- A phase II study in patients with Alzheimer's disease to assess the preliminary efficacy and maximum tolerated dose of rivastigmine (Exelon)F Forette
Centre de Gerontologie, Hopital Broca, 54 56 Rue Pascal, 75013, Paris, France
Eur J Neurol 6:423-9. 1999..Reports from larger phase III studies confirm this finding. The results of this study also suggest that b.i.d. is the more efficacious regimen and has comparable tolerability to the t.i.d. regimen...
- Detection of cerebral aging, an absolute need: predictive value of cognitive statusF Forette
Hopital Broca, CHU Cochin, Universite de Paris V, France
Eur Neurol 39:2-6. 1998....
- Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular diseaseL Traykov
INSERM Unit 324, 2ter rue d Alesia, 75014, Paris, France
Eur J Neurol 6:415-21. 1999..In contrast, ApoE epsilon4 allele-bearing individuals had greater risk of having late-onset AD (OR = 8.8; 95% CI 3.7-21.0), or non-vascular cognitive impairment (OR = 7.0; 95% CI 2.5-19.0)...
- The apolipoprotein E epsilon4 allele and the response to tacrine therapy in Alzheimer's diseaseA S Rigaud
Hopital Broca, 54 56 Rue Pascal, 75013, Paris, France
Eur J Neurol 7:255-8. 2000..Consequently, these results do not support the hypothesis that the ApoE phenotype and gender are predictors of the response to tacrine in AD patients...
- Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trialF Forette
Department of Geriatrics, Hopital Broca, University of Paris V, France
Lancet 352:1347-51. 1998..The vascular dementia project, set up in the framework of the double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial, investigated whether antihypertensive drug treatment could reduce the incidence of dementia...
- Patterns of loss of basic activities of daily living in Alzheimer patients: A cross-sectional study of the French REAL cohortLaurent Lechowski
Service de médecine gériatrique, AP HP, Hopital Sainte Perine, Paris, France
Dement Geriatr Cogn Disord 29:46-54. 2010..To characterize loss of basic activities of daily living (BADL) in 687 Alzheimer's disease (AD) community-dwelling patients included in the French REAL cohort...
- Absence of amusia and preserved naming of musical instruments in an aphasic composerC Tzortzis
U 324 INSERM, Centre Paul Broca, Paris, France
Cortex 36:227-42. 2000....
- Implications of the Impact Survey for payors across EuropeF Forette
University of Paris V, Foundation Nationale de Gerontologie, Paris, France
J Nutr Health Aging 14:553-7. 2010....
- Diuretics for cardiovascular prevention in the elderlyO Hanon
Department of Geriatrics, Hopital Broca, rue Pascal, Paris, France
J Hum Hypertens 18:S15-22. 2004....
- [Cognitive functions and hypertension]O Hanon
Service de Gerontologie, Hopital Broca, Paris
Arch Mal Coeur Vaiss 98:133-9. 2005..In this context, the effect of antihypertensive treatment on cognitive functions should represent one of the primary criteria of assessment in future morbidity and mortality studies in hypertensive patients...
- Evolution of blood pressure in patients with Alzheimer's disease: a one year survey of a French Cohort (REAL.FR)O Hanon
Department of Geriatrics, Hopital Broca, 75013 Paris, France
J Nutr Health Aging 9:106-11. 2005..To determine the evolution of blood pressure in patients with moderate Alzheimer's disease among a one year longitudinal survey and to evaluate the relationship between blood pressure and cognitive functions...
- Consensus statement on dementia of Alzheimer type in the severe stageB Vellas
J Nutr Health Aging 9:330-8. 2005
- [Consensus statement on severe dementia]B Vellas
CHU Casselardit, Toulouse
Rev Neurol (Paris) 161:868-77. 2005..Resource allocation and proximity care have to be targeted. Research areas necessary to improve the care of patients with severe dementia has been selected...
- Management of heart failure in the elderly: recommendations from the French Society of Cardiology (SFC) and the French Society of Gerontology and Geriatrics (SFGG)M Komajda
Department of Cardiology, Pitie Salpetriere Hospital, 47 83 boulevard de l Hopital, 75013 Paris, France
J Nutr Health Aging 10:434-44. 2006..The therapeutic programmes in which multidisciplinary teams are involved reduce the number and duration of hospitalisations and the costs generated by the disease...
- Treatment of hypertension in patients 80 years of age or olderNigel S Beckett
Care of the Elderly, Division of Medicine, Imperial College London, United Kingdom
N Engl J Med 358:1887-98. 2008..Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death...
- Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trialRuth Peters
Care of the Elderly, Imperial College London, London, UK
Lancet Neurol 7:683-9. 2008..The Hypertension in the Very Elderly trial (HYVET) was designed to assess the risks and benefits of treatment of hypertension in elderly patients and included an assessment of cognitive function...
- [Is there evidence that treatment of hypertension in the aged decreases the risk of cerebral ischaemic disease?]O Hanon
Service de Geriatrie, Hopital Broca, CHU Cochin Port Royal Université René Descartes, Paris V, 54 56, rue Pascal, 75013 Paris
Rev Neurol (Paris) 160:471-7. 2004
- [Relationship between arterial pressure and cognitive functions. Data for the French Network on Alzheimer's disease (REAL.FR)]O Hanon
Service de Geriatrie, Hopital Broca, 54 56, rue Pascal, 75013 Paris, France
Rev Med Interne 24:292s-300s. 2003..The relationships between arterial hypertension and cognitive decline are complex and studies indicate controversial results...
- [SYST-EUR: a multicenter trial of treatment of systolic hypertension in aged subjects. An initial report]X Girerd
, , Paris
Arch Mal Coeur Vaiss 85:1243-7. 1992..New centres are being recruited in order to randomize a total of 3,000 patients...
- [Treatment of isolated systolic arterial hypertension and prevention of dementia in aged patients. The Syst-Eur multicenter study]M L Seux
, , Paris
Arch Mal Coeur Vaiss 92:1083-7. 1999..At the rate observed in the placebo group, treating 1,000 patients for 5 years would prevent 19 cases of dementia...
- [Isolated systolic hypertension and cognitive function in the aged. Experience of the Syst-Eur study]M L Seux
Arch Mal Coeur Vaiss 90:1169-72. 1997..It also decreases with higher systolic blood pressure or lower diastolic blood pressure. The influence of antihypertensive therapy on cognitive status will be prospectively evaluated in Syst-Eur Vascular Dementia Project...
- [Arterial hypertension of the aged patient in general medicine. French national survey]M L Seux
, , Paris
Arch Mal Coeur Vaiss 92:1089-94. 1999..The risk of isolated systolic hypertension is under-estimated by 27% of physicians who reported a minimum systolic blood pressure level of 180 mmHg to initiate therapy...
- Hypertension in the Very Elderly Trial (HYVET): protocol for the main trialC Bulpitt
Imperial College School of Medicine, Section of Elderly Care, Hammersmith Hospital, London, England
Drugs Aging 18:151-64. 2001..We describe in detail the protocol for the main trial and discuss the reasons for the changes from the pilot, the use of the drug regimen, and the BP criteria to be used in the trial...
- [Antihypertensive treatment can normalize the geometry and the arterial function in the aged patient]O Hanon
, , Paris
Arch Mal Coeur Vaiss 92:1063-6. 1999..These results indicate that the arterial modifications observed in elderly hypertensives are consequence of the high blood pressure per se and not only consequent the modifications due to the aging...
- Association of the apolipoprotein E epsilon4 allele with late-onset depressionA S Rigaud
Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V 54 56, rue Pascal, F 75013 Paris, France
Neuroepidemiology 20:268-72. 2001..1, 95% CI, 1.9-19.0) than of EOD (OR = 0.7, 95% CI, 0.2-2.5). These results suggest an association between the ApoE epsilon4 allele frequency and LOD. Patients with LOD could be at risk of developing AD by an epsilon4-dependent pathway...
- [Reflexion of French experts on the key points of the symposium]J M Mallion
Presse Med 31:S27-30. 2002..Professor O. Dubourg recalled the beneficial effect of indapamid SR on LVH demonstrated in the LIVE study. Likewise, Professor M. Marre emphasized its important impact on microalbuminuria as shown in the NESTOR study...
- [Cognitive decline and hypertension]A S Rigaud
Hopital Broca, CHU Cochin Port Royal, Universite Rene Descartes, Paris V, 54 56, rue Pascal, 75013 Paris
Arch Mal Coeur Vaiss 96:47-51. 2003..In particular, the results of the Syst-Eur study, showing that a calcium inhibitor, nitrendipine, could reduce not only the incidence of stroke but also that of dementia, should be confirmed...
- [Significance of inhibitors of conversion enzymes in elderly subjects. The example of perindopril]F Forette
Arch Mal Coeur Vaiss 82:79-85. 1989..abstract truncated at 250 words)..
- Prognosis of Alzheimer's disease today: a two-year prospective study in 686 patients from the REAL-FR StudyFrederic Cortes
Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire Purpan Casselardit, Toulouse, France
Alzheimers Dement 4:22-9. 2008..The aim of the present study was to describe the long-term evolution of Alzheimer's disease (AD) in a prospective cohort of patients under treatment with a close follow-up...
- Healthy working life expectancies at age 50 in Europe: a new indicatorA Lievre
IRDES, Institut de Recherche et Documentation en Economie de la Santé, 10, rue Vauvenargues, 75010 Paris France
J Nutr Health Aging 11:508-14. 2007..To assess these concepts, we propose a new indicator the Healthy Working Life Expectancy (HWLE) that associates health status and productive engagement, in order to compare various situations in Europe...
- [Treating mental disorders in the elderly: avant-garde control or... lost cause? Address]F Forette
Conseiller Technique Personnes Agées, Ministere de la Sante
Encephale 32:S611-2. 2006
- [Consensus statement on severe dementia]B Vellas
CHU Casselardit, secteur A gériatrie, Toulouse
Presse Med 34:1545-55. 2005..The group also stressed the importance of clinical research to improve knowledge of disease course and assess management strategies and recommended specific area for research...
- Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trialS Gilman
Department of Neurology, University of Michigan, 300 N Ingalls 3D15, Ann Arbor, MI 48109 0489, USA
Neurology 64:1553-62. 2005..The authors report the results of a phase IIa immunotherapy trial of AN1792(QS-21) in patients with mild to moderate Alzheimer disease (AD) that was interrupted because of meningoencephalitis in 6% of immunized patients...
- [Recommendations for the diagnosis and management of cardic failure in the elderly subject]M Komajda
Arch Mal Coeur Vaiss 97:803-22. 2004
- Donepezil for the treatment of mild to moderate Alzheimer's disease in France: the economic implicationsF Fagnani
CEMKA, Bourg la Reine, France
Dement Geriatr Cogn Disord 17:5-13. 2004..Overall, these data suggest that donepezil is a cost-effective treatment for mild to moderately impaired AD patients living in France...