M Fontecave

Summary

Country: France

Publications

  1. ncbi request reprint Mechanisms of iron-sulfur cluster assembly: the SUF machinery
    M Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, CEA Grenoble, Grenoble Cedex 09, France
    J Biol Inorg Chem 10:713-21. 2005
  2. ncbi request reprint Biological radical sulfur insertion reactions
    Marc Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17, avenue des Martyrs, 38054 Grenoble Cedex 09, France
    Chem Rev 103:2149-66. 2003
  3. ncbi request reprint Adenosylmethionine as a source of 5'-deoxyadenosyl radicals
    M Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17 Avenue des Martyrs, 38054 Grenoble, Cedex 09, France
    Curr Opin Chem Biol 5:506-11. 2001
  4. doi request reprint Iron-sulfur cluster biosynthesis in bacteria: Mechanisms of cluster assembly and transfer
    Marc Fontecave
    CNRS UMR 5249, F 38054 Grenoble, France
    Arch Biochem Biophys 474:226-37. 2008
  5. ncbi request reprint Iron-sulfur clusters: ever-expanding roles
    Marc Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, CEA Grenoble, UMR 5047, 17 Avenue des Martyrs, 38504 Grenoble Cedex 09, France
    Nat Chem Biol 2:171-4. 2006
  6. ncbi request reprint S-adenosylmethionine: nothing goes to waste
    Marc Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, UMR no 5047, Universite Joseph Fourier, Departement Reponse et Dynamique Cellulaires, CEA CNRS Grenoble, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    Trends Biochem Sci 29:243-9. 2004
  7. doi request reprint Methylations: a radical mechanism
    Marc Fontecave
    Institut de Recherches en Technologie et Sciences pour le Vivant IRTSV LCBM, UMR 5249 CEA CNRS UJF, CEA Grenoble, France
    Chem Biol 18:559-61. 2011
  8. ncbi request reprint NADPH-sulfite reductase from Escherichia coli. A flavin reductase participating in the generation of the free radical of ribonucleotide reductase
    J Coves
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Unite de Recherche, Universite Joseph Fourier, Grenoble, France
    J Biol Chem 268:18604-9. 1993
  9. ncbi request reprint The flavoprotein component of the Escherichia coli sulfite reductase: expression, purification, and spectral and catalytic properties of a monomeric form containing both the flavin adenine dinucleotide and the flavin mononucleotide cofactors
    M Zeghouf
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, CEA Grenoble, DBMS CBCRB CNRS Université Joseph Fourier, France
    Biochemistry 37:6114-23. 1998
  10. ncbi request reprint The mechanism and substrate specificity of the NADPH:flavin oxidoreductase from Escherichia coli
    F Fieschi
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, URA 332, CNRS, Universite Joseph Fourier, Grenoble, France
    J Biol Chem 270:30392-400. 1995

Collaborators

Detail Information

Publications95

  1. ncbi request reprint Mechanisms of iron-sulfur cluster assembly: the SUF machinery
    M Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, CEA Grenoble, Grenoble Cedex 09, France
    J Biol Inorg Chem 10:713-21. 2005
    ....
  2. ncbi request reprint Biological radical sulfur insertion reactions
    Marc Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17, avenue des Martyrs, 38054 Grenoble Cedex 09, France
    Chem Rev 103:2149-66. 2003
  3. ncbi request reprint Adenosylmethionine as a source of 5'-deoxyadenosyl radicals
    M Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17 Avenue des Martyrs, 38054 Grenoble, Cedex 09, France
    Curr Opin Chem Biol 5:506-11. 2001
    ..Molecular details of the cluster-mediated reductive cleavage of S-adenosylmethionine to methionine and, presumably, a 5'-deoxyadenosyl radical are the targets of recent studies...
  4. doi request reprint Iron-sulfur cluster biosynthesis in bacteria: Mechanisms of cluster assembly and transfer
    Marc Fontecave
    CNRS UMR 5249, F 38054 Grenoble, France
    Arch Biochem Biophys 474:226-37. 2008
    ....
  5. ncbi request reprint Iron-sulfur clusters: ever-expanding roles
    Marc Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, CEA Grenoble, UMR 5047, 17 Avenue des Martyrs, 38504 Grenoble Cedex 09, France
    Nat Chem Biol 2:171-4. 2006
  6. ncbi request reprint S-adenosylmethionine: nothing goes to waste
    Marc Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, UMR no 5047, Universite Joseph Fourier, Departement Reponse et Dynamique Cellulaires, CEA CNRS Grenoble, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    Trends Biochem Sci 29:243-9. 2004
    ..SAM presents a unique situation in which all constituent parts have a chemical use...
  7. doi request reprint Methylations: a radical mechanism
    Marc Fontecave
    Institut de Recherches en Technologie et Sciences pour le Vivant IRTSV LCBM, UMR 5249 CEA CNRS UJF, CEA Grenoble, France
    Chem Biol 18:559-61. 2011
    ..On the basis of labeling experiments, Grove et al. (2011) have shown how an electrophilic carbon (from an RNA adenosine) can be methylated by S-adenosylmethionine-dependent methyltransferases though an original radical mechanism...
  8. ncbi request reprint NADPH-sulfite reductase from Escherichia coli. A flavin reductase participating in the generation of the free radical of ribonucleotide reductase
    J Coves
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Unite de Recherche, Universite Joseph Fourier, Grenoble, France
    J Biol Chem 268:18604-9. 1993
    ..Pure sulfite reductase has the ability to catalyze the reduction of free riboflavin, FMN, or FAD by NADPH and thus, as Fre, to transfer electrons to the iron center of metR2, a key step during the activation reaction...
  9. ncbi request reprint The flavoprotein component of the Escherichia coli sulfite reductase: expression, purification, and spectral and catalytic properties of a monomeric form containing both the flavin adenine dinucleotide and the flavin mononucleotide cofactors
    M Zeghouf
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, CEA Grenoble, DBMS CBCRB CNRS Université Joseph Fourier, France
    Biochemistry 37:6114-23. 1998
    ..Despite the conservation of the bi-flavin-domain structure between these proteins over evolutionary time, each of them provides significantly different flavin reactivities...
  10. ncbi request reprint The mechanism and substrate specificity of the NADPH:flavin oxidoreductase from Escherichia coli
    F Fieschi
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, URA 332, CNRS, Universite Joseph Fourier, Grenoble, France
    J Biol Chem 270:30392-400. 1995
    ..coli growing cells. As a consequence, it can enhance the antiproliferative effect of hydroxyurea, a cell-specific ribonucleotide reductase inactivator...
  11. ncbi request reprint Activation of class III ribonucleotide reductase from E. coli. The electron transfer from the iron-sulfur center to S-adenosylmethionine
    D Padovani
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier, 17, avenue des Martyrs, 38054 Grenoble Cedex 09, France
    Biochemistry 40:6713-9. 2001
    ....
  12. ncbi request reprint The anaerobic ribonucleotide reductase from Escherichia coli. The small protein is an activating enzyme containing a [4fe-4s](2+) center
    J Tamarit
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, Commissariat à l Energie Atomique CEA Département de Biologie Moléculaire et Structurale Chimie et Biochimie 1087 CNRS, Universite Joseph Fourier, 17 rue des Martyrs
    J Biol Chem 274:31291-6. 1999
    ..Furthermore, protein beta has the potential to activate several molecules of protein alpha, suggesting that protein beta is an activating enzyme rather than a component of an alpha(2)beta(2) complex as previously claimed...
  13. ncbi request reprint Reduction and mobilization of iron by a NAD(P)H:flavin oxidoreductase from Escherichia coli
    J Coves
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Universite Joseph Fourier, Grenoble, France
    Eur J Biochem 211:635-41. 1993
    ..We suggest that the reduction and the mobilization of iron from ferrisiderophores in the cell might be regulated by the presence of physiological ferrous traps such as apoproteins...
  14. ncbi request reprint The activating component of the anaerobic ribonucleotide reductase from Escherichia coli. An iron-sulfur center with only three cysteines
    J Tamarit
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, Commissariat à l Energie Atomique Département de Biologie Moléculaire et Structurale, EP 1087 CNRS, Universite Joseph Fourier, 17, rue des Martyrs, 38054 Grenoble, France
    J Biol Chem 275:15669-75. 2000
    ..Mutation of the two other cysteines of the protein did not result in inactivation. We thus conclude that the (4Fe-4S) cluster has, in the wild type protein, only three cysteine ligands and a fourth still unidentified ligand...
  15. ncbi request reprint Iron-sulfur center of biotin synthase and lipoate synthase
    S Ollagnier-de Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    Biochemistry 39:4165-73. 2000
    ..20 mm/s and delta = 0.44 mm/s for the diamagnetic (4Fe-4S)(2+) and g(par) = 2.039 and g(perp) = 1.93 for the S = (1)/(2) state of (4Fe-4S)(1+)], which reacts with oxygen to generate a (2Fe-2S)(2+) center...
  16. ncbi request reprint Iron-sulfur interconversions in the anaerobic ribonucleotide reductase from Escherichia coli
    E Mulliez
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier 17 Avenue des Martyrs, F 38054 Grenoble Cedex 09, France
    J Biol Inorg Chem 4:614-20. 1999
    ..This is the first report of a 2Fe to 3Fe cluster conversion...
  17. ncbi request reprint Superoxide reductase from Desulfoarculus baarsii: reaction mechanism and role of glutamate 47 and lysine 48 in catalysis
    M Lombard
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, , 38054 Grenoble, Cedex 9, France
    Biochemistry 40:5032-40. 2001
    ..In addition, we report that expression of the lysine 48 sor mutant gene hardly restored to a superoxide dismutase-deficient Escherichia coli mutant the ability to grow under aerobic conditions...
  18. ncbi request reprint Activation of class III ribonucleotide reductase by flavodoxin: a protein radical-driven electron transfer to the iron-sulfur center
    E Mulliez
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier, 17, avenue des Martyrs, 38054 Grenoble Cedex 09, France
    Biochemistry 40:3730-6. 2001
    ..The second reaction plays the major role on the basis that a Gly-to-Ala mutation results in a greatly decreased production of methionine...
  19. ncbi request reprint Activation of class III ribonucleotide reductase by thioredoxin
    D Padovani
    , , Grenoble, France
    J Biol Chem 276:9587-9. 2001
    ..Thus, in E. coli, thioredoxin has very different roles for class I ribonucleotide reductase where it is required for the substrate turnover and class III ribonucleotide reductase where it acts only for the activation of the enzyme...
  20. ncbi request reprint Reaction of the NAD(P)H:flavin oxidoreductase from Escherichia coli with NADPH and riboflavin: identification of intermediates
    V Niviere
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CEA, CNRS, Grenoble, France
    Biochemistry 37:11879-87. 1998
    ..These results support the initial hypothesis of a structural similarity between flavin reductase and the enzymes of the ferredoxin-NADP+ reductase family and extend it at a functional level...
  21. ncbi request reprint SufA/IscA: reactivity studies of a class of scaffold proteins involved in [Fe-S] cluster assembly
    S Ollagnier-de-Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    J Biol Inorg Chem 9:828-38. 2004
    ..No cluster transfer from IscA to IscU, another scaffold of the isc operon, could be observed, whereas IscU was shown to be an efficient cluster source for cluster assembly in IscA. Implications of these results are discussed...
  22. ncbi request reprint Flavin mononucleotide-binding domain of the flavoprotein component of the sulfite reductase from Escherichia coli
    J Coves
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Unité Mixte de Recherche du Centre National de la Recherche Scientifique 5616, Universite Joseph Fourier, Grenoble, France
    Biochemistry 36:5921-8. 1997
    ..Moreover, the FMN prosthetic group in SiR-FP23 and native SiR-FP is compared to that of cytochrome P450 reductase and bacterial cytochrome P450, which also contain one FAD and one FMN per polypeptide chain...
  23. ncbi request reprint The NAD(P)H:flavin oxidoreductase from Escherichia coli. Evidence for a new mode of binding for reduced pyridine nucleotides
    V Niviere
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CEA CNRS Université J Fourier, Batiment K, 17 Avenue des Martyrs, 38054 Grenoble, Cedex 9, France
    J Biol Chem 274:18252-60. 1999
    ..In addition, we have shown that the flavin reductase selectively transfers the pro-R hydrogen from the C-4 position of the nicotinamide ring and is therefore classified as an A-side-specific enzyme...
  24. ncbi request reprint Cys5 and Cys214 of NAD(P)H:flavin oxidoreductase from Escherichia coli are located in the active site
    F Fieschi
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, UMR C5616, CNRS, Universite Joseph Fourier, Grenoble, France
    Eur J Biochem 237:870-5. 1996
    ..This strongly suggested that Cys5 and Cys214 are located at the flavin-binding site of Fre and that flavin can bind to the enzyme in the absence of NADPH...
  25. ncbi request reprint Ferric reductases or flavin reductases?
    M Fontecave
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Unité de Recherche Associée au CNRS 332, Universite Joseph Fourier, Grenoble, France
    Biometals 7:3-8. 1994
    ..This strongly suggests that, in general, the reduction of iron depends on reduced flavins provided by flavin reductases...
  26. ncbi request reprint The flavoprotein component of the Escherichia coli sulfite reductase can act as a cytochrome P450c17 reductase
    M Zeghouf
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, CEA Grenoble, DBMS CBCRB CNRS Université Joseph Fourier, France
    Biochem Biophys Res Commun 246:602-5. 1998
    ..A cluster of negatively charged residues was found in SiR-FP by amino acid sequence comparison with rat cytochrome P450 reductase. These results argue in favour of the flavodoxin origin of the FMN-binding domain of SiR-FP...
  27. ncbi request reprint Pulse radiolysis studies on superoxide reductase from Treponema pallidum
    V Niviere
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CEA CNRS Université Joseph Fourier, Cedex 9, France
    FEBS Lett 497:171-3. 2001
    ..The reconstituted spectra for the two intermediates are consistent with formation of transient iron-peroxide species...
  28. ncbi request reprint Ferric reductases in Escherichia coli: the contribution of the haemoglobin-like protein
    M Eschenbrenner
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Universite Joseph Fourier, Grenoble, France
    Biochem Biophys Res Commun 198:127-31. 1994
    ..However, when compared to the two main ferric/flavin reductases of E. coli, i.e., the NAD(P)H: flavin oxidoreductase and the sulfite reductase, one can conclude that the contribution of HMP to iron reduction is negligible...
  29. ncbi request reprint High valent iron oxo intermediates might be involved during activation of ribonucleotide reductase: single oxygen atom donors generate the tyrosyl radical
    M Fontecave
    Laboratoire d Etudes Dynamiques de la Structure et de la Sélectivité, Universite Joseph Fourier, Grenoble, France
    Biochem Biophys Res Commun 168:659-64. 1990
    ..A mechanism of reductive activation of dioxygen by the binuclear non heme iron center involving iron-oxo intermediates is proposed...
  30. ncbi request reprint Enzymic and chemical reduction of the iron center of the Escherichia coli ribonucleotide reductase protein R2. The role of the C-terminus
    J Coves
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Universite Joseph Fourier, Grenoble, France
    Eur J Biochem 233:357-63. 1995
    ..The properties of the model reaction are described...
  31. ncbi request reprint The NAD(P)H:flavin oxidoreductase from Escherichia coli as a source of superoxide radicals
    P Gaudu
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Unité de Recherche Associée au Centre National de la REcherche Scientifique 332, Universite Joseph Fourier, Grenoble, France
    J Biol Chem 269:8182-8. 1994
    ..These results suggest that the flavin reductase might: (i) in vivo, be an important cytosolic site of O2-. generation; (ii) in vitro, serve as a simple, efficient, and selective O2-. generator...
  32. ncbi request reprint Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin
    S Ollagnier-de-Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    J Biol Chem 276:22604-7. 2001
    ..These results thus suggest that IscA is involved in ferredoxin cluster assembly and activation. This is an important function because a functional ferredoxin is required for maturation of other cellular Fe-S proteins...
  33. pmc Overexpression of the FAD-binding domain of the sulphite reductase flavoprotein component from Escherichia coli and its inhibition by iodonium diphenyl chloride
    J Coves
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, CEA Grenoble, DBMS CB CNRS Université Joseph Fourier, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Biochem J 342:465-72. 1999
    ..Taken together, our results have shown that flavoprotein inactivation by IDP is not a reliable indicator for a flavin radical intermediate in catalysis...
  34. ncbi request reprint Activation of the anaerobic ribonucleotide reductase from Escherichia coli. The essential role of the iron-sulfur center for S-adenosylmethionine reduction
    S Ollagnier
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Universite Joseph Fourier, CNRS UMR 5616, Chimie Recherche, BP 53, 38041 Grenoble Cedex 09, France
    J Biol Chem 272:24216-23. 1997
    ..e redox catalysis, as recently proposed by others (Staples, R. C., Ameyibor, E., Fu, W., Gardet-Salvi, L., Stritt-Etter, A. L., Schürmann, P., Knaff, D. B., and Johnson, M. K. (1996) Biochemistry 35, 11425-11434)...
  35. ncbi request reprint A simplifed functional version of the Escherichia coli sulfite reductase
    M Zeghouf
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, CEA Grenoble, France
    J Biol Chem 275:37651-6. 2000
    ....
  36. ncbi request reprint An iron-sulfur center and a free radical in the active anaerobic ribonucleotide reductase of Escherichia coli
    E Mulliez
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Universite Joseph Fourier, URA Centre National de la Recherche Scientifique 332, Chimie Recherche, Grenoble, France
    J Biol Chem 268:2296-9. 1993
    ..From other work it appears likely that the free radical is localized on glycine 681 of the polypeptide chain...
  37. ncbi request reprint Sulfite reductase of Escherichia coli is a ferrisiderophore reductase
    J Coves
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Unité de Recherche Associée au Centre National de la Recherche Scientifique n 332, Universite Joseph Fourier, Grenoble, France
    Biochem Biophys Res Commun 192:1403-8. 1993
    ..Free flavins, riboflavin, FMN, FAD were absolutely required, suggesting that this activity resides in the flavin reductase activity of sulfite reductase...
  38. ncbi request reprint Copper amine oxidase: a novel use for a tyrosine
    M Fontecave
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, URA CNRS 332, Universite Joseph Fourier, Grenoble, France
    Structure 3:1127-9. 1995
    ..TPQ binds to copper in the inactive form of the enzyme but not in the active form...
  39. ncbi request reprint 8-Azidoadenosine and ribonucleotide reductase
    B Roy
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, URA CNRS 332, Universite Joseph Fourier, Grenoble, France
    Biochem Biophys Res Commun 187:432-7. 1992
    ..One compound, 8-azidoadenosine, inhibits CDP reduction in cytosolic extracts from cancer cells. The corresponding diphosphate behaves as a substrate for ribonucleotide reductase while the triphosphate is an allosteric effector...
  40. ncbi request reprint Resveratrol, a remarkable inhibitor of ribonucleotide reductase
    M Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CEA CNRS Université Joseph Fourier, Grenoble, France
    FEBS Lett 421:277-9. 1998
    ..We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans...
  41. ncbi request reprint An active ribonucleotide reductase from Arabidopsis thaliana cloning, expression and characterization of the large subunit
    S Sauge-Merle
    Laboratoire de Chimie et Biochimie des Centres Rëdox Bioologiques, Universite Joseph Fourier, Grenoble, France
    Eur J Biochem 266:62-9. 1999
    ....
  42. doi request reprint New light on methylthiolation reactions
    M Fontecave
    Laboratoire de Chimie et Biologie des Metaux, UMR 5249, Universite Joseph Fourier, CEA, CNRS, 17 Avenue des Martyrs, 38054 Grenoble Cedex 9, France
    Chem Biol 15:209-10. 2008
    ..2008) catalyzes the methylthiolation of aspartate 88 of the S12 ribosomal protein in Escherichia coli and shows a strong similarity with the iron-sulfur enzyme MiaB involved in the methylthiolation of tRNAs...
  43. ncbi request reprint The lipoate synthase from Escherichia coli is an iron-sulfur protein
    S Ollagnier-de Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier, Grenoble, France
    FEBS Lett 453:25-8. 1999
    ..The possible involvement of the cluster in the insertion of sulfur atoms into the octanoic acid backbone is discussed...
  44. ncbi request reprint Ribonucleotide reductases and radical reactions
    M Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, CNRS, Universite J Fourier, Grenoble, France
    Cell Mol Life Sci 54:684-95. 1998
    ..Here we describe the reactivity of these radicals with respect to the natural ribonucleotide substrates as well as to a variety of enzyme inhibitors, radical scavengers, nitric oxide, superoxide radicals and substrate analogues...
  45. ncbi request reprint The NADPH: sulfite reductase of Escherichia coli is a paraquat reductase
    P Gaudu
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Universite Joseph Fourier, Grenoble, France
    Eur J Biochem 226:459-63. 1994
    ..These results suggest that the sulfite reductase is a major paraquat reductase in E. coli and is responsible for the toxic activation of the drug...
  46. ncbi request reprint Chemistry for an essential biological process: the reduction of ferric iron
    J L Pierre
    LEDSS, UMR CNRS 5616, Universite Joseph Fourier, Grenoble, France
    Biometals 15:341-6. 2002
    ..Finally the role of dissimilatory ferric reduction in microbial respiration and biomineralization is discussed...
  47. ncbi request reprint [Ni(xbsms)Ru(CO)2Cl2]: a bioinspired nickel-ruthenium functional model of [NiFe] hydrogenase
    Y Oudart
    Laboratoire de Chimie et Biochimie des Centres Rédox Biologiques UMR CNRS UJF CEA 5047, DRDC CB, 38054 Grenoble Cedex 9, France
    Inorg Chem 45:4334-6. 2006
    ..This complex catalyzes hydrogen evolution by electroreduction of the weakly acidic Et3NH+ ions in N,N-dimethylformamide and is therefore the first functional bioinspired model of [NiFe] hydrogenases...
  48. ncbi request reprint The flavin reductase activity of the flavoprotein component of sulfite reductase from Escherichia coli. A new model for the protein structure
    M Eschenbrenner
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Universite Joseph Fourier, Grenoble, France
    J Biol Chem 270:20550-5. 1995
    ..This result, together with the sequence homology between SiR-FP and NADPH-cytochrome P-450 reductase, suggests a new model for the structure of the protein with one FMN and one FAD prosthetic group per alpha subunit...
  49. ncbi request reprint NADPH-sulfite reductase flavoprotein from Escherichia coli: contribution to the flavin content and subunit interaction
    M Eschenbrenner
    Laboratoire d Etudes Dynamiques et Structurales de la Sélectivité, Unité de Recherche Associée au Centre National de la Recherche Scientifique no 332, Universite Joseph Fourier, Grenoble, France
    FEBS Lett 374:82-4. 1995
    ..One can conclude that each alpha-chain of SiR-FP is composed of two distinct domains, one binding FAD and the other FMN and that the FMN-binding domains cooperate for a head-to-head subunit interaction...
  50. doi request reprint The [4Fe-4S] cluster of quinolinate synthase from Escherichia coli: investigation of cluster ligands
    Carine Rousset
    Commissariat a l Energie Atomique, iRTSV, LCBM, 38054 Grenoble, France
    FEBS Lett 582:2937-44. 2008
    ..This result is in contrast to the previous proposal that pointed the three cysteines of the C(291)XXC(294)XXC(297) motif. Interestingly, we demonstrated that Cys291 and Cys294 form a disulfide bridge and are important for activity...
  51. ncbi request reprint The [Fe-Fe]-hydrogenase maturation protein HydF from Thermotoga maritima is a GTPase with an iron-sulfur cluster
    Xavier Brazzolotto
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, UMR Université Joseph Fourier CNRS Commissariat à l Energie Atomique No 5047, Grenoble, France
    J Biol Chem 281:769-74. 2006
    ..HYSCORE spectroscopy experiments were carried out to determine the nature of the fourth ligand of the cluster, and its exchangeability was demonstrated with the formation of a [4Fe-4S]-imidazole complex...
  52. ncbi request reprint Proton electroreduction catalyzed by cobaloximes: functional models for hydrogenases
    Mathieu Razavet
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, UMR 5047 CEA CNRS Université Joseph Fourier, CEA Grenoble, DRDC CB, Bat K, 17 rue des Martyrs, 38054 Grenoble Cedex 09, France
    Inorg Chem 44:4786-95. 2005
    ..The influence of the equatorial glyoxime ligand was also investigated and the capability of the stabilized BF2-bridged species [Co(dmgBF2)2(OH2)2] for electrocatalyzed hydrogen evolution confirmed...
  53. ncbi request reprint Analysis of the heteromeric CsdA-CsdE cysteine desulfurase, assisting Fe-S cluster biogenesis in Escherichia coli
    Laurent Loiseau
    Laboratoire de Chimie Bacterienne, UPR CNRS 9043, Institut de Biologie Structurale et Microbiologie, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Biol Chem 280:26760-9. 2005
    ..Moreover, both in vitro and in vivo investigations pointed to a specific connection between the CSD system and quinolinate synthetase NadA...
  54. ncbi request reprint Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU
    Gunhild Layer
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, Commissariat a l Energie Atomique CNRS Universite Joseph Fourier, CEA Grenoble, UMR 5047, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    J Biol Chem 281:16256-63. 2006
    ..All of these results point toward a link between CyaY and [Fe-S] cluster biosynthesis, and a possible mechanism for the process is discussed...
  55. ncbi request reprint Quinolinate synthetase, an iron-sulfur enzyme in NAD biosynthesis
    Sandrine Ollagnier-de Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    FEBS Lett 579:3737-43. 2005
    ..An enzymatic assay for quinolinate synthetase activity was set up and allowed to demonstrate that the cluster is absolutely required for NadA activity. Exposure to air leads to degradation of the cluster and inactivate enzyme...
  56. ncbi request reprint Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis
    Alexia Chandor
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, UMR 5047, Commissariat a l Energie Atomique CNRS Universite Joseph Fourier, 17 Rue des Martyrs 38054, Grenoble Cedex 09, France
    J Biol Chem 281:26922-31. 2006
    ....
  57. ncbi request reprint Biochemical characterization of the HydE and HydG iron-only hydrogenase maturation enzymes from Thermatoga maritima
    Jon K Rubach
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, UMR 5047, Département Réponses et Dynamiques Cellulaires, CEA Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    FEBS Lett 579:5055-60. 2005
    ..The HydG protein binds one [4Fe-4S] cluster, and probably an additional one. Both enzymes are able to reductively cleave S-adenosylmethionine (SAM) when reduced by dithionite, confirming that they are Radical-SAM enzymes...
  58. doi request reprint X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima
    Yvain Nicolet
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale J P Ebel, Commissariat a l Energie Atomique, CNRS, Universite J Fourier, 41 rue J Horowitz, 38027 Grenoble Cedex 1, France
    J Biol Chem 283:18861-72. 2008
    ..Although the overall triose-phosphate isomerase-barrel structure of HydE is very similar to that of biotin synthase, the residues that line the internal cavity are significantly different in the two enzymes...
  59. doi request reprint NfuA, a new factor required for maturing Fe/S proteins in Escherichia coli under oxidative stress and iron starvation conditions
    Sandra Angelini
    Laboratoire de Chimie Bacterienne, CNRS, UPR 9043, Marseille Cedex, France
    J Biol Chem 283:14084-91. 2008
    ..By taking into account results from numerous previous transcriptomic studies that had suggested a link between NfuA and protein misfolding, we discuss the possibility that NfuA could act as a scaffold/chaperone for damaged Fe/S proteins...
  60. pmc Mechanism and regulation of the Two-component FMN-dependent monooxygenase ActVA-ActVB from Streptomyces coelicolor
    Julien Valton
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 283:10287-96. 2008
    ..These results suggest that, in Streptomyces coelicolor, the reductase component ActVB can act as a regulatory component of the monooxygenase activity by controlling the transfer of reduced FMN to the monooxygenase...
  61. pmc ErpA, an iron sulfur (Fe S) protein of the A-type essential for respiratory metabolism in Escherichia coli
    Laurent Loiseau
    Unité Propre de Recherche 9043, Laboratoire de Chimie Bacterienne, Centre National de la Recherche Scientifique, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Proc Natl Acad Sci U S A 104:13626-31. 2007
    ..coli. Surprisingly, the erpA gene maps at a distance from any other Fe-S biogenesis-related gene. ErpA is an A-type Fe-S protein that is characterized by an essential role in cellular metabolism...
  62. ncbi request reprint Cobalt stress in Escherichia coli. The effect on the iron-sulfur proteins
    Caroline Ranquet
    Laboratoire de Chimie et Biologie des Metaux, iRTSV LCBM, Commissariat a l Energie Atomique CNRS Universite Joseph Fourier, CEA Grenoble, UMR 5249, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    J Biol Chem 282:30442-51. 2007
    ..We propose a model wherein cobalt competes out iron during synthesis of [Fe-S] clusters in metabolically essential proteins...
  63. ncbi request reprint Characterization of Arabidopsis thaliana SufE2 and SufE3: functions in chloroplast iron-sulfur cluster assembly and Nad synthesis
    Narayana Murthy U M
    Biology Department and Program in Molecular Plant Biology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 282:18254-64. 2007
    ..Knock-out of SufE3 in Arabidopsis is embryolethal. We conclude that SufE3 is the NadA enzyme of A. thaliana, involved in a critical step during NAD biosynthesis...
  64. ncbi request reprint MiaB, a bifunctional radical-S-adenosylmethionine enzyme involved in the thiolation and methylation of tRNA, contains two essential [4Fe-4S] clusters
    Heather L Hernandez
    Department of Chemistry and Center for Metalloenzyme Studies, University of Georgia, Athens, Georgia 30602, USA
    Biochemistry 46:5140-7. 2007
    ....
  65. ncbi request reprint SufE transfers sulfur from SufS to SufB for iron-sulfur cluster assembly
    Gunhild Layer
    Laboratoire de Chimie et Biologie des Metaux, iRTSV LCBM, Commissariat a l Energie Atomique CNRS Universite Joseph Fourier, CEA Grenoble, UMR 5249, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    J Biol Chem 282:13342-50. 2007
    ..The interaction occurs only if SufC is present. Furthermore, SufB can act as a site for Fe-S cluster assembly in the Suf system. This provides the first evidence of a novel site for Fe-S cluster assembly in the SufBCD complex...
  66. ncbi request reprint The SUF iron-sulfur cluster biosynthetic machinery: sulfur transfer from the SUFS-SUFE complex to SUFA
    Maïté Sendra
    Laboratoire de Chimie et Biologie des Metaux, iRTSV LCBM, UMR 5249, CEA Grenoble, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    FEBS Lett 581:1362-8. 2007
    ..Fe-S] clusters, characterized by Mössbauer spectroscopy, can be assembled during reaction of sulfurated SufA with ferrous iron in the presence of a source of electrons...
  67. ncbi request reprint Cobaloximes as functional models for hydrogenases. 2. Proton electroreduction catalyzed by difluoroborylbis(dimethylglyoximato)cobalt(II) complexes in organic media
    Carole Baffert
    Laboratoire de Chimie et Biologie des Metaux, Universite Joseph Fourier, CNRS, UMR 5249, and CEA, DSV iRT SV LCBM, 38054 Grenoble, France
    Inorg Chem 46:1817-24. 2007
    ....
  68. ncbi request reprint The flavin reductase ActVB from Streptomyces coelicolor: characterization of the electron transferase activity of the flavoprotein form
    Laurent Filisetti
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CEA CNRS Université Joseph Fourier, Grenoble, France
    FEBS Lett 579:2817-20. 2005
    ..This shows that ActVB active site exhibits a dual property with regard to the FMN. It can use it as a substrate that goes in and off the active site or as a cofactor to provide an electron transferase activity to the polypeptide...
  69. ncbi request reprint DNA detection through signal amplification by using NADH: flavin oxidoreductase and oligonucleotide-flavin conjugates as cofactors
    Philippe Simon
    Chimie Bioorganique, Departement de Pharmacochimie Moleculaire, UMR CNRS Université Joseph Fourier Meylan, France
    Angew Chem Int Ed Engl 44:2764-7. 2005
  70. ncbi request reprint The PLP-dependent biotin synthase from Escherichia coli: mechanistic studies
    Sandrine Ollagnier-de-Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17 Avenue des Martyrs, 38054 Cedex 09, Grenoble, France
    FEBS Lett 532:465-8. 2002
    ..Furthermore 5'-deoxyadenosine, a product of the reaction, strongly inhibited biotin formation, an observation that may explain why BioB is not able to make more than one turnover. However this enzyme inactivation is not irreversible...
  71. ncbi request reprint Mechanism and substrate specificity of the flavin reductase ActVB from Streptomyces coelicolor
    Laurent Filisetti
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CEA CNRS Université Joseph Fourier, 17 Avenue des Martyrs, 38054 Grenoble, Cedex 9, France
    J Biol Chem 278:296-303. 2003
    ..We show that both the ribitol-phosphate chain and the isoalloxazine ring contribute to the protein-flavin interaction. Such properties are unique and set the ActVB family apart from the well characterized Fre flavin reductase family...
  72. ncbi request reprint Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase
    Marc Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, UMR CNRS CEA Université Joseph DRDC CB, CEA Grenoble, France
    Prog Nucleic Acid Res Mol Biol 72:95-127. 2002
    ..This review article describes their structural and mechanistic properties as well as their complex allosteric regulation. Their evolutionnary relationship to class I and class II ribonucleotide reductases is also discussed...
  73. ncbi request reprint Redox-dependent structural changes in the superoxide reductase from Desulfoarculus baarsii and Treponema pallidum: a FTIR study
    Catherine Berthomieu
    CEA Cadarache, DSV DEVM, Laboratoire de Bioenergetique Cellulaire, UMR 163 CNRS CEA, Univ Méditerranée CEA 1000, Bât 156, F 13108 Saint Paul lez Durance, Cedex, France
    Biochemistry 41:10360-8. 2002
    ..Houée-Levin, C., Touati, D., Fontecave, M., and Nivière, V. (2001) Biochemistry 40, 5032-5040], is purely electrostatic, guiding superoxide toward the reduced iron...
  74. ncbi request reprint Biotin synthase is a pyridoxal phosphate-dependent cysteine desulfurase
    Sandrine Ollagnier-de-Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17, avenue des Martyrs, 38054 Grenoble Cedex 09, France
    Biochemistry 41:9145-52. 2002
    ..New scenarios for sulfur insertion into dethiobiotin, in which cysteine persulfides play a key role, are discussed...
  75. ncbi request reprint Identification of iron(III) peroxo species in the active site of the superoxide reductase SOR from Desulfoarculus baarsii
    Christelle Mathé
    Laboratoire de Biophysique du Stress Oxydant, SBE DBJC CEA SACLAY, 91191 Gif sur Yvette Cedex, France
    J Am Chem Soc 124:4966-7. 2002
    ..These data support the hypothesis that the reaction of SOR proceeds through such a Fe3+-peroxo intermediate. This also suggests that Glu47 might serve to help H2O2 release during the reaction with superoxide...
  76. ncbi request reprint Sulfide oxidation by hydrogen peroxide catalyzed by iron complexes: two metal centers are better than one
    Yasmina Mekmouche
    Laboratoire de Chimie et Biochimie, Centres Rédox Biologiques, Université Joseph Fourier DBMS CEA, UMR CNRS 5047 Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
    Chemistry 8:1196-204. 2002
    ..These results might help for the design of future enantioselective iron catalysts...
  77. ncbi request reprint Tyrosyl radicals and ribonucleotide reductase
    Marc Fontecave
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CEA CNRS Université Joseph Fourier, 38054 Grenoble, France
    Methods Enzymol 348:21-30. 2002
  78. ncbi request reprint Enzymatic modification of tRNAs: MiaB is an iron-sulfur protein
    Fabien Pierrel
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, Departement de Biologie Moléculaire et Structurale Chimie Biologie, UMR 5047 Commissariat à l Energie Atomique CEA CNRS Université Joseph Fourier, Grenoble, France
    J Biol Chem 277:13367-70. 2002
    ..MiaB is the first and only tRNA modification enzyme known to contain an Fe-S cluster...
  79. ncbi request reprint The iron-sulfur center of biotin synthase: site-directed mutants
    Kirsty S Hewitson
    Oxford Center for Molecular Sciences, Dyson Perrins Laboratory, South Parks Road, Oxford OX1 3QY, UK
    J Biol Inorg Chem 7:83-93. 2002
    ..Therefore it appears that for activity biotin synthase absolutely requires cysteines that are not involved in iron chelation...
  80. ncbi request reprint Reductive cleavage of S-adenosylmethionine by biotin synthase from Escherichia coli
    Sandrine Ollagnier-de Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, Departement de Biologie Moléculaire et Structurale Chimie Biologie, CEA CNRS Université Joseph Fourier, UMR 5047, Grenoble, France
    J Biol Chem 277:13449-54. 2002
    ....
  81. ncbi request reprint SufA from Erwinia chrysanthemi. Characterization of a scaffold protein required for iron-sulfur cluster assembly
    Sandrine Ollagnier-de Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, Département Résponse et Dynamique Cellulaire Chimie Biochimie, CEA CNRS Université Joseph Fourier, UMR 5047, 17 Ave des Martyrs, Grenoble 38054, Cedex 09, France
    J Biol Chem 278:17993-8001. 2003
    ..Mechanistic and physiological implications of these results are also discussed...
  82. pmc A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase
    Derek T Logan
    Department of Molecular Biophysics, Lund University, Box 124, 221 00 Lund, Sweden
    Proc Natl Acad Sci U S A 100:3826-31. 2003
    ..The possible roles of the metal center are discussed in relationship to the currently proposed reaction mechanism for generation of the glycyl radical in class III RNRs...
  83. ncbi request reprint A two-component flavin-dependent monooxygenase involved in actinorhodin biosynthesis in Streptomyces coelicolor
    Julien Valton
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CEA CNRS UniversitéJoseph Fourier, 17 Avenue des Martyrs, 38054 Grenoble 9, France
    J Biol Chem 279:44362-9. 2004
    ..A direct spectroscopic evidence for the formation of such species within ActVA-ORF5 is reported...
  84. ncbi request reprint MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA
    Fabien Pierrel
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, Unité Mixte de Recherche 5047 Commissariat à l Energie Atomique CNRS Université Joseph Fourier, Grenoble, France
    J Biol Chem 279:47555-63. 2004
    ..The origin of the sulfur atom is discussed...
  85. ncbi request reprint Discovery of superoxide reductase: an historical perspective
    Vincent Niviere
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DRDC CB, UMR CEA CNRS Université Joseph Fourier no 5047, CEA Grenoble, 17 Avenue des Martyrs, 38054 Grenoble Cedex 9, France
    J Biol Inorg Chem 9:119-23. 2004
    ..Having played a major role in this discovery, we describe here how the concept of superoxide reduction emerged and how it was experimentally substantiated independently in our laboratory...
  86. ncbi request reprint Assignment of the (1)H, (15)N and (13)C resonances of SufA from Escherichia coli involved in Fe-S cluster biosynthesis
    Nicolas Duraffourg
    J Biomol NMR 30:379-80. 2004
  87. ncbi request reprint Mechanistic studies of the SufS-SufE cysteine desulfurase: evidence for sulfur transfer from SufS to SufE
    Sandrine Ollagnier-de-Choudens
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS CB, CEA CNRS Université Joseph Fourier, UMR 5047, 17 Avenue des Martyrs, 38054 Grenoble Cedex 09, France
    FEBS Lett 555:263-7. 2003
    ..the direct transfer of the sulfur atom from the cysteine persulfide of SufS to SufE. A reaction mechanism is proposed for this novel two-component cysteine desulfurase...
  88. ncbi request reprint Biogenesis of Fe-S cluster by the bacterial Suf system: SufS and SufE form a new type of cysteine desulfurase
    Laurent Loiseau
    LCB CNRS, IBSM, 31 Chemin Joseph Aiguier, 13402 Marseille 20, France
    J Biol Chem 278:38352-9. 2003
    ..This is the first example of a two-component cysteine desulfurase enzyme...
  89. ncbi request reprint MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase
    Fabien Pierrel
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, Département Réponse et Dynamique Cellulaires Chimie Biologique, UMR 5047 Commissariat à l Energie Atomique CNRS Université Joseph Fourier, Commissariat a l Energie Atomique Grenoble, France
    J Biol Chem 278:29515-24. 2003
    ..Finally, the expression of MiaBTm from T. maritima in an E. coli mutant strain lacking functional miaB gene allowed production of ms2i6A-37. These results provide further information on the enzymes involved in methylthiolation of tRNAs...
  90. ncbi request reprint Hydrolysis of phosphodiesters by diiron complexes: design of nonequivalent iron sites in purple acid phosphatase models
    François Verge
    Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, Université Joseph Fourier DRDC CEA, UMR CNRS 5047, Grenoble, 17 rue des Martyrs, 38054 Grenoble, France
    Inorg Chem 42:499-507. 2003
    ..The activity of [Fe2O(bipy)3(33'44'Me2-Phen)(OH2)2](NO3)4 [33'44'Me2Phen = 3,3',4,4'-dimethyl-1,10-phenanthroline] was found to be comparable to that reported for Co(III) or Ce(IV) complexes...
  91. ncbi request reprint Mössbauer characterization of an unusual high-spin side-on peroxo-Fe3+ species in the active site of superoxide reductase from Desulfoarculus Baarsii. Density functional calculations on related models
    Olivier Horner
    Departement Reponse et Dynamique Cellulaires, Laboratoire de Physicochimie des Métaux en Biologie, UMR CEA CNRS Université Joseph Fourier 5155, France
    Biochemistry 43:8815-25. 2004
    ..58 mm/s range. The occurrence of a side-on peroxo intermediate in SOR is discussed in relation to the recent data published for a side-on peroxo-Fe(3+) species in another biological system [Karlsson et al. (2003) Science 299, 1039-1042]...
  92. ncbi request reprint Biochemical and electron paramagnetic resonance study of the iron superoxide dismutase from Plasmodium falciparum
    Sylvie Gratepanche
    Laboratory of Parasitic Diseases, Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Mol Biochem Parasitol 120:237-46. 2002
    ..The fact that the parasite SOD does not belong to classes of SOD present in humans may provide a novel approach for the design of antimalarial drugs...
  93. ncbi request reprint Activation of the anaerobic ribonucleotide reductase by S-adenosylmethionine
    Serge Gambarelli
    Service de Chimie Inorganique et Biologique, DRFMC SCIB, CEA Grenoble, 17 Avenue des Martyrs, 38054 Grenoble Cedex 9, France
    Chembiochem 6:1960-2. 2005
  94. pmc tRNA-modifying MiaE protein from Salmonella typhimurium is a nonheme diiron monooxygenase
    Carole Mathevon
    Commissariat à l Energie Atomique Centre National de la Recherche Scientifique Université Joseph Fourier, Commissariat a l Energie Atomique Grenoble, 38054 Grenoble Cedex 09, France
    Proc Natl Acad Sci U S A 104:13295-300. 2007
    ....
  95. ncbi request reprint Very high-field EPR study of glycyl radical enzymes
    Carole Duboc-Toia
    High Magnetic Field Laboratory of Grenoble, CNRS MPI, 25 av des Martyrs, 38042 Grenoble, France
    J Am Chem Soc 125:38-9. 2003
    ..Because the g-anisotropy is small, the complete resolution of the g-tensor could be only obtained at very high field (18.8 T)...