P Fenichel

Summary

Country: France

Publications

  1. pmc Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor
    Adil Bouskine
    Institut National de la recherché Médicale INSERM U895, Team 5 Environment and Reproduction Genomic and Nongenomic Mechanisms, University of Nice Sophia Antipolis, Faculty of Medicine, Nice, France
    Environ Health Perspect 117:1053-8. 2009
  2. pmc GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferation
    Nicolas Chevalier
    Institut National de la Santé et de la Recherche Médicale UMR U1065 UNS, Centre Méditerranéen de Médecine Moléculaire, équipe 5 Environnement, Reproduction et Cancers Hormono dépendants, Nice, France
    PLoS ONE 7:e34672. 2012
  3. doi request reprint Bisphenol A: an endocrine and metabolic disruptor
    Patrick Fenichel
    Inserm U1065 C3M, Service d endocrinologie, diabétologie et reproduction, Hopital de l Archet 2, CHU de Nice, 151, route Saint Antoine de Ginestiere, 06202 Nice Cedex 3, France
    Ann Endocrinol (Paris) 74:211-20. 2013
  4. doi request reprint Molecular diagnosis of 5α-reductase deficiency in 4 elite young female athletes through hormonal screening for hyperandrogenism
    Patrick Fenichel
    Department of Reproductive Endocrinology and Institut National de la Santé et de la Recherche Médicale Unité 1065, Hospital of L Archet, 06200 Nice, France
    J Clin Endocrinol Metab 98:E1055-9. 2013
  5. doi request reprint Delayed puberty
    Patrick Fenichel
    Service d endocrinologie et médecine de la reproduction, Centre Hospitalo Universitaire de Nice, Hopital de l Archet, Nice, France
    Endocr Dev 22:138-59. 2012
  6. doi request reprint Unconjugated bisphenol A cord blood levels in boys with descended or undescended testes
    P Fenichel
    Department of Reproductive Endocrinology, University Hospital of Nice, 06602 Nice, France
    Hum Reprod 27:983-90. 2012
  7. ncbi request reprint [Procreation in Turner's syndrome: which recommendations before, during and after pregnancy?]
    P Fenichel
    Service d endocrinologie et médecine de la reproduction, CECOS, Hopital de l Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Gynecol Obstet Fertil 36:891-7. 2008
  8. ncbi request reprint [Environmental endocrine disruptors and breast cancer: new risk factors?]
    P Fenichel
    INSERM U895, Service d endocrinologie et médecine de la reproduction, hôpital de l Archet I, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Gynecol Obstet Fertil 36:969-77. 2008
  9. ncbi request reprint [Medical preservation of ovarian function before and during radiochemotherapy]
    P Fenichel
    Service d endocrinologie et médecine de la reproduction, CECOS, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Gynecol Obstet Fertil 33:610-4. 2005
  10. ncbi request reprint Unilateral testicular tumour associated to congenital adrenal hyperplasia: Failure of specific tumoral molecular markers to discriminate between adrenal rest and leydigioma
    P Fenichel
    Service d endocrinologie et médecine de la reproduction, Hopital de l Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Ann Endocrinol (Paris) 69:453-8. 2008

Collaborators

Detail Information

Publications35

  1. pmc Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor
    Adil Bouskine
    Institut National de la recherché Médicale INSERM U895, Team 5 Environment and Reproduction Genomic and Nongenomic Mechanisms, University of Nice Sophia Antipolis, Faculty of Medicine, Nice, France
    Environ Health Perspect 117:1053-8. 2009
    ..Thus, several mechanisms have been suggested to explain how they could affect male germ cell proliferation at low environmental relevant concentrations...
  2. pmc GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferation
    Nicolas Chevalier
    Institut National de la Santé et de la Recherche Médicale UMR U1065 UNS, Centre Méditerranéen de Médecine Moléculaire, équipe 5 Environnement, Reproduction et Cancers Hormono dépendants, Nice, France
    PLoS ONE 7:e34672. 2012
    ..The aim of this study was to demonstrate that GPER was overexpressed in testicular tumours and was able to trigger JKT-1 seminoma cell proliferation...
  3. doi request reprint Bisphenol A: an endocrine and metabolic disruptor
    Patrick Fenichel
    Inserm U1065 C3M, Service d endocrinologie, diabétologie et reproduction, Hopital de l Archet 2, CHU de Nice, 151, route Saint Antoine de Ginestiere, 06202 Nice Cedex 3, France
    Ann Endocrinol (Paris) 74:211-20. 2013
    ....
  4. doi request reprint Molecular diagnosis of 5α-reductase deficiency in 4 elite young female athletes through hormonal screening for hyperandrogenism
    Patrick Fenichel
    Department of Reproductive Endocrinology and Institut National de la Santé et de la Recherche Médicale Unité 1065, Hospital of L Archet, 06200 Nice, France
    J Clin Endocrinol Metab 98:E1055-9. 2013
    ..Identifying the cause of XY,DSD raises medical and ethical concerns, especially with regard to issues of the eligibility to compete...
  5. doi request reprint Delayed puberty
    Patrick Fenichel
    Service d endocrinologie et médecine de la reproduction, Centre Hospitalo Universitaire de Nice, Hopital de l Archet, Nice, France
    Endocr Dev 22:138-59. 2012
    ..Therapeutic attitude will have to integrate etiological factors, statural prognosis, bone mass preservation and psychological factors...
  6. doi request reprint Unconjugated bisphenol A cord blood levels in boys with descended or undescended testes
    P Fenichel
    Department of Reproductive Endocrinology, University Hospital of Nice, 06602 Nice, France
    Hum Reprod 27:983-90. 2012
    ..Human epidemiological studies remain scarce, especially concerning testicular development. We have investigated the relationship between fetal exposure to BPA and cryptorchidism...
  7. ncbi request reprint [Procreation in Turner's syndrome: which recommendations before, during and after pregnancy?]
    P Fenichel
    Service d endocrinologie et médecine de la reproduction, CECOS, Hopital de l Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Gynecol Obstet Fertil 36:891-7. 2008
    ....
  8. ncbi request reprint [Environmental endocrine disruptors and breast cancer: new risk factors?]
    P Fenichel
    INSERM U895, Service d endocrinologie et médecine de la reproduction, hôpital de l Archet I, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Gynecol Obstet Fertil 36:969-77. 2008
    ....
  9. ncbi request reprint [Medical preservation of ovarian function before and during radiochemotherapy]
    P Fenichel
    Service d endocrinologie et médecine de la reproduction, CECOS, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Gynecol Obstet Fertil 33:610-4. 2005
    ..By consequence randomized studies need to be performed to verify the benefit, which one could expect from such a systematic clinical use...
  10. ncbi request reprint Unilateral testicular tumour associated to congenital adrenal hyperplasia: Failure of specific tumoral molecular markers to discriminate between adrenal rest and leydigioma
    P Fenichel
    Service d endocrinologie et médecine de la reproduction, Hopital de l Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Ann Endocrinol (Paris) 69:453-8. 2008
    ..However, lack of tumoral LH-R mRNA expression and a tumour-free 3-year follow-up led us to retain the diagnosis of adrenal rest tumour with loss of adrenal gene expression and progressive autonomous behaviour...
  11. ncbi request reprint Delayed puberty
    Patrick Fenichel
    Service d endocrinologie et médecine de la reproduction, Centre Hospitalo Universitaire de Nice, Hopital de l Archet, Nice, France
    Endocr Dev 7:106-28. 2004
  12. doi request reprint [Is there any medical treatment to preserve fertility during chemotherapy in women?]
    P Fenichel
    INSERM U, Hopital de l Archet, CHU de Nice, France
    Gynecol Obstet Fertil 39:63-6. 2011
    ..To prevent primordial follicle apoptosis, an inhibitor of tysosine kinase, imatinib, has recently been proposed and positively evaluated in mice. It could represent an interesting hope to preserve female fertility during chemotherapy...
  13. ncbi request reprint [Pregnancy in type 1 diabetes: insulin pump versus intensified conventional therapy]
    S Hieronimus
    Service d endocrinologie médecine de la reproduction, CHU de Nice, Hopital de l Archet, route Saint Antoine de Ginestiere, France
    Gynecol Obstet Fertil 33:389-94. 2005
    ..To evaluate and compare the outcome of pregnancies in women with type 1 diabetes treated with continuous subcutaneous insulin pump or multiple insulin injections...
  14. doi request reprint [Oocyte donation in patients with Turner syndrome: A high-risk pregnancy]
    N Chevalier
    Service d endocrinologie et médecine de la reproduction CECOS, hôpital de l Archet 1, 151, Route de Saint Antoine de Ginestiere, BP 3079, 06202 Nice Cedex 3, France
    Ann Endocrinol (Paris) 70:246-51. 2009
    ..This case also illustrates the very high risk of pregnancy in women with Turner's syndrome and the importance of a multidisciplinary care by professionals informed and been used to this obstetric practice...
  15. doi request reprint [Post-menopausal ovarian hyperthecosis]
    A L Castell
    Service d endocrinologie, gynécologie et reproduction, Hopital L Archet, CHU de Nice, 151 route de Saint Antoine Ginestiere, Nice, France
    Gynecol Obstet Fertil 40:316-9. 2012
    ..Bilateral annexectomy allowed histological confirmation of hyperthecosis showing specific luteinized stromal cells and led to the complete suppression of the inappropriate androgen secretion...
  16. doi request reprint Universal two-step screening strategy for gestational diabetes has weak relevance in French Mediterranean women: should we simplify the screening strategy for gestational diabetes in France?
    N Chevalier
    Service d endocrinologie, diabète et médecine de la reproduction, Hopital de l Archet, CHU de Nice, 151, Route de Saint Antoine de Ginestiere, BP 3079, 06202 Nice Cedex 3, France
    Diabetes Metab 37:419-25. 2011
    ..Currently, there is no international consensus for gestational diabetes mellitus (GDM) diagnosis. This is a report of our experience of GDM screening according to the 1996 French guidelines...
  17. ncbi request reprint Connexin43 gene expression and regulation in the rodent seminiferous epithelium
    C Batias
    INSERM CJF 95 04, EA 1760, IFR 50, Faculte de Medecine, Nice, France
    J Histochem Cytochem 48:793-805. 2000
    ..Moreover, they suggest that retinoids, through the RXRbeta receptors, could be involved in the control of Cx43 gene expression in Sertoli cells...
  18. ncbi request reprint [Environmental pollutants in maternal milk and cryptorchidism]
    F Brucker-Davis
    Service d endocrinologie diabétologie médecine de la reproduction, pôle Gore, Hopital l Archet 1, CHU de Nice, 151, Route de Saint Antoine de Ginestiere, 06200 Nice, France
    Gynecol Obstet Fertil 36:840-7. 2008
    ..Their role in the occurrence of genital malformation, dysfunction or cancer has been suggested. We wanted to study the exposure of our population and its potential association with cryptorchidism, as few clinical studies are available...
  19. doi request reprint [Iodine status and thyroid function of 330 pregnant women from Nice area assessed during the second part of pregnancy]
    S Hieronimus
    Service d endocrinologie médecine de la reproduction, Hopital L Archet, CHU de Nice, BP 3079, 06202 Nice Cedex 3, France
    Ann Endocrinol (Paris) 70:218-24. 2009
    ..Iodine deficiency (ID) is still common in Western Europe and its prevention remains a challenge, particularly during pregnancy...
  20. doi request reprint Adrenocortical incidentaloma with uncertain prognosis associated with an inadequately treated congenital adrenal hyperplasia
    N Chevalier
    Service d endocrinologie et médecine de la reproduction, CECOS, hôpital de l Archet 1, 151 route de Saint Antoine de Ginestiere, Nice Cedex 3, France
    Ann Endocrinol (Paris) 71:56-9. 2010
    ....
  21. doi request reprint Lethal acute demyelinization with encephalo-myelitis as a complication of cured Cushing's disease
    N Chevalier
    Hopital de l Archet, CHU de Nice, France
    Ann Endocrinol (Paris) 71:548-52. 2010
    ..We hypothesize that the recent correction of hypercortisolism triggered ADEM and that the atypical presentation, responsible for diagnosis delay, led to the death of this patient...
  22. doi request reprint Vascular placental abnormalities and newborn death in a pregnant diabetic woman with familial partial lipodystrophy type 3: a possible role for peroxisome proliferator-activated receptor γ
    A L Castell
    Service d endocrinologie, diabétologie et reproduction, INSERM U1065, Hopital L Archet, CHU de Nice, BP 3079, 06202 Nice Cedex 3, France
    Diabetes Metab 38:367-9. 2012
    ..It also supports a physiological role for PPARγ during placentation...
  23. pmc Iodine status has no impact on thyroid function in early healthy pregnancy
    F Brucker-Davis
    Department of Endocrinology, Diabetology and Reproductive Medicine, L Archet Hospital, CHU de Nice, 151 route de Saint Antoine, 06200 Nice, France
    J Thyroid Res 2012:168764. 2012
    ..The absence of correlation between UIE and thyroid tests at that stage contrasts with the impact of βhCG and, to a lesser degree, maternal smoking...
  24. doi request reprint Klinefelter's syndrome and bone mineral density: is osteoporosis a constant feature?
    S Hieronimus
    Service d endocrinologie médecine de la reproduction, Hopital L Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Ann Endocrinol (Paris) 72:14-8. 2011
    ..Data on bone mineral density (BMD) in Klinefelter syndrome (KS) are scarce and contradictory. The aim of the present study was to investigate BMD in patients with KS and in healthy controls with special attention to gonadal status...
  25. doi request reprint Prospective study on the prevalence and associated risk factors of cryptorchidism in 6246 newborn boys from Nice area, France
    K Wagner-Mahler
    Pediatrics Department, CHU Nice, Nice, France Conseil Général Des Alpes Maritimes, Nice, France
    Int J Androl 34:e499-510. 2011
    ..Prevalence of cryptorchidism in our area is on the lower bracket compared with other countries, and is associated with both familial and environmental risk factors...
  26. ncbi request reprint Update on cryptorchidism: endocrine, environmental and therapeutic aspects
    F Brucker-Davis
    Centre Hospitalier Universitaire de Nice, Service d endocrinologie, Diabétologie et Médecine de la Reproduction, Hopital l Archet 1, Nice, France
    J Endocrinol Invest 26:575-87. 2003
    ..There is a recent trend in proposing early therapeutic intervention, before 1 yr of age, in the hope of improving fertility; however, there is no proof that such a strategy can reduce the risk of testicular cancer...
  27. ncbi request reprint Adrenal tuberculosis after a pheochromocytoma: a misleading tumoral presentation
    S Hieronimus
    Services d endocrinologie médecine de la reproduction, Hopital L Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Ann Endocrinol (Paris) 68:191-5. 2007
    ..It stresses the importance of culture of biopsy tumor, whenever feasible, to avoid unnecessary operations. In the near future, interferon-gamma assay could be a valuable means to recognize extrapulmonary forms of tuberculosis...
  28. ncbi request reprint [Malignant struma ovarii: false positive PET image for suspected metastasis due to sarcoidosis]
    L Kunstmann
    Service d endocrinologie et médecine de la reproduction, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Ann Endocrinol (Paris) 68:51-4. 2007
    ..Hilar and mediastinal lymph node uptake was detected but histological verification concluded that there was a false-positive localization corresponding to sarcoidosis lesions without malignant aspect...
  29. ncbi request reprint Hypothalamic-pituitary Langerhans cell histiocytosis: a diagnostic challenge
    S Hieronimus
    Department of Endocrinology, hôpital de l Archet 1, BP 3079, 06202 Nice Cedex 3 France
    Ann Endocrinol (Paris) 61:512-516. 2000
    ..Diagnosis is confirmed by histological examination showing infiltration with CD1a positive histiocytes. General guidelines for diagnosis procedure are drawn out, including the neurosurgical biopsy in particular cases...
  30. ncbi request reprint [Oncofertility: a new focus in women health-care...]
    N Chevalier
    Service d endocrinologie et médecine de la reproduction, CECOS, hôpital de l Archet 1, 151, Route de Saint Antoine de Ginestiere, BP 3079, 06202 Nice Cedex 3
    Ann Endocrinol (Paris) 70:S33-41. 2009
    ..Continuous efforts to improve current strategies and to develop new strategies will benefit many women and children who are facing premature ovarian failure and sterility...
  31. ncbi request reprint [Pregnancy and type 2 diabetes: which fetal prognosis?]
    S Hieronimus
    Service d endocrinologie médecine de la reproduction, Hopital de l Archet, CHU de Nice, BP 3079, 06202 Nice 3, France
    Gynecol Obstet Fertil 32:23-7. 2004
    ..The rise in the prevalence of type 2 diabetes in women of childbearing age leads to an increasing number of pregnant women with type 2 diabetes. But published data on fetal outcome are scarce...
  32. ncbi request reprint Pregnancy in women with type 2 diabetes: an uncertain prognosis
    S Hieronimus
    Service d endocrinologie médecine de la reproduction, CHU de Nice, Hopital de l Archet, 1, BP 3079, 06202 Nice Cedex 3, France
    Diabetes Metab 30:281-4. 2004
    ..Furthermore, diabetes screening in high-risk women prior to pregnancy is warranted...
  33. ncbi request reprint [Struma ovarii, a rare form of ovarian tumor]
    L Kunstmann
    Service d endocrinologie et médecine de la reproduction, Hopital de l Archet, CHU de Nice, BP 3079, 06202 Nice cedex 03, France
    Gynecol Obstet Fertil 35:49-54. 2007
    ..Surgery is the main mode of treatment and prognosis is excellent. Struma ovarii can be associated with thyroid biology abnormalities, or exceptionally become malignant, and thus managed as a thyroid cancer...
  34. ncbi request reprint Modified expression of testicular gap-junction connexin 43 during normal spermatogenic cycle and in altered spermatogenesis
    C Batias
    INSERM CJF 95 04, EA 1760, IFR 50, Faculte de Medecine, Nice, France
    Cell Tissue Res 298:113-21. 1999
    ..The present study represents one of the first in vivo examples of alteration of seminiferous tubule Cx43 in testes with impaired spermatogenesis...
  35. ncbi request reprint Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)
    F Cervoni
    Institut National de la Sante et de la Recherche Medicale, Unité 210, Faculte de Medecine, Nice, France
    Mol Reprod Dev 34:107-13. 1993
    ....