I Florent

Summary

Country: France

Publications

  1. pmc Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole
    Omid Azimzadeh
    FRE3206 CNRS MNHN, Department Regulations, Development, Molecular Diversity, CP52, 61 rue Buffon, F 75005 Paris, France
    Malar J 9:189. 2010
  2. pmc Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum
    Laurent Bréhélin
    Méthodes et Algorithmes pour la Bioinformatique, LIRMM, Univ, Montpellier 2, CNRS 161 rue Ada, 34392 Montpellier, France
    BMC Genomics 11:35. 2010
  3. ncbi A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopeptidases is expressed in erythrocytic stages
    I Florent
    Laboratoire de Biologie Parasitaire, EP 1790 Biologie et Evolution des Parasites CNRS, Museum national d histoire naturelle, Paris, France
    Mol Biochem Parasitol 97:149-60. 1998
  4. pmc A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism
    Isabelle Florent
    FRE3206 CNRS MNHN, USM504, Biologie Fonctionnelle des Protozoaires, RDDM, Museum national d histoire naturelle, Paris, France
    BMC Genomics 10:235. 2009
  5. ncbi Bioinformatic strategies to provide functional clues to the unknown genes in Plasmodium falciparum genome
    I Florent
    Centre National de la Recherche Scientifique Muséum National d Histoire Naturelle, FRE3206, Molécules de Communication et Adaptation des Micro organismes, Adaptation des Protozoaires à leur Environnent, CP 52, 61, rue Buffon, 75231 Paris Cedex 05, France
    Parasite 17:273-83. 2010
  6. ncbi Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe
    Isabelle Florent
    Biologie Fonctionnelle des Protozoaires, Département Régulation, Developement, Diversité Moléculaire, Museum national d histoire naturelle, 61, rue Buffon, F 75005 Paris, France
    Biol Chem 386:401-6. 2005
  7. ncbi Plasmodium falciparum genes differentially expressed during merozoite morphogenesis
    Isabelle Florent
    Biologie Fonctionnelle des Protozoaires, USM504 EA3335, Département Regulations Développement Diversité Moléculaire, Museum national d histoire naturelle, 61 rue Buffon, 75005 Paris, France
    Mol Biochem Parasitol 135:143-8. 2004
  8. ncbi Involvement of calyculin A-sensitive phosphatase(s) in the differentiation of Trypanosoma cruzi trypomastigotes to amastigotes
    P Grellier
    Laboratoire de Biologie Parasitaire, EP CNRS 1790 Biologie et Evolution des Parasites, Museum national d histoire naturelle, Paris, France
    Mol Biochem Parasitol 98:239-52. 1999
  9. ncbi Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase
    M Allary
    Laboratoire de Biologie Parasitaire, Protistologie, Helminthologie, Museum national d histoire naturelle, EA 3335 et FR 63 CNRS, Paris, France
    Parasitology 125:1-10. 2002
  10. ncbi Discovery of new targets for antimalarial chemotherapy
    P Grellier
    National Museum of Natural History, USM504 EA3335, Functional biology of protozoa, Department RDDM, CP 52, 61, rue Buffon, F 75231 Paris Cedex 05, France
    Parasite 15:219-25. 2008

Collaborators

  • P Grellier
  • Eric Maréchal
  • O Gascuel
  • Elisabeth Mouray
  • Omid Azimzadeh
  • Laurent Bréhélin
  • Valérie Razakantoanina
  • Marion Flipo
  • Sebastien Charneau
  • Christian Sergheraert
  • Marian Flipo
  • M Allary
  • Cissé Sow
  • Julius Nyalwidhe
  • Marc Gèze
  • Ginette Jaureguiberry
  • Terence Beghyn
  • Mireille Moutiez
  • Jaime M Santana
  • Sophie Girault
  • Benoit P Deprez
  • Rebecca F Deprez-Poulain
  • Virginie Leroux
  • Izabela M Dourado Bastos
  • Bergmann Morais Ribeiro
  • Rebecca Deprez-Poulain
  • J Schrevel

Detail Information

Publications15

  1. pmc Plasmodium falciparum PfA-M1 aminopeptidase is trafficked via the parasitophorous vacuole and marginally delivered to the food vacuole
    Omid Azimzadeh
    FRE3206 CNRS MNHN, Department Regulations, Development, Molecular Diversity, CP52, 61 rue Buffon, F 75005 Paris, France
    Malar J 9:189. 2010
    ..Two recent studies using PfA-M1 transfections have also provided conflicting results on PfA-M1 localization within or outside the food vacuole. Alternative destinations, such as the nucleus, have also been proposed...
  2. pmc Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum
    Laurent Bréhélin
    Méthodes et Algorithmes pour la Bioinformatique, LIRMM, Univ, Montpellier 2, CNRS 161 rue Ada, 34392 Montpellier, France
    BMC Genomics 11:35. 2010
    ..Gene expression data have been widely used in the recent years to help functional annotation in an intra-species way via the so-called Guilt By Association (GBA) principle...
  3. ncbi A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopeptidases is expressed in erythrocytic stages
    I Florent
    Laboratoire de Biologie Parasitaire, EP 1790 Biologie et Evolution des Parasites CNRS, Museum national d histoire naturelle, Paris, France
    Mol Biochem Parasitol 97:149-60. 1998
    ..A polyclonal serum raised to a synthetic peptide deduced from the gene labelled schizont proteins of 96 and 68 kDa purified to homogeneity and both displaying aminopeptidase activity, as well as cytoplasmic structures in schizont stages...
  4. pmc A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism
    Isabelle Florent
    FRE3206 CNRS MNHN, USM504, Biologie Fonctionnelle des Protozoaires, RDDM, Museum national d histoire naturelle, Paris, France
    BMC Genomics 10:235. 2009
    ..falciparum gene models and 3) pinpointing genes displaying protein polymorphism between the FcB1 and 3D7 strains...
  5. ncbi Bioinformatic strategies to provide functional clues to the unknown genes in Plasmodium falciparum genome
    I Florent
    Centre National de la Recherche Scientifique Muséum National d Histoire Naturelle, FRE3206, Molécules de Communication et Adaptation des Micro organismes, Adaptation des Protozoaires à leur Environnent, CP 52, 61, rue Buffon, 75231 Paris Cedex 05, France
    Parasite 17:273-83. 2010
    ....
  6. ncbi Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe
    Isabelle Florent
    Biologie Fonctionnelle des Protozoaires, Département Régulation, Developement, Diversité Moléculaire, Museum national d histoire naturelle, 61, rue Buffon, F 75005 Paris, France
    Biol Chem 386:401-6. 2005
    ..This activity-based probe represents a potential tool for profiling active falcipains in parasites...
  7. ncbi Plasmodium falciparum genes differentially expressed during merozoite morphogenesis
    Isabelle Florent
    Biologie Fonctionnelle des Protozoaires, USM504 EA3335, Département Regulations Développement Diversité Moléculaire, Museum national d histoire naturelle, 61 rue Buffon, 75005 Paris, France
    Mol Biochem Parasitol 135:143-8. 2004
  8. ncbi Involvement of calyculin A-sensitive phosphatase(s) in the differentiation of Trypanosoma cruzi trypomastigotes to amastigotes
    P Grellier
    Laboratoire de Biologie Parasitaire, EP CNRS 1790 Biologie et Evolution des Parasites, Museum national d histoire naturelle, Paris, France
    Mol Biochem Parasitol 98:239-52. 1999
    ....
  9. ncbi Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase
    M Allary
    Laboratoire de Biologie Parasitaire, Protistologie, Helminthologie, Museum national d histoire naturelle, EA 3335 et FR 63 CNRS, Paris, France
    Parasitology 125:1-10. 2002
    ..The involvement of PfA-M1 in haemoglobin breakdown and erythrocyte reinvasion is discussed in light of the dual functions recently reported for several P. falciparum proteases...
  10. ncbi Discovery of new targets for antimalarial chemotherapy
    P Grellier
    National Museum of Natural History, USM504 EA3335, Functional biology of protozoa, Department RDDM, CP 52, 61, rue Buffon, F 75231 Paris Cedex 05, France
    Parasite 15:219-25. 2008
    ..This review discusses targets involved in calcium metabolism, protein prenylation and apicoplast functions that have emerged by different approaches...
  11. ncbi Characterization of PfDYN2, a dynamin-like protein of Plasmodium falciparum expressed in schizonts
    Sebastien Charneau
    USM504 EA3335, RDDM, Museum national d histoire naturelle, 61, rue Buffon, CP52, 75231 Paris Cedex 05, France
    Microbes Infect 9:797-805. 2007
    ..PfDYN2 and the previously described PfDYN1 are the only two dynamin superfamily members identified in the P. falciparum genome and the available data suggest that this situation is conserved in the Apicomplexa phylum...
  12. ncbi Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase
    Elisabeth Mouray
    USM 0504 Biologie Fonctionnelle des Protozoaires, EA3335, Departement Regulations, Developpement, Diversité Moléculaire, CP 52, Museum national d histoire naturelle, 75231 Paris Cedex 05, France
    Biochimie 89:337-46. 2007
    ....
  13. ncbi Plasmodium falciparum: functional mitochondrial ADP/ATP transporter in Escherichia coli plasmic membrane as a tool for selective drug screening
    Valérie Razakantoanina
    Biologie Fonctionnelle des Protozoaires, USM504 EA3335, Departement Regulations, Developpement, Diversité Moléculaire, Museum national d histoire naturelle, 61 rue Buffon, 75005 Paris, France
    Exp Parasitol 118:181-7. 2008
    ..This experimental model was evaluated using three Malagasy crude plants extracts which have shown antiplasmodial activity on in vitro parasite cultures...
  14. ncbi Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents
    Marion Flipo
    INSERM, U761, Biostructures and Drug Discovery, Lille F 59006 France
    J Med Chem 50:1322-34. 2007
    ..Further optimization of the best inhibitor yielded a nanomolar, selective inhibitor of PfA-M1. This inhibitor displays good physicochemical and pharmacokinetic properties and a promising antimalarial activity...
  15. ncbi Design, synthesis and antimalarial activity of novel, quinoline-based, zinc metallo-aminopeptidase inhibitors
    Marian Flipo
    UMR CNRS 8525, Institut Pasteur et Institut de Biologie de Lille, Universite de Lille 2, Lille, France
    Bioorg Med Chem Lett 13:2659-62. 2003
    ..The best inhibitor displays an IC(50) of 854 nM. The antimalarial activity on a CQ-resistant strain and the specificity towards mammalian aminopeptidase N are also discussed...