Pascal Ferre

Summary

Country: France

Publications

  1. ncbi Sterol-regulatory-element-binding protein 1c mediates insulin action on hepatic gene expression
    P Ferre
    INSERM Unit 465, Centre de Recherches Biomedicales des Cordeliers, Universite Paris VI, 15, rue de l Ecole de Medecine, 75270, Paris Cedex 06, France
    Biochem Soc Trans 29:547-52. 2001
  2. ncbi SREBP-1c transcription factor and lipid homeostasis: clinical perspective
    P Ferre
    INSERM, UMR S 671, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Horm Res 68:72-82. 2007
  3. ncbi [Action and secretion of insulin: a dual role for potassium channels]
    Pascal Ferre
    INSERM U 671, Centre de Recherches Biomedicales des Cordeliers, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Med Sci (Paris) 21:694-6. 2005
  4. ncbi [Adiponectin: from adipocyte to skeletal muscle]
    P Ferre
    INSERM U465, Centre de Recherches Biomedicales des Cordeliers, F 75270 Paris Cedex 06
    Ann Endocrinol (Paris) 65:S36-43. 2004
  5. ncbi The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity
    Pascal Ferre
    INSERM Unit 465, Cordeliers Biomedical Research Center, Paris, France
    Diabetes 53:S43-50. 2004
  6. ncbi AMP-activated protein kinase and hepatic genes involved in glucose metabolism
    P Ferre
    INSERM Unit 465, Centre de Recherches Biomedicales des Cordeliers, 15, rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Biochem Soc Trans 31:220-3. 2003
  7. ncbi In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis
    Laurent Yvan-Charvet
    INSERM, U671, Centre Biomédical des Cordeliers, 75270 Paris Cedex 06, France
    Arterioscler Thromb Vasc Biol 27:1340-5. 2007
  8. ncbi Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c
    Bronwyn D Hegarty
    Institut National de la Santé et de la Recherche Médicale Unit 465, Universite Paris 6, 15, rue de l Ecole de Medecine, 75006 Paris, France
    Proc Natl Acad Sci U S A 102:791-6. 2005
  9. ncbi GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    Hélène L Kammoun
    INSERM, UMR S, Centre de Recherche des Cordeliers, Paris, France
    J Clin Invest 119:1201-15. 2009
  10. ncbi Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
    Marie Daval
    INSERM U671, Centre de Recherches Biomedicales des Cordeliers, Universite Pierre et Marie Curie, 75270 Paris Cedex 06, France
    J Biol Chem 280:25250-7. 2005

Collaborators

Detail Information

Publications39

  1. ncbi Sterol-regulatory-element-binding protein 1c mediates insulin action on hepatic gene expression
    P Ferre
    INSERM Unit 465, Centre de Recherches Biomedicales des Cordeliers, Universite Paris VI, 15, rue de l Ecole de Medecine, 75270, Paris Cedex 06, France
    Biochem Soc Trans 29:547-52. 2001
    ..Here we review the evidence that has led to this proposal and the consequences for our understanding of insulin effects in physiological or pathological conditions...
  2. ncbi SREBP-1c transcription factor and lipid homeostasis: clinical perspective
    P Ferre
    INSERM, UMR S 671, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Horm Res 68:72-82. 2007
    ....
  3. ncbi [Action and secretion of insulin: a dual role for potassium channels]
    Pascal Ferre
    INSERM U 671, Centre de Recherches Biomedicales des Cordeliers, Universite Pierre et Marie Curie, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Med Sci (Paris) 21:694-6. 2005
  4. ncbi [Adiponectin: from adipocyte to skeletal muscle]
    P Ferre
    INSERM U465, Centre de Recherches Biomedicales des Cordeliers, F 75270 Paris Cedex 06
    Ann Endocrinol (Paris) 65:S36-43. 2004
    ..Recent works and the links between insulin resistance, adipose tIssue, adiponectin and its PPARgamma-enhanced secretion are reviewed in this paper...
  5. ncbi The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity
    Pascal Ferre
    INSERM Unit 465, Cordeliers Biomedical Research Center, Paris, France
    Diabetes 53:S43-50. 2004
    ..The PPARs are thus major regulators of lipid and glucose metabolism, allowing adaptation to the prevailing nutritional environment...
  6. ncbi AMP-activated protein kinase and hepatic genes involved in glucose metabolism
    P Ferre
    INSERM Unit 465, Centre de Recherches Biomedicales des Cordeliers, 15, rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Biochem Soc Trans 31:220-3. 2003
    ..Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs...
  7. ncbi In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis
    Laurent Yvan-Charvet
    INSERM, U671, Centre Biomédical des Cordeliers, 75270 Paris Cedex 06, France
    Arterioscler Thromb Vasc Biol 27:1340-5. 2007
    ..This study examines the role of insulin and angiotensin II in high-density lipoprotein (HDL) metabolism by focusing on the regulation and function of scavenger receptor type-BI (SR-BI) in adipose tissue...
  8. ncbi Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c
    Bronwyn D Hegarty
    Institut National de la Santé et de la Recherche Médicale Unit 465, Universite Paris 6, 15, rue de l Ecole de Medecine, 75006 Paris, France
    Proc Natl Acad Sci U S A 102:791-6. 2005
    ..Finally, we show through experiments in suckling mice that this acute action of insulin to stimulate the proteolytic processing of SREBP-1c is functional in vivo...
  9. ncbi GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    Hélène L Kammoun
    INSERM, UMR S, Centre de Recherche des Cordeliers, Paris, France
    J Clin Invest 119:1201-15. 2009
    ..These findings demonstrate that GRP78 inhibits both insulin-dependent and ER stress-dependent SREBP-1c proteolytic cleavage and explain the role of ER stress in hepatic steatosis in obese rodents...
  10. ncbi Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
    Marie Daval
    INSERM U671, Centre de Recherches Biomedicales des Cordeliers, Universite Pierre et Marie Curie, 75270 Paris Cedex 06, France
    J Biol Chem 280:25250-7. 2005
    ..We conclude that, in mature adipocytes, AMP-activated protein kinase activation has a clear anti-lipolytic effect...
  11. ncbi SREBP transcription factors: master regulators of lipid homeostasis
    Delphine Eberle
    INSERM U465, Universite Pierre et Marie Curie, 15, rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Biochimie 86:839-48. 2004
    ....
  12. ncbi Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression
    Isabelle Guillet-Deniau
    UPR 1524 CNRS, Institut Cochin de Genetique Moleculaire, Paris, France
    Diabetes 51:1722-8. 2002
    ..We conclude that in skeletal muscles, SREBP-1c expression is sensitive to insulin and can transduce the positive and negative actions of the hormone on specific genes and thus has a pivotal role in long-term muscle insulin sensitivity...
  13. ncbi New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c
    Fabienne Foufelle
    INSERM Unit 465, Centre de Recherches Biomedicales des Cordeliers, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Biochem J 366:377-91. 2002
    ..We discuss how these transcription factors are integrated in a regulatory network that allows a fine tuning of hepatic glucose storage or production, and their potential importance in metabolic diseases...
  14. ncbi Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance
    Laurent Yvan-Charvet
    Unit 465, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Diabetes 54:991-9. 2005
    ..These data support the idea that AT2R-dependent Ang II signaling increases adipose cell mass and glucose intolerance and thus could participate to the deleterious effects of a high-fat diet...
  15. ncbi Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development
    Alexandre Bobard
    INSERM U465, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 280:199-206. 2005
    ..This could be due to the concomitant induction of INSIG-2a by LXR and subsequent retention of SREBP-1c in the endoplasmic reticulum...
  16. ncbi Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling
    Cédric M Blouin
    Centre de Recherche des Cordeliers, INSERM, UMR S 872, Paris, France
    Diabetes 59:600-10. 2010
    ..We hypothesized that ceramide action through PKCzeta or PP2A might depend on plasma membrane (PM) structural organization and especially on caveolin-enriched domain (CEM) abundance...
  17. ncbi Prevention of adipose tissue depletion during food deprivation in angiotensin type 2 receptor-deficient mice
    Laurent Yvan-Charvet
    Institut National de la Sante et de la Recherche Medicale, Unité 671, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Endocrinology 147:5078-86. 2006
    ..These data reveal an important physiological role of AT2R in metabolic adaptations to fasting...
  18. ncbi SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts
    Delphine Eberle
    INSERM Unit 465, University Pierre et Marie Curie, Paris, France
    Diabetes 53:2153-7. 2004
    ..03) and increased prevalence of nephropathy (P = 0.028) in a diabetic cohort. Our results indicate a role of the SREBF-1 gene in genetic predisposition of metabolic diseases such as obesity, type 2 diabetes, and dyslipidemia...
  19. ncbi HDL-mediated cholesterol uptake and targeting to lipid droplets in adipocytes
    Georges Dagher
    INSERM Unité 465, Centre de Recherche Biomédicales des Cordeliers Université Paris 6, 15 rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    J Lipid Res 44:1811-20. 2003
    ....
  20. ncbi Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver
    Renaud Dentin
    INSERM, U1016, Paris, France
    J Hepatol 56:199-209. 2012
    ..Indeed, the current model of ChREBP activation, which depends on Serine 196 and Threonine 666 dephosphorylation, phosphatase 2A (PP2A) activity, and xylulose 5-phosphate (X5P) as a signaling metabolite, has been challenged...
  21. ncbi Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects
    Cédric M Blouin
    Centre de Recherche des Cordeliers, INSERM, U872, Universite Pierre et Marie Curie Paris 6, France
    J Lipid Res 51:945-56. 2010
    ..Altogether, these data demonstrate that the lipid droplet-caveolin pool impacts on phospholipid and protein surface composition of lipid droplets and suggest a functional role on lipid droplet expandability...
  22. ncbi Distinct roles of endothelial and adipocyte caveolin-1 in macrophage infiltration and adipose tissue metabolic activity
    Nolwenn Briand
    Centre de Recherche des Cordeliers, INSERM, U872, Paris, France
    Diabetes 60:448-53. 2011
    ..The goal of this study was to establish the relative contribution of endothelial cells and adipocytes, both highly expressing caveolin-1 to the lipoatrophic phenotype of mice with global caveolin-1 gene invalidation (Cav1-KO)...
  23. ncbi Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells
    Soazig Le Lay
    INSERM U465, Institut Biomedical des Cordeliers, 15, rue de l Ecole de Medecine, 75006 Paris, France
    J Lipid Res 44:1499-507. 2003
    ..This is consistent with the view of the adipocyte behaving as a cholesterol sink, with plasma cholesterol-buffering properties...
  24. ncbi Nutritional related liver disease: targeting the endoplasmic reticulum stress
    Hélène L Kammoun
    INSERM, UMR S 872, Centre de Recherche des Cordeliers and Université Pierre et Marie Curie Paris6, UMR S 872, 75006 Paris, France
    Curr Opin Clin Nutr Metab Care 12:575-82. 2009
    ..This review will evaluate the late discoveries highlighting ER stress as a major actor in the development of nutritional liver diseases...
  25. ncbi Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis
    Mélissa Flamment
    INSERM UMR S 872, Centre de Recherche des Cordeliers and Université Pierre et Marie Curie Paris 6, Paris, France
    Curr Opin Lipidol 21:239-46. 2010
    ..To examine the role of endoplasmic reticulum stress in the regulation of hepatic lipid metabolism and its contribution to the development of hepatic steatosis...
  26. ncbi Genetics and the pathophysiology of obesity
    Karine Clement
    INSERM Avenir, EA 3502 Paris 6 University and Service de Nutrition, AP HP, Hotel Dieu, Paris, France
    Pediatr Res 53:721-5. 2003
    ..When specific pharmacological treatments based on recent discoveries become available, however, genetic testing could help discriminate between the subtypes of obesity that may respond differentially to treatment...
  27. ncbi PPARγ contributes to PKM2 and HK2 expression in fatty liver
    Ganna Panasyuk
    INSERM, U845, Paris 75015, France
    Nat Commun 3:672. 2012
    ....
  28. ncbi [Unfolded protein response: its role in physiology and physiopathology]
    Fabienne Foufelle
    INSERM U671, Universite Pierre et Marie Curie Paris 6, UMR S671, Centre Biomédical des Cordeliers, France
    Med Sci (Paris) 23:291-6. 2007
    ....
  29. ncbi [Vitamin A, in the eye of the fat]
    Isabelle Dugail
    INSERM, U872, Paris, F-75006 France
    Med Sci (Paris) 23:1036-8. 2007
  30. ncbi New insights into ER stress-induced insulin resistance
    Mélissa Flamment
    Institut National de la Sante et de la Recherche Medicale INSERM, Centre de Recherche des Cordeliers, Unité Mixte de Recherche en Santé UMR S 872, Paris, F 75006 France
    Trends Endocrinol Metab 23:381-90. 2012
    ..This review aims to summarize and decipher the abundant new literature concerning the emerging and multifaceted involvement of ER stress in the development of metabolic dysfunctions in insulin target tissues...
  31. ncbi [Insulin signaling and insulin resistance]
    Pascal Ferre
    INSERM, UMR S 872, Centre de Recherches des Cordeliers, Paris, France Université Pierre et Marie Curie Paris 6, UMR S 872, Paris, France
    Therapie 62:277-84. 2007
    ..Therapies aimed at improving insulin sensitivity could then target proteins involved in the regulation of intacellular fatty acid availibility...
  32. ncbi Specific increase in leptin production in obese (falfa) rat adipose cells
    Sophie Turban
    U 465 INSERM, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Biochem J 362:113-8. 2002
    ..Increased leptin production might be related to disruption of leptin signalling by the fa mutation...
  33. ncbi [AMPK, an active player in the control of metabolism]
    Marie Daval
    INSERM U671, , , 15, , 75270 Paris 06
    J Soc Biol 200:99-105. 2006
    ..AMPK provides therefore a potential target for the treatment of metabolic diseases such as obesity and type II diabetes...
  34. ncbi Adipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat
    Isabelle Hainault
    , , , Paris, France
    Am J Physiol Endocrinol Metab 282:E59-66. 2002
    ..Our results demonstrate that the fa genotype exerts a control on the production of AGT in a tissue-specific manner, suggesting a local role of AGT in the overdevelopment of adipose tissue...
  35. ncbi A New Role for a Metabolic Star: AMP-Activated Protein Kinase Stimulates Fat Absorption
    Pascal Ferre
    INSERM, Centre de Recherches des Cordeliers, UMR S 872, 75006 Paris, France Université Pierre et Marie Curie Paris6, UMR S 872, 75006 Paris, France
    Cell Metab 13:1-2. 2011
    ..AMPK enhances the expression of the bile acid transporter, BSEP, by activating the coactivator SRC-2, thus promoting bile acid secretion...
  36. ncbi Novel insights in the interplay between inflammation and metabolic diseases: A role for the pathogen sensing kinase PKR
    Nicolas Marsollier
    INSERM UMR S 872, Centre de Recherches des Cordeliers, Paris, France Université Pierre et Marie Curie Paris 6, UMR S, 872 Paris, France
    J Hepatol 54:1307-9. 2011
    ..These findings demonstrate PKR as a critical component of an inflammatory complex that responds to nutrients and organelle dysfunction...
  37. ncbi Insulin and angiotensin II induce the translocation of scavenger receptor class B, type I from intracellular sites to the plasma membrane of adipocytes
    Anne-Laure Tondu
    INSERM U671, , , , 75006 Paris, France
    J Biol Chem 280:33536-40. 2005
    ..This suggests that SR-BI might participate in the storage of lipids in the adipose tissue...
  38. ncbi Role of adenosine monophosphate-activated protein kinase in the control of energy homeostasis
    Fabienne Foufelle
    INSERM Unit 671, University Pierre et Marie Curie, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Curr Opin Clin Nutr Metab Care 8:355-60. 2005
    ..Finally, adenosine monophosphate-activated protein kinase is a better target than LKB1 for the development of specific activating (or inhibiting) drugs...
  39. ncbi Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase
    O Bourron
    Centre de Recherche des Cordeliers, INSERM, UMR S 872, 15 rue de l Ecole de Medecine, Paris F 75006, France
    Diabetologia 53:768-78. 2010
    ..As the hypoglycaemic drugs metformin and thiazolidinediones activate this enzyme in rodents, we tested the hypothesis that in addition to their known actions they could have an anti-lipolytic effect in human adipocytes...