S Eddahibi

Summary

Country: France

Publications

  1. ncbi Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin
    S Eddahibi
    Departement de Physiologie, INSERM U492, Creteil, France
    Circ Res 84:329-36. 1999
  2. ncbi Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia
    Saadia Eddahibi
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circulation 113:1857-64. 2006
  3. pmc Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery
    Edouard Sage
    UPRES EA2705, Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Respir Res 9:19. 2008
  4. pmc Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
    S Eddahibi
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 492, Departement de Physiologie, CHU Henri Mondor Assistance Publique Hopitaux de Paris, Creteil, France
    J Clin Invest 105:1555-62. 2000
  5. ncbi Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats
    S Eddahibi
    INSERM U492, Departement de Physiologie, Faculté de Médecine de Créteil, Hôpital H Mondor, 94010 Creteil, France
    J Pharmacol Exp Ther 297:148-54. 2001
  6. ncbi Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?
    Saadia Eddahibi
    Department of Physiology, INSERM U492, CHU Henri Mondor, 94010 Creteil, France
    J Lab Clin Med 139:194-201. 2002
  7. ncbi Lung overexpression of angiostatin aggravates pulmonary hypertension in chronically hypoxic mice
    Marie Aude Pascaud
    INSERM U492, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Am J Respir Cell Mol Biol 29:449-57. 2003
  8. ncbi Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice
    M Izikki
    1Institut National de la Santé et de la Recherche Médicale U841 and Département de Physiologie, Hôpital H Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Am J Physiol Lung Cell Mol Physiol 293:L1045-52. 2007
  9. doi Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension
    L Dewachter
    INSERM U955, Institut Mondor de Recherche Biomedicale, Creteil, France
    Eur Respir J 34:1100-10. 2009
  10. ncbi Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats
    S Eddahibi
    , Centre Hospitalier Universitaire Henri Mondor, Creteil, France
    Am J Physiol 272:H1173-81. 1997

Collaborators

Detail Information

Publications40

  1. ncbi Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin
    S Eddahibi
    Departement de Physiologie, INSERM U492, Creteil, France
    Circ Res 84:329-36. 1999
    ..In vivo expression of 5-HTT by PA-SMC may play a key role in serotonin-mediated pulmonary vascular remodeling...
  2. ncbi Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia
    Saadia Eddahibi
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circulation 113:1857-64. 2006
    ..We investigated the role of pulmonary microvascular endothelial cells (P-ECs) in controlling PA-SMC growth...
  3. pmc Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery
    Edouard Sage
    UPRES EA2705, Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Le Plessis Robinson, France
    Respir Res 9:19. 2008
    ..We hypothesized that endothelial dysfunction is related to increased endothelial-cell (EC) death...
  4. pmc Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
    S Eddahibi
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 492, Departement de Physiologie, CHU Henri Mondor Assistance Publique Hopitaux de Paris, Creteil, France
    J Clin Invest 105:1555-62. 2000
    ..This occurred despite potentiation of acute hypoxic pulmonary vasoconstriction in the 5-HTT(-/-) mice. These data further support a key role of 5-HTT in hypoxia-induced pulmonary vascular SMC proliferation and pulmonary hypertension...
  5. ncbi Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats
    S Eddahibi
    INSERM U492, Departement de Physiologie, Faculté de Médecine de Créteil, Hôpital H Mondor, 94010 Creteil, France
    J Pharmacol Exp Ther 297:148-54. 2001
    ..01) than in rats pretreated with the vehicle. These data show that, in rats, the increased 5-HTT expression that follows dexfenfluramine discontinuation promotes the development of hypoxic pulmonary hypertension...
  6. ncbi Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?
    Saadia Eddahibi
    Department of Physiology, INSERM U492, CHU Henri Mondor, 94010 Creteil, France
    J Lab Clin Med 139:194-201. 2002
    ....
  7. ncbi Lung overexpression of angiostatin aggravates pulmonary hypertension in chronically hypoxic mice
    Marie Aude Pascaud
    INSERM U492, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
    Am J Respir Cell Mol Biol 29:449-57. 2003
    ..K3. The results show that inhibition of hypoxia-induced stimulation of lung angiogenic processes aggravates development of hypoxic PH. This suggests that endogenous lung angiogenesis counteracts development of hypoxic PH...
  8. ncbi Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice
    M Izikki
    1Institut National de la Santé et de la Recherche Médicale U841 and Département de Physiologie, Hôpital H Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Am J Physiol Lung Cell Mol Physiol 293:L1045-52. 2007
    ..These results provide evidence that dysregulation of 5-HT synthesis is closely linked to the hypoxic PH phenotype in mice and that Tph1 and Tph2 may contribute to PH development...
  9. doi Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension
    L Dewachter
    INSERM U955, Institut Mondor de Recherche Biomedicale, Creteil, France
    Eur Respir J 34:1100-10. 2009
    ..Most heterogeneous BMPR-2 mutations are associated with defective Smad signalling compensated for by an activation of p38MAPK signalling, accounting for PASMC proliferation and deficient apoptosis...
  10. ncbi Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats
    S Eddahibi
    , Centre Hospitalier Universitaire Henri Mondor, Creteil, France
    Am J Physiol 272:H1173-81. 1997
    ..No changes occurred in 15% O2 hypoxic rats (n = 12 each). The present findings show that 5-HT potentiates development of pulmonary hypertension in rats exposed to chronic hypoxia...
  11. ncbi Pathobiology of pulmonary arterial hypertension
    S Eddahibi
    INSERM U492 and Dept of Physiology, Hôpital H Mondor, AP HP, Creteil, France
    Eur Respir J 20:1559-72. 2002
    ..This should soon lead to the development of new and more selective therapeutic approaches to pulmonary hypertension...
  12. ncbi Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice
    A Mekontso-Dessap
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 651, Departement de Physiologie, Universite Paris XII, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Circulation 113:81-9. 2006
    ..Here we investigated whether 5-HTT-deficient (5-HTT-KO) mice developed structural and/or functional cardiac abnormalities and valvulopathy...
  13. ncbi Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension
    H Lepetit
    INSERM U492, Dept de Physiologie, Faculte de Medecine, CHU Henri Mondor Créteil, 94010 Creteil, France
    Eur Respir J 25:834-42. 2005
    ..Whether these abnormalities are potential therapeutic targets deserves further investigation...
  14. ncbi The serotonin pathway in pulmonary hypertension
    S Eddahibi
    INSERM U651, Departement de Physiologie, Hopital Henri Mondor, Creteil
    Arch Mal Coeur Vaiss 99:621-5. 2006
    ..Agents capable of selectively inhibiting 5-HTT-mediated PA-SMC proliferation deserve to be investigated as potential treatments for pulmonary hypertension...
  15. ncbi [Serotonin and pulmonary arterial hypertension]
    S Eddahibi
    INSERM U651 et Département de Physiologie, Hopital Henri Mondor, AP HP, Creteil, France
    Rev Mal Respir 23:4S45-4S51. 2006
    ..Pulmonary arterial hypertension (PAH) is related to hypertrophic remodelling of the pulmonary vessels. Proliferation of pulmonary vascular smooth muscle cells (PA-SMCs) plays a key role in these changes...
  16. ncbi Hyperplasia of pulmonary artery smooth muscle cells is causally related to overexpression of the serotonin transporter in primary pulmonary hypertension
    Saadia Eddahibi
    INSERM U492 et Departement de Physiologie, Creteil, France
    Chest 121:97S-98S. 2002
  17. doi Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension
    Frederic Perros
    Centre National de Référence de l Hypertension Artérielle Pulmonaire, Service de Pneumologie et Reanimation Respiratoire, Institut Paris Sud Cytokines, Hopital Antoine Beclere, Universite Paris Sud 11, UPRES EA 2705, Clamart, France
    Am J Respir Crit Care Med 178:81-8. 2008
    ....
  18. ncbi Vascular-wall remodeling of 3 human bypass vessels: organ culture and smooth muscle cell properties
    Armand Mekontso-Dessap
    Institut National de la Sante et de la Recherche Medicale, Faculté de Médecine de Créteil, Creteil, France
    J Thorac Cardiovasc Surg 131:651-8. 2006
    ..The aim of the present study was to compare the vascular-wall remodeling of human internal thoracic artery, radial artery, and saphenous vein bypass conduits...
  19. ncbi Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension
    Christophe Guignabert
    INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
    Circ Res 98:1323-30. 2006
    ..They further support a central role for 5-HTT in the pathogenesis of PH, making 5-HTT a potential therapeutic target...
  20. ncbi Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension
    Olivier Sanchez
    INSERM U841 and Département de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, Creteil, France
    Am J Respir Crit Care Med 176:1041-7. 2007
    ..CC chemokine ligand 2 (CCL2) is synthesized by vascular cells and can stimulate monocyte/macrophage migration and smooth muscle cell (SMC) proliferation...
  21. ncbi Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension
    Laurence Dewachter
    INSERM U651, Faculte de Medecine, 8, rue Général Sarrail, Creteil, France
    Am J Respir Crit Care Med 174:1025-33. 2006
    ..Angiopoietins are involved in blood vessel maturation and remodeling...
  22. pmc Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice
    William Raoul
    Unité INSERM TGU841 Université Paris XII, Creteil, France
    Respir Res 8:8. 2007
    ..Bone marrow -derived cells (BMDCs) can either limit or contribute to the process of pulmonary vascular remodeling. Whether the difference in their effects depends on the mechanism of pulmonary hypertension (PH) remains unknown...
  23. ncbi Granulocyte colony-stimulating factor enhances alpha-naphthylthiourea-induced pulmonary hypertension
    Elie Azoulay
    Institut National de la Santè et de la Recherche Mèdicale U492, Faculté de Médecine Université Paris XII, 75475 Paris, France
    J Appl Physiol 94:2027-33. 2003
    ..Repeated ANTU administration induces PH with vascular remodeling that can be further aggravated by the neutrophil activator G-CSF...
  24. ncbi Regression of postobstructive vasculopathy after revascularization of chronically obstructed pulmonary artery
    Elie Fadel
    Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Universite Paris Sud, France
    J Thorac Cardiovasc Surg 127:1009-17. 2004
    ..We hypothesized that postobstructive pulmonary vasculopathy may regress after reperfusion in a piglet model of chronic (5 weeks) left pulmonary artery obstruction...
  25. ncbi Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats
    Antoine Vieillard-Baron
    INSERM U492, Faculte de Medecine, 94010 Creteil, France
    Hum Gene Ther 14:861-9. 2003
    ..hTIMP-1-treated rats. These data support a deleterious role for proteases in toxic and inflammatory PH and indicate that MMPs may have opposite effects in different PH models...
  26. ncbi Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertension
    Elisabeth Marcos
    INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, Creteil, France
    Circ Res 94:1263-70. 2004
    ..We conclude that 5-HTT overexpression is a common pathogenic mechanism in various forms of PH...
  27. ncbi Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension
    Elisabeth Marcos
    INSERM U492, Faculte de Medecine, CHU Henri Mondor, 94010 Creteil, France
    Am J Respir Crit Care Med 168:487-93. 2003
    ..These data indicate that 5-HTT plays a key role in hypoxia-induced pulmonary vascular remodeling. The effects of serotonin transporter inhibitors on PH in humans deserve investigation...
  28. ncbi [Genetics and physiopathology of primary or secondary pulmonary artery hypertension]
    Serge Adnot
    INSERM U492 Département de Physiologie Explorations Fonctionnelles Hôpital H Mondor AP HP Faculté de Médecine de Créteil, 94010 Creteil, France
    Bull Acad Natl Med 187:1529-42; discussion 1543-5. 2003
    ..This should lead soon to the development of new and more selective therapeutic approaches to pulmonary hypertension...
  29. ncbi Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension
    Vanessa Louzier
    Departement de Physiologie, Institut National de la Santé et de La Recherche Médicale Unité 492, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, 94010 Creteil, France
    Am J Physiol Lung Cell Mol Physiol 284:L926-37. 2003
    ..However, when overexpressed in the lung, VEGF-B can be as potent as VEGF-A in attenuating pulmonary hypertension, although it has no effect on eNOS expression or vascular permeability...
  30. ncbi Cardiac modulations of ANG II receptor expression in rats with hypoxic pulmonary hypertension
    Christophe Adamy
    Institut National de la Santé et de la Recherche Médicale INSERM U127 572, Institut Fédératif de Recherche Circulation Paris VII, Hopital Lariboisiere, Universite Denis Diderot, 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, France
    Am J Physiol Heart Circ Physiol 283:H733-40. 2002
    ....
  31. ncbi Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats
    Christophe Guignabert
    Departement de Physiologie, INSERM U492, AP HP, CHU Henri Mondor, Creteil, France
    Circulation 111:2812-9. 2005
    ..Selective 5-HT(1B/1D), 5-HT(2A), and 5-HT(2B) receptor antagonists were used for comparative testing...
  32. ncbi Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease
    Saadia Eddahibi
    INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, 94010 Creteil, France
    Circulation 108:1839-44. 2003
    ..Because hypoxia and 5-HTT gene polymorphism control 5-HTT expression, we examined 5-HTT gene polymorphism and PH in hypoxemic patients with advanced chronic obstructive pulmonary disease (COPD)...
  33. pmc Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis
    Saadia Eddahibi
    INSERM U492, Departement de Physiologie, Hôpital H Mondor, Creteil, France
    Respir Res 3:9. 2002
    ....
  34. ncbi Decrease in lung nitric oxide production after peritonitis in mice with sickle cell disease
    Pablo Bartolucci
    Unité INSERM U492 Université Paris XII, Creteil, and Laboratoire de Thérapie Génique Hématopoïétique, Hopital Saint Louis, Paris, France
    Crit Care Med 35:502-9. 2007
    ....
  35. ncbi Interleukin-6 gene polymorphism confers susceptibility to pulmonary hypertension in chronic obstructive pulmonary disease
    Saadia Eddahibi
    INSERM U492 and Département de Physiologie, Hôpital H Mondor, Creteil, France
    Proc Am Thorac Soc 3:475-476. 2006
  36. ncbi Serotonin transporter and receptors in various forms of human pulmonary hypertension
    Elisabeth Marcos
    INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Creteil, Paris, France
    Chest 128:552S-553S. 2005
  37. ncbi Decreased exhaled nitric oxide as a marker of postinsult immune paralysis
    Habiba L Attalah
    Institut National de la Santé et de la Recherche Medicale U492 Université Paris XII, France
    J Appl Physiol 97:1188-94. 2004
    ..8 (3.9-5.7) vs. 1.6 (1.3-1.7) ppb, respectively, P < 0.05]. In conclusion, the decrease in exhaled NO observed after mild peritonitis could serve as a marker for lung immunodepression...
  38. ncbi Genetic basis of pulmonary arterial hypertension: current understanding and future directions
    John H Newman
    Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom
    J Am Coll Cardiol 43:33S-39S. 2004
    ..Advances in genetic testing, presymptomatic screening, and biomarkers should permit early detection of disease in those at risk of PAH and allow trials of preventive therapy in carriers...
  39. ncbi From functional to genetic studies of a candidate gene for pulmonary hypertension: Any point?
    Saadia Eddahibi
    Am J Respir Crit Care Med 173:693-4. 2006
  40. ncbi Serotonin in pulmonary arterial hypertension
    Robert Naeije
    Am J Respir Crit Care Med 170:209-10. 2004