Joseph Emmerich

Summary

Country: France

Publications

  1. ncbi request reprint Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism
    J Emmerich
    Hopital Europeen Georges Pompidou, Service de Medecine Vasculaire, Centre Claude Bernard et Laboratoire d Hémostase, Paris, France
    Thromb Haemost 86:809-16. 2001
  2. ncbi request reprint [Thrombophilia and pregnancy: which tests for which patients? The clinician's point of view]
    Joseph Emmerich
    Service de Médecine Vasculaire et INSERM U428, Hopital Europeen Georges Pompidou, 20 40, rue Leblanc, 75908 Paris Cedex 15
    Ann Med Interne (Paris) 154:345-53. 2003
  3. ncbi request reprint [Epidemiology of venous thrombosis]
    Joseph Emmerich
    Service de Médecine Vasculaire HEGP et Unité INSERM U428, 20 40 rue Leblanc 75908 Paris
    Bull Acad Natl Med 187:19-32; discussion 32-3. 2003
  4. ncbi request reprint Infection and venous thrombosis
    Joseph Emmerich
    Service de Médecine Vasculaire et HTA, Centre Claude Bernard de Recherche sur les Maladies Vasculaires, INSERM U428, University Paris 5, Paris, France
    Pathophysiol Haemost Thromb 32:346-8. 2002
  5. ncbi request reprint [Frequency and risk factors of thrombo-embolic venous disease]
    Joseph Emmerich
    Service de médecine vasculaire Hôpital européen Georges Pompidou et INSERM Unité 428 75908 Paris
    Rev Prat 53:14-9. 2003
  6. doi request reprint Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model
    Anne Godier
    Department of Anaesthesia and Critical Care, Paris Descartes University, Hotel Dieu University Hospital, Paris, France
    Anesthesiology 116:94-102. 2012
  7. pmc Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis
    Marine Germain
    INSERM UMR_S 937, ICAN Institute, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 7:e38538. 2012
  8. doi request reprint Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia
    David M Smadja
    Universite Paris Descartes, Paris, France Sorbonne Paris Cite, France
    Cytotherapy 14:232-9. 2012
  9. doi request reprint Efficacy of prothrombin complex concentrate to reverse the anticoagulant effect of the pentasaccharide fondaparinux in a rabbit model
    Anne Godier
    Department of Anesthesia and Critical Care, Paris Descartes University Hôtel Dieu, Paris, France
    Thromb Haemost 105:161-8. 2011
  10. doi request reprint Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties
    David M Smadja
    Universite Paris Descartes, Paris, France
    Arterioscler Thromb Vasc Biol 31:551-9. 2011

Detail Information

Publications53

  1. ncbi request reprint Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism
    J Emmerich
    Hopital Europeen Georges Pompidou, Service de Medecine Vasculaire, Centre Claude Bernard et Laboratoire d Hémostase, Paris, France
    Thromb Haemost 86:809-16. 2001
    ..69). Conversely, factor II G20210A mutation was equally balanced in both patient groups...
  2. ncbi request reprint [Thrombophilia and pregnancy: which tests for which patients? The clinician's point of view]
    Joseph Emmerich
    Service de Médecine Vasculaire et INSERM U428, Hopital Europeen Georges Pompidou, 20 40, rue Leblanc, 75908 Paris Cedex 15
    Ann Med Interne (Paris) 154:345-53. 2003
    ..When a laboratory work-up of thrombophilia is required, all the known causes of thrombophilia must be checked as none of them is specific of a single clinical feature, but also because they can be associated in the same patient...
  3. ncbi request reprint [Epidemiology of venous thrombosis]
    Joseph Emmerich
    Service de Médecine Vasculaire HEGP et Unité INSERM U428, 20 40 rue Leblanc 75908 Paris
    Bull Acad Natl Med 187:19-32; discussion 32-3. 2003
    ..The association of several environmental or genetic and their analysis in the physiopathology of the disease and in the risk of recurrency is important in order to allow a better prevention of the disease and of its recurrencies...
  4. ncbi request reprint Infection and venous thrombosis
    Joseph Emmerich
    Service de Médecine Vasculaire et HTA, Centre Claude Bernard de Recherche sur les Maladies Vasculaires, INSERM U428, University Paris 5, Paris, France
    Pathophysiol Haemost Thromb 32:346-8. 2002
    ..Other studies did not confirm such an association or found a lower odds ratio. This association remains to be confirmed in other case-control or prospective studies...
  5. ncbi request reprint [Frequency and risk factors of thrombo-embolic venous disease]
    Joseph Emmerich
    Service de médecine vasculaire Hôpital européen Georges Pompidou et INSERM Unité 428 75908 Paris
    Rev Prat 53:14-9. 2003
    ..Association between cancer and venous thromboembolism has been recently studied, and is most often associated with a bad prognosis of the underlying cancer...
  6. doi request reprint Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model
    Anne Godier
    Department of Anaesthesia and Critical Care, Paris Descartes University, Hotel Dieu University Hospital, Paris, France
    Anesthesiology 116:94-102. 2012
    ....
  7. pmc Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis
    Marine Germain
    INSERM UMR_S 937, ICAN Institute, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 7:e38538. 2012
    ..This variant was in fact the rs1799963, also known as the FII G20210A prothrombin mutation. This work may be of major interest not only for its scientific impact but also for its methodological findings...
  8. doi request reprint Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia
    David M Smadja
    Universite Paris Descartes, Paris, France Sorbonne Paris Cite, France
    Cytotherapy 14:232-9. 2012
    ....
  9. doi request reprint Efficacy of prothrombin complex concentrate to reverse the anticoagulant effect of the pentasaccharide fondaparinux in a rabbit model
    Anne Godier
    Department of Anesthesia and Critical Care, Paris Descartes University Hôtel Dieu, Paris, France
    Thromb Haemost 105:161-8. 2011
    ..EXTEM and FIBTEM tests were not modified. Regarding safety, PCC did not increase CFRs. PCC reduced bleeding without increasing thrombosis and was effective to reverse the haemorrhagic effect of fondaparinux in this rabbit model...
  10. doi request reprint Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties
    David M Smadja
    Universite Paris Descartes, Paris, France
    Arterioscler Thromb Vasc Biol 31:551-9. 2011
    ..We examined whether plasma levels of angiogenic factors are altered in plasma of patients with peripheral arterial disease (PAD) and whether these factors affect endothelial progenitor cell-induced angiogenesis...
  11. doi request reprint Venous thromboembolism: risk factors for recurrence
    Tienan Zhu
    University Paris Descartes, INSERM U765, Service de Médecine Vasculaire HTA, Paris, France
    Arterioscler Thromb Vasc Biol 29:298-310. 2009
    ..Future studies are needed to refine the predictive value of known risk factors for VTE recurrence and to discover better markers...
  12. doi request reprint Bone marrow-derived mononuclear cell therapy induces distal angiogenesis after local injection in critical leg ischemia
    Jean Paul Duong Van Huyen
    University Paris Descartes, Paris, France
    Mod Pathol 21:837-46. 2008
    ....
  13. ncbi request reprint P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study
    Pierre Fontana
    INSERM U 428, Hôpital Européen Georges Pompidou et Université Paris V, Paris, France
    Circulation 108:2971-3. 2003
    ..Because platelets play a key role in atherosclerosis and arterial thrombosis, we tested the possible link between the H2 haplotype and the risk of peripheral arterial disease (PAD) in a case-control study...
  14. doi request reprint Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells
    David M Smadja
    Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    J Cell Mol Med 13:2534-46. 2009
    ..In conclusion, PAR-1 activation induces IL-8 synthesis by late EPC. This could potentially enhance cooperation between late and early EPC during neovascularization, through a paracrine effect...
  15. doi request reprint Association of influenza vaccination with reduced risk of venous thromboembolism
    Tienan Zhu
    Deparment of Vascular Medicine, University Paris Decartes and INSERM U765, Paris, France
    Thromb Haemost 102:1259-64. 2009
    ..71, 95% CI, 0.53-0.94) and for both provoked (OR 0.71, 95% CI, 0.53-0.97) and unprovoked VTE (OR 0.85, 95% CI, 0.59-1.23). This case-control study suggests that influenza vaccination is associated with a reduced risk of VTE...
  16. doi request reprint Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach
    David Alexandre Tregouet
    INSERM, Unite Mixte de Recherche S, Paris, France
    Blood 113:5298-303. 2009
    ..However, using this large cohort of subjects, we were able to replicate the mild effects of 2 nonsynonymous SNPs, rs1613662 in GP6 and rs13146272 in CYP4V2, recently suspected to be associated with VTE...
  17. ncbi request reprint [Coagulation factor mutations and thrombosis]
    Martine Aiach
    Service d Hematologie Biologique, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75908 Paris Cedex 15, France
    Med Sci (Paris) 22:985-9. 2006
    ..The exposition to acquired risk factors such as estrogen based oral contraception may also have a synergistic effect favoring thrombosis in patients with FV Leiden or other genetic risk factors...
  18. doi request reprint [Treatment perspectives for critical limb ischemia: gene and cell therapy]
    Elisa Pasqualoni
    Service de Médecine Vasculaire HTA, Hopital Europeen Georges Pompidou, F75908 Paris Cedex 15, France
    Presse Med 37:1039-46. 2008
    ..These innovative approaches appear both feasible and safe. Large randomized clinical trials are necessary to demonstrate their benefits and long-term safety...
  19. pmc Genetics of venous thrombosis: insights from a new genome wide association study
    Marine Germain
    INSERM UMR_S 937 ICAN Institute, Universite Pierre et Marie Curie, Paris 6, Paris, France
    PLoS ONE 6:e25581. 2011
    ..Genetics factors are known to contribute to the susceptibility of the disease but how many genes are involved and their contribution to VT risk still remain obscure. We aimed to identify genetic variants associated with VT risk...
  20. ncbi request reprint The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers
    Jean Luc Reny
    Service d Hématologie Biologique A, Hôpital Européen Georges Pompidou INSERM Unité 428, Paris, France
    Thromb Haemost 91:248-54. 2004
    ..The TF-603A/G gene promoter polymorphism thus significantly influences constitutive TF gene expression in human monocytes but has no major effect on TF gene expression or on WBCT in LPS stimulated conditions...
  21. ncbi request reprint The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations
    Nejma Ameziane
    INSERM 479, Faculte Xavier Bichat, Paris, France
    Thromb Haemost 88:195-9. 2002
    ..These results suggest that the CC genotype of the TFPI intron 7 polymorphism is an independent protective factor for venous thromboembolism, an effect probably mediated by increased TFPI levels...
  22. ncbi request reprint Cleaved protein S (PS), total PS, free PS, and activated protein C cofactor activity as risk factors for venous thromboembolism
    Delphine Borgel
    Service d Hématologie Biologique A, Hopital Europeen Georges Pompidou, AP HP, Paris, France
    Clin Chem 49:575-80. 2003
    ..To clarify this issue, we designed a case-control study to evaluate the role of different molecular forms of plasma PS...
  23. ncbi request reprint Role of fibrinolysis and interventional therapy for acute venous thromboembolism
    Joseph Emmerich
    University Paris Descartes, Hopital Europeen Georges Pompidou, Paris, France
    Thromb Haemost 96:251-7. 2006
    ....
  24. ncbi request reprint A two adenine insertion polymorphism in the 3' untranslated region of factor VII gene is associated with peripheral arterial disease but not with venous thrombosis. Results of case-control studies
    Emilie Serve
    INSERM, Unité 765, Paris, France
    Thromb Haemost 98:733-7. 2007
    ..24 [95% CI 0.06-0.99]. In conclusion, the 2 adenine insertion in the 3'UTR of FVII gene, related to lower plasma FVII levels, is a genetic variation that may contribute to reduce the risk of PAD...
  25. doi request reprint Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel
    Clemence Hindy-François
    INSERM UMRS 765, Pharmaceutical Sciences University, Paris, France
    Thromb Haemost 104:823-30. 2010
    ..These effects were unaffected by either rFVIIa dose. rFVIIa accelerated thrombin generation but had no effect on platelet aggregation in citrated platelet-rich plasma. rFVIIa did not modify HS blood loss associated with cAPA in rabbits...
  26. ncbi request reprint Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status
    Sylvain Clauser
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service d Hématologie Biologique A, Paris, France
    Clin Chem 53:1808-13. 2007
    ..We report the development and validation of an ELISA for Gas6, and the variation of plasma Gas6 with hormonal status in a study designed to evaluate the effect of oral contraception on plasma markers...
  27. ncbi request reprint [Stem cells and cardiovascular therapy: results in peripheral artery disease]
    Joseph Emmerich
    Medecine vasculaire, HTA, HEPG, 20 rue Leblanc, 75908 Paris Cedex 15, Universite Paris Descartes, IFR Necker Enfants Malades, Paris, France, INSERM U765
    Bull Acad Natl Med 193:549-57; discussion 557-8. 2009
    ..Several teams are also testing allogeneic stem cells and autologous progenitor endothelial cells for the treatment of peripheral artery disease but they are encountering significant hurdles...
  28. ncbi request reprint Alpha1-antitrypsin gene polymorphisms are not associated with renal arterial fibromuscular dysplasia
    Jérôme Perdu
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Medical Genetics, Paris, France
    J Hypertens 24:705-10. 2006
    ..Case reports have associated alpha1-antitrypsin deficiency and FMD. The aim of this study was to test the implication of the alpha1-antitrypsin (AAT) gene in a large cohort of patients with renal FMD...
  29. doi request reprint Venous thromboembolism risk and prophylaxis in hospitalised medically ill patients. The ENDORSE Global Survey
    Jean Francois Bergmann
    Hopital Lariboisiere, University Paris 7, Paris, France
    Thromb Haemost 103:736-48. 2010
    ..These data support the necessity to improve implementation of available guidelines for evaluating VTE risk and providing prophylaxis to hospitalised medical patients...
  30. ncbi request reprint Association of Takayasu's arteritis and Crohn's disease. Results of a study on 44 Takayasu patients and review of the literature
    Jean Luc Reny
    Service de Medecine Vasculaire, Hopital Europeen Georges Pompidou, 75908 Paris Cedex 15
    Ann Med Interne (Paris) 154:85-90. 2003
    ..Our results and previous reports suggest that this association of rare diseases is not fortuitous. With respect to the indolent course of Takayasu's arteritis, early diagnosis of vascular lesions in Crohn patients is encouraged...
  31. doi request reprint [How to manage Takayasu arteritis?]
    Tristan Mirault
    Pôle Cardiovasculaire, Hopital Europeen Georges Pompidou, Universite Paris Descartes, Unité de médecine vasculaire, Paris, France
    Presse Med 41:975-85. 2012
    ..Monitoring of therapy should be clinical and supported by biological markers and imaging. Reconstructive surgery should be performed in the quiescent phase of disease...
  32. doi request reprint Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial
    Kim Thanh Ong
    Assistance Publique, Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France
    Lancet 376:1476-84. 2010
    ..Our aim was to assess the ability of celiprolol, a β(1)-adrenoceptor antagonist with a β(2)-adrenoceptor agonist action, to prevent arterial dissections and ruptures in vascular Ehlers-Danlos syndrome...
  33. doi request reprint Anti TNF-α in refractory Takayasu's arteritis: cases series and review of the literature
    Cloé Comarmond
    Department of Internal Medicine French Reference Center for Rare Auto immune diseases Groupe hospitalier Pitié Salpêtrière, AP HP, 47 83 Bd de l Hopital, 75013, Paris, France
    Autoimmun Rev 11:678-84. 2012
    ..Further studies are warranted to assess the long term efficacy and safety of anti-TNF in TA and to better define if they should be prescribed earlier in the course of TA...
  34. ncbi request reprint [Cellular therapy in atherosclerotic arteriopathies: is there hope for those with severe prognosis?]
    Joseph Emmerich
    Service de medicine vasculaire HTA et Inserm U428, Hopital Europeen Georges Pompidou, 75908 Paris Cedex 15
    Rev Prat 55:1201-2. 2005
  35. ncbi request reprint Current state and perspective on medical treatment of critical leg ischemia: gene and cell therapy
    Joseph Emmerich
    University Paris Descartes, Department of Vascular Medicine and Hypertension, Hopital Europeen Georges Pompidou, Paris
    Int J Low Extrem Wounds 4:234-41. 2005
    ..These studies demonstrated the short-term safety and feasibility of these new approaches, but larger randomized studies remain necessary to demonstrate their clinical benefits and longterm safety...
  36. doi request reprint Detection and characterisation of large SERPINC1 deletions in type I inherited antithrombin deficiency
    Veronique Picard
    Service d Hematologie Biologique, AP HP, Hopital Europeen Georges Pompidou, 75908 Paris Cedex 15, France
    Hum Genet 127:45-53. 2010
    ..Distinct mutational mechanisms explaining these Alu sequence-related deletions are proposed. Overall, in this series, large deletions detected by MLPA explain almost half of otherwise unexplained type I AT-inherited deficiency cases...
  37. ncbi request reprint Initial treatment of venous thromboembolism
    Cecilia Becattini
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy
    Thromb Haemost 96:242-50. 2006
    ..An oral anticoagulant agent to be used without laboratory monitoring for both acute and long-term treatment of VTE remains an unsolved clinical need in the treatment of VTE...
  38. ncbi request reprint [How to assess thrombophilia and which one?]
    Joseph Emmerich
    Service de medecine vascularie, HTA et unite Inserm U765, Universite Paris Descartes, Hopital Europeen Georges Pompidou, 75980 Paris Cedex 15
    Rev Prat 57:714-5. 2007
  39. ncbi request reprint A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis
    Beatrice Saposnik
    INSERM U 428, 4 avenue de l Observatoire, 75006 Paris, France
    Blood 103:1311-8. 2004
    ..8; P =.004). Thus, the A3 haplotype, which is associated with elevated plasma sEPCR levels, is a candidate risk factor for venous thrombosis...
  40. ncbi request reprint [Risk factors of the recurrence of venous thromboembolism]
    Joseph Emmerich
    Rev Prat 57:717-8. 2007
  41. ncbi request reprint Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study
    Marianne Canonico
    INSERM Unit 780, Cardiovascular Epidemiology Section, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Circulation 115:840-5. 2007
    ..Transdermal estrogen may be safer. However, currently available data have limited the ability to investigate the wide variety of types of progestogen...
  42. ncbi request reprint Uptake of new treatment strategies for deep vein thrombosis: an international audit
    Drahomir A Aujesky
    University of Lausanne
    Int J Qual Health Care 16:193-200. 2004
    ....
  43. ncbi request reprint Can fishing for new genes catch patients at risk of coronary artery disease?
    Joseph Emmerich
    Clin Chem 54:453-5. 2008
  44. ncbi request reprint Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism
    Robert Y L Zee
    Laboratory of Genetic and Molecular Epidemiology, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medial School, 900 CommonwealthAvenue East, Boston, MA 02215, USA
    Atherosclerosis 197:694-9. 2008
    ..The present investigation provides evidence for an association of the P2RY12 haplotype H2 with lower risk of DVT/PE; however these findings require replication in other well-designed studies...
  45. ncbi request reprint Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24,000 years ago
    Ariella Zivelin
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Blood 107:4666-8. 2006
    ....
  46. ncbi request reprint Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration
    Celine Straczek
    INSERM, Cardiovascular Epidemiology Unit, Villejuif, France
    Circulation 112:3495-500. 2005
    ..Transdermal estrogen may be safe with respect to VTE. We investigated the impact of the route of estrogen administration on the association between a prothrombotic mutation (factor V Leiden or prothrombin G20210A mutation) and VTE risk...
  47. doi request reprint No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease
    David M Smadja
    Thromb Haemost 99:970-2. 2008
  48. ncbi request reprint [Medical treatment of critical leg ischemia: current status and future perspectives of gene and cell therapy]
    Joseph Emmerich
    Universite Paris Descartes, INSERM U765, Service de Médecine Vasculaire HTA, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75908 Paris 15
    Bull Acad Natl Med 190:667-80; discussion 680-1, 683-4. 2006
    ..These approaches appear to be feasible and safe in the short-term, but large randomized studies are necessary to demonstrate their clinical benefits and long-term safety...
  49. ncbi request reprint Evaluating chronic venous disease with a new venous severity scoring system
    Michael A Ricci
    Department of Surgery, Vermont College of Medicine, Burlington, 05405 0068, USA
    J Vasc Surg 38:909-15. 2003
    ..However, validation of the VCSS against an objective test is lacking. The purpose of this study was to test the VCSS against abnormalities found on venous ultrasound (US) scans...
  50. ncbi request reprint Residual venous thrombosis and recurrent thromboembolism
    Joseph Emmerich
    Ann Intern Med 139:303; author reply 304. 2003
  51. ncbi request reprint Antithrombin Cambridge II (A384S): prevalence in patients of the Paris Thrombosis Study (PATHROS)
    Veronique Picard
    Blood 110:2777-8. 2007
  52. ncbi request reprint Paraneoplastic acral vascular syndrome: epidemiologic features, clinical manifestations, and disease sequelae
    Ewa Poszepczynska-Guigné
    Department of Dermatology, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
    J Am Acad Dermatol 47:47-52. 2002
    ..Acral vascular syndromes associated with malignancy have rarely been reported...
  53. doi request reprint Therapeutic angiogenesis with intramuscular NV1FGF improves amputation-free survival in patients with critical limb ischemia
    Sigrid Nikol
    Department of Cardiology and Angiology, Universitatsklinikum, Munster, Germany
    Mol Ther 16:972-8. 2008
    ..In patients with CLI, plasmid-based NV1FGF gene transfer was well tolerated, and resulted in a significantly reduced risk of major amputation when compared with placebo...