Jessica Zucman-Rossi

Summary

Affiliation: Fondation Jean Dausset
Country: France

Publications

  1. ncbi NF2 gene in neurofibromatosis type 2 patients
    J Zucman-Rossi
    Laboratoire de Genetique des Tumeurs, INSERM U434 and CEPH Fondation Jean Dausset, 27 rue Juliette Dodu, 75010 Paris, France
    Hum Mol Genet 7:2095-101. 1998
  2. ncbi Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    Sandrine Boyault
    INSERM U674, CEPH Fondation Jean Dausset, Paris, France
    Hepatology 45:42-52. 2007
  3. doi MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations
    Yannick Ladeiro
    INSERM U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Hepatology 47:1955-63. 2008
  4. pmc Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage
    Emmanuelle Jeannot
    Institut National de Santé et de Recherche Médicale, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Diabetes 59:1836-44. 2010
  5. pmc Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
    Camilla Pilati
    Génomique fonctionnelle des tumeurs solides, Institut National de la Sante et de la Recherche Medicale INSERM, U674, Paris, F 75010, France
    J Exp Med 208:1359-66. 2011
  6. pmc Molecular classification of hepatocellular adenomas
    Jean Charles Nault
    Inserm UMR 674, Génomique fonctionnelle des tumeurs solides, IUH, 75010 Paris, France Labex Immuno Oncology, Faculte de Medecine, Universite Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France
    Int J Hepatol 2013:315947. 2013
  7. ncbi Molecular classification of hepatocellular carcinoma
    Jessica Zucman-Rossi
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, F 75010 Paris, France
    Dig Liver Dis 42:S235-41. 2010
  8. ncbi Genetic alterations in hepatocellular adenomas: recent findings and new challenges
    Jessica Zucman-Rossi
    INSERM U434, Fondation Jean Dausset, 27 rue Juliette Dodu, 75010 Paris, France
    J Hepatol 40:1036-9. 2004
  9. ncbi Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC
    Jessica Zucman-Rossi
    INSERM, U674, IUH, CEPH, Paris, France
    Hepatology 43:515-24. 2006
  10. doi Human and mouse hepatocellular adenoma and carcinoma display similar tumorigenesis pathway alterations
    Jessica Zucman-Rossi
    INSERM U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    J Hepatol 48:884-6. 2008

Detail Information

Publications68

  1. ncbi NF2 gene in neurofibromatosis type 2 patients
    J Zucman-Rossi
    Laboratoire de Genetique des Tumeurs, INSERM U434 and CEPH Fondation Jean Dausset, 27 rue Juliette Dodu, 75010 Paris, France
    Hum Mol Genet 7:2095-101. 1998
    ..The remaining three patients who express two functional NF2 alleles are all sporadic cases, an observation compatible with the presence of mosaicism for NF2 mutation...
  2. ncbi Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    Sandrine Boyault
    INSERM U674, CEPH Fondation Jean Dausset, Paris, France
    Hepatology 45:42-52. 2007
    ..G5 and G6 were strongly related to beta-catenin mutations that lead to Wnt pathway activation; in particular, G6 tumors were characterized by satellite nodules, higher activation of the Wnt pathway, and E-cadherin underexpression...
  3. doi MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations
    Yannick Ladeiro
    INSERM U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Hepatology 47:1955-63. 2008
    ..Thus, this strongly suggests that beta-catenin and HNF1alpha could regulate miR-375 and miR-107 expression levels, respectively...
  4. pmc Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage
    Emmanuelle Jeannot
    Institut National de Santé et de Recherche Médicale, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Diabetes 59:1836-44. 2010
    ..To better understand a relationship between the development of MODY3 and HCA, we compared both germline and somatic spectra of HNF1A mutations...
  5. pmc Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas
    Camilla Pilati
    Génomique fonctionnelle des tumeurs solides, Institut National de la Sante et de la Recherche Medicale INSERM, U674, Paris, F 75010, France
    J Exp Med 208:1359-66. 2011
    ..Thus, we identified for the first time somatic STAT3 mutations in human tumors, revealing a new mechanism of recurrent STAT3 activation and underscoring the role of the IL-6-STAT3 pathway in benign hepatocellular tumorigenesis...
  6. pmc Molecular classification of hepatocellular adenomas
    Jean Charles Nault
    Inserm UMR 674, Génomique fonctionnelle des tumeurs solides, IUH, 75010 Paris, France Labex Immuno Oncology, Faculte de Medecine, Universite Paris Descartes, Sorbonne Paris Cité, 75005 Paris, France
    Int J Hepatol 2013:315947. 2013
    ..Here, we will review the different molecular classes of HCA...
  7. ncbi Molecular classification of hepatocellular carcinoma
    Jessica Zucman-Rossi
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, F 75010 Paris, France
    Dig Liver Dis 42:S235-41. 2010
    ..Finally, a refinement of the molecular classification of HCC, taking into account the geographical and genetic diversity of the patients, will be essential for an efficient design of the forthcoming personalized clinical treatments...
  8. ncbi Genetic alterations in hepatocellular adenomas: recent findings and new challenges
    Jessica Zucman-Rossi
    INSERM U434, Fondation Jean Dausset, 27 rue Juliette Dodu, 75010 Paris, France
    J Hepatol 40:1036-9. 2004
  9. ncbi Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC
    Jessica Zucman-Rossi
    INSERM, U674, IUH, CEPH, Paris, France
    Hepatology 43:515-24. 2006
    ....
  10. doi Human and mouse hepatocellular adenoma and carcinoma display similar tumorigenesis pathway alterations
    Jessica Zucman-Rossi
    INSERM U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    J Hepatol 48:884-6. 2008
  11. doi [Fundamental and translational research on hepatocellular carcinoma in 2008: forces and priorities]
    J Zucman-Rossi
    INSERM, U674 université Paris Diderot Paris VII, 75010 Paris, France
    Bull Cancer 96:45-50. 2009
    ..The aim of this work was to identify in the international context, forces and priorities of the fundamental and translational HCC research...
  12. ncbi Bi-allelic inactivation of TCF1 in hepatic adenomas
    Olivier Bluteau
    INSERM U434, Fondation Jean Dausset, 27 rue Juliette Dodu, 75010 Paris, France
    Nat Genet 32:312-5. 2002
    ..These results indicate that inactivation of TCF1, whether sporadic or associated with MODY3, is an important genetic event in the occurrence of human liver adenoma, and may be an early step in the development of some HCCs...
  13. pmc High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
    Jean Charles Nault
    INSERM, UMR 674, Génomique fonctionnelle des tumeurs solides, IUH, Paris F 75010, France
    Nat Commun 4:2218. 2013
    ....
  14. ncbi HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response element-binding protein (ChREBP) activation
    Sandra Rebouissou
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, Paris Cedex, France
    J Biol Chem 282:14437-46. 2007
    ..Finally, our findings have potential clinical implications since lipogenesis can be efficiently inhibited by targeted therapies...
  15. ncbi The beta-catenin pathway is activated in focal nodular hyperplasia but not in cirrhotic FNH-like nodules
    Sandra Rebouissou
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, 27 rue Juliette Dodu, Paris F 75010, France
    J Hepatol 49:61-71. 2008
    ..In contrast, FNH-like lesions/nodules occur in cirrhotic liver but share similar histopathological features. We conducted a transcriptome analysis to identify biological pathways deregulated in FNH...
  16. pmc Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli
    Emmanuelle Jeannot
    INSERM, U674, IUH, Universite Paris 7, Paris, France
    J Hepatol 45:883-6. 2006
    ..Altogether, these results suggest that benign hepatocellular carcinogenesis may be dependent on or independent of the Wnt/beta-catenin pathway in patients with FAP...
  17. doi Identification of novel oncogenes and tumor suppressors in hepatocellular carcinoma
    Sandrine Imbeaud
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Semin Liver Dis 30:75-86. 2010
    ....
  18. pmc Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
    Sandra Rebouissou
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, Paris F 75010, France
    Nature 457:200-4. 2009
    ....
  19. doi ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway
    Julien Calderaro
    INSERM, UMR 674, Génomique fonctionnelle des tumeurs solides, Institut Universitaire d Hematologie, 27 rue Juliette Dodu, Paris, 75010, France
    Virchows Arch 464:53-60. 2014
    ..Further studies may help to elucidate the potential role of ALDH3A1 in HCC development and resistance to chemotherapy. ..
  20. doi Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis
    Laura Pelletier
    Institut National de la Sante et de la Recherche Medicale, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Hepatology 51:557-66. 2010
    ..In the cell model, inhibition of HNF1alpha recapitulated most of these identified transcriptional deregulations, demonstrating that they were related to HNF1alpha inhibition...
  21. pmc Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma
    Didier Jean
    INSERM, U674, Paris, France
    Am J Pathol 178:881-94. 2011
    ..Overall, these data show similarities between murine and human disease, and contribute to the understanding of the influence of fibers in the pathogenesis of mesothelioma and validation of the murine model for preclinical testing...
  22. ncbi Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma
    Emmanuelle Jeannot
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Cancer Res 67:2611-6. 2007
    ..In conclusion, our data suggested that CYP1B1 germ line-inactivating mutations might increase the incidence of HCA in women with HNF1alpha mutations...
  23. doi Genomic profiling reveals alternative genetic pathways of meningioma malignant progression dependent on the underlying NF2 status
    Stéphane Goutagny
    Université Paris 5 Descartes, Paris, France
    Clin Cancer Res 16:4155-64. 2010
    ..WHO defines three grades predictive of the risk of recurrence. Clinical data supporting histologic malignant progression of meningiomas are sparse and underlying molecular mechanisms are not clearly depicted...
  24. doi GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation
    Jean Charles Nault
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    J Hepatol 56:184-91. 2012
    ..Identification of a hepatocellular adenoma (HCA) in two MCA patients led us to search for GNAS activation in benign and malignant hepatocellular carcinogenesis...
  25. pmc HNF1α inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines
    Laura Pelletier
    Inserm U674 Génomique fonctionnelle des tumeurs solides, Paris, France
    BMC Cancer 11:427. 2011
    ..We studied the consequences of HNF1α silencing in hepatic cell lines, HepG2 and Hep3B and we reproduced most of the deregulations identified in H-HCA...
  26. ncbi Mutation of TCF1 encoding hepatocyte nuclear factor 1alpha in gynecological cancer
    Sandra Rebouissou
    INSERM U434, 27 rue Juliette Dodu, 75010 Paris, France
    Oncogene 23:7588-92. 2004
    ..These results suggest that HNF1alpha may contribute to endometrial carcinogenesis through complete HNF1alpha inactivation like in liver cell adenoma or by haploinsufficiency like in MSI-H colorectal cancer...
  27. ncbi Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation
    Camilla Pilati
    INSERM, UMR 1162, Génomique fonctionnelle des tumeurs solides, IUH, 75010 Paris, France Labex Immuno Oncology, Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, 75006 Paris, France
    Cancer Cell 25:428-41. 2014
    ..In conclusion, we identified the genomic diversity in benign hepatocyte proliferation, several therapeutic targets, and the key genomic determinants of the adenoma-carcinoma transformation sequence. ..
  28. doi A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection
    Jean Charles Nault
    INSERM, UMR 674, Génomique fonctionnelle des tumeurs solides, IUH, Paris, France
    Gastroenterology 145:176-87. 2013
    ..Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is a challenge to determine a patient's prognosis. We aimed to identify new prognostic markers of patients with HCC treated by liver resection...
  29. doi Hepatocellular benign tumors-from molecular classification to personalized clinical care
    Jean Charles Nault
    INSERM, UMR 674, Génomique fonctionnelle des tumeurs solides, IUH, Paris, France
    Gastroenterology 144:888-902. 2013
    ..We review the molecular pathways involved in benign hepatocyte proliferation and discuss how this basic knowledge has been progressively translated into personalized clinical care...
  30. doi Molecular characterization of hepatocellular adenomas developed in patients with glycogen storage disease type I
    Julien Calderaro
    INSERM, UMR 674, Génomique fonctionnelle des tumeurs solides, IUH, F 75010 Paris, France
    J Hepatol 58:350-7. 2013
    ..Glycogen storage disease type I (GSD) is a rare hereditary metabolic disease that predisposes to HCA development. The aim of our study was to characterize the molecular profile of GSD-associated HCA...
  31. ncbi Recurrent inactivating mutations of ARID2 in non-small cell lung carcinoma
    Gilles Manceau
    Molecular Basis of Response to Xenobiotics, Inserm UMR S775, Paris, France
    Int J Cancer 132:2217-21. 2013
    ....
  32. doi Identification of molecular pathways involved in oxaliplatin-associated sinusoidal dilatation
    Julie Agostini
    Paris Descartes University, Paris Sorbonne Cité, Inserm UMR S775, Paris, France
    J Hepatol 56:869-76. 2012
    ..A better understanding of the molecular mechanisms of oxaliplatin liver toxicity may allow the identification of biomarkers and adaptation of chemotherapy delivery...
  33. doi KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis
    Isabelle Gasnereau
    Université Pierre et Marie Curie UPMC, Paris, France
    Am J Pathol 180:131-40. 2012
    ....
  34. ncbi Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma
    Sandra Rebouissou
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, Génétique des tumeurs hépatiques, Paris, France
    J Hepatol 48:163-70. 2008
    ..These findings may modify our clinical practice, particularly in the diagnosis and follow-up of HCA patients...
  35. doi Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers
    Sebastien Gaujoux
    Institut Cochin, Université Paris Descartes Faculté de Médecine, CNRS UMR 8104, Paris, France
    Clin Cancer Res 16:5133-41. 2010
    ..Both APC and WTX are involved in Wnt/β-catenin pathway regulation and may play a role in ACT tumorigenesis. The aim of this study was to report if APC and WTX may be associated with FAP-associated and sporadic ACT...
  36. ncbi [Towards a new diagnostic approach to benign hepatocytic nodules]
    Paulette Bioulac-Sage
    Service d Anatomie Pathologique, Hopital Pellegrin, Paris, France
    Gastroenterol Clin Biol 29:641-4. 2005
  37. doi Genetics of hepatobiliary carcinogenesis
    Jean Charles Nault
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Semin Liver Dis 31:173-87. 2011
    ..The validation of sorafenib as the first targeted therapy useful in HCC has opened up new prospects for biotherapy in this cancer. In the future, mapping of genetic alterations will be essential to adapt treatment to HCC and CC biology...
  38. ncbi Similar tumor suppressor gene alteration profiles in asbestos-induced murine and human mesothelioma
    Céline Lecomte
    INSERM U674, Fondation Jean Dausset CEPH, Paris, France
    Cell Cycle 4:1862-9. 2005
    ..Thus, the mouse mesothelioma model could be useful for human risk assessment, taking into account interindividual variations in genetic sensitivity to carcinogens...
  39. pmc Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
    Cecile Guichard
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité Mixte de Recherche UMR 674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Nat Genet 44:694-8. 2012
    ..This study provides insight into the somatic mutational landscape in HCC and identifies interactions between mutations in oncogene and tumor suppressor gene mutations related to specific risk factors...
  40. doi Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion
    Florence Grise
    INSERM, Physiopathologie du Cancer du Foie, U1053, Bordeaux, France
    Hepatology 55:1766-75. 2012
    ..Rnd3 knockdown mediated tumor hepatocyte invasion in a matrix-metalloproteinase-independent, and Rac1-dependent manner...
  41. ncbi Germline hepatocyte nuclear factor 1alpha and 1beta mutations in renal cell carcinomas
    Sandra Rebouissou
    INSERM U674, CEPH, IUH Saint Louis, Paris, France
    Hum Mol Genet 14:603-14. 2005
    ..Furthermore, we suggest that HNF1beta functions as a tumor suppressor gene in chromophobe renal cell carcinogenesis through a PKHD1 expression control...
  42. ncbi Genetic diversity of hepatocellular carcinomas and its potential impact on targeted therapies
    Jessica Zucman-Rossi
    INSERM, U674, Functional Genomics of Solid Tumors, F 75010 Paris, France
    Pharmacogenomics 8:997-1003. 2007
    ..Together with the analysis of defined oncogenic proteins, such global classifications could be useful in the prediction of future-targeted therapy efficiency...
  43. ncbi HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis
    Paola Ballerini
    Service d Hematologie Biologique, Hopital Armand Trousseau, Paris, France
    Blood 100:991-7. 2002
    ..Finally, our data show that HOX11L2 expression was a suitable marker for minimal residual disease follow-up and was significantly associated with relapse (P =.02)...
  44. ncbi Characterisation of 16 polymorphic markers in the NF2 gene: application to hemizygosity detection
    P Legoix
    Laboratoire de Genetique des Tumeurs, Fondation Jean Dausset CEPH, Paris, France
    Hum Mutat 13:290-3. 1999
    ..To facilitate the deletion screening, 16 polymorphic markers were identified in the NF2 genomic sequence enabling an hemizygosity test in familial studies...
  45. ncbi Specific association between alcohol intake, high grade of differentiation and 4q34-q35 deletions in hepatocellular carcinomas identified by high resolution allelotyping
    Olivier Bluteau
    INSERM U434, CEPH 27 Rue Juliette Dodu, 75010 Paris, France
    Oncogene 21:1225-32. 2002
    ..In the light of these new findings, which link different 4q LOH regions to different etiologic factors, the molecular mechanisms underlying 4q deletions in HCC and the targeted gene(s) remain to be identified...
  46. ncbi Overexpression of phosphatidylinositol 4-kinase type IIIα is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma
    Adeodat Ilboudo
    INSERM, UMR 1085, Institut de Recherche Santé Environnement and Travail IRSET, F 35043, Rennes, France
    BMC Cancer 14:7. 2014
    ..Also, phosphatidylinositol 4-kinase type IIIα (PI4KA) is necessary for the propagation of the hepatitis C virus, a major etiological factor for HCC...
  47. ncbi Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas
    J Zucman-Rossi
    INSERM U674 IFR105, Paris Saint Louis, CEPH, Paris, France
    Oncogene 26:774-80. 2007
    ..Our results also suggest that the tumor suppressor function of Axin1 in HCC may be related to another, non-Wnt pathway...
  48. ncbi Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity
    P Legoix
    Centre d Etude du Polymorphisme Humain, INSERM U434 Laboratoire de Génétique des Tumeurs, Fondation Jean Dausset CEPH, Paris, France
    Oncogene 18:4044-6. 1999
    ..The first mechanism implies a beta catenin activating mutation associated with a low rate of loss of heterozygosity. The second mechanism, operating in a context of chromosomal instability, would involve tumor suppressor genes...
  49. ncbi Interethnic polymorphism of EWS intron 6: genome plasticity mediated by Alu retroposition and recombination
    J Zucman-Rossi
    INSERM U 434 Genetique des Tumeurs, Institut Curie, Section de Recherche, Paris, France
    Hum Genet 99:357-63. 1997
    ..This rare allele has only been observed in individuals of African origin, a population that is characterized by the lowest incidence of Ewing's sarcoma...
  50. ncbi Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region
    J Zucman-Rossi
    INSERM U434 Génétique des Tumeurs, Institut Curie, Section de Recherche, Paris, France
    Genomics 38:247-54. 1996
    ..Although no mutation was observed in a small set of meningiomas and schwannomas, alteration of these new genes should now be searched in other tumors with frequent allelic losses on chromosome 22 not associated with NF2 mutation...
  51. ncbi Genotype phenotype classification of hepatocellular adenoma
    Paulette Bioulac-Sage
    World J Gastroenterol 13:2649-54. 2007
    ..The optimal care of patients with a liver nodule will benefit from the recent knowledge coming from molecular biology and the combined expertise of hepatologists, pathologists, radiologists, and surgeons...
  52. ncbi Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha
    Konstantin Khetchoumian
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Department of Functional Genomics, Centre National de la Recherche Scientifique UMR7104, Universite Louis Pasteur, College de France, Illkirch, France
    Nat Genet 39:1500-6. 2007
    ..Our results not only provide genetic evidence that Trim24 and Rara co-regulate hepatocarcinogenesis in an antagonistic manner but also suggest that aberrant activation of Rara is deleterious to liver homeostasis...
  53. ncbi The identification of small nodules in liver adenomatosis
    Sebastien Lepreux
    Service d Anatomie Pathologique, CHU Bordeaux, France
    J Hepatol 39:77-85. 2003
    ..Liver adenomatosis is characterized by the presence of multiple adenomas of various sizes in the liver. The aim of this study was to characterize the morphology of small nodules which can be difficult to identify...
  54. ncbi Hepatocyte nuclear factor-1 alpha gene inactivation: cosegregation between liver adenomatosis and diabetes phenotypes in two maturity-onset diabetes of the young (MODY)3 families
    Yves Reznik
    Department of Endocrinology, Centre Hospitalier Universitaire of Caen, 14033 Cannes, France
    J Clin Endocrinol Metab 89:1476-80. 2004
    ..Moreover, such screening may help to determine if a particular mutational spectrum of HNF-1 alpha is associated with liver adenomatosis and to establish its prevalence in this frequent form of diabetes in the young adult...
  55. ncbi Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers
    Astrid Lievre
    1INSERM U490 Laboratoire de Toxicologie Moléculairei, Universite Rene Descartes, 75006 Paris, France
    Oncogene 24:7253-6. 2005
    ..Our data suggest a minor role of KLF6 mutation in colorectal carcinogenesis and underline the fact that the validity of sequence informations obtained from DNA extracted from formalin-fixed tissues may be limited...
  56. ncbi Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver
    Paulette Bioulac-Sage
    Department of Pathology, Centre Hospitalier Universitaire de Bordeaux, France
    Gastroenterology 128:1211-8. 2005
    ..The aim of this study was to use molecular markers, in addition to morphologic features, to better characterize TFNH...
  57. ncbi Absence of KLF6 gene mutation in 71 hepatocellular carcinomas
    Sandrine Boyault
    Hepatology 41:681-2; author reply 682-3. 2005
  58. doi Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification
    Hervé Laumonier
    Department of Radiology, CHU de Bordeaux, Hôpital Saint André, Bordeaux, France
    Hepatology 48:808-18. 2008
    ..5%, a negative predictive value of 84%, a sensitivity of 85.2%, and a specificity of 87.5% for the diagnosis of inflammatory HCA...
  59. ncbi Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis
    Magali Svrcek
    Services d Anatomie et Cytologie Pathologiques, AP HP, Hopital Saint Antoine, F 75571 Paris Cedex 12, France
    Eur J Endocrinol 156:617-21. 2007
    ..Only two cases of regressive LA after hormone withdrawal therapy have been described so far but without any information concerning the molecular characteristics of the tumours...
  60. ncbi Mutation of TP53 gene is involved in carcinogenesis of hepatic undifferentiated (embryonal) sarcoma of the adult, in contrast with Wnt or telomerase pathways: an immunohistochemical study of three cases with genomic relation in two cases
    Sebastien Lepreux
    Service d Anatomie Pathologique, Hopital Pellegrin, CHU Bordeaux, 33076 Bordeaux, France
    J Hepatol 42:424-9. 2005
    ..Hepatic undifferentiated (embryonal) sarcoma (HUS) is an exceptional hepatic malignant tumor in adults. Genetic studies were never reported in adult cases...
  61. ncbi Genetic alterations in hepatocellular adenomas
    Paulette Bioulac-Sage
    Hepatology 37:480; author reply 480-1. 2003
  62. ncbi Clinical and molecular analysis of combined hepatocellular-cholangiocarcinomas
    Dominique Cazals-Hatem
    Department of Pathology, Hopital Beaujon, AP HP, 92110 Clichy, France
    J Hepatol 41:292-8. 2004
    ..To better understand the relations between cholangiocarcinoma (CC), HCC-CC and hepatocellular carcinoma (HCC), we screened for genetic alterations...
  63. ncbi [Precancerous lesions in the cirrhotic and non-cirrhotic liver]
    Jean Frédéric Blanc
    Hépato Gastroentérologie, Hôpital Saint André, 1, rue Jean Burguet, 33076 Bordeaux Cedex
    Gastroenterol Clin Biol 28:D158-70. 2004
  64. ncbi Familial liver adenomatosis associated with hepatocyte nuclear factor 1alpha inactivation
    Yannick Bacq
    Department of Hepatogastroenterology, Centre Hospitalier de Tours, Hopital Trousseau, 37044 Tours Cedex, France
    Gastroenterology 125:1470-5. 2003
    ..This study investigated cosegregation of HNF-1alpha germline mutations with diabetes and liver adenomatosis in 2 families...
  65. ncbi Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma
    Benoit Rousseau
    INSERM, U889, Bordeaux, F 33076 France
    Hepatology 46:1108-18. 2007
    ..03), had increased resistance to C2 ceramide-induced apoptosis (P < 0.001), and gave rise to significantly larger tumors when injected into immunodeficient Rag2/gammac mice (P = 0.016)...
  66. ncbi Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
    Paulette Bioulac-Sage
    Department of Pathology, CHU Bordeaux, France
    Hepatology 46:740-8. 2007
    ..04). Previously described associations were confirmed and in particular the significant association between beta-catenin-activated HCA and hepatocellular carcinomas (HCC) at diagnosis or during follow-up (P < 10(-5))...
  67. ncbi Frequent mutations of hepatocyte nuclear factor 1 in colorectal cancer with microsatellite instability
    Pierre Laurent-Puig
    INSERM Unité 434, CEPH Fondation Jean Dausset, Paris
    Gastroenterology 124:1311-4. 2003
    ..The impact of HNF1 in colorectal carcinogenesis has not been studied until now. Colorectal cancer is characterized by the existence of different molecular mechanisms known as microsatellite stable or unstable tumors...