Laurent Schwartz

Summary

Affiliation: Ecole Polytechnique
Country: France

Publications

  1. ncbi request reprint Metabolic treatment of cancer: intermediate results of a prospective case series
    Laurent Schwartz
    Ecole Polytechnique Laboratoire LIX, 91128 Palaiseau, France
    Anticancer Res 34:973-80. 2014
  2. doi request reprint Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin
    Laurent Schwartz
    Ecole Polytechnique, Laboratoire d Informatique, Palaiseau, France
    Invest New Drugs 31:256-64. 2013
  3. pmc The metabolic advantage of tumor cells
    Maurice Israël
    Ecole Polytechnique Palaiseau 91128 and Hôpital Raymond Poincaré, 104 Bd Raymond Poincaré Garches 92380m, France
    Mol Cancer 10:70. 2011
  4. doi request reprint Hyperosmotic stress contributes to mouse colonic inflammation through the methylation of protein phosphatase 2A
    Laurent Schwartz
    Service de Radiothérapie Hôpital Pitié Salpétrière, Bd de l Hopital, 75013 Paris, France
    Am J Physiol Gastrointest Liver Physiol 295:G934-41. 2008
  5. doi request reprint Carbon dioxide is largely responsible for the acute inflammatory effects of tobacco smoke
    Laurent Schwartz
    Service de Radiotherapie, AP HP Hopital Pitie Salpetriere, Boulevard de l Hopital, Paris, France
    Inhal Toxicol 22:543-51. 2010
  6. ncbi request reprint A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results
    Laurent Schwartz
    Service de Radiothérapie Hôpital Pitié Salpétrière, Bd de l Hopital, 75013 Paris, France
    Oncol Rep 23:1407-16. 2010
  7. pmc Is inflammation a consequence of extracellular hyperosmolarity?
    Laurent Schwartz
    Service de Radiothérapie Hôpital Pitié Salpétrière, Paris, 75013 France
    J Inflamm (Lond) 6:21. 2009
  8. doi request reprint Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice
    Mohammad Abolhassani
    Biorébus, Paris, France
    Invest New Drugs 30:1331-42. 2012
  9. doi request reprint Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report
    Adeline Guais
    Biorébus, Paris, France
    Invest New Drugs 30:200-11. 2012
  10. doi request reprint Carbon dioxide inhalation causes pulmonary inflammation
    Mohammad Abolhassani
    Service de Radiothérapie Hôpital Pitié Salpétrière, 75013 Paris, France
    Am J Physiol Lung Cell Mol Physiol 296:L657-65. 2009

Collaborators

  • Maurice Israël
  • Annie J Sasco
  • Philippe Icard
  • Adeline Guais
  • Mohammad Abolhassani
  • Edward Sanders
  • Giammaria Fiorentini
  • Frederic Campion
  • Gianfranco Baronzio
  • Jacques Bonte
  • Iduna Fichtner
  • Carlo Mainini
  • Francesco Montagnani
  • Mahsa Behzadi
  • Mireille Regnier
  • Gerard Brand
  • Georges Grevillot
  • Laurence Jacquot
  • Sam Dukan
  • Thierry Jo Molina
  • Melanie Karrer
  • Philippe Chaumet-Riffaud

Detail Information

Publications11

  1. ncbi request reprint Metabolic treatment of cancer: intermediate results of a prospective case series
    Laurent Schwartz
    Ecole Polytechnique Laboratoire LIX, 91128 Palaiseau, France
    Anticancer Res 34:973-80. 2014
    ..The combination of hydroxycitrate and lipoic acid has been demonstrated by several laboratories to be effective in reducing murine cancer growth...
  2. doi request reprint Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin
    Laurent Schwartz
    Ecole Polytechnique, Laboratoire d Informatique, Palaiseau, France
    Invest New Drugs 31:256-64. 2013
    ..The dramatic efficacy of treatment suggests that cancer may simply be a disease of dysregulated cellular metabolism...
  3. pmc The metabolic advantage of tumor cells
    Maurice Israël
    Ecole Polytechnique Palaiseau 91128 and Hôpital Raymond Poincaré, 104 Bd Raymond Poincaré Garches 92380m, France
    Mol Cancer 10:70. 2011
    ..6- An excess of IGF induces a decrease of the major histocompatibility complex MHC1, Natural killer lymphocytes should eliminate such cells that start the tumor, unless the fever prostaglandin PGE2 or inflammation, inhibit them.....
  4. doi request reprint Hyperosmotic stress contributes to mouse colonic inflammation through the methylation of protein phosphatase 2A
    Laurent Schwartz
    Service de Radiothérapie Hôpital Pitié Salpétrière, Bd de l Hopital, 75013 Paris, France
    Am J Physiol Gastrointest Liver Physiol 295:G934-41. 2008
    ..Short inhibiting RNAs (siRNAs) targeted toward PP2Ac reverse the effect of hyperosmotic DSS. The present study strongly suggests that DSS-induced chronic colitis is a consequence of the methylation of PP2Ac induced by hyperosmolarity...
  5. doi request reprint Carbon dioxide is largely responsible for the acute inflammatory effects of tobacco smoke
    Laurent Schwartz
    Service de Radiotherapie, AP HP Hopital Pitie Salpetriere, Boulevard de l Hopital, Paris, France
    Inhal Toxicol 22:543-51. 2010
    ..Given that there is an extensive literature linking a chronic inflammatory response to the major smoking-related diseases, these data suggest that carbon dioxide may play a key role in the causation of these diseases by tobacco smoking...
  6. ncbi request reprint A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results
    Laurent Schwartz
    Service de Radiothérapie Hôpital Pitié Salpétrière, Bd de l Hopital, 75013 Paris, France
    Oncol Rep 23:1407-16. 2010
    ..This preliminary study suggests that this combination of drugs is efficient against cancer cell proliferation both in vitro and in vivo. A clinical trial is warranted...
  7. pmc Is inflammation a consequence of extracellular hyperosmolarity?
    Laurent Schwartz
    Service de Radiothérapie Hôpital Pitié Salpétrière, Paris, 75013 France
    J Inflamm (Lond) 6:21. 2009
    ....
  8. doi request reprint Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice
    Mohammad Abolhassani
    Biorébus, Paris, France
    Invest New Drugs 30:1331-42. 2012
    ..The effectiveness of this combination in several animal models, as well as the low toxicity of these inexpensive drugs, emphasizes the necessity of rapidly setting up a clinical trial...
  9. doi request reprint Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report
    Adeline Guais
    Biorébus, Paris, France
    Invest New Drugs 30:200-11. 2012
    ..The in vivo data, coupled with the case study results, suggest a possible advantage in using a treatment targeted at cancer metabolism in association with classical chemotherapy...
  10. doi request reprint Carbon dioxide inhalation causes pulmonary inflammation
    Mohammad Abolhassani
    Service de Radiothérapie Hôpital Pitié Salpétrière, 75013 Paris, France
    Am J Physiol Lung Cell Mol Physiol 296:L657-65. 2009
    ..In conclusion, this study strongly suggests that exposure to carbon dioxide may be more toxic than previously thought. This may be relevant for carcinogenic effects of combustion products...
  11. doi request reprint Toxicity of carbon dioxide: a review
    Adeline Guais
    Biorébus, Paris, France
    Chem Res Toxicol 24:2061-70. 2011
    ..As smokers are exposed to a high level of carbon dioxide (13%) that is about 350 times the level in normal air, we propose the hypothesis that carbon dioxide plays a major role in the long term toxicity of tobacco smoke...