Alexis Elbaz

Summary

Country: France

Publications

  1. ncbi S18Y polymorphism in the UCH-L1 gene and Parkinson's disease: evidence for an age-dependent relationship
    Alexis Elbaz
    Institut National de la Sante et de la Recherche Medicale, Unit 360, Hopital de la Salpetriere, Paris, France
    Mov Disord 18:130-7. 2003
  2. ncbi Bias in association studies resulting from gene-environment interactions and competing risks
    Alexis Elbaz
    Institut National de la Sante et de la Recherche Medicale INSERM, Unit 360, Paris, France
    Am J Epidemiol 155:265-72. 2002
  3. ncbi CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease
    Alexis Elbaz
    National Institute of Health and Medical Research INSERM Unit 360, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Ann Neurol 55:430-4. 2004
  4. ncbi Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure
    Jean Philippe Galanaud
    Institut National de la Santé et de la Recherche Médicale Unit 360, Paris, France
    Mov Disord 20:181-9. 2005
  5. doi Professional exposure to pesticides and Parkinson disease
    Alexis Elbaz
    INSERM, U, Paris, France
    Ann Neurol 66:494-504. 2009
  6. ncbi Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease
    Fabien Dutheil
    Inserm UMR S775, Bases Moléculaires de la Réponse aux Xénobiotiques, Universite Paris Descartes, Paris, France
    Arch Neurol 67:739-45. 2010
  7. doi Prediction model of Parkinson's disease based on antiparkinsonian drug claims
    Frédéric Moisan
    Unité Neuroepidemiology, INSERM, Paris, France
    Am J Epidemiol 174:354-63. 2011
  8. pmc Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, F 75013, Paris, France
    Ann Neurol 69:778-92. 2011
  9. pmc Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study
    Julien Dumurgier
    INSERM, U708, F 75013, Paris, France
    BMJ 339:b4460. 2009
  10. ncbi Common carotid artery intima-media thickness, carotid plaques, and walking speed
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Stroke 36:2198-202. 2005

Detail Information

Publications48

  1. ncbi S18Y polymorphism in the UCH-L1 gene and Parkinson's disease: evidence for an age-dependent relationship
    Alexis Elbaz
    Institut National de la Sante et de la Recherche Medicale, Unit 360, Hopital de la Salpetriere, Paris, France
    Mov Disord 18:130-7. 2003
    ..In this community-based case-control study, carriers of the Y allele were at decreased risk of developing PD at a young age, independently of pesticides and smoking...
  2. ncbi Bias in association studies resulting from gene-environment interactions and competing risks
    Alexis Elbaz
    Institut National de la Sante et de la Recherche Medicale INSERM, Unit 360, Paris, France
    Am J Epidemiol 155:265-72. 2002
    ..Because competing risks of death are likely to be present in older subjects, researchers studying the etiology of late-onset diseases should be aware of the possibility of this bias...
  3. ncbi CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease
    Alexis Elbaz
    National Institute of Health and Medical Research INSERM Unit 360, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Ann Neurol 55:430-4. 2004
    ....
  4. ncbi Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure
    Jean Philippe Galanaud
    Institut National de la Santé et de la Recherche Médicale Unit 360, Paris, France
    Mov Disord 20:181-9. 2005
    ..The relationship between PD and cigarette smoking was not significantly modified or confounded by exposure to pesticides...
  5. doi Professional exposure to pesticides and Parkinson disease
    Alexis Elbaz
    INSERM, U, Paris, France
    Ann Neurol 66:494-504. 2009
    ..Our objective was to investigate the role of specific pesticide families and to perform dose-effect analyses...
  6. ncbi Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease
    Fabien Dutheil
    Inserm UMR S775, Bases Moléculaires de la Réponse aux Xénobiotiques, Universite Paris Descartes, Paris, France
    Arch Neurol 67:739-45. 2010
    ....
  7. doi Prediction model of Parkinson's disease based on antiparkinsonian drug claims
    Frédéric Moisan
    Unité Neuroepidemiology, INSERM, Paris, France
    Am J Epidemiol 174:354-63. 2011
    ..Similar approaches could be developed for other conditions...
  8. pmc Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, F 75013, Paris, France
    Ann Neurol 69:778-92. 2011
    ....
  9. pmc Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study
    Julien Dumurgier
    INSERM, U708, F 75013, Paris, France
    BMJ 339:b4460. 2009
    ..To study the relation between low walking speed and the risk of death in older people, both overall and with regard to the main causes of death...
  10. ncbi Common carotid artery intima-media thickness, carotid plaques, and walking speed
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Stroke 36:2198-202. 2005
    ..We studied the association between carotid ultrasound parameters and measures of gait and balance in subjects 65 to 85 years of age who participated in the baseline phase of the Three-City Study in the Dijon center...
  11. ncbi White matter lesions volume and motor performances in the elderly
    Aïcha Soumaré
    INSERM U708, Neuroepidemiology, Hopital de la Salpetriere, 47 bvd de l Hôpital, Paris, France
    Ann Neurol 65:706-15. 2009
    ..To investigate the cross-sectional and longitudinal associations between performance-based measures of motor function and volume of white matter lesions (WMLs), and to examine the influence of the localization of these lesions...
  12. doi Risk factors of multiple system atrophy: a case-control study in French patients
    Jean Sébastien Vidal
    INSERM U708, Neuroepidemiology, Paris, France
    Mov Disord 23:797-803. 2008
    ..004). This case-control study provided new findings about risk factors of MSA. On another hand, it did not confirm the previously reported association between MSA and exposure to pesticides...
  13. doi MRI atrophy of the caudate nucleus and slower walking speed in the elderly
    Julien Dumurgier
    INSERM, U708, Neuroepidemiology, F 75005, Paris, France
    Neuroimage 60:871-8. 2012
    ..001). These results underline the role of gray matter subcortical structures, in particular of the caudate nucleus, in the age-related decline of motor performances among community-dwelling elderly subjects...
  14. doi A cross-sectional and longitudinal study of the relationship between walking speed and cognitive function in community-dwelling elderly people
    Aïcha Soumaré
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    J Gerontol A Biol Sci Med Sci 64:1058-65. 2009
    ..We investigated cross-sectional and longitudinal relationships between performance in five cognitive tests and walking speed among community-dwelling elderly people in the Dijon center (France) of the Three-City Study...
  15. doi The relation between type of farming and prevalence of Parkinson's disease among agricultural workers in five French districts
    Frédéric Moisan
    INSERM, Paris, France
    Mov Disord 26:271-9. 2011
    ..Our findings are consistent with studies reporting an association between PD and insecticide use and show that workers in farms specialized in fruits or permanent crops may be an occupational group at higher PD risk...
  16. pmc Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, 75013, Paris, France
    Age (Dordr) 35:943-52. 2013
    ..39, 95% CI = 1.04-1.84). In conclusion, walking speed measured in late midlife seems to be an important marker of mortality risk; multiple factors, in particular inflammatory markers, partially explain this association...
  17. doi Association between Parkinson's disease and the HLA-DRB1 locus
    Ismail Ahmed
    INSERM, U708, Neuroepidemiology, Paris, France
    Mov Disord 27:1104-10. 2012
    ..The highly polymorphic HLA-DRB1 locus contains rs660895, which represents a more legitimate candidate than previous ones. Our finding is in agreement with the hypothesis of an immune component in PD pathophysiology...
  18. pmc Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Lancet Neurol 5:917-23. 2006
    ..Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain...
  19. pmc Timing of onset of cognitive decline: results from Whitehall II prospective cohort study
    Archana Singh-Manoux
    Institut National de la Sante et de la Recherche Medicale, U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, 94807 Villejuif Cedex, France
    BMJ 344:d7622. 2012
    ..To estimate 10 year decline in cognitive function from longitudinal data in a middle aged cohort and to examine whether age cohorts can be compared with cross sectional data to infer the effect of age on cognitive decline...
  20. doi Risk factors for spinal cord lesions in dystonic cerebral palsy and generalised dystonia
    Emilie Guettard
    AP HP, Department of Neurology, Groupe Hospitalier Pitie Salpetriere, Paris, France
    J Neurol Neurosurg Psychiatry 83:159-63. 2012
    ..The aim of this study is to identify the risk factors and clinical characteristics of CM in patients with generalised dystonia, including dystonic CP...
  21. doi Hypertension and lower walking speed in the elderly: the Three-City study
    Julien Dumurgier
    INSERM, U708, Hopital de la Salpetriere, Paris, France
    J Hypertens 28:1506-14. 2010
    ..The brain is one of the main targets of hypertension. However, little is known about the relation between hypertension and motor performances. We studied the association between hypertension and walking speed in a cohort of elderly people...
  22. doi Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study
    Richard H Tuligenga
    Inserm U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif, France Université Paris Sud 11, Paris, France
    Lancet Diabetes Endocrinol 2:228-35. 2014
    ..We investigated whether duration of diabetes in late midlife and poor glycaemic control were associated with accelerated cognitive decline...
  23. pmc Predicting cognitive decline: a dementia risk score vs. the Framingham vascular risk scores
    Sara Kaffashian
    INSERM, U1018, Centre for research in Epidemiology and Population Health, Villejuif Université de Versailles St Quentin, France
    Neurology 80:1300-6. 2013
    ..Our aim was to compare 2 Framingham vascular risk scores with a dementia risk score in relation to 10-year cognitive decline in late middle age...
  24. ncbi [Parkinson's disease and rural environment]
    Alexis Elbaz
    INSERM, U 708, Paris, F 75013, France
    Rev Prat 57:37-9. 2007
    ..However, some questions remain to be answered, particularly the role of low-dose exposure, the gene-environment interactions and the implied biological mechanisms...
  25. ncbi Epidemiologic studies of environmental exposures in Parkinson's disease
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, Hopital de la Salpetriere, Paris, France
    J Neurol Sci 262:37-44. 2007
    ..Understanding the mechanisms underlying these epidemiological associations is an essential step for the understanding of the etiology of this neurodegenerative condition and, ideally, to develop neuroprotective drugs...
  26. ncbi Polymorphism R92Q of the tumour necrosis factor receptor 1 gene is associated with myocardial infarction and carotid intima-media thickness--the ECTIM, AXA, EVA and GENIC Studies
    Odette Poirier
    INSERM U525, Epidemiologic and Molecular Genetics of Cardiovascular Diseases, Paris, France
    Eur J Hum Genet 12:213-9. 2004
    ..70 (0.09) vs 0.67 (0.13), P=0.02). No significant association of the 92Q allele was found with BI in the GENIC Study. Overall, these results may suggest that carriers of the 92Q allele may be at increased risk of atherosclerosis...
  27. ncbi Blood lipids in brain infarction subtypes
    Pierre Amarenco
    Department of Neurology and Stroke Centre, Bichat Hospital, Denis Diderot University, INSERM U 360, Paris, France
    Cerebrovasc Dis 22:101-8. 2006
    ..Little is known about the relationship between hypercholesterolaemia and specific aetiological subtypes of brain infarction (BI)...
  28. doi Predicting survival of patients with amyotrophic lateral sclerosis at presentation: a 15-year experience
    Paul H Gordon
    UMR_S 708, UPMC Universite Paris 06, Paris, France
    Neurodegener Dis 12:81-90. 2013
    ..To describe the clinical features at first evaluation that best predict survival of the amyotrophic lateral sclerosis (ALS) population from the Salpêtrière Hospital between 1995 and 2009...
  29. doi Update in the epidemiology of Parkinson's disease
    Alexis Elbaz
    INSERM, U708, Paris, F 75013, France
    Curr Opin Neurol 21:454-60. 2008
    ....
  30. ncbi Restoration of normal motor control in Parkinson's disease during REM sleep
    Valerie Cochen De Cock
    Service de Neurologie, Hopital Saint Antoine, Paris, France
    Brain 130:450-6. 2007
    ..These movements would eventually be transmitted to lower motor neurons because of brainstem lesions interrupting the pontomedullary pathways which mediate the REM sleep atonia...
  31. ncbi Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus
    Michael W M Schüpbach
    centre d investigation clinique, Fédération de Neurologie and National Institute of Health and Medical Research INSERM Unit 679 former Unit 289, Hopital de la Salpetriere, Paris, France
    Mov Disord 22:257-61. 2007
    ..6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1)...
  32. ncbi Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 296:661-70. 2006
    ..Alpha-synuclein (SNCA) has been one of the most promising susceptibility genes, but large-scale studies have been lacking...
  33. ncbi Interaction between genes and environment in neurodegenerative diseases
    Alexis Elbaz
    INSERM, U708 Neuroépidémiologie and université Pierre et Marie Curie Paris 6, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
    C R Biol 330:318-28. 2007
    ..A few interactions between the epsilon polymorphism and possible risk factors for AD have been described. However, these interactions had no biological plausibility and were likely due to chance...
  34. ncbi Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 22:1607-14. 2007
    ..These findings suggest that PD and ET may share familial susceptibility factors...
  35. ncbi Nonfatal cancer preceding Parkinson's disease: a case-control study
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Epidemiology 13:157-64. 2002
    ..We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer...
  36. ncbi Case-control study of estrogen receptor gene polymorphisms in Parkinson's disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 17:509-12. 2002
    ..While exogenous and endogenous estrogen may modify the risk of PD in women, the two estrogen receptor gene polymorphisms considered here do not seem to contribute to PD susceptibility...
  37. ncbi Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study
    Clotilde Levecque
    INSERM Unit 508 Institut Pasteur de Lille, 59019 Lille, France
    Hum Mol Genet 12:79-86. 2003
    ..05; nNOS 29, P=0.04). All together, these data favour an involvement of these two genes as new modifier genes in PD...
  38. ncbi Myeloperoxidase polymorphisms in brain infarction. Association with infarct size and functional outcome
    Aline Hoy
    INSERM Unite 525 equipe 4, Centre de Medecine Preventive, 2 Avenue du Doyen Jacques Parisot, 54501 Vandoeuvre Les Nancy, Nancy, France
    Atherosclerosis 167:223-30. 2003
    ..02). In conclusion, MPO polymorphisms were associated with the extent of brain damage and the functional outcome rather than with the risk of developing a BI...
  39. ncbi Risk of cancer after the diagnosis of Parkinson's disease: a historical cohort study
    Alexis Elbaz
    Departments of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Mov Disord 20:719-25. 2005
    ..Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications...
  40. ncbi UCHL1 is a Parkinson's disease susceptibility gene
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Ann Neurol 55:512-21. 2004
    ..These findings confirm that UCHL1 is a susceptibility gene for PD and a potential target for disease-modifying therapies...
  41. ncbi Chemical exposures and Parkinson's disease: a population-based case-control study
    Roberta Frigerio
    Division of Epidemiology, Department of Health Sciences Research, Mayo College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 21:1688-92. 2006
    ..This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women...
  42. ncbi Familial aggregation of Parkinson's disease: The Mayo Clinic family study
    Walter A Rocca
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 56:495-502. 2004
    ..62; 95% confidence interval, 1.66-4.15), whereas relatives of probands with later onset had no increased risk. The relative risk decreased when the incidence of all types of parkinsonism was considered...
  43. ncbi Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
    Julien Chapuis
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Hum Mol Genet 17:2863-7. 2008
    ..In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD...
  44. ncbi Complex segregation analysis of Parkinson's disease: The Mayo Clinic Family Study
    Shannon K McDonnell
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 59:788-95. 2006
    ..To conduct complex segregation analyses of Parkinson's disease (PD)...
  45. doi LRRK2: bridging the gap between sporadic and hereditary Parkinson's disease
    Alexis Elbaz
    Lancet Neurol 7:562-4. 2008
  46. ncbi Risk tables for parkinsonism and Parkinson's disease
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Epidemiol 55:25-31. 2002
    ..Lifetime risk estimates are useful in clinical practice, epidemiologic research, and public health...
  47. ncbi Survival study of Parkinson disease in Olmsted County, Minnesota
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Arch Neurol 60:91-6. 2003
    ..To compare survival in incident cases of Parkinson disease (PD) with survival in subjects free of PD from the general population...
  48. ncbi Risk of cognitive impairment or dementia in relatives of patients with Parkinson disease
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 64:1458-64. 2007
    ..The evidence for increased risk of dementia in relatives of patients with Parkinson disease (PD) remains conflicting...