Robert Feil

Summary

Country: France

Publications

  1. ncbi request reprint Environmental and nutritional effects on the epigenetic regulation of genes
    Robert Feil
    Institute of Molecular Genetics, CNRS, UMR 5535, University of Montpellier II, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Mutat Res 600:46-57. 2006
  2. pmc Genome-wide DNA demethylation in mammals
    Lionel A Sanz
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, Montpellier, France
    Genome Biol 11:110. 2010
  3. pmc PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome
    Michael Girardot
    Institute of Molecular Genetics IGMM, CNRS UMR 5535, University of Montpellier, 1919 Route de Mende, 34293 Montpellier, Laboratoire Epigénétique et Destin Cellulaire, UMR7216, CNRS, Universite Paris Diderot, 35 rue Helene Brion, 75013 Paris, France and Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    Nucleic Acids Res 42:235-48. 2014
  4. pmc PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse
    Maelle Pannetier
    Institute of Molecular Genetics, CNRS and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
    EMBO Rep 9:998-1005. 2008
  5. doi request reprint Epigenetic asymmetry in the zygote and mammalian development
    Robert Feil
    Institute of Molecular Genetics, CNRS and University of Montpellier, Montpellier, France
    Int J Dev Biol 53:191-201. 2009
  6. doi request reprint Epigenetics, an emerging discipline with broad implications
    Robert Feil
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, Montpellier, France
    C R Biol 331:837-43. 2008
  7. ncbi request reprint Convergent evolution of genomic imprinting in plants and mammals
    Robert Feil
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
    Trends Genet 23:192-9. 2007
  8. pmc G9a histone methyltransferase contributes to imprinting in the mouse placenta
    Alexandre Wagschal
    Institute of Molecular Genetics, CNRS UMR 5535, and University of Montpellier, 1919, route de Mende, 34293 Montpellier, France
    Mol Cell Biol 28:1104-13. 2008
  9. pmc A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10
    Lionel A Sanz
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, Montpellier, France
    EMBO J 27:2523-32. 2008
  10. doi request reprint Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals
    Amandine Henckel
    Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, Montpellier, France
    Hum Mol Genet 18:3375-83. 2009

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Environmental and nutritional effects on the epigenetic regulation of genes
    Robert Feil
    Institute of Molecular Genetics, CNRS, UMR 5535, University of Montpellier II, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Mutat Res 600:46-57. 2006
    ..Unexpectedly, and not unlike genetic mutations, aberrant epigenetic alterations and their phenotypic effects can sometimes be passed on to the next generation...
  2. pmc Genome-wide DNA demethylation in mammals
    Lionel A Sanz
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, Montpellier, France
    Genome Biol 11:110. 2010
    ..The cytidine deaminase AID and elongator-complex proteins contribute to the extensive removal of DNA methylation in mammalian primordial germ cells and in the paternal pronucleus of the zygote...
  3. pmc PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome
    Michael Girardot
    Institute of Molecular Genetics IGMM, CNRS UMR 5535, University of Montpellier, 1919 Route de Mende, 34293 Montpellier, Laboratoire Epigénétique et Destin Cellulaire, UMR7216, CNRS, Universite Paris Diderot, 35 rue Helene Brion, 75013 Paris, France and Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USA
    Nucleic Acids Res 42:235-48. 2014
    ..Furthermore, comparative bioinformatics analyses suggest a putative role of PRMT5-mediated H4R3me2s in chromatin configuration in the nucleus. ..
  4. pmc PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse
    Maelle Pannetier
    Institute of Molecular Genetics, CNRS and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
    EMBO Rep 9:998-1005. 2008
    ..Our data show not only new similarities but also differences between ICRs and heterochromatin, both of which show constitutive maintenance of methylation of DNA in somatic cells...
  5. doi request reprint Epigenetic asymmetry in the zygote and mammalian development
    Robert Feil
    Institute of Molecular Genetics, CNRS and University of Montpellier, Montpellier, France
    Int J Dev Biol 53:191-201. 2009
    ..Perturbation of the differential organisation of the maternally and paternally derived genomes, before fertilisation, or in the early embryo, can give rise to aberrant growth and developmental disorders in humans...
  6. doi request reprint Epigenetics, an emerging discipline with broad implications
    Robert Feil
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, Montpellier, France
    C R Biol 331:837-43. 2008
    ..A recent discussion meeting in Paris at the French Academy of Sciences reviewed our current understanding of 'Epigenetics and Cellular Memory' and where this novel discipline in life sciences is heading...
  7. ncbi request reprint Convergent evolution of genomic imprinting in plants and mammals
    Robert Feil
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
    Trends Genet 23:192-9. 2007
    ..Here we discuss the emerging parallels in imprinting in both taxa. We also describe the significance of imprinting for reproduction and discuss potential models for its evolution...
  8. pmc G9a histone methyltransferase contributes to imprinting in the mouse placenta
    Alexandre Wagschal
    Institute of Molecular Genetics, CNRS UMR 5535, and University of Montpellier, 1919, route de Mende, 34293 Montpellier, France
    Mol Cell Biol 28:1104-13. 2008
    ..These findings provide the first evidence for the involvement of an HMT and suggest that histone methylation contributes to imprinted gene repression in the trophoblast...
  9. pmc A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10
    Lionel A Sanz
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, Montpellier, France
    EMBO J 27:2523-32. 2008
    ..Our data indicate that bivalent chromatin, in combination with neuronal factors, controls the paternal expression of Grb10 in brain. This finding highlights a novel mechanism to control tissue-specific imprinting...
  10. doi request reprint Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals
    Amandine Henckel
    Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, Montpellier, France
    Hum Mol Genet 18:3375-83. 2009
    ..Combined, our data establish that DNA methylation is involved in the acquisition and/or maintenance of histone methylation at ICRs...
  11. pmc Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes
    Cecile Fournier
    Institute of Molecular Genetics, CNRS, UMR 5535, 1919 Route de Mende, 34293 Montpellier, France
    EMBO J 21:6560-70. 2002
    ....
  12. ncbi request reprint Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes
    David Umlauf
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919, route de Mende, 34090 Montpellier, France
    Nat Genet 36:1296-300. 2004
    ....
  13. ncbi request reprint Perturbation of genomic imprinting in oligozoospermia
    Doria Filipponi
    Institute of Molecular Genetics, CNRS UMR, University of Montpellier I and II, France
    Epigenetics 4:27-30. 2009
    ..In addition, they raise concerns as to whether aberrant imprints in the male germ cells can have health implications for the next generation...
  14. doi request reprint Epigenetic transitions in germ cell development and meiosis
    Satya K Kota
    Institute of Molecular Genetics, CNRS UMR5535 and University of Montpellier I and II, 1919 Route de Mende, 34293 Montpellier, France
    Dev Cell 19:675-86. 2010
    ..Here, we review epigenetic transitions during gametogenesis and discuss novel insights from animal and human studies...
  15. pmc Transcription and histone methylation changes correlate with imprint acquisition in male germ cells
    Amandine Henckel
    Institute of Molecular Genetics IGMM, CNRS, Universities of Montpellier I and II, Montpellier, France
    EMBO J 31:606-15. 2012
    ..Combined, our data evoke a model in which differential histone modification states linked to transcriptional events may signal the specificity of imprint acquisition during spermatogenesis...
  16. ncbi request reprint Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells
    Richard I Gregory
    Institute of Molecular Genetics, CNRS UMR 5535, IFR 24, 34293 Montpellier Cedex 5, France
    J Biol Chem 277:11728-34. 2002
    ..Furthermore, it seems that the allelic U2af1-rs1 acetylation determines DNase I sensitivity/chromatin conformation...
  17. ncbi request reprint Stochastic imprinting in the progeny of Dnmt3L-/- females
    Philippe Arnaud
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919 Route de Mende, 34090 Montpellier, France
    Hum Mol Genet 15:589-98. 2006
    ..This observation can provide a basis to understand mechanisms involved in some sporadic cases of imprinting-related diseases and polymorphic imprinting in human...
  18. ncbi request reprint MEDEA takes control of its own imprinting
    Philippe Arnaud
    Institute of Molecular Genetics, CNRS UMR 5535 and the University of Montpellier II, 1919 Route de Mende, 34090 Montpellier, France
    Cell 124:468-70. 2006
    ..Remarkably, they also find that silencing of the paternal MEDEA allele is independent of DNA methylation and is controlled by maternal expression of MEDEA itself...
  19. pmc Differential histone modifications mark mouse imprinting control regions during spermatogenesis
    Katia Delaval
    Institute of Molecular Genetics, CNRS and University of Montpellier II, Montpellier, France
    EMBO J 26:720-9. 2007
    ..These differences could influence the way ICRs are assembled into specific structures in late spermatogenesis, and may thus influence events after fertilisation...
  20. ncbi request reprint Genomic imprinting and its effects on genes and chromosomes in mammals
    Yuji Goto
    Institute of Molecular Genetics, Centre National de la Recherche Scientifique, Montpelier, France
    Methods Mol Biol 240:53-75. 2004
  21. ncbi request reprint Epigenetic deregulation of imprinting in congenital diseases of aberrant growth
    Katia Delaval
    Institute of Molecular Genetics, CNRS, UMR 5535, University of Montpellier II, France
    Bioessays 28:453-9. 2006
    ..Thus, fetal and postnatal growth is epigenetically controlled by different ICRs, at 11p15 and other chromosomal regions...
  22. ncbi request reprint Epigenetic regulation of mammalian genomic imprinting
    Katia Delaval
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919, route de Mende, 34293 Montpellier Cedex 5, France
    Curr Opin Genet Dev 14:188-95. 2004
    ..At other domains, non-coding RNAs could be involved, possibly by attracting chromatin-modifying complexes. The latter silencing mechanism has similarities with X-chromosome inactivation...
  23. doi request reprint A KRAB domain zinc finger protein in imprinting and disease
    Ryutaro Hirasawa
    Institute of Molecular Genetics, CNRS and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
    Dev Cell 15:487-8. 2008
    ..At one locus, Zfp57 is also involved in imprint establishment. These findings provide a mechanistic interpretation for Mackay et al.'s recently reported ZFP57 mutations in patients with transient neonatal diabetes...
  24. doi request reprint Genomic imprinting and human disease
    Ryutaro Hirasawa
    Institute of Molecular Genetics, CNRS UMR 5535 and the University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France
    Essays Biochem 48:187-200. 2010
    ..The involvement of imprinting in specific human pathologies (and in cancer) emphasizes the need to further explore the underlying molecular mechanisms...
  25. doi request reprint Chromatin mechanisms in genomic imprinting
    Slim Kacem
    CNRS and University of Montpellier I and II, Montpellier, France
    Mamm Genome 20:544-56. 2009
    ..Together, the newly discovered chromatin mechanisms provide further clues for addressing imprinting-related pathologies in humans...
  26. doi request reprint [Differential epigenetic marking on imprinted genes and consequences in human diseases]
    Amandine Henckel
    Institut de Genetique Moleculaire de Montpellier, CNRS et Université de Montpellier, 34293 Montpellier Cedex 5, France
    Med Sci (Paris) 24:747-52. 2008
    ..Alteration of imprints is thought to occur early in carcinogenesis and shows similarities with the acquisition of aberrant DNA methylation at tumour suppressor genes. This suggests that similar underlying mechanisms could be involved...
  27. ncbi request reprint Epigenetic stability of embryonic stem cells and developmental potential
    Maelle Pannetier
    Institute of Molecular Genetics, CNRS, 1919, route de Mende, 34293 Montpellier, France
    Trends Biotechnol 25:556-62. 2007
    ..Here, we discuss the maintenance of epigenetic information in cultured stem cells and embryos and how this influences their developmental potential...
  28. doi request reprint Chromatin Immunoprecipitation (ChIP) on Unfixed Chromatin from Cells and Tissues to Analyze Histone Modifications
    Alexandre Wagschal
    Institute of Molecular Genetics, CNRS and University of Montpellier, 34293 Montpellier, France
    CSH Protoc 2007:pdb.prot4767. 2007
    ..These protocols are suitable only for analyzing histones and their modifications. For other applications, chromatin immunoprecipitation should be performed on cross-linked chromatin...
  29. doi request reprint PCR-Based Analysis of Immunoprecipitated Chromatin
    Alexandre Wagschal
    Institute of Molecular Genetics, CNRS and University of Montpellier, 34293 Montpellier, France
    CSH Protoc 2007:pdb.prot4768. 2007
    ..Hence, in nondenaturing gel conditions, each single strand will migrate differently. These four PCR-based methodologies to analyze immunoprecipitated chromatin (real-time PCR, duplex PCR, hot-stop PCR, and SSCP) are presented here...
  30. ncbi request reprint Epigenetic deregulation of genomic imprinting in human disorders and following assisted reproduction
    Philippe Arnaud
    Institute of Molecular Genetics, Centre National de la Recherche Scientifique CNRS Université de Montpellier II, 1919 Route de Mende, 34293 Montpellier Cedex 05, France
    Birth Defects Res C Embryo Today 75:81-97. 2005
    ..This finding warrants careful monitoring of the epigenetic effects, and absolute risks, of currently used and novel reproduction technologies...
  31. pmc Small regulatory RNAs controlled by genomic imprinting and their contribution to human disease
    Michael Girardot
    Institute of Molecular Genetics, CNRS and the University of Montpellier, Montpellier, France
    Epigenetics 7:1341-8. 2012
    ..Here, we review our current understanding of imprinted small RNAs in the human genome and discuss how perturbation of their expression contributes to disease...
  32. doi request reprint Epigenetic deregulation of genomic imprinting in humans: causal mechanisms and clinical implications
    Michael Girardot
    Institute of Molecular Genetics IGMM, CNRS UMR 5535, 1919 Route de Mende, 34293 Montpellier, France
    Epigenomics 5:715-28. 2013
    ..Trans-acting factors known to be causally involved are discussed and other trans-acting factors that are potentially implicated are also presented. ..
  33. doi request reprint Epigenetics and the environment: emerging patterns and implications
    Robert Feil
    Institute of Molecular Genetics IGMM, CNRS UMR 5535 and University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France cnrs fr
    Nat Rev Genet 13:97-109. 2011
    ..These have implications for structuring future research and understanding disease and development...
  34. ncbi request reprint Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer
    Lorraine E Young
    School of Human Development, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Mech Dev 120:1433-42. 2003
    ..Although the underlying mechanisms remain to be determined, our data indicate that somatic cell nuclear transfer procedures can lead to epigenetic deregulation at imprinted loci...
  35. pmc Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing
    David Monk
    Institute of Child Health, London, UK
    Genome Res 18:1270-81. 2008
    ..This unexpected general lack of repressive histone modifications suggests that this domain may utilize a different silencing mechanism as compared to other imprinted domains...
  36. pmc Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus
    Candice Coombes
    Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 23:5475-88. 2003
    ..This is the second gametic mark identified at Gnas and suggests that the Nesp and Gnasxl promoters are under separate control from the Gnas promoter. We propose models to account for the regulation of imprinting at the locus...
  37. ncbi request reprint Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Nat Genet 36:1291-5. 2004
    ....
  38. ncbi request reprint Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes
    Maria Rosaria Matarazzo
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    Hum Mol Genet 11:3191-8. 2002
    ....
  39. ncbi request reprint Global hypomethylation of the genome in XX embryonic stem cells
    Ilona Zvetkova
    MRC Clinical Sciences Centre, ICFM, Hammersmith Hospital, DuCane Road, London, W12 ONN, UK
    Nat Genet 37:1274-9. 2005
    ..Finally, we show that hypomethylation is associated with reduced levels of the de novo DNA methyltransferases Dnmt3a and Dnmt3b and that ectopic expression of these factors restores global methylation levels...
  40. ncbi request reprint Nuclei of nonviable ovine somatic cells develop into lambs after nuclear transplantation
    Pasqualino Loi
    Dipartimento di Strutture, Funzioni, Patologie e Biotecnologie, Università di Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy
    Biol Reprod 67:126-32. 2002
    ....
  41. ncbi request reprint Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation
    Masami Shimizu-Albergine
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 23:6452-9. 2003
    ....
  42. ncbi request reprint Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory
    Thomas Kleppisch
    Institut fur Pharmakologie und Toxikologie, 80802 Munchen, Germany, Max Planck Institut fur Psychiatrie, 80804 München, Germany
    J Neurosci 23:6005-12. 2003
    ..These results suggest that hippocampal cGKI supports an age- and protein synthesis-dependent form of hippocampal LTP, whereas it is dispensable for hippocampus-dependent spatial reference and contextual memory...
  43. ncbi request reprint cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock
    Henrik Oster
    Department of Medicine, Division of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland
    Curr Biol 13:725-33. 2003
    ..The major stimulus for adjustment (resetting) of the clock is nocturnal light. It evokes activation of signaling pathways in the SCN that ultimately lead to expression of mPer1 and mPer2 genes conveying adjustment of the clock...
  44. ncbi request reprint cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium
    Jörg W Wegener
    Pharmakologisches Institut, Universitat Mainz, Germany
    Circ Res 90:18-20. 2002
    ..These results demonstrate that cGKI mediates the negative inotropic effect of cGMP in the myocardium of juvenile and adult mice...
  45. pmc Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration
    Kenichi Yamahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 100:3404-9. 2003
    ....
  46. pmc Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling
    Florian Mullershausen
    Abteilung für Pharmakologie und Toxikologie, Medizinische Fakultat, Ruhr Universitat Bochum, MA N1 43, Universitaetsstr 150, 44780 Bochum, Germany
    J Cell Biol 160:719-27. 2003
    ..In sum, we suggest NO-induced activation and phosphorylation of PDE5 as the mechanism for a long-lasting negative feedback loop shaping the cGMP response in human platelets in order to adapt to the amount of NO available...
  47. pmc Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2
    Andreas Ludwig
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, D 80802 München, Germany
    EMBO J 22:216-24. 2003
    ..Our results define the physiological role of the HCN2 subunit as a major determinant of membrane resting potential that is required for regular cardiac and neuronal rhythmicity...
  48. ncbi request reprint Functional reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms
    Robert Feil
    Institut fur Pharmakologie und Toxikologie der Technischen Universitat Munchen, Universitat Munchen, Munchen, Germany
    Circ Res 90:1080-6. 2002
    ..These results suggest that one component of NO/cGMP-induced smooth muscle relaxation is the activation of the cGKIalpha isoform, which decreases the noradrenaline-stimulated cytosolic Ca(2+) level...
  49. pmc cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons
    Hannes Schmidt
    Developmental Neurobiology Group, Medical Research Council, Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    J Cell Biol 159:489-98. 2002
    ..Our studies therefore reveal that cGMP signaling is important for axonal growth in vivo and in vitro...
  50. ncbi request reprint Placental abnormalities associated with post-natal mortality in sheep somatic cell clones
    Pasqualino Loi
    Dipartimento di Scienze Biomediche Comparate, Teramo University, Piazza Aldo Moro 45, 64100 Teramo, Italy
    Theriogenology 65:1110-21. 2006
    ..Our results strongly suggest that post-mortality in cloned lambs is mainly caused by placental abnormalities...
  51. ncbi request reprint A stimulatory role for cGMP-dependent protein kinase in platelet activation
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois, 835 South Wolcott Avenue, Chicago, IL 60612, USA
    Cell 112:77-86. 2003
    ..The cGMP-stimulated platelet responses are biphasic, consisting of an initial transient stimulatory response that promotes platelet aggregation and a subsequent inhibitory response that limits the size of thrombi...
  52. pmc Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I
    Robert Feil
    Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Str 29, D 80802 München, Germany
    J Cell Biol 163:295-302. 2003
    ..These results indicate that cGKI in PCs is dispensable for general motor coordination, but that it is required for cerebellar LTD and specific forms of motor learning, namely the adaptation of the VOR...
  53. pmc Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice
    Wei Qi He
    Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China
    Gastroenterology 135:610-20. 2008
    ..We generated tamoxifen-inducible and smooth muscle-specific MLCK knockout (KO) mice and provide direct loss-of-function evidence that shows the primary importance of MLCK in phasic smooth muscle contractions...
  54. ncbi request reprint Insights into cGMP signalling derived from cGMP kinase knockout mice
    Jens Schlossmann
    Institute for Pharmacology and Toxicology, Technical University Munich, Biedersteiner Strasse 29, 80802 Munich, Germany
    Front Biosci 10:1279-89. 2005
    ..cGKII is involved in intestinal water secretion, bone growth and circardian rhythmicity. The cGK mutant mice are important tools to obtain detailed insights into cGMP-mediated signalling pathways in health and disease...
  55. ncbi request reprint Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice
    Matthias Sausbier
    Pharmakologie und Toxikologie, Pharmazeutisches Institut der Universität Tübingen, Tubingen, Germany
    Circulation 112:60-8. 2005
    ..However, the BK channel may also affect blood pressure by regulating salt and fluid homeostasis, particularly by adjusting the renin-angiotensin-aldosterone system...
  56. pmc Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3
    Zhenyu Li
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Blood 107:965-72. 2006
    ..Thus, p38 plays an important role in mediating PKG-dependent activation of ERK. These data delineate a novel signaling pathway in which platelet agonists sequentially activate PKG, p38, and ERK pathways leading to integrin activation...
  57. ncbi request reprint An essential role of Cav1.2 L-type calcium channel for urinary bladder function
    Jörg W Wegener
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Str 29, D 80802 München, Germany
    FASEB J 18:1159-61. 2004
    ..These results show that the Cav1.2 Ca2+ channel is essential for normal bladder function. The Rho-kinase and Ca2+-release pathways cannot compensate the lack of the L-type Ca2+ channel...
  58. ncbi request reprint SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis
    Susanne Feil
    Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Str 29, 80802 Munchen, Germany
    Circ Res 94:863-5. 2004
    ..These results identify a role for SM22alpha in the regulation of SMC phenotype during atherogenesis...
  59. ncbi request reprint Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition
    Britta Döring
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
    J Cell Sci 119:1715-22. 2006
    ..Our results indicate the important function of Cx43 during parturition in the living animal and suggest further strategies to investigate the role of connexins in uterine contractility in transgenic mice...
  60. pmc Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 101:3253-7. 2004
    ..The paucity of substance P in laminae I-III may contribute to the reduction of nociception in PKG-I(-/-) mice and suggests a role of PKG-I in substance P synthesis...
  61. ncbi request reprint A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bradley E Bernstein
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Cell 125:315-26. 2006
    ..These results highlight the importance of DNA sequence in defining the initial epigenetic landscape and suggest a novel chromatin-based mechanism for maintaining pluripotency...
  62. ncbi request reprint Control of intestinal motility by the Ca(v)1.2 L-type calcium channel in mice
    Jörg W Wegener
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Str 29, München 80802, Germany
    FASEB J 20:1260-2. 2006
    ..In conclusion, the Ca(v)1.2 channel is essential for electromechanical coupling and important for pharmaco-mechanical coupling in intestinal smooth muscle and cannot be substituted functionally by other Ca2+ entry pathways...
  63. ncbi request reprint GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase
    Stuart J Marshall
    Department of Pharmacology, University of Oxford, UK
    Blood 103:2601-9. 2004
    ..These results demonstrate a critical role for Src kinases but not MAP kinases in VWF-dependent platelet activation and demonstrate an inhibitory role for cGMP-elevating agents in regulating this process...
  64. pmc Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation
    Sven Moosmang
    Institut fur Pharmakologie und Toxikologie, TU Munchen, Biedersteiner Strasse 29, D 80802 München, Germany
    EMBO J 22:6027-34. 2003
    ..2 channel. These results show that Cav1.2 calcium channels are key players in the hormonal regulation of blood pressure and development of myogenic tone...
  65. pmc Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution
    Layla Parker-Katiraee
    Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS Genet 3:e65. 2007
    ..Thus, KLF14 may be the first example of an imprinted transcript undergoing accelerated evolution in the human lineage...
  66. ncbi request reprint Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme
    Silke Weber
    Institut für Pharmakologie und Toxikologie der Technischen Universität, Biedersteiner Str 29, D 80802 München, Germany
    Circ Res 101:1096-103. 2007
    ..These results show that cGKI in smooth muscle is essential and that either cGKI isozyme alone can rescue basic vascular and intestinal smooth muscle functions...
  67. pmc A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells
    Wiebke Wolfsgruber
    Institut fur Pharmakologie und Toxikologie, Technische Universitat, Biedersteiner Strasse 29, 80802 Munich, Germany
    Proc Natl Acad Sci U S A 100:13519-24. 2003
    ..We suggest that activation of smooth muscle cGKI contributes to the proatherogenic effect of NO and that inhibition of cGKI might be a therapeutic option for treating atherosclerosis in humans...
  68. doi request reprint LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
    Pekka Katajisto
    Genome Scale Biology Program and Institute of Biomedicine, Biomedicum Helsinki, 00014 University of Helsinki, Finland
    Nat Genet 40:455-9. 2008
    ..We also noted TGFbeta signaling defects in polyps of individuals with PJS, suggesting that the identified stromal-derived mechanism of tumor suppression is also relevant in PJS...
  69. pmc Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis
    Robert Lukowski
    Institut für Pharmakologie und Toxikologie der TUM, Biedersteiner Str 29, D 80802 München, Germany
    Arterioscler Thromb Vasc Biol 28:1244-50. 2008
    ..The purpose of this study was to examine the functional role of the smooth muscle cGMP/cGKI signaling cascade in restenosis of vessels...
  70. ncbi request reprint cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
    Michael Koeppen
    Physiologisches Institut, Universitat Lubeck, Germany
    Hypertension 44:952-5. 2004
    ..However, the NO/cGMP/cGKI pathway is not essential for ACh-induced dilation of arterioles and for basal blood pressure regulation in mice...