Loïc Faye

Summary

Country: France

Publications

  1. doi request reprint Plant-specific glycosylation patterns in the context of therapeutic protein production
    Véronique Gomord
    Universite de Rouen, UFR des Sciences, Mont Saint Aignan, France
    Plant Biotechnol J 8:564-87. 2010
  2. doi request reprint [Plants, medicine and genetics, which applications for tomorrow?]
    Loïc Faye
    CNRS, Universite de Rouen, IFRMP23, UFR des Sciences, 76821 Mont Saint Aignan Cedex, France
    Med Sci (Paris) 24:939-45. 2008
  3. ncbi request reprint Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming
    Loïc Faye
    CNRS UMR 6037, IFRMP 23, GDR 2590, Université de Rouen Bâtiment de biologie extension, Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France
    Vaccine 23:1770-8. 2005
  4. pmc Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER
    Aurelia Boulaflous
    Laboratoire GLYCAD, IFRMP 23, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    BMC Plant Biol 9:144. 2009
  5. ncbi request reprint Protein N-glycosylation is similar in the moss Physcomitrella patens and in higher plants
    Remco Viëtor
    CNRS UMR 6037, IFRMP 23, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    Planta 218:269-75. 2003
  6. ncbi request reprint Biopharmaceutical production in plants: problems, solutions and opportunities
    Véronique Gomord
    CNRS UMR6037, University of Rouen, IFRMP23, GDR2590, UFR des Sciences, 76 821 Mont Saint Aignan, France
    Trends Biotechnol 23:559-65. 2005
  7. pmc N-glycan trimming by glucosidase II is essential for Arabidopsis development
    Pravina Soussilane
    CNRS, UMR 6037, IFRMP 23, Bâtiment Biologie Extension, Faculte des Sciences, Mont Saint Aignan, France
    Glycoconj J 26:597-607. 2009
  8. ncbi request reprint From planta to pharma with glycosylation in the toolbox
    Claude Saint-Jore-Dupas
    CNRS UMR 6037, IFRMP 23, GDR 2590, Universite de Rouen, Faculté des Sciences Bât Ext Biologie, 76821 Mont Saint Aignan Cedex, France
    Trends Biotechnol 25:317-23. 2007
  9. ncbi request reprint [GMOs and production of pharmaceutical molecules]
    Loïc Faye
    CNRS UMR 6037 IFRMP23, Universite de Rouen, 76821 Mont St Aignan, France
    Bull Acad Natl Med 186:1411-25. 2002
  10. pmc Plant N-glycan processing enzymes employ different targeting mechanisms for their spatial arrangement along the secretory pathway
    Claude Saint-Jore-Dupas
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6037, IFRMP 23, GDR 2590, UFR des Sciences, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    Plant Cell 18:3182-200. 2006

Collaborators

  • Véronique Gomord
  • Aurelia Boulaflous
  • Philippe Moingeon
  • Christophe Ritzenthaler
  • Azeddine Driouich
  • Andreas Nebenführ
  • Roy Jefferis
  • R van Ree
  • C R Hawes
  • David Lienard
  • Anne Catherine Fitchette
  • Muriel Bardor
  • Claude Saint-Jore-Dupas
  • Christophe Sourrouille
  • Thomas Paccalet
  • Patrice Lerouge
  • Marie Laure Follet-Gueye
  • Sophie Pagny
  • Pravina Soussilane
  • Carole Plasson
  • Olivia Tran Dinh
  • Remco Viëtor
  • Cecilia D'Alessio
  • Armando J Parodi
  • Brian Marshall
  • Pravina Soussillane
  • Richard Williamson
  • Pascal Cosette
  • Alain Didier-Laurent
  • Eric Wambre
  • Erika van Oort
  • François Dorlhac de Borne
  • Laurence Van Overtvelt
  • Frédéric Delmas
  • Christophe Rihouey
  • Caroline Bonneau
  • Christian Chevalier
  • Rene Delon
  • Louis Vezina
  • Christelle Faveeuw
  • Francois Trottein
  • Daniele Gilbert
  • Pierre Margerie
  • Lise Anne Denmat-Ouisse
  • Ludovic Galas
  • Martine Gonneau
  • Corinne Loutelier-Bourhis

Detail Information

Publications19

  1. doi request reprint Plant-specific glycosylation patterns in the context of therapeutic protein production
    Véronique Gomord
    Universite de Rouen, UFR des Sciences, Mont Saint Aignan, France
    Plant Biotechnol J 8:564-87. 2010
    ..This review describes protein N- and O-linked glycosylation in plants and highlights the limitations and advantages of plant-specific glycosylation on plant-made biopharmaceuticals...
  2. doi request reprint [Plants, medicine and genetics, which applications for tomorrow?]
    Loïc Faye
    CNRS, Universite de Rouen, IFRMP23, UFR des Sciences, 76821 Mont Saint Aignan Cedex, France
    Med Sci (Paris) 24:939-45. 2008
    ....
  3. ncbi request reprint Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming
    Loïc Faye
    CNRS UMR 6037, IFRMP 23, GDR 2590, Université de Rouen Bâtiment de biologie extension, Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France
    Vaccine 23:1770-8. 2005
    ..We also address the practical implications of these important processes on the effectiveness of plant molecular pharming systems...
  4. pmc Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER
    Aurelia Boulaflous
    Laboratoire GLYCAD, IFRMP 23, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    BMC Plant Biol 9:144. 2009
    ....
  5. ncbi request reprint Protein N-glycosylation is similar in the moss Physcomitrella patens and in higher plants
    Remco Viëtor
    CNRS UMR 6037, IFRMP 23, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    Planta 218:269-75. 2003
    ..patens appears to be a new promising model organism for the investigation of the biological significance of protein N-glycosylation in the plant kingdom, taking advantage of the potential for gene targeting in this moss...
  6. ncbi request reprint Biopharmaceutical production in plants: problems, solutions and opportunities
    Véronique Gomord
    CNRS UMR6037, University of Rouen, IFRMP23, GDR2590, UFR des Sciences, 76 821 Mont Saint Aignan, France
    Trends Biotechnol 23:559-65. 2005
    ..The benefits that could accrue are lower manufacturing costs, relative to mammalian cell culture, and a reduced risk of transmission of mammalian pathogens...
  7. pmc N-glycan trimming by glucosidase II is essential for Arabidopsis development
    Pravina Soussilane
    CNRS, UMR 6037, IFRMP 23, Bâtiment Biologie Extension, Faculte des Sciences, Mont Saint Aignan, France
    Glycoconj J 26:597-607. 2009
    ..Inactivation of the alpha subunit in a temperature sensitive Arabidopsis mutant blocked N-glycan processing after a first trimming by glucosidase I and strongly affected seedling development...
  8. ncbi request reprint From planta to pharma with glycosylation in the toolbox
    Claude Saint-Jore-Dupas
    CNRS UMR 6037, IFRMP 23, GDR 2590, Universite de Rouen, Faculté des Sciences Bât Ext Biologie, 76821 Mont Saint Aignan Cedex, France
    Trends Biotechnol 25:317-23. 2007
    ....
  9. ncbi request reprint [GMOs and production of pharmaceutical molecules]
    Loïc Faye
    CNRS UMR 6037 IFRMP23, Universite de Rouen, 76821 Mont St Aignan, France
    Bull Acad Natl Med 186:1411-25. 2002
    ..In this paper, we will focus on transgenic plants as a promising large scale production and processing system...
  10. pmc Plant N-glycan processing enzymes employ different targeting mechanisms for their spatial arrangement along the secretory pathway
    Claude Saint-Jore-Dupas
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6037, IFRMP 23, GDR 2590, UFR des Sciences, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    Plant Cell 18:3182-200. 2006
    ..We conclude that the localization of N-glycan processing enzymes corresponds to an assembly line in the early secretory pathway and depends on both TMD length and signals in the cytoplasmic tail...
  11. ncbi request reprint Engineering of a sialic acid synthesis pathway in transgenic plants by expression of bacterial Neu5Ac-synthesizing enzymes
    Thomas Paccalet
    CNRS UMR 6037, GDR2590, IFRMP 23, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    Plant Biotechnol J 5:16-25. 2007
    ..Experiments were carried out on two models, Bright Yellow 2 (BY2) tobacco cells and Medicago sativa (alfalfa), the perennial legume crop...
  12. ncbi request reprint Plant proteomics and glycosylation
    Anne Catherine Fitchette
    CNRS UMR 6037, IFRMP 23, GDR 2590, Universite de Rouen, Mont Saint Aignan, France
    Methods Mol Biol 355:317-42. 2007
    ..The last part of this chapter is dedicated to the specific purification and identification of glycoprotein populations in plant cells, so-called glycoproteomics...
  13. ncbi request reprint Pharming and transgenic plants
    David Lienard
    Universite de Rouen, CNRS UMR 6037, IFRMP 23, GDR 2590, Faculte des Sciences, Bât Ext Biologie, 76821 Mont Saint Aignan Cedex, France
    Biotechnol Annu Rev 13:115-47. 2007
    ....
  14. doi request reprint From Neanderthal to nanobiotech: from plant potions to pharming with plant factories
    Christophe Sourrouille
    Faculte des Sciences, Universite de Rouen, Mont Saint, Aignan, France
    Methods Mol Biol 483:1-23. 2009
    ..In this short review, we will illustrate that current improvements in plant expression systems are making them suitable as alternative factories for the production of either simple or highly complex therapeutic proteins...
  15. ncbi request reprint Fusion with HDEL protects cell wall invertase from early degradation when N-glycosylation is inhibited
    Sophie Pagny
    CNRS UMR 6037, IFRMP 23, Universite de Rouen, F 76 821 Mont Saint Aignan, France
    Plant Cell Physiol 44:173-82. 2003
    ..Consistent with our results and the well-known stabilization of recombinant proteins retained in the ER, the addition of an ER retention signal to a protein would prevent its targeting to an ER domain devoted to degradation...
  16. ncbi request reprint Suspension-cultured BY-2 tobacco cells produce and mature immunologically active house dust mite allergens
    David Lienard
    CNRS UMR 6037, IFRMP 23, GDR 2590, Universite de Rouen, 76821 Mont Saint Aignan, France
    Plant Biotechnol J 5:93-108. 2007
    ....
  17. ncbi request reprint Posttranslational modification of therapeutic proteins in plants
    Véronique Gomord
    CNRS UMR 6037 IFRMP 23 GDR 2590, Université de Rouen Bâtiment de biologie extension, Blvd de Broglie, 76821 Mont Saint Aignan Cedex, France
    Curr Opin Plant Biol 7:171-81. 2004
    ..Hence, plants have become a suitable alternative to animal cell factories for the production of therapeutic proteins...
  18. ncbi request reprint Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha(1,3)-fucose and core xylose
    Muriel Bardor
    CNRS UMR 6037, IFRMP 23, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    Glycobiology 13:427-34. 2003
    ....
  19. ncbi request reprint An improved chemical fixation method suitable for immunogold localization of green fluorescent protein in the Golgi apparatus of tobacco Bright Yellow (BY-2) cells
    Marie Laure Follet-Gueye
    CNRS UMR 6037, IFRMP23, Universite de Rouen, UFR des Sciences, Centre Commun de Microscopie Electronique, 76821 Mont Saint Aignan Cedex, France
    J Histochem Cytochem 51:931-40. 2003
    ....