is considered a human pathogen...
Sequence and annotation of Rickettsia sibirica sibirica genomeErwin Sentausa
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236, IRD 190, IFR48, Faculte de Medecine, Aix Marseille Universite, Marseille, France
J Bacteriol 194:2377. 2012..Here we present the draft genome of Rickettsia sibirica sibirica strain BJ-90 isolated from Dermacentor sinicus ticks collected in Beijing, China...
Spotted fever rickettsioses in southern and eastern EuropePhilippe Brouqui
Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
FEMS Immunol Med Microbiol 49:2-12. 2007..Finally, the mite-transmitted Rickettsia akari, the agent of rickettsialpox, is also known to be prevalent in Europe. We present here an overview of these rickettsioses, focusing on emerging diseases...
Outcome and treatment of Bartonella endocarditisDidier Raoult
Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Arch Intern Med 163:226-30. 2003..Endocarditis caused by Bartonella species is a potentially lethal infection characterized by a subacute evolution and severe valvular lesions...
Burden of emerging anaerobes in the MALDI-TOF and 16S rRNA gene sequencing eraBernard La Scola
Pôle des Maladies Infectieuses, Assistance Publique Hopitaux de Marseille, Marseille, France
Anaerobe 17:106-12. 2011..MALDI-TOF MS-based identification, which will become more effective with future spectra database improvement, will be likely responsible of a burden of emerging anaerobes in clinical microbiology...
Sub-acute neuropathy in patients with African tick bite feverMogens Jensenius
Universite de la Mediterranee, Marseille, France
Scand J Infect Dis 38:114-8. 2006..Given the current increase of international safari tourism to sub-Saharan Africa, more cases of sub-acute neuropathy following ATBF may well be encountered in Europe and elsewhere in the y to come...
Rapid and cost-effective identification of Bartonella species using mass spectrometryPierre Edouard Fournier
Fédération de Microbiologie Clinique, Hopital de la Timone, 13385 Marseille Cedex 05, France
J Med Microbiol 58:1154-9. 2009..Altogether, these data demonstrate that MS is an accurate and reproducible tool for rapid and inexpensive identification of Bartonella species...
Naming of Rickettsiae and rickettsial diseasesDidier Raoult
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
Ann N Y Acad Sci 1063:1-12. 2005..In this paper, we review taxonomic rules and appropriate approaches to valid naming of rickettsial species and the diseases they cause...
Strikes, flooding, rats, and leptospirosis in Marseille, FranceCristina Socolovschi
Universite de la Mediterranee, URMITE UMR 6236, CNRS IRD, Faculte de Medecine et de Pharmacie, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Int J Infect Dis 15:e710-5. 2011..The aim of this study was to examine the mechanisms by which weather conditions, the incidence of Leptospira in reservoir populations, and various socio-ecological factors are driving the emergence of leptospirosis in Marseille, France...
Evidence that the intra-amoebal Legionella drancourtii acquired a sterol reductase gene from eukaryotesClaire Moliner
URMITE CNRS IRD UMR 6236, , 27 Boulevard Jean Moulin, 13385 Marseille, Cedex 05, France
BMC Res Notes 2:51. 2009..drancourtii and Coxiella burnetii. The role of the sterol delta-7 reductase in prokaryotes is as yet unknown but we speculate that it is involved in host cholesterol parasitism...
The epidemiology and control of Acinetobacter baumannii in health care facilitiesPierre Edouard Fournier
Structural and Genetic Information Laboratory, , Marseille, France
Clin Infect Dis 42:692-9. 2006..baumannii infection, such as bacteremia or pneumonia in patients in the intensive care unit who are undergoing intubation, do not seem to be associated with a higher attributable mortality rate or an increased length of hospital stay...
What does the future hold for clinical microbiology?Didier Raoult
Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
Nat Rev Microbiol 2:151-9. 2004....
Genomic variation of Bartonella henselae strains detected in lymph nodes of patients with cat scratch diseaseZaher Zeaiter
, CNRS UPRES-A 6020, , Marseille, France
J Clin Microbiol 40:1023-30. 2002..Patients infected with either one or the other genogroup did not exhibit different epidemiological or clinical characteristics. Our study highlights the genotypic heterogeneity of B. henselae in patients with CSD...
The geographical segregation of human lice preceded that of Pediculus humanus capitis and Pediculus humanus humanusZhu Yong
, IFR48, CNRS UMR 6020, , , 27, bd Jean-Moulin, 13385 Marseille, France
C R Biol 326:565-74. 2003..Our results indicate that the earliest divergence within human pediculidae occurred between African lice and other lice, and the divergence between head and body lice was not the result from a single event...
Genotyping, Orientalis-like Yersinia pestis, and plague pandemicsMichel Drancourt
, Marseille, France
Emerg Infect Dis 10:1585-92. 2004..pestis Orientalis. These data indicate that Y. pestis caused cases of Justinian plague. The two historical plague pandemics were likely caused by Orientalis-like strains...
Multispacer typing to study the genotypic distribution of Bartonella henselae populationsWenjun Li
, IFR 48, CNRS UMR 6020, , , 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
J Clin Microbiol 44:2499-506. 2006..Finally, we provide a free-access MST-Rick online software program (http://ifr48.timone.univ-mrs.fr/MST_BHenselae/mst) that investigators may use to compare their own MST sequences to our database...
Lymphangitis-associated rickettsiosis, a new rickettsiosis caused by Rickettsia sibirica mongolotimonae: seven new cases and review of the literaturePierre-Edouard Fournier
, , , Marseille, France
Clin Infect Dis 40:1435-44. 2005..quot; Lymphangitis-associated rickettsiosis should be considered in the differential diagnosis of tick-borne rickettsioses in Europe, Africa, and Asia...
Characterization of the naturally occurring oxacillinase of Acinetobacter baumanniiClaire Héritier
Service de Bacteriologie Virologie, Hopital de Bicetre, Le Kremlin Bicetre, France
Antimicrob Agents Chemother 49:4174-9. 2005..By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species...
Diversity of Borrelia burgdorferi sensu lato in Russian Far EastOleg Y Mediannikov
Laboratory of Rickettsial Ecology, Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia
Microbiol Immunol 49:191-7. 2005..burgdorferi sensu lato genogroup, such as B. afzelii or Borrelia bissettii. Further investigations of genetic and serologic properties of the strains belonging to those groups are required in order to clarify their taxonomic status...
"Candidatus Rickettsia tarasevichiae" in Ixodes persulcatus ticks collected in RussiaStanislav Shpynov
Omsk Research Institute of Natural Infectious Foci, Omsk, Russia
Ann N Y Acad Sci 990:162-72. 2003..canadensis, and three uncultured rickettsiae from plant insects...
Mycobacterium setense infection in humansAlexandre Toro
Emerg Infect Dis 14:1330-2. 2008
Molecular detection of a new Anaplasma species closely related to Anaplasma phagocytophilum in canine blood from South AfricaHisashi Inokuma
Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
J Clin Microbiol 43:2934-7. 2005..This suggests that a new Anaplasma species closely related to A. phagocytophilum occurs in Africa...
Rickettsia asiatica sp. nov., isolated in JapanHiromi Fujita
Ohara Research Laboratory, Ohara General Hospital, Fukushima 960-0195, Japan
Int J Syst Evol Microbiol 56:2365-8. 2006....
Bartonella australis sp. nov. from kangaroos, AustraliaPierre-Edouard Fournier
Emerg Infect Dis 13:1961-2. 2007
