- Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipientsTorsten Bohler
Department of Internal Medicine Nephrology, Charite Campus Mitte, Humboldt University, Berlin, Germany
Int Immunopharmacol 7:88-95. 2007..In conclusion FTY720 treatment reduces B-cells expressing CD62L to a significant lesser degree than T-cells expressing CD62L...
- Validation of immunological biomarkers for the pharmacodynamic monitoring of immunosuppressive drugs in humansTorsten Bohler
INSERM U466, Institut Louis Bugnard, Toulouse, France
Ther Drug Monit 29:77-86. 2007..We conclude that these biomarkers used in whole-blood assays are suitable for PD of immune modulators in clinical trials...
- Effect of FTY720 on apoptosis of smooth muscle cellsT Bohler
INSERM U858, CHU Rangueil, 31403 Toulouse, France
Transplant Proc 39:2624-6. 2007..Hyperproliferation of smooth muscle cells (SMCs) plays a key role in allograft arteriosclerosis. This prompted us to investigate the effect of the novel immune modulator and synthetic sphingolipid FTY720 on apoptosis of SMCs...
- Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferationTorsten Bohler
INSERM U858, Institute Louis Bugnard, CHU Rangueil, Toulouse, France
Transpl Immunol 18:319-23. 2008..Further experiments showed that the immune inhibitory effects by Tabebuia were not mediated by its pharmacological lead compound beta-lapachone and only observed in aqueous but not in ethanol plant extracts...
- Pharmacodynamic monitoring of the conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in stable kidney-allograft recipientsTorsten Bohler
INSERM U858, Equipe 10, IFR 31, Institut Louis Bugnard, Batiment L3, CHU Rangueil, France
Int Immunopharmacol 8:769-73. 2008....
- Pharmacodynamic effects of everolimus on anti-CD3 antibody-stimulated T-lymphocyte proliferation and interleukin-10 synthesis in stable kidney-transplant patientsTorsten Bohler
INSERM U858, I2MR, Eq 10, Institut Louis Bugnard, Batiment L3, CHU Rangueil, 1 avenue J Poulhes, 31403 Toulouse Cedex 4, France
Cytokine 42:306-11. 2008..In vitro, everolimus inhibited lymphocyte proliferation and IL-10 synthesis dose dependently in anti-CD3 mAb and LPS stimulated peripheral blood mononuclear cell cultures derived from human volunteers...
- Cytokines correlate with age in healthy volunteers, dialysis patients and kidney-transplant patientsTorsten Bohler
INSERM U 858 EQ 10, Institut Louis Bugnard, 1 Ave J Poulhès, CHU Rangueil, 3100 Toulouse, France
Cytokine 45:169-73. 2009....
- FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle CellsT Bohler
INSERM U858 I2MR EQ 10 Artériosclérose et Artériosclérose de Greffe, CHU Rangueil, Toulouse, France
Transplant Proc 41:705-6. 2009..We concluded that FTY720 may be a useful drug to inhibit chronic vascular rejection...