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Genomes and Genes
Species | Robert FeilSummaryCountry: France Publications
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Publications
Environmental and nutritional effects on the epigenetic regulation of genesRobert Feil
Institute of Molecular Genetics, CNRS, UMR 5535, University of Montpellier II, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
Mutat Res 600:46-57. 2006..Unexpectedly, and not unlike genetic mutations, aberrant epigenetic alterations and their phenotypic effects can sometimes be passed on to the next generation...
Epigenetic asymmetry in the zygote and mammalian developmentRobert Feil
Institute of Molecular Genetics, CNRS and University of Montpellier, Montpellier, France
Int J Dev Biol 53:191-201. 2009..Perturbation of the differential organisation of the maternally and paternally derived genomes, before fertilisation, or in the early embryo, can give rise to aberrant growth and developmental disorders in humans...- Convergent evolution of genomic imprinting in plants and mammalsRobert Feil
Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
Trends Genet 23:192-9. 2007..Here we discuss the emerging parallels in imprinting in both taxa. We also describe the significance of imprinting for reproduction and discuss potential models for its evolution... - Epigenetics, an emerging discipline with broad implicationsRobert Feil
Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, Montpellier, France
C R Biol 331:837-43. 2008..A recent discussion meeting in Paris at the French Academy of Sciences reviewed our current understanding of 'Epigenetics and Cellular Memory' and where this novel discipline in life sciences is heading... - Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammalsAmandine Henckel
Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, Montpellier, France
Hum Mol Genet 18:3375-83. 2009..Combined, our data establish that DNA methylation is involved in the acquisition and/or maintenance of histone methylation at ICRs... 
A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10Lionel A Sanz
Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, Montpellier, France
EMBO J 27:2523-32. 2008..Our data indicate that bivalent chromatin, in combination with neuronal factors, controls the paternal expression of Grb10 in brain. This finding highlights a novel mechanism to control tissue-specific imprinting...- G9a histone methyltransferase contributes to imprinting in the mouse placentaAlexandre Wagschal
Institute of Molecular Genetics, CNRS UMR 5535, and University of Montpellier, 1919, route de Mende, 34293 Montpellier, France
Mol Cell Biol 28:1104-13. 2008..These findings provide the first evidence for the involvement of an HMT and suggest that histone methylation contributes to imprinted gene repression in the trophoblast... - Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genesCecile Fournier
Institute of Molecular Genetics, CNRS, UMR 5535, 1919 Route de Mende, 34293 Montpellier, France
EMBO J 21:6560-70. 2002.... - Epigenetic transitions in germ cell development and meiosisSatya K Kota
Institute of Molecular Genetics, CNRS UMR5535 and University of Montpellier I and II, 1919 Route de Mende, 34293 Montpellier, France
Dev Cell 19:675-86. 2010..Here, we review epigenetic transitions during gametogenesis and discuss novel insights from animal and human studies... - PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouseMaelle Pannetier
Institute of Molecular Genetics, CNRS and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
EMBO Rep 9:998-1005. 2008..Our data show not only new similarities but also differences between ICRs and heterochromatin, both of which show constitutive maintenance of methylation of DNA in somatic cells... - Transcription and histone methylation changes correlate with imprint acquisition in male germ cellsAmandine Henckel
Institute of Molecular Genetics IGMM, CNRS, Universities of Montpellier I and II, Montpellier, France
EMBO J 31:606-15. 2012..Combined, our data evoke a model in which differential histone modification states linked to transcriptional events may signal the specificity of imprint acquisition during spermatogenesis... - Perturbation of genomic imprinting in oligozoospermiaDoria Filipponi
Institute of Molecular Genetics, CNRS UMR, University of Montpellier I and II, France
Epigenetics 4:27-30. 2009..In addition, they raise concerns as to whether aberrant imprints in the male germ cells can have health implications for the next generation... - Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexesDavid Umlauf
Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919, route de Mende, 34090 Montpellier, France
Nat Genet 36:1296-300. 2004.... - Differential histone modifications mark mouse imprinting control regions during spermatogenesisKatia Delaval
Institute of Molecular Genetics, CNRS and University of Montpellier II, Montpellier, France
EMBO J 26:720-9. 2007..These differences could influence the way ICRs are assembled into specific structures in late spermatogenesis, and may thus influence events after fertilisation... - MEDEA takes control of its own imprintingPhilippe Arnaud
Institute of Molecular Genetics, CNRS UMR-5535 and the University of Montpellier II, 1919 Route de Mende, 34090 Montpellier, France
Cell 124:468-70. 2006..Remarkably, they also find that silencing of the paternal MEDEA allele is independent of DNA methylation and is controlled by maternal expression of MEDEA itself... - Genomic imprinting and its effects on genes and chromosomes in mammalsYuji Goto
Institute of Molecular Genetics, Centre National de la Recherche Scientifique, Montpelier, France
Methods Mol Biol 240:53-75. 2004 - Epigenetic deregulation of imprinting in congenital diseases of aberrant growthKatia Delaval
Institute of Molecular Genetics, CNRS, UMR-5535, University of Montpellier II, France
Bioessays 28:453-9. 2006..Thus, fetal and postnatal growth is epigenetically controlled by different ICRs, at 11p15 and other chromosomal regions... - Genomic imprinting and human diseaseRyutaro Hirasawa
Institute of Molecular Genetics, CNRS UMR 5535 and the University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
Essays Biochem 48:187-200. 2010..The involvement of imprinting in specific human pathologies (and in cancer) emphasizes the need to further explore the underlying molecular mechanisms... - Stochastic imprinting in the progeny of Dnmt3L-/- femalesPhilippe Arnaud
Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919 Route de Mende, 34090 Montpellier, France
Hum Mol Genet 15:589-98. 2006..This observation can provide a basis to understand mechanisms involved in some sporadic cases of imprinting-related diseases and polymorphic imprinting in human... - Chromatin mechanisms in genomic imprintingSlim Kacem
CNRS and University of Montpellier I and II, Montpellier, France
Mamm Genome 20:544-56. 2009..Together, the newly discovered chromatin mechanisms provide further clues for addressing imprinting-related pathologies in humans... - [Differential epigenetic marking on imprinted genes and consequences in human diseases]Amandine Henckel
Institut de Genetique Moleculaire de Montpellier, CNRS et Université de Montpellier, 34293 Montpellier Cedex 5, France
Med Sci (Paris) 24:747-52. 2008..Alteration of imprints is thought to occur early in carcinogenesis and shows similarities with the acquisition of aberrant DNA methylation at tumour suppressor genes. This suggests that similar underlying mechanisms could be involved... - Genome-wide DNA demethylation in mammalsLionel A Sanz
Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, Montpellier, France
Genome Biol 11:110. 2010..The cytidine deaminase AID and elongator-complex proteins contribute to the extensive removal of DNA methylation in mammalian primordial germ cells and in the paternal pronucleus of the zygote... - Epigenetic regulation of mammalian genomic imprintingKatia Delaval
Institute of Molecular Genetics, CNRS UMR-5535 and University of Montpellier-II, 1919, route de Mende, 34293 Montpellier Cedex 5, France
Curr Opin Genet Dev 14:188-95. 2004..At other domains, non-coding RNAs could be involved, possibly by attracting chromatin-modifying complexes. The latter silencing mechanism has similarities with X-chromosome inactivation... - A KRAB domain zinc finger protein in imprinting and diseaseRyutaro Hirasawa
Institute of Molecular Genetics, CNRS and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
Dev Cell 15:487-8. 2008..At one locus, Zfp57 is also involved in imprint establishment. These findings provide a mechanistic interpretation for Mackay et al.'s recently reported ZFP57 mutations in patients with transient neonatal diabetes... - PCR-Based Analysis of Immunoprecipitated ChromatinAlexandre Wagschal
Institute of Molecular Genetics, CNRS and University of Montpellier, 34293 Montpellier, France
CSH Protoc 2007:pdb.prot4768. 2007..Hence, in nondenaturing gel conditions, each single strand will migrate differently. These four PCR-based methodologies to analyze immunoprecipitated chromatin (real-time PCR, duplex PCR, hot-stop PCR, and SSCP) are presented here... - Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproductionPhilippe Arnaud
Institute of Molecular Genetics, Centre National de la Recherche Scientifique CNRS Université de Montpellier II, 1919 Route de Mende, 34293 Montpellier Cedex 05, France
Birth Defects Res C Embryo Today 75:81-97. 2005..This finding warrants careful monitoring of the epigenetic effects, and absolute risks, of currently used and novel reproduction technologies... - Chromatin Immunoprecipitation (ChIP) on Unfixed Chromatin from Cells and Tissues to Analyze Histone ModificationsAlexandre Wagschal
Institute of Molecular Genetics, CNRS and University of Montpellier, 34293 Montpellier, France
CSH Protoc 2007:pdb.prot4767. 2007..These protocols are suitable only for analyzing histones and their modifications. For other applications, chromatin immunoprecipitation should be performed on cross-linked chromatin... - Epigenetic stability of embryonic stem cells and developmental potentialMaelle Pannetier
Institute of Molecular Genetics, CNRS, 1919, route de Mende, 34293 Montpellier, France
Trends Biotechnol 25:556-62. 2007..Here, we discuss the maintenance of epigenetic information in cultured stem cells and embryos and how this influences their developmental potential... - Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cellsRichard I Gregory
Institute of Molecular Genetics, CNRS UMR 5535, IFR 24, 34293 Montpellier Cedex 5, France
J Biol Chem 277:11728-34. 2002..Furthermore, it seems that the allelic U2af1-rs1 acetylation determines DNase I sensitivity/chromatin conformation... - Epigenetics and the environment: emerging patterns and implicationsRobert Feil
Institute of Molecular Genetics IGMM, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France cnrs fr
Nat Rev Genet 13:97-109. 2011..These have implications for structuring future research and understanding disease and development... - Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencingDavid Monk
Institute of Child Health, London, UK
Genome Res 18:1270-81. 2008..This unexpected general lack of repressive histone modifications suggests that this domain may utilize a different silencing mechanism as compared to other imprinted domains... - Global hypomethylation of the genome in XX embryonic stem cellsIlona Zvetkova
MRC Clinical Sciences Centre, ICFM, Hammersmith Hospital, DuCane Road, London, W12 ONN, UK
Nat Genet 37:1274-9. 2005..Finally, we show that hypomethylation is associated with reduced levels of the de novo DNA methyltransferases Dnmt3a and Dnmt3b and that ectopic expression of these factors restores global methylation levels... - Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transferLorraine E Young
School of Human Development, University of Nottingham, Queens Medical Centre, Nottingham, UK
Mech Dev 120:1433-42. 2003..Although the underlying mechanisms remain to be determined, our data indicate that somatic cell nuclear transfer procedures can lead to epigenetic deregulation at imprinted loci... - Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomesMaria Rosaria Matarazzo
Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
Hum Mol Genet 11:3191-8. 2002.... - Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylationAnnabelle Lewis
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
Nat Genet 36:1291-5. 2004.... - Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locusCandice Coombes
Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
Mol Cell Biol 23:5475-88. 2003..This is the second gametic mark identified at Gnas and suggests that the Nesp and Gnasxl promoters are under separate control from the Gnas promoter. We propose models to account for the regulation of imprinting at the locus... - Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activationMasami Shimizu-Albergine
Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA
J Neurosci 23:6452-9. 2003.... - Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase IRobert Feil
Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Str 29, D 80802 München, Germany
J Cell Biol 163:295-302. 2003..These results indicate that cGKI in PCs is dispensable for general motor coordination, but that it is required for cerebellar LTD and specific forms of motor learning, namely the adaptation of the VOR... - A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cellsWiebke Wolfsgruber
Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Strasse 29, 80802 Munich, Germany
Proc Natl Acad Sci U S A 100:13519-24. 2003..We suggest that activation of smooth muscle cGKI contributes to the proatherogenic effect of NO and that inhibition of cGKI might be a therapeutic option for treating atherosclerosis in humans... - Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memoryThomas Kleppisch
Institut fur Pharmakologie und Toxikologie, 80802 Munchen, Germany, Max Planck Institut fur Psychiatrie, 80804 München, Germany
J Neurosci 23:6005-12. 2003..These results suggest that hippocampal cGKI supports an age- and protein synthesis-dependent form of hippocampal LTP, whereas it is dispensable for hippocampus-dependent spatial reference and contextual memory... - cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clockHenrik Oster
Department of Medicine, Division of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
Curr Biol 13:725-33. 2003..The major stimulus for adjustment (resetting) of the clock is nocturnal light. It evokes activation of signaling pathways in the SCN that ultimately lead to expression of mPer1 and mPer2 genes conveying adjustment of the clock... - Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regenerationKenichi Yamahara
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
Proc Natl Acad Sci U S A 100:3404-9. 2003.... - A stimulatory role for cGMP-dependent protein kinase in platelet activationZhenyu Li
Department of Pharmacology, College of Medicine, University of Illinois, 835 South Wolcott Avenue, Chicago, IL 60612, USA
Cell 112:77-86. 2003..The cGMP-stimulated platelet responses are biphasic, consisting of an initial transient stimulatory response that promotes platelet aggregation and a subsequent inhibitory response that limits the size of thrombi... - Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signalingFlorian Mullershausen
Abteilung für Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, MA N1 43, Universitaetsstr 150, 44780 Bochum, Germany
J Cell Biol 160:719-27. 2003..In sum, we suggest NO-induced activation and phosphorylation of PDE5 as the mechanism for a long-lasting negative feedback loop shaping the cGMP response in human platelets in order to adapt to the amount of NO available... - Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2Andreas Ludwig
Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, D 80802 München, Germany
EMBO J 22:216-24. 2003..Our results define the physiological role of the HCN2 subunit as a major determinant of membrane resting potential that is required for regular cardiac and neuronal rhythmicity... - cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axonsHannes Schmidt
Developmental Neurobiology Group, Medical Research Council, Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, D 13092 Berlin, Germany
J Cell Biol 159:489-98. 2002..Our studies therefore reveal that cGMP signaling is important for axonal growth in vivo and in vitro... - Nuclei of nonviable ovine somatic cells develop into lambs after nuclear transplantationPasqualino Loi
Dipartimento di Strutture, Funzioni, Patologie e Biotecnologie, Università di Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
Biol Reprod 67:126-32. 2002.... - Functional reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoformsRobert Feil
Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Universitat Munchen, Munchen, Germany
Circ Res 90:1080-6. 2002..These results suggest that one component of NO/cGMP-induced smooth muscle relaxation is the activation of the cGKIalpha isoform, which decreases the noradrenaline-stimulated cytosolic Ca(2+) level... - cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardiumJörg W Wegener
Pharmakologisches Institut, Universitat Mainz, Germany
Circ Res 90:18-20. 2002..These results demonstrate that cGKI mediates the negative inotropic effect of cGMP in the myocardium of juvenile and adult mice... - Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulationSven Moosmang
Institut fur Pharmakologie und Toxikologie, TU Munchen, Biedersteiner Strasse 29, D 80802 München, Germany
EMBO J 22:6027-34. 2003..2 channel. These results show that Cav1.2 calcium channels are key players in the hormonal regulation of blood pressure and development of myogenic tone... - Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3Zhenyu Li
Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
Blood 107:965-72. 2006..Thus, p38 plays an important role in mediating PKG-dependent activation of ERK. These data delineate a novel signaling pathway in which platelet agonists sequentially activate PKG, p38, and ERK pathways leading to integrin activation... - Placental abnormalities associated with post-natal mortality in sheep somatic cell clonesPasqualino Loi
Dipartimento di Scienze Biomediche Comparate, Teramo University, Piazza Aldo Moro 45, 64100 Teramo, Italy
Theriogenology 65:1110-21. 2006..Our results strongly suggest that post-mortality in cloned lambs is mainly caused by placental abnormalities... - Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient miceMatthias Sausbier
Pharmakologie und Toxikologie, Pharmazeutisches Institut der Universität Tübingen, Tubingen, Germany
Circulation 112:60-8. 2005..However, the BK channel may also affect blood pressure by regulating salt and fluid homeostasis, particularly by adjusting the renin-angiotensin-aldosterone system... - Insights into cGMP signalling derived from cGMP kinase knockout miceJens Schlossmann
Institute for Pharmacology and Toxicology, Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany
Front Biosci 10:1279-89. 2005..cGKII is involved in intestinal water secretion, bone growth and circardian rhythmicity. The cGK mutant mice are important tools to obtain detailed insights into cGMP-mediated signalling pathways in health and disease... - Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturitionBritta Döring
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
J Cell Sci 119:1715-22. 2006..Our results indicate the important function of Cx43 during parturition in the living animal and suggest further strategies to investigate the role of connexins in uterine contractility in transgenic mice... - A bivalent chromatin structure marks key developmental genes in embryonic stem cellsBradley E Bernstein
Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
Cell 125:315-26. 2006..These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency... - Control of intestinal motility by the Ca(v)1.2 L-type calcium channel in miceJörg W Wegener
Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Str 29, München 80802, Germany
FASEB J 20:1260-2. 2006..In conclusion, the Ca(v)1.2 channel is essential for electromechanical coupling and important for pharmaco-mechanical coupling in intestinal smooth muscle and cannot be substituted functionally by other Ca2+ entry pathways... - An essential role of Cav1.2 L-type calcium channel for urinary bladder functionJörg W Wegener
Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Str 29, D 80802 München, Germany
FASEB J 18:1159-61. 2004..These results show that the Cav1.2 Ca2+ channel is essential for normal bladder function. The Rho-kinase and Ca2+-release pathways cannot compensate the lack of the L-type Ca2+ channel... - cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivoMichael Koeppen
Physiologisches Institut, Universitat Lubeck, Germany
Hypertension 44:952-5. 2004..However, the NO/cGMP/cGKI pathway is not essential for ACh-induced dilation of arterioles and for basal blood pressure regulation in mice... - SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesisSusanne Feil
Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Str 29, 80802 Munchen, Germany
Circ Res 94:863-5. 2004..These results identify a role for SM22alpha in the regulation of SMC phenotype during atherogenesis... - Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolutionLayla Parker-Katiraee
Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
PLoS Genet 3:e65. 2007..Thus, KLF14 may be the first example of an imprinted transcript undergoing accelerated evolution in the human lineage... - Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozymeSilke Weber
Institut für Pharmakologie und Toxikologie der Technischen Universität, Biedersteiner Str 29, D 80802 München, Germany
Circ Res 101:1096-103. 2007..These results show that cGKI in smooth muscle is essential and that either cGKI isozyme alone can rescue basic vascular and intestinal smooth muscle functions... - Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase IIrmgard Tegeder
Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
Proc Natl Acad Sci U S A 101:3253-7. 2004..The paucity of substance P in laminae I-III may contribute to the reduction of nociception in PKG-I(-/-) mice and suggests a role of PKG-I in substance P synthesis... - GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinaseStuart J Marshall
Department of Pharmacology, University of Oxford, UK
Blood 103:2601-9. 2004..These results demonstrate a critical role for Src kinases but not MAP kinases in VWF-dependent platelet activation and demonstrate an inhibitory role for cGMP-elevating agents in regulating this process... - LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposisPekka Katajisto
Genome Scale Biology Program and Institute of Biomedicine, Biomedicum Helsinki, 00014 University of Helsinki, Finland
Nat Genet 40:455-9. 2008..We also noted TGFbeta signaling defects in polyps of individuals with PJS, suggesting that the identified stromal-derived mechanism of tumor suppression is also relevant in PJS... - Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosisRobert Lukowski
Institut für Pharmakologie und Toxikologie der TUM, Biedersteiner Str 29, D 80802 München, Germany
Arterioscler Thromb Vasc Biol 28:1244-50. 2008..The purpose of this study was to examine the functional role of the smooth muscle cGMP/cGKI signaling cascade in restenosis of vessels... - Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in miceWei Qi He
Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
Gastroenterology 135:610-20. 2008..We generated tamoxifen-inducible and smooth muscle-specific MLCK knockout (KO) mice and provide direct loss-of-function evidence that shows the primary importance of MLCK in phasic smooth muscle contractions...