Richard Hamelin

Summary

Affiliation: Fondation Jean Dausset
Country: France

Publications

  1. ncbi request reprint MBD4 mutations are rare in gastric carcinomas with microsatellite instability
    Mafalda Pinto
    IPATIMUP Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    Cancer Genet Cytogenet 145:103-7. 2003
  2. doi request reprint [Clinical and molecular consequences of microsatellite instability in human cancers]
    Richard Hamelin
    INSERM, UMRS 762, 27 rue Juliette Dodu, 75010 Paris, France
    Bull Cancer 95:121-32. 2008
  3. pmc A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines
    Guro E Lind
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Mol Cancer 3:28. 2004
  4. pmc BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
    Sergia Velho
    Institute of Molecular Pathology and Immunology, University of Porto, Portugal
    BMC Cancer 8:255. 2008
  5. ncbi request reprint An immunogenic process leading to cancer in the context of immunodeficiency
    Richard Hamelin
    INSERM U434, Paris, France
    Cell Cycle 3:1130-2. 2004
  6. ncbi request reprint Detection of microsatellite instability in endometrial cancer: advantages of a panel of five mononucleotide repeats over the National Cancer Institute panel of markers
    Yick Fu Wong
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, China and Inserm, U762, Paris, F 75010 France, Univ Paris 6, Paris, F 75005 France
    Carcinogenesis 27:951-5. 2006
  7. ncbi request reprint Mononucleotide repeats BAT-26 and BAT-25 accurately detect MSI-H tumors and predict tumor content: implications for population screening
    Caroline Brennetot
    INSERM U434, Centre d Etudes du Polymorphisme Humain, Paris, France
    Int J Cancer 113:446-50. 2005
  8. doi request reprint The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms
    Claire Borie
    INSERM, UMR_S 938, Team Microsatellite Instability and Cancers, Paris, France
    Int J Cancer 125:2360-6. 2009
  9. ncbi request reprint Multipopulation analysis of polymorphisms in five mononucleotide repeats used to determine the microsatellite instability status of human tumors
    Olivier Buhard
    Institut National de la Santé et de la Recherche Médicale U434, Centre d Etude du Polymorphisme Humain, Paris, France
    J Clin Oncol 24:241-51. 2006
  10. ncbi request reprint [Analysis of the microsatellite instability gene mutation in the urothelial tumor of the upper urinary tract]
    Pierre Mongiat-Artus
    Service d Urologie, Universite Paris VII, Hopital Saint Louis, Paris, France
    Prog Urol 15:1286-92. 2005

Detail Information

Publications39

  1. ncbi request reprint MBD4 mutations are rare in gastric carcinomas with microsatellite instability
    Mafalda Pinto
    IPATIMUP Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    Cancer Genet Cytogenet 145:103-7. 2003
    ..We conclude that MBD4 mutations in the entire coding sequence, including the two poly(A) tracts, are rare in MSI gastric carcinomas. MBD4 is likely to be a bystander target gene in MSI-H tumors...
  2. doi request reprint [Clinical and molecular consequences of microsatellite instability in human cancers]
    Richard Hamelin
    INSERM, UMRS 762, 27 rue Juliette Dodu, 75010 Paris, France
    Bull Cancer 95:121-32. 2008
    ..All these points will be discussed in details in the present review...
  3. pmc A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines
    Guro E Lind
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Mol Cancer 3:28. 2004
    ..We compared the DNA methylation profiles of the cell lines with those of the primary tumors. Finally, we examined if the epigenetic changes were associated with known genetic markers and/or clinicopathological variables...
  4. pmc BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
    Sergia Velho
    Institute of Molecular Pathology and Immunology, University of Porto, Portugal
    BMC Cancer 8:255. 2008
    ..In the series of polyps CIMP, MLH1 methylation and MSI were also studied...
  5. ncbi request reprint An immunogenic process leading to cancer in the context of immunodeficiency
    Richard Hamelin
    INSERM U434, Paris, France
    Cell Cycle 3:1130-2. 2004
    ..Specific attention to the host immune system should thus be considered in the treatment of patients with MSI tumors...
  6. ncbi request reprint Detection of microsatellite instability in endometrial cancer: advantages of a panel of five mononucleotide repeats over the National Cancer Institute panel of markers
    Yick Fu Wong
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong, China and Inserm, U762, Paris, F 75010 France, Univ Paris 6, Paris, F 75005 France
    Carcinogenesis 27:951-5. 2006
    ..As demonstrated previously in gastric and colon MSI cases, the pentaplex PCR reaction using mononucleotide repeats is thus an easier and more sensitive method than the NCI panel, for the screening of MSI status in endometrial tumors...
  7. ncbi request reprint Mononucleotide repeats BAT-26 and BAT-25 accurately detect MSI-H tumors and predict tumor content: implications for population screening
    Caroline Brennetot
    INSERM U434, Centre d Etudes du Polymorphisme Humain, Paris, France
    Int J Cancer 113:446-50. 2005
    ..Our results have implications for large-scale screening of cancer patients to determine MSI-H status and prognosis...
  8. doi request reprint The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms
    Claire Borie
    INSERM, UMR_S 938, Team Microsatellite Instability and Cancers, Paris, France
    Int J Cancer 125:2360-6. 2009
    ..They give the exact way how to make the diagnosis of MSI in these tumors and may help to define biological and clinicalrisk factors associated with their emergence in such a clinicalcontext...
  9. ncbi request reprint Multipopulation analysis of polymorphisms in five mononucleotide repeats used to determine the microsatellite instability status of human tumors
    Olivier Buhard
    Institut National de la Santé et de la Recherche Médicale U434, Centre d Etude du Polymorphisme Humain, Paris, France
    J Clin Oncol 24:241-51. 2006
    ..Moreover, these markers are quasimonomorphic in germline DNA of the white population (ie, individuals of Eurasian origin), and could be used for tumor MSI determination without the requirement for matching normal DNA in this group...
  10. ncbi request reprint [Analysis of the microsatellite instability gene mutation in the urothelial tumor of the upper urinary tract]
    Pierre Mongiat-Artus
    Service d Urologie, Universite Paris VII, Hopital Saint Louis, Paris, France
    Prog Urol 15:1286-92. 2005
  11. ncbi request reprint Specific clinical and biological features characterize inflammatory bowel disease associated colorectal cancers showing microsatellite instability
    Magali Svrcek
    Assistance Publique Hopitaux de Paris AP HP, Hopital Saint Antoine, Service d Anatomie Pathologique, Paris, France
    J Clin Oncol 25:4231-8. 2007
    ..We investigated a large series of IBD-N for associations between MSI and several biologic and clinical parameters related to tumors, patients, and their treatment...
  12. ncbi request reprint Quasimonomorphic mononucleotide repeats for high-level microsatellite instability analysis
    Olivier Buhard
    INSERM U434, CEPH, Paris, France
    Dis Markers 20:251-7. 2004
    ..We have already proposed a pentaplex MSI screening test comprising 5 quasimonomorphic mononucleotide repeats. This article compares the advantages of mono or dinucleotide repeats in determining microsatellite instability...
  13. ncbi request reprint Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers
    Jamila El-Bchiri
    INSERM U434, Hopital Saint Louis, Paris, France
    Hum Mol Genet 14:2435-42. 2005
    ..We thus propose that NMD might play an important role in the selection of target gene mutations with a functional role in MSI-H carcinogenesis...
  14. ncbi request reprint [Replication error repair, microsatellites, and cancer]
    Alex Duval
    INSERM U 434, CEPH, 27, rue Juliette Dodu, 75010 Paris, France
    Med Sci (Paris) 19:55-62. 2003
    ..We provide here an overview of the genetic changes that occur in MSI-H tumors and that appear to constitute a new genetic mutator pathway leading a normal cell to become malignant...
  15. doi request reprint Screening for Lynch syndrome in colorectal cancer: are we doing enough?
    Guillaume Canard
    Department of Digestive Surgery, Hopital Saint Antoine, Universite Pierre et Marie Curie, Paris, France
    Ann Surg Oncol 19:809-16. 2012
    ..The purpose of this study was to assess the efficacy of screening for the detection of Lynch syndrome (LS) in an unselected population undergoing surgery for a colorectal cancer...
  16. pmc Chromosomal instability in near-diploid colorectal cancer: a link between numbers and structure
    Martine Muleris
    French National Institute for Health and Medical Research INSERM, UMRS_762, Centre de Recherche CDR Saint Antoine, Paris, France
    PLoS ONE 3:e1632. 2008
    ....
  17. doi request reprint Lynch or not Lynch? Is that always a question?
    Chrystelle Colas
    INSERM, UMRS 938, Centre de Recherche Saint Antoine, Equipe Instabilité des Microsatellites et Cancers, Paris, France
    Adv Cancer Res 113:121-66. 2012
    ..LS tumors are therefore at the junction of inherited and MSI cases. We describe here the defining characteristics of LS tumors that differentiate them from inherited non-MSI tumors and from non-inherited MSI tumors...
  18. pmc MiRNA genes constitute new targets for microsatellite instability in colorectal cancer
    Nizar El-Murr
    INSERM, UMRS 938 Centre de Recherche Saint Antoine, Equipe Instabilité des Microsatellites et Cancers, Paris, France
    PLoS ONE 7:e31862. 2012
    ..Functional studies are now required to conclude whether mutated miRNAs, and especially the miR-1303, might have a role in MSI tumorigenesis...
  19. ncbi request reprint Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR
    Nirosha Suraweera
    INSERM U434, Centre d Etudes du Polymorphisme Humain, Paris, France
    Gastroenterology 123:1804-11. 2002
    ..Analysis of BAT-26 is sufficient for detecting the MSI phenotype in most, but not all, cases. Additional results with dinucleotide markers can sometimes lead to incorrect classification of MSI tumors...
  20. ncbi request reprint Genetic instability in human mismatch repair deficient cancers
    Alex Duval
    INSERM U434 CEPH, 27, rue Juliette Dodu, 75010, Paris, France
    Ann Genet 45:71-5. 2002
    ..This mechanism appears to be the main "genetic pathway" by which functional changes with putative oncogenic effects are accumulated in these tumors...
  21. ncbi request reprint Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability
    Alex Duval
    Institut National de la Santé et de la Recherche Médicale U434 CEPH, 75010 Paris, France
    Cancer Res 62:2447-54. 2002
    ..In light of these recent data, the concept of target genes for instability and their possible role in MSI-H cancers is reconsidered here...
  22. ncbi request reprint Comparative analysis of mutation frequency of coding and non coding short mononucleotide repeats in mismatch repair deficient colorectal cancers
    Alex Duval
    INSERM U434, CEPH, Paris, France
    Oncogene 21:8062-6. 2002
    ..It should allow identification of those that are genuinely selected for during MSI-H tumoral progression from others that play a less important role, if any, in MSI-H carcinogenesis...
  23. ncbi request reprint Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and contributes to prostaglandin E2 production
    Valentine Panel
    INSERM, UMR S538, Paris, F 75012 France
    Cancer Lett 243:255-63. 2006
    ..cPLA2 expression is correlated with COX-2 expression. Both cPLA2 and COX-2 expressions are important in regard to PGE2 production. Our data suggest that cPLA2 might be involved in colon tumor development...
  24. ncbi request reprint Target gene mutation profile differs between gastrointestinal and endometrial tumors with mismatch repair deficiency
    Alex Duval
    INSERM U434 CEPH, 75010 Paris, France
    Cancer Res 62:1609-12. 2002
    ..Our results show that the profile of target gene mutations in MSI-H tumors is tissue specific, with both qualitative and quantitative differences between gastrointestinal and endometrial MSI-H cancers...
  25. pmc The mutator pathway is a feature of immunodeficiency-related lymphomas
    Alex Duval
    Institut National de la Santé et de la Recherche Médicale U434, Centre d Etude du Polymorphisme Humain, 75010 Paris, France
    Proc Natl Acad Sci U S A 101:5002-7. 2004
    ..Because MSI-H-positive cases were found to be either Epstein-Barr virus-positive or -negative, the mutator pathway should act synergistically or not with this other oncogenic factor, playing an important role in ID-RL...
  26. ncbi request reprint Infrequent microsatellite instability in urothelial cell carcinoma of the bladder in young patients
    Pierre Mongiat-Artus
    Department of Urology, Saint Louis Hospital and University Paris VII, Paris, France
    Eur Urol 49:685-90. 2006
    ..In this study, we have evaluated the occurrence of MSI in primary bladder UCC arising in seventeen young patients selected for being below 45 years of age at diagnosis...
  27. ncbi request reprint Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer
    Carla Oliveira
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s n, Porto 4200 465, Portugal
    Oncogene 24:7630-4. 2005
    ....
  28. ncbi request reprint Frequent Ki-ras mutations in gastric tumors of the MSI phenotype
    Caroline Brennetot
    Gastroenterology 125:1282. 2003
  29. ncbi request reprint Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation
    Enric Domingo
    Molecular Pathology Program, Centre d Investigacions en Bioquimica i Biologia Molecular, Barcelona, Spain
    Genes Chromosomes Cancer 39:138-42. 2004
    ....
  30. pmc Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    Asad Umar
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:261-8. 2004
    ....
  31. ncbi request reprint Genome signatures of colon carcinoma cell lines
    Kristine Kleivi
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Ullernschauseen 70, Oslo N 0310, Norway
    Cancer Genet Cytogenet 155:119-31. 2004
    ..In conclusion, the large variation in genetic complexity of the cell lines highlights the importance of a comprehensive reference of genomic profiles for investigators engaged in functional studies using these research tools...
  32. ncbi request reprint Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status
    Carla Oliveira
    Institute of Molecular Pathology and Immunology, The University of Porto, IPATIMUP, 4200 465 Porto, Portugal
    Hum Mol Genet 13:2303-11. 2004
    ....
  33. ncbi request reprint RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas
    David Shibata
    Division of Gastrointestinal Oncology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Int J Cancer 119:801-6. 2006
    ..Given its similar involvement in colon cancer, RAB32 inactivation may represent a component of the oncogenic pathway of microsatellite-unstable gastrointestinal adenocarcinomas...
  34. ncbi request reprint [Microsatellite instability: a new mechanism of carcinogenesis associated with immunodepression in non Hodgkin lymphomas in humans]
    Claire Borie
    Med Sci (Paris) 20:641-2. 2004
  35. ncbi request reprint The prevalence of PIK3CA mutations in gastric and colon cancer
    Sergia Velho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Portugal
    Eur J Cancer 41:1649-54. 2005
    ..016). In colorectal carcinoma, PIK3CA mutations occur preferentially together with activating KRAS-BRAF mutations (MSI and MSS) while in gastric carcinomas PIK3CA mutations tend to occur as isolated events (MSI)...
  36. ncbi request reprint A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition
    Santiago Ropero
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Nat Genet 38:566-9. 2006
    ..As such drugs may serve as therapeutic agents for cancer, our findings support the use of HDAC2 mutational status in future pharmacogenetic treatment of these individuals...
  37. ncbi request reprint BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency
    Carla Oliveira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, Porto 4200 465, Portugal
    Oncogene 22:9192-6. 2003
    ..Accordingly, our results show evidences that BRAF mutations characterize colon but not gastric tumors with MMR deficiency and are not involved in the tumorigenesis of gastric cancer of the mutator phenotype pathway...
  38. ncbi request reprint Tissue microarray technology: validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistochemical expression
    Florence Jourdan
    Department of Pathology, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012 Paris, France
    Virchows Arch 443:115-21. 2003
    ..We showed that 48.5% overexpressed p53 and 8.7% lost hMLH1 or hMSH2. Tissue microarray technology, validated in colorectal carcinoma, appears as a useful research tool for rapid analysis of the clinical interest of molecular alterations...
  39. ncbi request reprint [Recent advances for the identification and screening of Lynch syndrome]
    Sylviane Olschwang
    INSERM UMR599, Institut Paoli Calmettes, Marseille
    Gastroenterol Clin Biol 31:136-40. 2007