Ramesh S Pillai

Summary

Affiliation: European Molecular Biology Laboratory
Country: France

Publications

  1. ncbi request reprint Inhibition of translational initiation by Let-7 MicroRNA in human cells
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Science 309:1573-6. 2005
  2. doi request reprint piRNAs and their involvement in male germline development in mice
    Ramesh S Pillai
    European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181 CNRS UJF EMBL International Unit UMI 3265 for Virus Host Cell Interactions UVHCI, 38042 Grenoble, France
    Dev Growth Differ 54:78-92. 2012
  3. ncbi request reprint Repression of protein synthesis by miRNAs: how many mechanisms?
    Ramesh S Pillai
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, 38042 Grenoble Cedex 9, France
    Trends Cell Biol 17:118-26. 2007
  4. doi request reprint A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing
    Jordi Xiol
    European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181, 38042 Grenoble, France
    Mol Cell 47:970-9. 2012
  5. pmc Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice
    Radha Raman Pandey
    European Molecular Biology Laboratory, Grenoble Outstation and Unit for Virus Host Cell Interactions, Université Grenoble Alpes, European Molecular Biology Laboratory, Centre National de la Recherche Scientifique, 38042 Grenoble, France
    Proc Natl Acad Sci U S A 110:16492-7. 2013
  6. ncbi request reprint RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts
    Jordi Xiol
    European Molecular Biology Laboratory, Grenoble Outstation, University Grenoble Alpes EMBL CNRS, 71 avenue des Martyrs, 38042, France Unit for Virus Host Cell Interactions, University Grenoble Alpes EMBL CNRS, 71 avenue des Martyrs, 38042, France
    Cell 157:1698-711. 2014
  7. pmc The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs
    Elisa Cora
    European Molecular Biology Laboratory, Grenoble Outstation, 38042 Grenoble, France Unit for Virus Host Cell Interactions, University of Grenoble Alpes EMBL CNRS, 38042 Grenoble, France
    RNA 20:773-81. 2014
  8. doi request reprint Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing
    Michael Reuter
    European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181, 38042 Grenoble, France
    Nature 480:264-7. 2011
  9. doi request reprint Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile
    Michael Reuter
    European Molecular Biology Laboratory, Grenoble Outstation, France
    Nat Struct Mol Biol 16:639-46. 2009
  10. pmc The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors
    Nikolas Mathioudakis
    European Molecular Biology Laboratory, Grenoble Outstation and Unit of Virus Host Cell Interactions, UJF EMBL CNRS, UMI 3265, BP181, 38042 Grenoble Cedex 9, France
    RNA 18:2056-72. 2012

Collaborators

  • Ravi Sachidanandam
  • Shinichiro Chuma
  • Stephen Cusack
  • Anne Ephrussi
  • Marko Kaksonen
  • Sebastien Muller
  • Witold Filipowicz
  • Nahum Sonenberg
  • Yuri V Svitkin
  • Yohann Coute
  • Alexander Stark
  • Gunter Meister
  • Jordi Xiol
  • Michael Reuter
  • Elisa Cora
  • Zhaolin Yang
  • Jan Kadlec
  • Radha Raman Pandey
  • Andres Palencia
  • Nikolas Mathioudakis
  • Philipp Berninger
  • Mihoko Hosokawa
  • Geraldine Mathonnet
  • Daniela Schmitter
  • Teldja N Azzouz
  • Pietro Spinelli
  • David Homolka
  • Josh Taylor
  • Simon Conn
  • Maike A Laussmann
  • Andrew A McCarthy
  • Radha R Pandey
  • Shinya Yamanaka
  • Eri Hayashi
  • Tetsuo Kunieda
  • Yoshimi Tokuzawa
  • Tomoko Ichisaka
  • Yuka Asano
  • Shimpei Kajita
  • Rubina Koglgruber
  • Sailakshmi Subramanian
  • Vladimir Benes
  • Josef Penninger
  • Adam Round
  • Konstantinos Tripsianes
  • Michael Sattler
  • Charlotta Funaya
  • Claude Antony
  • Hardik Shah
  • Takashi Tanaka
  • Thomas Franz
  • Stefano Biffo
  • Marc R Fabian
  • Edward Darzynkiewicz
  • Thomas F Duchaine
  • Armen Parsyan
  • Takayuki Murata
  • Laurent Huck
  • William C Merrick
  • Edward J Oakeley
  • Jody Filkowski
  • Petr Svoboda
  • Mihaela Zavolan
  • Alain Sewer
  • Ashwin Chari
  • Utz Fischer
  • Daniel Schumperli
  • Christoph Däpp
  • Christian Kambach

Detail Information

Publications17

  1. ncbi request reprint Inhibition of translational initiation by Let-7 MicroRNA in human cells
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Science 309:1573-6. 2005
    ..Repressed mRNAs, Ago proteins, and miRNAs were all found to accumulate in processing bodies. We propose that localization of mRNAs to these structures is a consequence of translational repression...
  2. doi request reprint piRNAs and their involvement in male germline development in mice
    Ramesh S Pillai
    European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181 CNRS UJF EMBL International Unit UMI 3265 for Virus Host Cell Interactions UVHCI, 38042 Grenoble, France
    Dev Growth Differ 54:78-92. 2012
    ....
  3. ncbi request reprint Repression of protein synthesis by miRNAs: how many mechanisms?
    Ramesh S Pillai
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, 38042 Grenoble Cedex 9, France
    Trends Cell Biol 17:118-26. 2007
    ..Recent data support different microRNA mechanisms and a role for cytoplasmic processing bodies in the degradation and storage of mRNAs targeted by microRNA regulators...
  4. doi request reprint A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing
    Jordi Xiol
    European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181, 38042 Grenoble, France
    Mol Cell 47:970-9. 2012
    ..We propose that the chaperone machinery normally ejects these inhibitory RNAs, allowing turnover of Piwi complexes for their continued participation in piRNA amplification...
  5. pmc Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice
    Radha Raman Pandey
    European Molecular Biology Laboratory, Grenoble Outstation and Unit for Virus Host Cell Interactions, Université Grenoble Alpes, European Molecular Biology Laboratory, Centre National de la Recherche Scientifique, 38042 Grenoble, France
    Proc Natl Acad Sci U S A 110:16492-7. 2013
    ..Cell-culture studies with the insect ortholog of TDRD12 suggest a role for the multidomain protein in mediating complex formation with other participants during secondary piRNA biogenesis. ..
  6. ncbi request reprint RNA Clamping by Vasa Assembles a piRNA Amplifier Complex on Transposon Transcripts
    Jordi Xiol
    European Molecular Biology Laboratory, Grenoble Outstation, University Grenoble Alpes EMBL CNRS, 71 avenue des Martyrs, 38042, France Unit for Virus Host Cell Interactions, University Grenoble Alpes EMBL CNRS, 71 avenue des Martyrs, 38042, France
    Cell 157:1698-711. 2014
    ..Our results reveal the molecular basis for the small RNA amplification that confers adaptive immunity against transposons. ..
  7. pmc The MID-PIWI module of Piwi proteins specifies nucleotide- and strand-biases of piRNAs
    Elisa Cora
    European Molecular Biology Laboratory, Grenoble Outstation, 38042 Grenoble, France Unit for Virus Host Cell Interactions, University of Grenoble Alpes EMBL CNRS, 38042 Grenoble, France
    RNA 20:773-81. 2014
    ..Our work identifies structural features that allow distinguishing individual Piwi members during piRNA biogenesis. ..
  8. doi request reprint Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing
    Michael Reuter
    European Molecular Biology Laboratory, 6 rue Jules Horowitz, BP 181, 38042 Grenoble, France
    Nature 480:264-7. 2011
    ..Thus, Piwi proteins seem to act in a two-pronged mammalian transposon silencing strategy: one promotes transcriptional repression in the embryo, the other reinforces silencing at the post-transcriptional level after birth...
  9. doi request reprint Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile
    Michael Reuter
    European Molecular Biology Laboratory, Grenoble Outstation, France
    Nat Struct Mol Biol 16:639-46. 2009
    ..Our data suggest that Tdrd1 ensures the entry of correct transcripts into the normal piRNA pool...
  10. pmc The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors
    Nikolas Mathioudakis
    European Molecular Biology Laboratory, Grenoble Outstation and Unit of Virus Host Cell Interactions, UJF EMBL CNRS, UMI 3265, BP181, 38042 Grenoble Cedex 9, France
    RNA 18:2056-72. 2012
    ..Overall, the results show that TDRD1 can accommodate different peptides from different proteins, and can therefore act as a scaffold protein for complex assembly in the piRNA pathway...
  11. doi request reprint [The piRNAs forge an immune system for the genome]
    Sebastien Muller
    European Molecular Biology Laboratory EMBL, 6, rue Jules Horowitz, BP 181, 38042 Grenoble, France
    Med Sci (Paris) 29:487-94. 2013
    ..This review summarizes some of the recent advances on this exceptional immunity that protects transmission of genetic information...
  12. ncbi request reprint MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
    Geraldine Mathonnet
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Science 317:1764-7. 2007
    ..Our results indicate that inhibition of translation initiation is the earliest molecular event effected by miRNAs. Other mechanisms, such as mRNA degradation, may subsequently consolidate mRNA silencing...
  13. pmc Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells
    Daniela Schmitter
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4002 Basel, Switzerland
    Nucleic Acids Res 34:4801-15. 2006
    ..Taken together, our data suggest that, independent of the effect on translation, miRNAs affect levels of a few hundred mRNAs in HEK293 cells...
  14. pmc MicroRNA function: multiple mechanisms for a tiny RNA?
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    RNA 11:1753-61. 2005
    ..The finding that microRNAs are misexpressed in cancers has reinforced the idea that their regulatory roles are very important...
  15. ncbi request reprint Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes
    Teldja N Azzouz
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
    J Biol Chem 280:34435-40. 2005
    ..Furthermore, we present evidence for two separate binding sites in SMN for Sm/Lsm proteins. One recognizes Sm domains and the second one, the sDMA-modified RG-tails, which are present only in a subset of these proteins...
  16. ncbi request reprint Post-transcriptional gene silencing by siRNAs and miRNAs
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Curr Opin Struct Biol 15:331-41. 2005
    ..The first structural information on protein components of the RNA interference (RNAi) and miRNA machineries is emerging, and provides some insight into the mechanism of RNA-silencing reactions...
  17. pmc Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, 4002 Basel, Switzerland
    RNA 10:1518-25. 2004
    ..These findings indicate that a primary function of miRNAs is to guide their associated proteins to the mRNA...