Ramesh S Pillai

Summary

Affiliation: European Molecular Biology Laboratory
Country: France

Publications

  1. ncbi Repression of protein synthesis by miRNAs: how many mechanisms?
    Ramesh S Pillai
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, 38042 Grenoble Cedex 9, France
    Trends Cell Biol 17:118-26. 2007
  2. ncbi Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, P.O. Box 2543, 4002 Basel, Switzerland
    RNA 10:1518-25. 2004
  3. ncbi Post-transcriptional gene silencing by siRNAs and miRNAs
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Curr Opin Struct Biol 15:331-41. 2005
  4. ncbi Inhibition of translational initiation by Let-7 MicroRNA in human cells
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Science 309:1573-6. 2005
  5. ncbi Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes
    Teldja N Azzouz
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
    J Biol Chem 280:34435-40. 2005
  6. ncbi MicroRNA function: multiple mechanisms for a tiny RNA?
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    RNA 11:1753-61. 2005
  7. ncbi Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells
    Daniela Schmitter
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4002 Basel, Switzerland
    Nucleic Acids Res 34:4801-15. 2006
  8. ncbi MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
    Geraldine Mathonnet
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Science 317:1764-7. 2007

Collaborators

  • Witold Filipowicz
  • Yuri V Svitkin
  • Nahum Sonenberg
  • Gunter Meister
  • Geraldine Mathonnet
  • Daniela Schmitter
  • Teldja N Azzouz
  • Laurent Huck
  • Stefano Biffo
  • Edward Darzynkiewicz
  • Marc R Fabian
  • Takayuki Murata
  • Thomas F Duchaine
  • Armen Parsyan
  • William C Merrick
  • Petr Svoboda
  • Jody Filkowski
  • Edward J Oakeley
  • Mihaela Zavolan
  • Alain Sewer
  • Christoph Däpp
  • Christian Kambach
  • Daniel Schumperli
  • Utz Fischer
  • Ashwin Chari

Detail Information

Publications8

  1. ncbi Repression of protein synthesis by miRNAs: how many mechanisms?
    Ramesh S Pillai
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, 38042 Grenoble Cedex 9, France
    Trends Cell Biol 17:118-26. 2007
    ..Recent data support different microRNA mechanisms and a role for cytoplasmic processing bodies in the degradation and storage of mRNAs targeted by microRNA regulators...
  2. ncbi Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, P.O. Box 2543, 4002 Basel, Switzerland
    RNA 10:1518-25. 2004
    ..These findings indicate that a primary function of miRNAs is to guide their associated proteins to the mRNA...
  3. ncbi Post-transcriptional gene silencing by siRNAs and miRNAs
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Curr Opin Struct Biol 15:331-41. 2005
    ..The first structural information on protein components of the RNA interference (RNAi) and miRNA machineries is emerging, and provides some insight into the mechanism of RNA-silencing reactions...
  4. ncbi Inhibition of translational initiation by Let-7 MicroRNA in human cells
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Science 309:1573-6. 2005
    ..Repressed mRNAs, Ago proteins, and miRNAs were all found to accumulate in processing bodies. We propose that localization of mRNAs to these structures is a consequence of translational repression...
  5. ncbi Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes
    Teldja N Azzouz
    Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
    J Biol Chem 280:34435-40. 2005
    ..Furthermore, we present evidence for two separate binding sites in SMN for Sm/Lsm proteins. One recognizes Sm domains and the second one, the sDMA-modified RG-tails, which are present only in a subset of these proteins...
  6. ncbi MicroRNA function: multiple mechanisms for a tiny RNA?
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    RNA 11:1753-61. 2005
    ..The finding that microRNAs are misexpressed in cancers has reinforced the idea that their regulatory roles are very important...
  7. ncbi Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells
    Daniela Schmitter
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4002 Basel, Switzerland
    Nucleic Acids Res 34:4801-15. 2006
    ..Taken together, our data suggest that, independent of the effect on translation, miRNAs affect levels of a few hundred mRNAs in HEK293 cells...
  8. ncbi MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
    Geraldine Mathonnet
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Science 317:1764-7. 2007
    ..Our results indicate that inhibition of translation initiation is the earliest molecular event effected by miRNAs. Other mechanisms, such as mRNA degradation, may subsequently consolidate mRNA silencing...