Jean Francois Flejou

Summary

Country: France

Publications

  1. pmc Chromosomal instability in near-diploid colorectal cancer: a link between numbers and structure
    Martine Muleris
    French National Institute for Health and Medical Research INSERM, UMRS_762, Centre de Recherche CDR Saint Antoine, Paris, France
    PLoS ONE 3:e1632. 2008
  2. ncbi request reprint [Macroscopic examination of esophagectomy specimens]
    Jean Francois Flejou
    Service d Anatomie et de Cytologie Pathologiques, Hopital Saint Antoine, AP HP, 184, rue du Faubourg St Antoine, 75571, Paris Cedex 12
    Ann Pathol 23:371-8. 2003
  3. pmc Barrett's oesophagus: from metaplasia to dysplasia and cancer
    J F Flejou
    Service d Anatomie Pathologique, CHU Saint Antoine, Assistance Publique Hopitaux de Paris, 184 rue du Faubourg Saint Antoine, F 75571, Paris, Cedex 12, France
    Gut 54:i6-12. 2005
  4. ncbi request reprint Mucinous colon carcinomas with microsatellite instability have a lower microvessel density and lower vascular endothelial growth factor expression
    Dominique Wendum
    Department of Pathology, Hopital Saint Antoine, AP HP, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    Virchows Arch 442:111-7. 2003
  5. ncbi request reprint Tissue microarray technology: validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistochemical expression
    Florence Jourdan
    Department of Pathology, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012 Paris, France
    Virchows Arch 443:115-21. 2003
  6. ncbi request reprint Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 [correction of hMLH6] immunostaining
    Valerie Rigau
    Department of Pathology, AP HP, Hopital Saint Antoine, Paris, France
    Arch Pathol Lab Med 127:694-700. 2003
  7. ncbi request reprint Mononucleotide repeats BAT-26 and BAT-25 accurately detect MSI-H tumors and predict tumor content: implications for population screening
    Caroline Brennetot
    INSERM U434, Centre d Etudes du Polymorphisme Humain, Paris, France
    Int J Cancer 113:446-50. 2005
  8. ncbi request reprint Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions
    Benoit Terris
    Services d anatomie pathologique, Hopital Cochin, Paris, France
    J Pathol 197:632-7. 2002
  9. doi request reprint MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions
    Jeremie H Lefevre
    Department of Digestive Surgery, Hopital Saint Antoine AP HP, University Pierre et Marie Curie Paris VI, 184 rue du Faubourg Saint Antoine, 75571 Paris, France
    Fam Cancer 9:589-94. 2010
  10. ncbi request reprint Macrocystic form of serous pancreatic cystadenoma
    Denis Chatelain
    Service d Anatomie Pathologique, Hĵpital Saint Antoine, Assistance Publique Hĵpitaux de Paris, France
    Am J Gastroenterol 97:2566-71. 2002

Detail Information

Publications86

  1. pmc Chromosomal instability in near-diploid colorectal cancer: a link between numbers and structure
    Martine Muleris
    French National Institute for Health and Medical Research INSERM, UMRS_762, Centre de Recherche CDR Saint Antoine, Paris, France
    PLoS ONE 3:e1632. 2008
    ....
  2. ncbi request reprint [Macroscopic examination of esophagectomy specimens]
    Jean Francois Flejou
    Service d Anatomie et de Cytologie Pathologiques, Hopital Saint Antoine, AP HP, 184, rue du Faubourg St Antoine, 75571, Paris Cedex 12
    Ann Pathol 23:371-8. 2003
    ..This article describes a protocol for the examination of these specimens in surgical pathology departments...
  3. pmc Barrett's oesophagus: from metaplasia to dysplasia and cancer
    J F Flejou
    Service d Anatomie Pathologique, CHU Saint Antoine, Assistance Publique Hopitaux de Paris, 184 rue du Faubourg Saint Antoine, F 75571, Paris, Cedex 12, France
    Gut 54:i6-12. 2005
    ....
  4. ncbi request reprint Mucinous colon carcinomas with microsatellite instability have a lower microvessel density and lower vascular endothelial growth factor expression
    Dominique Wendum
    Department of Pathology, Hopital Saint Antoine, AP HP, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    Virchows Arch 442:111-7. 2003
    ..A low COX-2 expression could be related to the medullary phenotype. However, this has to be confirmed in a larger series. Finally, the low MVD of MSI+ mucinous colon adenocarcinomas could participate in their overall better prognosis...
  5. ncbi request reprint Tissue microarray technology: validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistochemical expression
    Florence Jourdan
    Department of Pathology, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75012 Paris, France
    Virchows Arch 443:115-21. 2003
    ..We showed that 48.5% overexpressed p53 and 8.7% lost hMLH1 or hMSH2. Tissue microarray technology, validated in colorectal carcinoma, appears as a useful research tool for rapid analysis of the clinical interest of molecular alterations...
  6. ncbi request reprint Microsatellite instability in colorectal carcinoma. The comparison of immunohistochemistry and molecular biology suggests a role for hMSH6 [correction of hMLH6] immunostaining
    Valerie Rigau
    Department of Pathology, AP HP, Hopital Saint Antoine, Paris, France
    Arch Pathol Lab Med 127:694-700. 2003
    ..The identification of cancers associated with MSI requires classical molecular testing as the gold standard...
  7. ncbi request reprint Mononucleotide repeats BAT-26 and BAT-25 accurately detect MSI-H tumors and predict tumor content: implications for population screening
    Caroline Brennetot
    INSERM U434, Centre d Etudes du Polymorphisme Humain, Paris, France
    Int J Cancer 113:446-50. 2005
    ..Our results have implications for large-scale screening of cancer patients to determine MSI-H status and prognosis...
  8. ncbi request reprint Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions
    Benoit Terris
    Services d anatomie pathologique, Hopital Cochin, Paris, France
    J Pathol 197:632-7. 2002
    ....
  9. doi request reprint MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions
    Jeremie H Lefevre
    Department of Digestive Surgery, Hopital Saint Antoine AP HP, University Pierre et Marie Curie Paris VI, 184 rue du Faubourg Saint Antoine, 75571 Paris, France
    Fam Cancer 9:589-94. 2010
    ..588 + 5G > T) leading to a complete deletion of exon 7 at the RNA level. This observation demonstrates that MLH1 can be a target of MYH transversions leading to MSI phenotype...
  10. ncbi request reprint Macrocystic form of serous pancreatic cystadenoma
    Denis Chatelain
    Service d Anatomie Pathologique, Hĵpital Saint Antoine, Assistance Publique Hĵpitaux de Paris, France
    Am J Gastroenterol 97:2566-71. 2002
    ..We aimed to describe clinicopathological and imaging features with cyst fluid analysis in a series of patients undergoing surgery for macrocystic serous cystadenoma...
  11. ncbi request reprint Expression of inflammatory secretory phospholipase A2 and cytosolic phospholipase A2 in premalignant and malignant Barrett's oesophagus
    Christine Lagorce-Pages
    Service d Anatomie Pathologique, Hopital Avicenne, AP HP, Bobigny, France
    Virchows Arch 444:426-35. 2004
    ....
  12. ncbi request reprint COX-2, inflammatory secreted PLA2, and cytoplasmic PLA2 protein expression in small bowel adenocarcinomas compared with colorectal adenocarcinomas
    Dominique Wendum
    Department of Pathology, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    Mod Pathol 16:130-6. 2003
    ..The same pattern of protein expression found in both types of adenocarcinoma contradicts experimental results in mice. Moreover, our results strengthen the similarities between these two types of human cancer...
  13. doi request reprint Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic mucosa: an initiating step in the development of mismatch repair-deficient colorectal cancers
    Magali Svrcek
    Equipe Instabilité des Microsatellites et Cancers, Hopital Saint Antoine, Paris Cedex, France
    Gut 59:1516-26. 2010
    ..It was therefore hypothesised that an MGMT field defect may constitute a preneoplastic event for the development of MMR-deficient tumours displaying microsatellite instability (MSI)...
  14. doi request reprint Overexpression of microRNAs-155 and 21 targeting mismatch repair proteins in inflammatory bowel diseases
    Magali Svrcek
    INSERM UMR S 938 Centre de Recherche Saint Antoine, Equipe Instabilité des Microsatellites et Cancers, Equipe Labellisée Ligue contre le Cancer, Paris, France
    Carcinogenesis 34:828-34. 2013
    ..The detection and monitoring of miR-155 field defect may, therefore, have implications for the prevention and treatment of MSI IBD CRCs...
  15. pmc Implication of MYH in colorectal polyposis
    Jeremie H Lefevre
    Department of Digestive Surgery, Hopital Saint Antoine AP HP, University Pierre et Marie Curie, Paris, France
    Ann Surg 244:874-9; discussion 879-80. 2006
    ..The aim of this study was to determine the frequency of MYH mutations in one large population of polyposis patients without APC mutation identified...
  16. doi request reprint Lynch or not Lynch? Is that always a question?
    Chrystelle Colas
    INSERM, UMRS 938, Centre de Recherche Saint Antoine, Equipe Instabilité des Microsatellites et Cancers, Paris, France
    Adv Cancer Res 113:121-66. 2012
    ..LS tumors are therefore at the junction of inherited and MSI cases. We describe here the defining characteristics of LS tumors that differentiate them from inherited non-MSI tumors and from non-inherited MSI tumors...
  17. doi request reprint Screening for Lynch syndrome in colorectal cancer: are we doing enough?
    Guillaume Canard
    Department of Digestive Surgery, Hopital Saint Antoine, Universite Pierre et Marie Curie, Paris, France
    Ann Surg Oncol 19:809-16. 2012
    ..The purpose of this study was to assess the efficacy of screening for the detection of Lynch syndrome (LS) in an unselected population undergoing surgery for a colorectal cancer...
  18. ncbi request reprint Unilocular acinar cell cystadenoma of the pancreas an unusual acinar cell tumor
    Denis Chatelain
    Anatomic Pathology Department, St Antoine Hospital, Paris, France
    Am J Clin Pathol 118:211-4. 2002
    ..We report a case of cystic acinar cell tumor of the pancreas with benign gross and histologic features that could be added to the list of cystic neoplasms of the pancreas as acinar cell cystadenoma...
  19. ncbi request reprint Adenocarcinoma of the upper esophagus arising in heterotopic gastric mucosa: common pathogenesis with Barrett's adenocarcinoma?
    Denis Chatelain
    Service d Anatomie Pathologique, Hopital Saint Antoine, Paris, France
    Virchows Arch 441:406-11. 2002
    ....
  20. doi request reprint Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma
    Adriana Handra-Luca
    Service d Anatomie Pathologique, APHP Groupe Hospitalier Universitaire Nord, Bobigny, France
    Pancreas 41:416-21. 2012
    ....
  21. doi request reprint Isolated metastatic tumors to the pancreas: Hôpital St-Antoine experience
    Najat Mourra
    Department of Pathology, Hopital St Antoine, AP HP, Paris, France
    Pancreas 39:577-80. 2010
    ..The leading sources of metastases are breast, lung, kidney, and skin (melanoma). We present our experience with 12 cases of isolated pancreatic metastasis...
  22. ncbi request reprint Multipopulation analysis of polymorphisms in five mononucleotide repeats used to determine the microsatellite instability status of human tumors
    Olivier Buhard
    Institut National de la Santé et de la Recherche Médicale U434, Centre d Etude du Polymorphisme Humain, Paris, France
    J Clin Oncol 24:241-51. 2006
    ..Moreover, these markers are quasimonomorphic in germline DNA of the white population (ie, individuals of Eurasian origin), and could be used for tumor MSI determination without the requirement for matching normal DNA in this group...
  23. doi request reprint Clinical challenges and images in GI. Extrahepatic biliary cystadenoma with mesenchymal stroma
    Najat Mourra
    Department of Pathology, Hopital St Antoine, Paris, France
    Gastroenterology 134:1295, 1637. 2008
  24. doi request reprint Extensive characterization of sphere models established from colorectal cancer cell lines
    Ada Collura
    INSERM, UMRS_938, Centre de Recherche Saint Antoine, Equipe Instabilité des Microsatellites et Cancers, 75012, Paris, France
    Cell Mol Life Sci 70:729-42. 2013
    ..In conclusion, CFS models derived from CRC cell lines possess interesting phenotypic features that may have clinical relevance for drug resistance and disease relapse...
  25. ncbi request reprint Liver adenomatosis: classification of MR imaging features and comparison with pathologic findings
    Maïté Lewin
    Department of Radiology, Hopital Saint Antoine, Assistance Publique Hopitaux de Paris, 184 rue du Faubourg Saint Antoine, 75012 Paris, France
    Radiology 241:433-40. 2006
    ..To retrospectively compare the clinical manifestation and magnetic resonance (MR) imaging features of liver adenomatosis with pathologic findings...
  26. doi request reprint SMAD4 protein expression and cell proliferation in colorectal adenocarcinomas
    Adriana Handra-Luca
    Service d Anatomie Pathologique, APHP Avicenne Université Paris 13 Nord Medecine, EA3406, 125 rue de Stalingrad, 93000 Bobigny, France
    Virchows Arch 459:511-9. 2011
    ..Although the advantage of immunohistochemistry is high throughput, our results allow only an initial evaluation, and subsequent studies, including genetic analyses, are required...
  27. ncbi request reprint [Pancreatectomy for adenocarcinoma: prognostic factors, recommendations for pathological reports]
    Denis Chatelain
    Service d Anatomie Pathologique, CHU Amiens, Place Victor Pauchet, 80054 Amiens cedex 01, France
    Ann Pathol 22:422-31. 2002
    ..We propose a pre-established form including these items for pathological reports of pancreatectomy for adenocarcinomas...
  28. ncbi request reprint Ex vivo sentinel lymph node mapping in colorectal cancer
    Stephen W Bell
    Department of Digestive Surgery, Saint Antoine Hospital, AP HP, CancerEst, Universite Pierre et Marie Curie, Paris, France
    Dis Colon Rectum 48:74-9. 2005
    ..Most published series have used the in vivo technique and only three studies have been published in which the ex vivo technique was used. The aim of this study was to report the results of a larger study of ex vivo sentinel node mapping...
  29. doi request reprint Azathioprine-induced carcinogenesis in mice according to Msh2 genotype
    Alexandra Chalastanis
    INSERM, UMRS, Paris, France
    J Natl Cancer Inst 102:1731-40. 2010
    ..It has also been suggested that thiopurine drugs might constitute a risk factor for the emergence of human neoplasms displaying microsatellite instability (MSI) because of deficient DNA mismatch repair...
  30. ncbi request reprint Involvement of Meckel diverticulum in Crohn disease associated with pancreatic heterotopia
    Najat Mourra
    Department of Pathology, Hopital St Antoine, Paris, France
    Arch Pathol Lab Med 127:E99-E100. 2003
    ..We report herein the presence of Crohn disease within a Meckel diverticulum, with a normal small bowel immediately adjacent to the diverticulum, associated with pancreatic heterotopia...
  31. ncbi request reprint Cyclooxygenase-2 and its role in colorectal cancer development
    Dominique Wendum
    Service d Anatomie Pathologique, Hopital Saint Antoine, AP HP, 184 rue du Faubourg Saint Antoine, 75571, Paris Cedex 12, France
    Virchows Arch 445:327-33. 2004
    ..However, their real efficiency and the cost/benefit balance are currently evaluated, and no definite conclusion can be made at the moment...
  32. ncbi request reprint [Lympho-epithelial cyst of the pancreas: a difficult diagnosis. About two cases]
    Denis Chatelain
    Service d Anatomie Pathologique, Hopital Saint Antoine, Paris, France
    Gastroenterol Clin Biol 26:935-8. 2002
    ..Cytological and histological analysis of fine needle aspiration material is of diagnostic interest and can avoid surgical resection when patients are symptom-free...
  33. ncbi request reprint Assessment of MRI and MRCP in diagnosis of biliary cystadenoma and cystadenocarcinoma
    Maïté Lewin
    Department of Radiology, Saint Antoine University Hospital, Assistance Publique des Hopitaux de Paris, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
    Eur Radiol 16:407-13. 2006
    ..Gadolinium-enhanced MRI in combination with MRCP is a valuable tool for the diagnosis of BCA or BCAC. However, no specific information is gained for POS detection...
  34. ncbi request reprint Presacral neuroendocrine carcinoma developed in a tailgut cyst: report of a case
    Najat Mourra
    Department of Pathology, Hopital Saint Antoine, 184 rue du Faubourg St Antoine, AP HP, 75012 Paris, France
    Dis Colon Rectum 46:411-3. 2003
    ..To the best of our knowledge this is only the second such tumor reported in the literature...
  35. ncbi request reprint Vessels' morphology in SMAD4 and BMPR1A-related juvenile polyposis
    Adriana Handra-Luca
    Hopital Jean Verdier, Department of Pathology, Paris, France
    Am J Med Genet A 138:113-7. 2005
    ..The presence of malformative vessels within the stromal component might be a useful tool to drive the subsequent genetic and clinical management...
  36. ncbi request reprint High-grade dysplasia and superficial adenocarcinoma in Barrett's esophagus: histological mapping and expression of p53, p21 and Bcl-2 oncoproteins
    Denis Chatelain
    Service d Anatomie Pathologique, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine 75541, Paris Cedex 12, France
    Virchows Arch 442:18-24. 2003
    ..p53 dysfunction plays a major role in the progression from dysplasia to carcinoma in Barrett's esophagus and appears unrelated to p21 and Bcl-2 expression...
  37. doi request reprint Regulation of colon cancer cell proliferation and migration by MD-2 activity
    Virginie Grondin
    ER7 UPMC, University of Paris 6, Paris, France
    Innate Immun 17:414-22. 2011
    ..Our data attest to a role of MD-2 activity in colon cancer epithelial cell proliferation and migration, which may be important in the general correlation between innate immune response, chronic inflammation, and cancer...
  38. ncbi request reprint Human chorionic gonadotrophin beta expression in malignant Barrett's oesophagus
    Anne Couvelard
    Service d Anatomie Pathologique, Hopital Beaujon, 92118 Clichy Cedex, France
    Virchows Arch 445:279-84. 2004
    ..Human chorionic gonadotrophin beta (hCGbeta) is expressed in several non-trophoblastic tumours, and this is usually associated with aggressive behaviour. Little is known about hCGbeta expression in Barrett's adenocarcinoma...
  39. ncbi request reprint [Precancerous lesions and IBD - pathological aspects]
    Jean Francois Flejou
    Anatomie Pathologique, Hopital Saint Antoine, 184, rue du Faubourg Saint Antoine, 75571 Paris Cedex 12
    Gastroenterol Clin Biol 28:D140-8. 2004
  40. pmc MiRNA genes constitute new targets for microsatellite instability in colorectal cancer
    Nizar El-Murr
    INSERM, UMRS 938 Centre de Recherche Saint Antoine, Equipe Instabilité des Microsatellites et Cancers, Paris, France
    PLoS ONE 7:e31862. 2012
    ..Functional studies are now required to conclude whether mutated miRNAs, and especially the miR-1303, might have a role in MSI tumorigenesis...
  41. doi request reprint [Role of the pathologist in the processing of adenocarcinoma of the stomach, oesophagogastric junction and lower third of the oesophagus]
    Magali Svrcek
    Service d Anatomie et Cytologie Pathologiques, Hopital Saint Antoine, hôpitaux universitaires Paris Est, AP HP, France
    Ann Pathol 31:419-26. 2011
    ..A standardized assessment of the histological tumour response is a necessary prerequisite for future studies looking at the adaptation of chemotherapy depending on the histological tumour response...
  42. doi request reprint Defective mismatch repair status as a prognostic biomarker of disease-free survival in stage III colon cancer patients treated with adjuvant FOLFOX chemotherapy
    Aziz Zaanan
    Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, AP HP, Paris, France
    Clin Cancer Res 17:7470-8. 2011
    ..The aim of this study was to evaluate the prognostic value of MMR status for DFS in patients with stage III colon cancer receiving adjuvant FOLFOX chemotherapy...
  43. doi request reprint Aspects of liver pathology in adult patients with MDR3/ABCB4 gene mutations
    Dominique Wendum
    Service d Anatomie Pathologique, APHP, Hopital St Antoine, 75012 Paris, France
    Virchows Arch 460:291-8. 2012
    ..Lipid crystals in bile ducts may be suggestive of MDR3/ABCB4 mutation. MDR3 immunostaining on formalin-fixed paraffin-embedded sections does not seem to be sensitive for the diagnosis of heterozygous MDR3/ABCB4 mutations...
  44. ncbi request reprint Mucinous cystadenoma with mesenchymal over-growth: a new variant among pancreatic mucinous cystadenomas?
    Adriana Handra-Luca
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Virchows Arch 445:203-5. 2004
    ..It is conceivable that the mesenchymal component described in our case could represent an early stage in the development of sarcoma in mucinous cystadenoma of the pancreas...
  45. ncbi request reprint Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer
    Marie Elisabeth Forgue-Lafitte
    INSERM U673, 184 rue du Faubourg Saint Antoine, F 75012 Paris, France
    Int J Cancer 121:1543-9. 2007
    ..In macroscopically normal mucosa, ACF were the most important source of M1/MUC5AC mucin. Testing of M1/MUC5AC can enhance the detection of precancerous lesions and colon cancer...
  46. ncbi request reprint Cytoplasmic phospholipase A2 alpha overexpression in stromal cells is correlated with angiogenesis in human colorectal cancer
    Dominique Wendum
    Department of Pathology, Hopital Saint Antoine, 75571 Paris, France
    Mod Pathol 18:212-20. 2005
    ..The lower number of cytoplasmic PLA2-positive stromal cells in carcinomas with microsatellite instability could be related to their lower microvessel density and VEGF expression...
  47. ncbi request reprint Photodynamic therapy with green light and m-tetrahydroxyphenyl chlorin for intramucosal adenocarcinoma and high-grade dysplasia in Barrett's esophagus
    Jacques Etienne
    Centre de Thérapie Photodynamique Pluridisciplinaire, Institut Mutualiste Montsouris, Paris, France
    Gastrointest Endosc 59:880-9. 2004
    ....
  48. ncbi request reprint Correlation between patterns of DNA mismatch repair hmlh1 and hmsh2 protein expression and progression of dysplasia in intraductal papillary mucinous neoplasms of the pancreas
    Adriana Handra-Luca
    Department of Pathology, Hopital Beaujon, AP HP, Paris, France
    Virchows Arch 444:235-8. 2004
    ..Two patterns of protein expression were observed and were correlated with the progression of dysplasia in intraductal papillary mucinous neoplasms...
  49. pmc Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli
    Emmanuelle Jeannot
    INSERM, U674, IUH, Universite Paris 7, Paris, France
    J Hepatol 45:883-6. 2006
    ..Altogether, these results suggest that benign hepatocellular carcinogenesis may be dependent on or independent of the Wnt/beta-catenin pathway in patients with FAP...
  50. ncbi request reprint Malignant intrahepatic biliary papillomatosis associated with viral C cirrhosis
    Najat Mourra
    Department of Pathology, Hopital St Antoine, Paris, France
    Arch Pathol Lab Med 126:369-71. 2002
    ..We report herein a case of malignant intrahepatic biliary papillomatosis associated with cirrhosis secondary to hepatitis C. To the best of our knowledge, this is the first report of this association...
  51. ncbi request reprint [Gastrointestinal bleeding: a difficult diagnosis]
    Eva Comperat
    Service d Anatomie et Cytologie Pathologiques, Hopital Saint Antoine, AP HP, Paris
    Ann Pathol 23:455-6. 2003
  52. ncbi request reprint Epithelioid solitary fibrous tumor in the ischioanal fossa
    Najat Mourra
    Department of Pathology, Hopital St Antoine, 184, rue du Faubourg St Antoine, 75012 Paris, France
    Virchows Arch 446:674-6. 2005
  53. doi request reprint What is the incidence of metastatic lymph node involvement after significant pathologic response of primary tumor following neoadjuvant treatment for locally advanced rectal cancer?
    Hadrien Tranchart
    Department of General and Digestive Surgery, AP HP, Saint Antoine Hospital, Paris, France
    Ann Surg Oncol 20:1551-9. 2013
    ..The aim of this study was to evaluate the rate of lymph node (LN) involvement in patients with complete (ypT0) or major (TRG1: very few viable tumor cells) response...
  54. ncbi request reprint Lymph node metastases of prostatic adenocarcinoma in the mesorectum in patients with adenocarcinoma or villous tumor of the rectum with collision phenomenon in a single lymph node: report of five cases
    Najat Mourra
    Department of Pathology, Hopital Saint Antoine, Assistance Public Hôpitaux de Paris, Universite Pierre et Marie Curie, 184 rue du Faubourg Saint Antoine, 75012 Paris, France
    Dis Colon Rectum 48:384-9. 2005
    ..We report five patients with metastatic prostatic carcinoma to mesorectal lymph nodes, with the "collision phenomenon" in one lymph node. The diagnosis of prostate cancer was clinically unsuspected in two cases...
  55. doi request reprint Changing pathology with changing drugs: tumors of the gastrointestinal tract
    Pascale Cervera
    Service d Anatomie et Cytologie Pathologiques, Hopital Saint Antoine, Paris, France
    Pathobiology 78:76-89. 2011
    ..They express the KIT protein, a membrane receptor, and respond to imatinib which is a tyrosine kinase receptor inhibitor, depending on the mutational status of the tumor...
  56. ncbi request reprint [Quality assessment of intraoperative frozen sections in a teaching hospital: an analysis of 847 consecutive cases]
    Dominique Wendum
    Service d Anatomie et Cytologie Pathologiques, Hopital Saint Antoine AP HP, 184 rue du Faubourg Saint Antoine, 75571 Paris 12
    Ann Pathol 23:393-9. 2003
    ..Although a high rate of differed diagnosis was observed in thyroid neoplasms, frozen sections remain useful for these lesions. Imprint cytology of thyroid nodules is advisable...
  57. doi request reprint Adrenalectomy for clinically isolated metastasis from colorectal carcinoma: report of eight cases
    Najat Mourra
    Department of Pathology, Hopital St Antoine, Paris, France
    Dis Colon Rectum 51:1846-9. 2008
    ..Metastasis to the adrenal glands is a relatively frequent finding at autopsy. Adrenal metastasis of colorectal carcinoma is rare (14 percent). Isolated adrenal metastasis is even rarer, and presents a therapeutic dilemma...
  58. ncbi request reprint Acute hepatitis E: a cause of lymphocytic destructive cholangitis
    Dominique Wendum
    Department of Pathology, Hopital Saint Antoine AP HP, 75571 Paris Cedex 12, France
    Hum Pathol 36:436-8. 2005
    ..Therefore, hepatitis E should be considered as a diagnostic possibility when liver biopsy shows acute hepatitis and lymphocytic destructive cholangitis. The mechanism of bile duct damage in hepatitis E remains unknown...
  59. ncbi request reprint [Fatal Dieulafoy's type ulcer in a case of gastric AL-amyloidosis]
    Nelly Youssef
    Service d Anatomie Pathologique, Hopital Necker Enfants Malades, 149 rue de Sèvres 75743 Paris cedex 15
    Ann Pathol 24:256-8. 2004
    ..Pathogenesis of Dieulafoy's ulcer remains unclear. In our case, local ischemia may have facilitated gastric ulceration, and amyloid deposits may have contributed to arterial rupture...
  60. ncbi request reprint [Liver involvement revealing systemic mastocytosis: report of two cases]
    Dominique Wendum
    Service d Anatomie et Cytologie Pathologiques, Hopital Jean Verdier, AP HP, Avenue du 14 Juillet, 93143 Bondy Cedex
    Gastroenterol Clin Biol 28:80-3. 2004
    ..The diagnosis is often difficult. Mast cell tissular infiltration can be identified on paraffin sections by tryptase or CD117 (c-kit) immuno-staining...
  61. ncbi request reprint Brunner gland hamartoma with predominant adipose tissue and ciliated cysts
    Denis Chatelain
    Service d Anatomie Pathologique, Hopital Saint Antoine, Paris, France
    Arch Pathol Lab Med 126:734-5. 2002
    ..The presence of ciliated cells in the gut mucosa is a rare phenomenon, which has already been described in the esophagus and stomach. We report an unusual case of ciliated metaplasia in a duodenal Brunner gland hamartoma...
  62. doi request reprint Pathology analysis reveals that dysplastic pancreatic ductal lesions are frequent in patients with hereditary pancreatitis
    Vinciane Rebours
    Pôle des Maladies de l Appareil Digestif, Service de Gastroentérologie Pancréatologie, Hopital Beaujon, AP HP, Paris, Clichy, France
    Clin Gastroenterol Hepatol 8:206-12. 2010
    ....
  63. ncbi request reprint [Heterotopic mesenteric ossification: a rare cause of postoperative occlusion]
    Eva Comperat
    Service d Anatomie et Cytologie Pathologiques, Hopital Saint Antoine, AP HP, 184, rue du Faubourg Saint Antoine, 75571 Paris Cedex 12
    Gastroenterol Clin Biol 28:188-9. 2004
    ..In all reported series, there was a history of traumatic injury of the abdomen. We report two cases of heterotopic mesenteric ossification occurring after laparotomy in adults...
  64. ncbi request reprint Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary cirrhosis: an observational study
    Lawrence Serfaty
    Service d Hepato Gastroenterologie, Service d Anatomopathologie, Hopital Saint Antoine, INSERM U370, Paris, France
    Hepatology 38:203-9. 2003
    ..These results are strengthened by the significant reduction in colon epithelial cell proliferation seen in patients treated with UDCA...
  65. ncbi request reprint Malignant deciduoid mesothelioma: a diagnostic challenge
    Najat Mourra
    Department of Pathology, Hopital St Antoine, Paris, France
    Arch Pathol Lab Med 129:403-6. 2005
    ..The patient died 14 months after the first operation. This observation confirms the poor prognosis of this entity and the importance of the differential diagnosis of pseudotumoral deciduosis...
  66. pmc Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value
    Laetitia Marisa
    Cartes d Identité des Tumeurs program, Ligue Nationale Contre Cancer, Paris, France
    PLoS Med 10:e1001453. 2013
    ..The aim of this study was to establish a comprehensive molecular classification of CC based on mRNA expression profile analyses...
  67. doi request reprint EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies
    Virginie Poindessous
    Laboratory of Cancer Biology and Therapeutics, Centre de Recherche Saint Antoine, Paris, France
    Clin Cancer Res 17:6522-30. 2011
    ..We speculated that inhibition of surface receptors and ligands might only partly prevent oncogenic signaling whereas small-molecule tyrosine kinase inhibitors (TKI) would also influence intracellular signaling...
  68. ncbi request reprint Neurotensin receptor 1 gene activation by the Tcf/beta-catenin pathway is an early event in human colonic adenomas
    Frédérique Souazé
    INSERM U673 UPMC, Department of Pathology, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    Carcinogenesis 27:708-16. 2006
    ..In this report we establish a novel link in vitro between the Tcf/beta-catenin pathway and NT1 receptor promoter activation...
  69. doi request reprint Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis
    Coralie Dorard
    Institut National de la Sante et de la Recherche Medicale INSERM, Centre de Recherche Saint Antoine, Equipe Instabilité des Microsatellites et Cancers, Paris, France
    Nat Med 17:1283-9. 2011
    ..The survival and response to chemotherapy of subjects with MSI CRCs was associated with the tumor expression level of HSP110ΔE9. HSP110 may thus constitute a major determinant for both prognosis and treatment response in CRC...
  70. doi request reprint Imprint cytology in tumor tissue bank quality control: an efficient method to evaluate tumor necrosis and to detect samples without tumor cells
    Pascaline Boudou-Rouquette
    Service d Anatomie et Cytologie Pathologiques, AP HP, Hopital Saint Antoine, 184 rue du Faubourg St Antoine, 75571 Paris Cedex 12, France
    Virchows Arch 456:443-7. 2010
    ..We show that IC is efficient to semiquantify necrosis in a tumor sample and to detect significant necrosis. IC seems to be less efficient to quantify tumor cells...
  71. doi request reprint Microsatellite instability in colorectal cancer: from molecular oncogenic mechanisms to clinical implications
    Aziz Zaanan
    INSERM, UMR_S, Centre de Recherche Saint Antoine, Paris, France
    Cell Oncol (Dordr) 34:155-76. 2011
    ....
  72. doi request reprint Risk of colorectal high-grade dysplasia and cancer in a prospective observational cohort of patients with inflammatory bowel disease
    Laurent Beaugerie
    Department of Gastroenterology, AP HP, Hôpital Saint Antoine F 75012 and UPMC Univ Paris 06 F 75005, Paris, France
    Gastroenterology 145:166-175.e8. 2013
    ..We analyzed data on CRC development among patients with IBD enrolled in the observational cohort Cancers et Surrisque Associé aux Maladies Inflammatoires Intestinales En France (CESAME)...
  73. pmc Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis
    Ralph Epaud
    Inserm UMRS 938, Hopital Saint Antoine, Paris, France
    PLoS ONE 7:e48071. 2012
    ..Lethal respiratory failure in neonatal IGF-1R knockout mice suggested a particular role for this receptor in pulmonary development, and we therefore investigated the consequences of IGF-1R inactivation in lung tissue...
  74. ncbi request reprint [Acinar cell carcinoma of the pancreas with predominant intraductal growth: report of a case]
    Magali Svrcek
    Service d Anatomie et Cytologie Pathologiques Hôpital Saint Antoine, APHP, Paris, France
    Gastroenterol Clin Biol 31:543-6. 2007
    ..These rare forms of ACC can be confused with intraductal papillary-mucinous neoplasms. In our report, fine needle aspiration cytology performed during endoscopic ultrasound examination was a valuable tool in the diagnostic assessment...
  75. ncbi request reprint Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis
    Magali Svrcek
    Services d Anatomie et Cytologie Pathologiques, AP HP, Hopital Saint Antoine, F 75571 Paris Cedex 12, France
    Eur J Endocrinol 156:617-21. 2007
    ..Only two cases of regressive LA after hormone withdrawal therapy have been described so far but without any information concerning the molecular characteristics of the tumours...
  76. doi request reprint High-resolution genotyping of chromosome 8 in colon adenocarcinomas reveals recurrent break point but no gene mutation in the 8p21 region
    Najat Mourra
    CHU St Antoine, Department of Pathology, Paris, France
    Diagn Mol Pathol 17:90-3. 2008
    ..No mutation was found, suggesting more complex mechanisms of inactivation or side effects of chromosome arm 8q duplication, which might be up-regulating oncogenes not located within the deleted region...
  77. doi request reprint Histological assessment of oesophageal columnar mucosa
    Jean Francois Flejou
    Service d Anatomie Pathologique, Hopital Saint Antoine, AP HP, Faculte de Medecine Pierre et Marie Curie, Paris, France
    Best Pract Res Clin Gastroenterol 22:671-86. 2008
    ..The role of pathologists is now extended to the evaluation of new therapeutic modalities of early neoplastic lesions in Barrett's oesophagus, especially endoscopic mucosal resection...
  78. doi request reprint Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas
    Virginie Audard
    Institut Cochin, Universite Paris Descartes, CNRS, Paris, France
    Pancreas 36:80-3. 2008
    ....
  79. doi request reprint Value of cytologic Papanicolaou smears and polymerase chain reaction screening for human papillomavirus DNA in detecting anal intraepithelial neoplasia: comparison with histology of a surgical sample
    Isabelle Etienney
    Proctology Service Medical Intervention, Diaconesses Croix St Simon Group Hospitals, Paris, France
    Cancer 118:6031-8. 2012
    ..The objective of the current study was to analyze the significance of abnormal smears relative to the histology and PCR detection of HPV DNA...
  80. doi request reprint Ovarian metastases from breast cancer: report of 29 cases
    Veronique Bigorie
    Department of Gynecologic and Breast Cancers, Tenon Hospital, Public Assistance Hospitals of Paris, Paris, France
    Cancer 116:799-804. 2010
    ..The objective of this study was to describe the characteristics and survival outcomes of patients with breast cancer who had ovarian metastases...
  81. ncbi request reprint [Uncommon types of chronic pancreatitis]
    Nelly Youssef
    Service d Anatomie Pathologique, Hopital Necker Enfants Malades, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Ann Pathol 22:387-96. 2002
    ..New insights into the understanding of chronic pancreatitis lead to new physiopathological concepts, and many arguments suggest that combined factors may lead to chronic inflammatory lesions of the pancreas...
  82. ncbi request reprint Specific clinical and biological features characterize inflammatory bowel disease associated colorectal cancers showing microsatellite instability
    Magali Svrcek
    Assistance Publique Hopitaux de Paris AP HP, Hopital Saint Antoine, Service d Anatomie Pathologique, Paris, France
    J Clin Oncol 25:4231-8. 2007
    ..We investigated a large series of IBD-N for associations between MSI and several biologic and clinical parameters related to tumors, patients, and their treatment...
  83. pmc Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers
    Jamila El-Bchiri
    INSERM, UMR S893, Team 13 Microsatellite Instability and Cancers, Paris, France
    PLoS ONE 3:e2583. 2008
    ....
  84. doi request reprint APC, MYH, and the correlation genotype-phenotype in colorectal polyposis
    Jeremie H Lefevre
    Department of Digestive Surgery, Hopital Saint Antoine, University Paris VII Pierre and Marie Curie, Paris, France
    Ann Surg Oncol 16:871-7. 2009
    ..The aim of our study was to investigate patients with polyposis treated in our institution for a correlation between genotype and phenotype...
  85. doi request reprint KSHV/HHV8-associated intestinal Kaposi's sarcoma in patient with ulcerative colitis receiving immunosuppressive drugs: report of a case
    Magali Svrcek
    Service d Anatomie et Cytologie Pathologiques, Hopital Saint Antoine, Assistance Publique Hopitaux de Paris, Paris, France
    Dis Colon Rectum 52:154-8. 2009
    ..However, discontinuation of the immunosuppression is not always possible and in those cases chemotherapy may be indicated...
  86. doi request reprint The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms
    Claire Borie
    INSERM, UMR_S 938, Team Microsatellite Instability and Cancers, Paris, France
    Int J Cancer 125:2360-6. 2009
    ..They give the exact way how to make the diagnosis of MSI in these tumors and may help to define biological and clinicalrisk factors associated with their emergence in such a clinicalcontext...