Research Topics
| L EtienneSummaryCountry: France Publications
|
Detail Information
Publications
Differential effects of single dose FTY720 on CD62L+ B-cells in stable renal allograft recipientsTorsten Bohler
Department of Internal Medicine Nephrology, Charite Campus Mitte, Humboldt University, Berlin, Germany
Int Immunopharmacol 7:88-95. 2007..In conclusion FTY720 treatment reduces B-cells expressing CD62L to a significant lesser degree than T-cells expressing CD62L...
Validation of immunological biomarkers for the pharmacodynamic monitoring of immunosuppressive drugs in humansTorsten Bohler
INSERM U466, Institut Louis Bugnard, Toulouse, France
Ther Drug Monit 29:77-86. 2007..We conclude that these biomarkers used in whole-blood assays are suitable for PD of immune modulators in clinical trials...
Effect of FTY720 on apoptosis of smooth muscle cellsT Bohler
INSERM U858, CHU Rangueil, 31403 Toulouse, France
Transplant Proc 39:2624-6. 2007..Hyperproliferation of smooth muscle cells (SMCs) plays a key role in allograft arteriosclerosis. This prompted us to investigate the effect of the novel immune modulator and synthetic sphingolipid FTY720 on apoptosis of SMCs...
Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferationTorsten Bohler
INSERM U858, Institute Louis Bugnard, CHU Rangueil, Toulouse, France
Transpl Immunol 18:319-23. 2008..Further experiments showed that the immune inhibitory effects by Tabebuia were not mediated by its pharmacological lead compound beta-lapachone and only observed in aqueous but not in ethanol plant extracts...
Pharmacodynamic monitoring of the conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium in stable kidney-allograft recipientsTorsten Bohler
INSERM U858, Equipe 10, IFR 31, Institut Louis Bugnard, Batiment L3, CHU Rangueil, France
Int Immunopharmacol 8:769-73. 2008....
Pharmacodynamic effects of everolimus on anti-CD3 antibody-stimulated T-lymphocyte proliferation and interleukin-10 synthesis in stable kidney-transplant patientsTorsten Bohler
INSERM U858, I2MR, Eq 10, Institut Louis Bugnard, Batiment L3, CHU Rangueil, 1 avenue J Poulhes, 31403 Toulouse Cedex 4, France
Cytokine 42:306-11. 2008..In vitro, everolimus inhibited lymphocyte proliferation and IL-10 synthesis dose dependently in anti-CD3 mAb and LPS stimulated peripheral blood mononuclear cell cultures derived from human volunteers...
Cytokines correlate with age in healthy volunteers, dialysis patients and kidney-transplant patientsTorsten Bohler
INSERM U 858 EQ 10, Institut Louis Bugnard, 1 Ave J Poulhès, CHU Rangueil, 3100 Toulouse, France
Cytokine 45:169-73. 2009....
FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle CellsT Bohler
INSERM U858 I2MR EQ 10 Artériosclérose et Artériosclérose de Greffe, CHU Rangueil, Toulouse, France
Transplant Proc 41:705-6. 2009..We concluded that FTY720 may be a useful drug to inhibit chronic vascular rejection...
