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Genomes and Genes | S EddahibiSummaryCountry: France Publications
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Publications
Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotoninS Eddahibi
Departement de Physiologie, INSERM U492, Creteil, France
Circ Res 84:329-36. 1999..In vivo expression of 5-HTT by PA-SMC may play a key role in serotonin-mediated pulmonary vascular remodeling...- Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasiaSaadia Eddahibi
INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
Circulation 113:1857-64. 2006..We investigated the role of pulmonary microvascular endothelial cells (P-ECs) in controlling PA-SMC growth... 
Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary arteryEdouard Sage
UPRES EA2705, Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Le Plessis Robinson, France
Respir Res 9:19. 2008..We hypothesized that endothelial dysfunction is related to increased endothelial-cell (EC) death...- Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter geneS Eddahibi
Institut National de la Santé et de la Recherche Médicale INSERM Unité 492, Departement de Physiologie, CHU Henri Mondor Assistance Publique Hopitaux de Paris, Creteil, France
J Clin Invest 105:1555-62. 2000..This occurred despite potentiation of acute hypoxic pulmonary vasoconstriction in the 5-HTT(-/-) mice. These data further support a key role of 5-HTT in hypoxia-induced pulmonary vascular SMC proliferation and pulmonary hypertension... - Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in ratsS Eddahibi
INSERM U492, Departement de Physiologie, Faculté de Médecine de Créteil, Hôpital H Mondor, 94010 Creteil, France
J Pharmacol Exp Ther 297:148-54. 2001..01) than in rats pretreated with the vehicle. These data show that, in rats, the increased 5-HTT expression that follows dexfenfluramine discontinuation promotes the development of hypoxic pulmonary hypertension... - Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?Saadia Eddahibi
Department of Physiology, INSERM U492, CHU Henri Mondor, 94010 Creteil, France
J Lab Clin Med 139:194-201. 2002.... - Lung overexpression of angiostatin aggravates pulmonary hypertension in chronically hypoxic miceMarie Aude Pascaud
INSERM U492, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
Am J Respir Cell Mol Biol 29:449-57. 2003..K3. The results show that inhibition of hypoxia-induced stimulation of lung angiogenic processes aggravates development of hypoxic PH. This suggests that endogenous lung angiogenesis counteracts development of hypoxic PH... - Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in miceM Izikki
1Institut National de la Santé et de la Recherche Médicale U841 and Département de Physiologie, Hôpital H Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
Am J Physiol Lung Cell Mol Physiol 293:L1045-52. 2007..These results provide evidence that dysregulation of 5-HT synthesis is closely linked to the hypoxic PH phenotype in mice and that Tph1 and Tph2 may contribute to PH development... - Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic ratsS Eddahibi
, Centre Hospitalier Universitaire Henri Mondor, Creteil, France
Am J Physiol 272:H1173-81. 1997..No changes occurred in 15% O2 hypoxic rats (n = 12 each). The present findings show that 5-HT potentiates development of pulmonary hypertension in rats exposed to chronic hypoxia... 
Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertensionL Dewachter
INSERM U955, Institut Mondor de Recherche Biomedicale, Creteil, France
Eur Respir J 34:1100-10. 2009..Most heterogeneous BMPR-2 mutations are associated with defective Smad signalling compensated for by an activation of p38MAPK signalling, accounting for PASMC proliferation and deficient apoptosis...- Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in miceA Mekontso-Dessap
Institut National de la Santé et de la Recherche Médicale INSERM Unité 651, Departement de Physiologie, Universite Paris XII, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
Circulation 113:81-9. 2006..Here we investigated whether 5-HTT-deficient (5-HTT-KO) mice developed structural and/or functional cardiac abnormalities and valvulopathy... - Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertensionH Lepetit
INSERM U492, Dept de Physiologie, Faculte de Medecine, CHU Henri Mondor Créteil, 94010 Creteil, France
Eur Respir J 25:834-42. 2005..Whether these abnormalities are potential therapeutic targets deserves further investigation... - Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertensionOlivier Sanchez
INSERM U841 and Département de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, Creteil, France
Am J Respir Crit Care Med 176:1041-7. 2007..CC chemokine ligand 2 (CCL2) is synthesized by vascular cells and can stimulate monocyte/macrophage migration and smooth muscle cell (SMC) proliferation... - Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in ratsChristophe Guignabert
, INSERM U492, AP-HP, CHU Henri Mondor, , France
Circulation 111:2812-9. 2005..Complete reversal of established PH by fluoxetine provides a rationale for new therapeutic strategies in human PH... - Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertensionVanessa Louzier
Departement de Physiologie, Institut National de la Santé et de La Recherche Médicale Unité 492, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, 94010 Creteil, France
Am J Physiol Lung Cell Mol Physiol 284:L926-37. 2003..However, when overexpressed in the lung, VEGF-B can be as potent as VEGF-A in attenuating pulmonary hypertension, although it has no effect on eNOS expression or vascular permeability... - Vascular-wall remodeling of 3 human bypass vessels: organ culture and smooth muscle cell propertiesArmand Mekontso-Dessap
Institut National de la Sante et de la Recherche Medicale, Faculté de Médecine de Créteil, Creteil, France
J Thorac Cardiovasc Surg 131:651-8. 2006..The aim of the present study was to compare the vascular-wall remodeling of human internal thoracic artery, radial artery, and saphenous vein bypass conduits... - Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertensionFrederic Perros
Centre National de Référence de l Hypertension Artérielle Pulmonaire, Service de Pneumologie et Reanimation Respiratoire, Institut Paris Sud Cytokines, Hopital Antoine Beclere, Universite Paris Sud 11, UPRES EA 2705, Clamart, France
Am J Respir Crit Care Med 178:81-8. 2008.... - Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertensionLaurence Dewachter
INSERM U651, Faculte de Medecine, 8, rue Général Sarrail, Creteil, France
Am J Respir Crit Care Med 174:1025-33. 2006..Angiopoietins are involved in blood vessel maturation and remodeling... - Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in miceWilliam Raoul
Unité INSERM TGU841 Université Paris XII, Creteil, France
Respir Res 8:8. 2007..Bone marrow -derived cells (BMDCs) can either limit or contribute to the process of pulmonary vascular remodeling. Whether the difference in their effects depends on the mechanism of pulmonary hypertension (PH) remains unknown... - Hyperplasia of pulmonary artery smooth muscle cells is causally related to overexpression of the serotonin transporter in primary pulmonary hypertensionSaadia Eddahibi
INSERM U492 et Departement de Physiologie, , France
Chest 121:97S-98S. 2002 - Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertensionChristophe Guignabert
INSERM U651, Departement de Physiologie, Hôpital H Mondor, AP HP, Creteil, France
Circ Res 98:1323-30. 2006..They further support a central role for 5-HTT in the pathogenesis of PH, making 5-HTT a potential therapeutic target... - Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary diseaseSaadia Eddahibi
INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, AP HP, 94010 Creteil, France
Circulation 108:1839-44. 2003..Because hypoxia and 5-HTT gene polymorphism control 5-HTT expression, we examined 5-HTT gene polymorphism and PH in hypoxemic patients with advanced chronic obstructive pulmonary disease (COPD)... - Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in ratsAntoine Vieillard-Baron
INSERM U492, Faculte de Medecine, 94010 Creteil, France
Hum Gene Ther 14:861-9. 2003..hTIMP-1-treated rats. These data support a deleterious role for proteases in toxic and inflammatory PH and indicate that MMPs may have opposite effects in different PH models... - Regression of postobstructive vasculopathy after revascularization of chronically obstructed pulmonary arteryElie Fadel
Laboratoire de Chirurgie Experimentale, Hopital Marie Lannelongue, Universite Paris Sud, France
J Thorac Cardiovasc Surg 127:1009-17. 2004..We hypothesized that postobstructive pulmonary vasculopathy may regress after reperfusion in a piglet model of chronic (5 weeks) left pulmonary artery obstruction... - Serotonin-induced smooth muscle hyperplasia in various forms of human pulmonary hypertensionElisabeth Marcos
INSERM U492 and Service de Physiologie Explorations Fonctionnelles, Hôpital H Mondor, Creteil, France
Circ Res 94:1263-70. 2004..We conclude that 5-HTT overexpression is a common pathogenic mechanism in various forms of PH... - Serotonin transporter inhibitors protect against hypoxic pulmonary hypertensionElisabeth Marcos
INSERM U492, , CHU Henri Mondor, , France
Am J Respir Crit Care Med 168:487-93. 2003..These data indicate that 5-HTT plays a key role in hypoxia-induced pulmonary vascular remodeling. The effects of serotonin transporter inhibitors on PH in humans deserve investigation... - [Genetics and physiopathology of primary or secondary pulmonary artery hypertension]Serge Adnot
INSERM U492 Département de Physiologie Explorations Fonctionnelles Hôpital H Mondor AP HP Faculté de Médecine de Créteil, 94010 Creteil, France
Bull Acad Natl Med 187:1529-42; discussion 1543-5. 2003..This should lead soon to the development of new and more selective therapeutic approaches to pulmonary hypertension... - Cardiac modulations of ANG II receptor expression in rats with hypoxic pulmonary hypertensionChristophe Adamy
, , , , 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, France
Am J Physiol Heart Circ Physiol 283:H733-40. 2002.... - Granulocyte colony-stimulating factor enhances alpha-naphthylthiourea-induced pulmonary hypertensionElie Azoulay
, , 75475 Paris, France
J Appl Physiol 94:2027-33. 2003..Repeated ANTU administration induces PH with vascular remodeling that can be further aggravated by the neutrophil activator G-CSF... - Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesisSaadia Eddahibi
INSERM U492, , , , France
Respir Res 3:9. 2002.... - Serotonin in pulmonary arterial hypertensionRobert Naeije
Am J Respir Crit Care Med 170:209-10. 2004 - Decrease in lung nitric oxide production after peritonitis in mice with sickle cell diseasePablo Bartolucci
Unité INSERM U492 Université Paris XII, Creteil, and Laboratoire de Thérapie Génique Hématopoïétique, Hopital Saint Louis, Paris, France
Crit Care Med 35:502-9. 2007.... - Interleukin-6 gene polymorphism confers susceptibility to pulmonary hypertension in chronic obstructive pulmonary diseaseSaadia Eddahibi
, , Creteil, France
Proc Am Thorac Soc 3:475-476. 2006 - Decreased exhaled nitric oxide as a marker of postinsult immune paralysisHabiba L Attalah
, France
J Appl Physiol 97:1188-94. 2004..8 (3.9-5.7) vs. 1.6 (1.3-1.7) ppb, respectively, P < 0.05]. In conclusion, the decrease in exhaled NO observed after mild peritonitis could serve as a marker for lung immunodepression... - From functional to genetic studies of a candidate gene for pulmonary hypertension: Any point?Saadia Eddahibi
Am J Respir Crit Care Med 173:693-4. 2006 - Serotonin transporter and receptors in various forms of human pulmonary hypertensionElisabeth Marcos
INSERM U492 and Service de Physiologie Explorations Fonctionnelles, , Paris, France
Chest 128:552S-553S. 2005 - Genetic basis of pulmonary arterial hypertension: current understanding and future directionsJohn H Newman
Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom
J Am Coll Cardiol 43:33S-39S. 2004..Advances in genetic testing, presymptomatic screening, and biomarkers should permit early detection of disease in those at risk of PAH and allow trials of preventive therapy in carriers...