Charles Duyckaerts

Summary

Country: France

Publications

  1. ncbi request reprint [Update on the pathophysiology of Parkinson' disease]
    Charles Duyckaerts
    Laboratoire de neuropathologie Escourolle Hôpital de la Pitié Salpêtrière 47 bld de l Hôpital, 75651 Paris Cedex 13
    Bull Acad Natl Med 194:1287-303; discussion 1303-4. 2010
  2. doi request reprint Neuropathologic classification of dementias: introduction
    Charles Duyckaerts
    Escourolle Neuropathology Laboratory, La Salpetriere Hospital, Paris, France
    Handb Clin Neurol 89:147-59. 2008
  3. doi request reprint Neurodegenerative lesions: seeding and spreading
    C Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Pitie Salpetriere, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France Centre de recherche de l ICM, équipe Alzheimer Prion, 47, Boulevard de l Hopital, 750713 Paris, France Electronic address
    Rev Neurol (Paris) 169:825-33. 2013
  4. ncbi request reprint [Progress in neuropathology changes the understanding of neurodegenerative diseases]
    Charles Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Groupe Hospitalier Pitie Salpetriere, AP HP, 75013 Paris, France
    Rev Prat 63:655-61. 2013
  5. doi request reprint [Morphologic and molecular neuropathology of Alzheimer's disease]
    C Duyckaerts
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, AP HP, Paris, France
    Ann Pharm Fr 67:127-35. 2009
  6. doi request reprint Classification and basic pathology of Alzheimer disease
    Charles Duyckaerts
    Laboratoire de Neuropathologie Escourolle, APHP, Hôpital de La Salpêtrière et Université Pierre et Marie Curie, Paris Universitas, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Acta Neuropathol 118:5-36. 2009
  7. ncbi request reprint [The lesions of Alzheimer's disease: which therapeutic perspectives?]
    Charles Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Groupe Hospitalier Pitie Salpetriere, 75651 Paris
    Bull Acad Natl Med 192:303-18; discussion 318-21. 2008
  8. ncbi request reprint [Nosology of dementias: the neuropathologist's point of view]
    C Duyckaerts
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, Paris, France
    Rev Neurol (Paris) 162:921-8. 2006
  9. pmc Alzheimer disease models and human neuropathology: similarities and differences
    Charles Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Acta Neuropathol 115:5-38. 2008
  10. doi request reprint A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
    Sandrine Greffard
    Geriatrics Centre, Pavillon M Bottard, La Salpetriere Hospital, Pierre and Marie Curie Paris VI University, Paris, France
    Neurobiol Aging 31:99-103. 2010

Detail Information

Publications91

  1. ncbi request reprint [Update on the pathophysiology of Parkinson' disease]
    Charles Duyckaerts
    Laboratoire de neuropathologie Escourolle Hôpital de la Pitié Salpêtrière 47 bld de l Hôpital, 75651 Paris Cedex 13
    Bull Acad Natl Med 194:1287-303; discussion 1303-4. 2010
    ..Non-autonomous cell death, caused by neuro-inflammation or gliosis, has also been incriminated...
  2. doi request reprint Neuropathologic classification of dementias: introduction
    Charles Duyckaerts
    Escourolle Neuropathology Laboratory, La Salpetriere Hospital, Paris, France
    Handb Clin Neurol 89:147-59. 2008
  3. doi request reprint Neurodegenerative lesions: seeding and spreading
    C Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Pitie Salpetriere, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France Centre de recherche de l ICM, équipe Alzheimer Prion, 47, Boulevard de l Hopital, 750713 Paris, France Electronic address
    Rev Neurol (Paris) 169:825-33. 2013
    ..These data suggest that the protein that accumulates in a specific disease is initially misfolded and that this misfolding contaminates normal protein in a prion-like manner - in some cases through the neuronal connections. ..
  4. ncbi request reprint [Progress in neuropathology changes the understanding of neurodegenerative diseases]
    Charles Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Groupe Hospitalier Pitie Salpetriere, AP HP, 75013 Paris, France
    Rev Prat 63:655-61. 2013
    ....
  5. doi request reprint [Morphologic and molecular neuropathology of Alzheimer's disease]
    C Duyckaerts
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, AP HP, Paris, France
    Ann Pharm Fr 67:127-35. 2009
    ..The link between altered Abeta peptide metabolism and tau pathology has not been fully elucidated. Animal models mimic several aspects of the disease and have contributed to a better understanding of the mechanisms of the lesions...
  6. doi request reprint Classification and basic pathology of Alzheimer disease
    Charles Duyckaerts
    Laboratoire de Neuropathologie Escourolle, APHP, Hôpital de La Salpêtrière et Université Pierre et Marie Curie, Paris Universitas, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Acta Neuropathol 118:5-36. 2009
    ....
  7. ncbi request reprint [The lesions of Alzheimer's disease: which therapeutic perspectives?]
    Charles Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Groupe Hospitalier Pitie Salpetriere, 75651 Paris
    Bull Acad Natl Med 192:303-18; discussion 318-21. 2008
    ..Post mortem studies showed a relative scarcity of Abeta deposits. Forthcoming immunotherapy studies should soon show whether the prevention of Abeta deposition interrupts disease progression...
  8. ncbi request reprint [Nosology of dementias: the neuropathologist's point of view]
    C Duyckaerts
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, Paris, France
    Rev Neurol (Paris) 162:921-8. 2006
    ..It should however be stressed that whenever their composition has been elucidated, the inclusions have given important clues to the pathogenesis of the disease in which they had been found...
  9. pmc Alzheimer disease models and human neuropathology: similarities and differences
    Charles Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Acta Neuropathol 115:5-38. 2008
    ..A number of modulators of Abeta or of tau accumulation have been tested. A transgenic model may be analyzed at three levels at least (symptoms, lesions, cause of the disease), and a reading key is proposed to summarize this analysis...
  10. doi request reprint A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
    Sandrine Greffard
    Geriatrics Centre, Pavillon M Bottard, La Salpetriere Hospital, Pierre and Marie Curie Paris VI University, Paris, France
    Neurobiol Aging 31:99-103. 2010
    ..With the hypothesis that neuronal death is directly related to Lewy bodies, it is possible to estimate their life span, which was calculated to be 6.2 months (15.9 months for any type of alpha-synuclein inclusion)...
  11. ncbi request reprint Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions
    Danielle Seilhean
    Laboratoire de Neuropathologie Raymond Escourolle, INSERM U360, Association Claude Bernard, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    Acta Neuropathol 108:81-7. 2004
    ..At the ultrastructural level, the nuclear inclusions were made of straight filaments (10-12 nm in diameter) arranged at random, reminiscent of the polyglutamine intranuclear hyaline inclusions...
  12. ncbi request reprint PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases
    Junko Takahashi
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, AP HP, Paris, France
    Neurobiol Dis 13:230-7. 2003
    ..These data suggest that NIIs originate from nuclear bodies, where mutant proteins accumulate for degradation...
  13. pmc Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice
    Dominique Langui
    Laboratoire de Neuropathologie Raymond Escourolle, Groupe Hospitalier Pitie Salpetriere, 47, Boulevard de l Hopital, 75013 Paris, France
    Am J Pathol 165:1465-77. 2004
    ..Multivesicular bodies could secondarily liberate their content in the extracellular space as suggested by the association of cathepsin D with Abeta peptide in the extracellular space...
  14. ncbi request reprint Cerebral amyloid angiopathy in the elderly: vessel walls changes and relationship with dementia
    Dina Zekry
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, INSERM U 106 and 360, Association Claude Bernard, Pierre et Marie Curie University, 47 bd de l Hopital, 75013 Paris, France
    Acta Neuropathol 106:367-73. 2003
    ....
  15. ncbi request reprint C9ORF72 repeat expansions in the frontotemporal dementias spectrum of diseases: a flow-chart for genetic testing
    Isabelle Le Ber
    CRicm UMRS975, Paris, France AP HP, Hopital de la Pitie Salpetriere, Centre de Référence des Démences Rares, Paris, France
    J Alzheimers Dis 34:485-99. 2013
    ..Penetrance was age- and gender-dependent: by age 50, 78% of male carriers were symptomatic, but only 52% of females. This can also guide genetic testing and counseling. A flowchart for genetic testing is thus proposed...
  16. ncbi request reprint [Vascular dementia and mixed dementia]
    Dina Zekry
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, Paris 75
    Presse Med 36:1469-76. 2007
    ..Preventive therapeutic interventions include control of vascular risk factors and especially treatment of hypertension...
  17. doi request reprint SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7
    Alexandre Janer
    INSERM, UMRS 975, CNRS UMR 7225, Paris, France
    Hum Mol Genet 19:181-95. 2010
    ..Our results demonstrate an influence of SUMOylation on the multistep aggregation process of ATXN7 and implicate a role for ATXN7 SUMOylation in SCA7 pathogenesis...
  18. ncbi request reprint [Animal models of neurodegenerative diseases]
    Dominique Langui
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Med Sci (Paris) 23:180-6. 2007
    ..Human diseases have to be studied in parallel with their animal models to ensure that the model mimic at least a few original mechanisms, on which new therapeutics may be tested...
  19. pmc Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
    Vanessa Brochard
    INSERM, UMR S679, Experimental Neurology and Therapeutics, Hopital de la Salpetriere, Paris, France
    J Clin Invest 119:182-92. 2009
    ..Further, our data may provide a rationale for targeting the adaptive arm of the immune system as a therapeutic strategy in PD...
  20. ncbi request reprint [Lewy bodies, a misleading marker for Parkinson's disease?]
    Charles Duyckaerts
    Laboratoire de Neuropathologie Raymond Escourolle, Groupe Hospitalier Pitie Salpetriere, 75651 Paris
    Bull Acad Natl Med 187:277-92; discussion 292-3. 2003
    ..A large number of senile plaques is frequently associated. 3) In dementia with Lewy bodies, the same lesions are observed but the cognitive deficit occurs first or shortly (less than one year) after the motor symptoms...
  21. doi request reprint Tau-positive grains are constant in centenarians' hippocampus
    Chi Tuan Pham
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Neurobiol Aging 32:1296-303. 2011
    ..As neurofibrillary tangles, they appear to be a constant accompaniment of age but, contrarily to neurofibrillary tangles, do not seem to be strongly associated with dementia...
  22. doi request reprint Fronto-temporal lobar degeneration: neuropathology in 60 cases
    Danielle Seilhean
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Inserm UMR_S975, CNRS UMR7225, Groupe Hospitalier Pitie Salpetriere, AP HP and UPMC Sorbonne Universités, Paris, France
    J Neural Transm 118:753-64. 2011
    ..The prevalence of the different types of FTD is tightly linked to the recruitment. This series was enriched in motor neuron disease (explaining the overall predominance of type 2 TDP inclusions)...
  23. ncbi request reprint Alzheimer's disease and brain infarcts in the elderly. Agreement with neuropathology
    Dina Zekry
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, 47 83, Bd de l Hopital, 75651, Paris, Cedex 13, France
    J Neurol 249:1529-34. 2002
    ..The NINDS-AIREN criteria were the most discriminating for the accurate identification of patients with mixed dementia...
  24. doi request reprint Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis
    Catherine Marquer
    Centre de Recherche de l Institut du Cerveau et de la Moelle, UPMC, Inserm UMR S975, Centre National de la Recherche Scientifique CNRS UMR7225, Hopital de la Pitie Salpetriere, Paris, France
    FASEB J 25:1295-305. 2011
    ..This change in accessibility is mediated by clustering in lipid rafts, followed by rapid endocytosis...
  25. ncbi request reprint The vascular lesions in vascular and mixed dementia: the weight of functional neuroanatomy
    Dina Zekry
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, INSERM U 106 and 360, Association Claude Bernard, Pierre et Marie Curie University, Paris, France
    Neurobiol Aging 24:213-9. 2003
    ..It may be useful for developing neuropathological criteria in multi-infarct and mixed dementias...
  26. ncbi request reprint Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra
    Sandrine Greffard
    Geriatric Center, Pitie Salpetriere Hospital, Assistance Publique des Hopitaux de Paris, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Arch Neurol 63:584-8. 2006
    ..How well the motor symptoms assessed by the motor section of the Unified Parkinson Disease Rating Scale (UPDRS3) reflect the neuronal loss observed in the substantia nigra is not known...
  27. doi request reprint Abnormal TDP-43 and FUS proteins in muscles of sporadic IBM: similarities in a TARDBP-linked ALS patient
    Aurelio Hernandez Lain
    Fédération des Maladies du Système Nerveux, Bat Paul Castaigne, Hopital Pitie Salpetriere, 83 bd de l hopital, 75013 Paris, France
    J Neurol Neurosurg Psychiatry 82:1414-6. 2011
  28. doi request reprint Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation
    Danielle Seilhean
    Département de Neuropathologie, UPMC Universite Paris 06, AP HP, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, INSERM UMR S 546 DS and UMR S 679 CD, 47 83 boulevard de l Hopital, Paris Cedex 13, France
    Acta Neuropathol 118:561-73. 2009
    ..Angiogenin is known to interact with actin. Like other proteins involved in ALS pathogenesis, such as senataxin, TDP-43 and FUS/TLS, it plays a role in RNA maturation...
  29. doi request reprint Is moderate atherosclerotic stenosis in the middle cerebral artery a cause of or a coincidental finding in ischemic stroke?
    Isabelle F Klein
    INSERM U 698 and Denis Diderot University, Paris, France
    Cerebrovasc Dis 29:140-5. 2010
    ..The objective of this study was to investigate the cause of middle cerebral artery (MCA) atherosclerotic disease in patients with fatal stroke...
  30. doi request reprint Cholesterol in the senile plaque: often mentioned, never seen
    Thibaud Lebouvier
    Escourolle Neuropathology Laboratory, La Salpetriere Hospital, Assistance Publique, Hôpitaux de Paris and UPMC, Paris Universitas, Paris, France
    Acta Neuropathol 117:31-4. 2009
    ..In conclusion, the probable cholesterol enrichment of the SPs has never been proven so far, and might necessitate non-histological methods to be ascertained...
  31. doi request reprint Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease
    Jérémie Vitte
    Laboratory of Molecular Basis, Physiopathology and Treatment of Neurodegenerative Diseases, Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, UMR S975, Paris, France
    J Neuropathol Exp Neurol 69:959-72. 2010
    ..The localization of LRRK2 protein in the core of a subset of LBs demonstrates the contribution of LRRK2 to LB formation and disease pathogenesis...
  32. ncbi request reprint The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy
    Günter U Höglinger
    INSERM U679, Hopital de la Salpetriere, Paris, France
    J Neurochem 95:930-9. 2005
    ..Our data suggest that chronic respiratory chain dysfunction might trigger a form of neurodegeneration in which accumulation of hyperphosphorylated tau protein predominates over deposits of alpha-synuclein...
  33. doi request reprint Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: possible applications to Alzheimer disease
    Adina N Lazar
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, AP HP, 47 bd de l Hopital, Paris, France
    Nanomedicine 9:712-21. 2013
    ..Curcumin-conjugated nanoliposomes could find application in the diagnosis and targeted drug delivery in AD...
  34. doi request reprint Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains
    Kunie Ando
    Laboratoire de Neuropathologie Escourolle, Hopital de la Pitie Salpetriere, AP HP, Paris, France
    Acta Neuropathol 125:861-78. 2013
    ..PICALM was highly expressed in microglia in LOAD. These observations suggest that PICALM is associated with the development of AD tau pathology. PICALM cleavage could contribute to endocytic dysfunction in AD...
  35. ncbi request reprint [Mixed dementia: a neuropathologic point od view]
    Dina Zekry
    Laboratoire de Neuropathologie, Hopital de la Salpetriere, Paris, France
    Psychol Neuropsychiatr Vieil 3:251-9. 2005
    ..This review will provide an overview of neuropathological aspects of MD in the elderly, which appears to be one of the most common forms of dementia...
  36. doi request reprint TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration
    Lina Benajiba
    Institut National de la Santé et de la Recherche Médicale UMRS975 CRicm formerly INSERM UMR_S679, F 75013, Paris, France
    Ann Neurol 65:470-3. 2009
    ..We now describe TARDBP mutations in two patients with FTLD-MND, presenting with a behavioral variant of FTLD and semantic dementia, suggesting that TDP-43 may also have a direct pathogenic role in FTLD disorders...
  37. ncbi request reprint Prevalence and determinants of subdiaphragmatic visceral infarction in patients with fatal stroke
    Halim Abboud
    Assistance Publique Hopitaux de Paris, Paris, France
    Stroke 38:1442-6. 2007
    ..We therefore investigated the prevalence of SDVI in subjects who died from stroke. We also evaluated the yield of SDVI diagnosis for stroke subtyping...
  38. ncbi request reprint Association of small-vessel disease with dilatative arteriopathy of the brain: neuropathologic evidence
    Fernando Pico
    Department of Neuropathology Raymond Escourolle, AP HP Pitié Salpêtrière Hospital, Pierre et Marie Curie University, Paris, France
    Stroke 38:1197-202. 2007
    ..We used a large brain-autopsy collection to investigate the relation between IADE and pathologically assessed cerebral SVD...
  39. doi request reprint Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients
    Adina N Lazar
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, AP HP, 47 bd de l Hopital, 75013 Paris, France
    Acta Neuropathol 125:133-44. 2013
    ..Cholesterol overload thus appears a new and independent alteration of AD cerebral cortex. The structure in which cholesterol accumulates and the mechanism of this accumulation remain to be elucidated...
  40. ncbi request reprint Cholesterol changes in Alzheimer's disease: methods of analysis and impact on the formation of enlarged endosomes
    Jack Christophe Cossec
    Centre de Recherche de l Institut du Cerveau et de la Moelle, CNRS UMR7225, INSERM UMR975 and UPMC, Hopital de la Pitie Salpetriere, 75013 Paris, France
    Biochim Biophys Acta 1801:839-45. 2010
    ..These studies are particularly relevant to AD pathology, since enlarged endosomes are believed to be the first morphological change observed in AD brains, in both sporadic cases and Down syndrome...
  41. ncbi request reprint Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly
    Dina Zekry
    Laboratoire de Neuropathologie Raymond Escourolle, Hopital de la Salpetriere, INSERM U 106 and 360, Association Claude Bernard, Pierre et Marie Curie University, 47 bd de l Hopital, 75013 Paris, France
    Acta Neuropathol 103:481-7. 2002
    ..For similar clinical severity of dementia, there were fewer AD lesions in patients with vascular lesions than in those without vascular lesions...
  42. ncbi request reprint Looking for the link between plaques and tangles
    Charles Duyckaerts
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Neurobiol Aging 25:735-9; discussion 743-6. 2004
  43. ncbi request reprint FUS mutations in frontotemporal lobar degeneration with amyotrophic lateral sclerosis
    Oriane Broustal
    CRicm INSERM UMRS_975, Hopital de la Pitie Salpetriere, Paris, France
    J Alzheimers Dis 22:765-9. 2010
    ..Although the frequency of mutations is low, our study enlarges the phenotypes associated with FUS mutations and shows that FUS could also play a direct pathogenic role in FTLD spectrum of diseases...
  44. pmc Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry
    Mai Panchal
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, AP HP Paris, France
    J Lipid Res 51:598-605. 2010
    ..The highly significant increase in the cholesterol concentration, associated with the increased risk of Alzheimer's disease linked to the apo epsilon 4 allele, suggests new pathogenetic mechanisms...
  45. pmc Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
    Julio Salazar
    Institut National de la Sante et de la Recherche Medicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l Hopital, 75013 Paris, France
    Proc Natl Acad Sci U S A 105:18578-83. 2008
    ..This study supports a critical role for DMT1 in iron-mediated neurodegeneration in PD...
  46. doi request reprint CHMP2B mutations are rare in French families with frontotemporal lobar degeneration
    Mustapha Ghanim
    CRicm INSERM UMRS_975, 75013, Paris, France
    J Neurol 257:2032-6. 2010
    ..The previously reported C-truncating CHMP2B mutations may be private to the Danish and Belgian pedigrees...
  47. pmc Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy
    Margot Fournier
    Universite Pierre et Marie Curie Paris 6, CRICM Centre de Recherche de l Institut du Cerveau et de la Moelle épinière, UMR S975, Paris, France
    PLoS ONE 4:e6629. 2009
    ..These findings raise the possibility that effective compensatory mechanisms modulate the phenotypic expression of disease in parkin-related parkinsonism...
  48. ncbi request reprint Parkinson's disease, subthalamic stimulation, and selection of candidates: a pathological study
    Bechir Jarraya
    Federation de Neurologie, Centre d Investigation Clinique and Institut National de la Santé et de la Recherche Médicale INSERM U289, Hopital de la Salpetriere, Paris, France
    Mov Disord 18:1517-20. 2003
    ..The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment...
  49. ncbi request reprint [What is dementia? 3. The neuropathologist point of view]
    Charles Duyckaerts
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, Paris
    Psychol Neuropsychiatr Vieil 1:71-7. 2003
    ..Most of these findings were made possible only thanks to post-mortem examination, more useful to-day than ever...
  50. ncbi request reprint Vaccination with Sarkosyl insoluble PHF-tau decrease neurofibrillary tangles formation in aged tau transgenic mouse model: a pilot study
    Kunie Ando
    Laboratory of Histology, Neuroanatomy and Neuropathology, UNI ULB Neuroscience Institute, Universite Libre de Bruxelles, Brussels, Belgium Laboratoire de Neuropathologie Escourolle, Hôpital de la Pitiére Salpêtrière, AP HP, Paris, France Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, UM 75, U 1127, UMR 7225, ICM, F 75013, Paris, France
    J Alzheimers Dis 40:S135-45. 2014
    ..These results indicate that an immunization protocol using fibrillar PHF-tau proteins is an efficient and tolerated approach to reduce tau pathology in an aged tauopathy animal model. ..
  51. ncbi request reprint Behavioral symptoms after pallido-nigral lesions: a clinico-pathological case
    Julien Adam
    Raymond Escourolle Neuropathology Laboratory, Hopital de la Salpetriere, INSERM U679, APHP, Pierre et Marie Curie Paris VI University, Paris, France
    Neurocase 14:125-30. 2008
    ....
  52. ncbi request reprint Was the ataxia of Pierre Marie Machado-Joseph disease?: A reappraisal based on the last autopsy case from la Salpêtrière Hospital
    Toshiki Uchihara
    Laboratoire Raymond Escourolle, Service de Neuropathologie, Association Claude Bernard, Groupe Hospitalier, Pitie Salpetriere, Paris, France
    Arch Neurol 61:784-90. 2004
    ..It would then be possible to conclude that some of the patients historically considered to have HAC would today be classified as having Machado-Joseph disease...
  53. doi request reprint Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol
    Jack Christophe Cossec
    Centre de Recherche de l Institut du Cerveau et de la Moelle, CNRS UMRS7225 INSERM UMRS975 UPMC, Hopital de la Salpetriere, 75651, Paris Cedex 13, France
    Biochim Biophys Acta 1801:846-52. 2010
    ..These results suggest that cholesterol increase in AD could be responsible for the enhanced internalization of clathrin-, dynamin2-, Eps15- and Rab5-dependent endocytosis of APP and the ensuing overproduction of Abeta...
  54. ncbi request reprint A grading system of Alzheimer disease lesions in neocortical areas
    Wieneke P Metsaars
    Laboratoire de Neuropathologie R Escourolle, Hopital de la Salpetriere, 47, Boulevard de l Hopital, Cedex 13 75651, Paris, France
    Neurobiol Aging 24:563-72. 2003
    ..The sequence of isocortical lesions from grade 1 to grade 4 is compatible with a cascade of events beginning with deposition of Abeta peptide and ending with neurofibrillary tangle...
  55. doi request reprint Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies
    Claire Perruchini
    INSERM U289, Hopital de la Salpetriere, Paris, France
    Acta Neuropathol 118:685-95. 2009
    ..The VHH was shown to diffuse on a longer distance than conventional monoclonal antibodies in fixed cortical tissue: a property that may be useful in immunolabeling of thick sections...
  56. ncbi request reprint Dementia, the fate of brain? Neuropathological point of view
    Jean Jacques Hauw
    Universite Paris 6, Académie de médecine, Raymond Escourolle Neuropathology Laboratory, Centre Hospitalo Universitaire Pitie Salpetriere, Paris, France
    C R Biol 325:655-64. 2002
    ..For such objectives, the study of human brain tissue will remain mandatory until non-invasive markers and additional models are available. Ethical reasons banish the use of cerebral biopsy and favour the promotion of autopsy...
  57. ncbi request reprint Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force
    Bruno Dubois
    INSERM UPMC UMRS 610, Federation of Neurology, AP HP, Salpêtrière Hospital Université Paris6, Paris, France
    Mov Disord 22:2314-24. 2007
    ..We accept, however, that further validation of certain tests and modifications in the recommended cut off values will be required through future studies...
  58. doi request reprint The 2007 WHO classification of tumors of the central nervous system - what has changed?
    Audrey Rousseau
    Neuropathology Department, Pitie Salpetriere Hospital, Paris, France
    Curr Opin Neurol 21:720-7. 2008
    ....
  59. doi request reprint Ceramides and sphingomyelinases in senile plaques
    Mai Panchal
    Laboratoire de Neuropathologie Escourolle, Hopital de la Salpetriere, AP HP, Paris, France Centre de recherche de l ICM, UPMC, INSERM UMR S 975, CNRS UMR 7225, France
    Neurobiol Dis 65:193-201. 2014
    ..Accumulation of ceramides could be, at least partially, the result of a local production by acid and neutral sphingomyelinases that we found to be present in the corona of the senile plaques. ..
  60. ncbi request reprint Two populations of neuronal intranuclear inclusions in SCA7 differ in size and promyelocytic leukaemia protein content
    Junko Takahashi
    Laboratoire de Neuropathologie Raymond Escourolle, Paris, France
    Brain 125:1534-43. 2002
    ..CREB-binding protein (CBP), another component of NBs, was distributed like PML in NIIs. Our results suggest that NIIs are formed by the accumulation of ataxin-7 in NBs, which become enlarged as they recruit related proteins...
  61. ncbi request reprint The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates
    Wen Jie Gu
    INSERM U 289, Hopital de la Salpetriere, 75013 Paris, France
    Neurobiol Dis 14:357-64. 2003
    ..They also contribute to our understanding of the cellular mechanism underlying the aggregation of mutant Parkin...
  62. ncbi request reprint [Lipid rafts, flotillin-1 and Alzheimer disease]
    Nadège Girardot
    Laboratoire de Neuropathologie Raymond Escourolle et Inserm U106, Hopital de la Salpetriere, Paris
    J Soc Biol 197:223-9. 2003
    ..Our data suggest that the A beta peptide, which is poorly soluble in water, is actually linked with cholesterol, possibly from cellular membranes, in the extracellular space...
  63. ncbi request reprint SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients
    Patricia Facchinetti
    Inserm UMR 894, Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, Paris, France
    Neurobiol Aging 35:958-68. 2014
    ..These data suggest that increase in APPcc in CA1 neurons could be an early event leading to the translocation of SET and the progression of AD through tau hyperphosphorylation. ..
  64. pmc Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
    Jack Christophe Cossec
    Centre de Recherche de l Institut du Cerveau et de la Moelle, CNRS UMR7225, UPMC, INSERM UMRS975, Hopital Pitie Salpetriere, Paris, France
    Hum Mol Genet 21:3156-72. 2012
    ..These findings provide new insights into the contribution of SYNJ1 overexpression to the endosomal changes observed in DS and suggest an attractive new target for rescuing endocytic dysfunction and lipid metabolism in DS and in AD...
  65. pmc Association between a Primitive Brain Tumor and Cerebral Aspergillosis
    Siegfried Hélage
    Laboratoire de Neuropathologie Escourolle, institut du cerveau et de la moelle épinière, Universite Pierre et Marie Curie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    Case Report Med 2012:748202. 2012
    ..A case of lethal cerebral aspergillosis in a patient with an infiltrative glioma treated with corticotherapy and radiotherapy is reported. Clinicopathological aspects and therapeutic approach are described...
  66. doi request reprint Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia
    Reena Prity Murmu
    INSERM, U975, Universite Pierre et Marie Curie Paris 6, UMR_S975, Centre de Recherche de l Institut du Cerveau et de la Moelle épinière CR icm, GHU Pitié Salpêtrière, CNRS, Paris, France
    Mol Cell Neurosci 47:191-202. 2011
    ..This first study of the endogenous expression of spatacsin and spastizin shows similarities in their expression patterns that could account for their overlapping clinical phenotypes and involvement in a common protein complex...
  67. ncbi request reprint They have shaped Alzheimer disease: the protagonists, well known and less well known
    Francois Boller
    INSERM U 549, Centre Paul Broca, Paris, France
    Cortex 43:565-9. 2007
    ..Many of these have also become famous for work unrelated to AD...
  68. doi request reprint The French series of autosomal dominant early onset Alzheimer's disease cases: mutation spectrum and cerebrospinal fluid biomarkers
    David Wallon
    Inserm U1079, CHU et Faculté de Médecine Pharmacie, Rouen, France
    J Alzheimers Dis 30:847-56. 2012
    ..Overall, these results support further genetic heterogeneity in the determinism of ADEOAD and suggest that other major genes remain to be characterized...
  69. pmc Evidence of a role for lactadherin in Alzheimer's disease
    Jacques Boddaert
    Institut National de la Sante et de la Recherche Medicale, Centre de Recherché Cardiovasculaire Lariboisière, Paris, France
    Am J Pathol 170:921-9. 2007
    ..Alterations in lactadherin production/function may contribute to the initiation and/or progression of Alzheimer's disease...
  70. doi request reprint Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function
    Fabien Dutheil
    Universite Paris Descartes, Paris, France
    Drug Metab Dispos 37:1528-38. 2009
    ....
  71. ncbi request reprint Progranulin null mutations in both sporadic and familial frontotemporal dementia
    Isabelle Le Ber
    INSERM, UMR679, Paris, France
    Hum Mutat 28:846-55. 2007
    ..Taking this into account, genetic testing should be now considered more systematically, even in patients without obvious familial history of FTD...
  72. ncbi request reprint Metabolic changes in the basal ganglia of patients with Huntington's disease: an in situ hybridization study of cytochrome oxidase subunit I mRNA
    Isabelle Gourfinkel-An
    INSERM U289, Hopital de la Salpetriere, Paris, France
    J Neurochem 80:466-76. 2002
    ....
  73. ncbi request reprint Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice
    Veronique Blanchard
    Neurodegenerative Disease Group, Centre de Recherche de Paris, Aventis Pharma 94403, Vitry sur Seine Cedex, France
    Exp Neurol 184:247-63. 2003
    ..The present study demonstrates that oxidative and mitochondrial stress factors are present at several phases of Abeta pathology progression, confirming the neuronal dysfunction in APP transgenic mice...
  74. pmc Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
    Nigel J Cairns
    Department of Neurology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO, 63110, USA
    Acta Neuropathol 114:5-22. 2007
    ..These criteria will be of value to the practicing neuropathologist and provide a foundation for clinical, clinico-pathologic, mechanistic studies and in vivo models of pathogenesis of FTLD...
  75. ncbi request reprint Biological effects of four PSEN1 gene mutations causing Alzheimer disease with spastic paraparesis and cotton wool plaques
    Cecile Dumanchin
    INSERM U614, IFRMP, Faculte de Medecine, Rouen, France
    Hum Mutat 27:1063. 2006
    ..We conclude that none of the previously proposed mechanisms, i.e. exceptionally large increases in secreted Abeta42 levels or loss of PSEN1 exons 8 or 9, provides complete explanation of the CWP/SP phenotype...
  76. ncbi request reprint Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load
    Dominique Santiard-Baron
    Neurodegenerative Diseases Group, Aventis, Vitry sur Seine, France
    J Neurochem 93:330-8. 2005
    ..The present work provides evidence that FE65 plays a role in the regulation of APP processing in an in vivo model...
  77. ncbi request reprint Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    ..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...
  78. ncbi request reprint The etiopathogenesis of Parkinson disease and suggestions for future research. Part II
    Irene Litvan
    University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neuropathol Exp Neurol 66:329-36. 2007
    ..Topics reviewed in Part II are genetics, animal models, and oxidative stress...
  79. ncbi request reprint Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy
    Dominique Caparros-Lefebvre
    Neurologie, Centre Hospitalier Universitaire de la Guadeloupe, Pointe a Pitre, French West Indies
    Brain 125:801-11. 2002
    ..A cluster of cases presenting with atypical parkinsonism is reported. Guadeloupean parkinsonism may prove to be a tauopathy identical or closely related to PSP...
  80. ncbi request reprint Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images
    Marc Dhenain
    Curie Institute, U350 INSERM, Centre Universitaire Laboratoire 112, 91405 Orsay Cedex, France
    NMR Biomed 15:197-203. 2002
    ..This suggests that susceptibility effects are not associated with senile plaques and do not provide a mechanism to differentiate them from surrounding tissue...
  81. doi request reprint The black stuff and Konstantin Nikolaevich Tretiakoff
    Andrew J Lees
    The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Mov Disord 23:777-83. 2008
    ....
  82. ncbi request reprint The etiopathogenesis of Parkinson disease and suggestions for future research. Part I
    Irene Litvan
    University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neuropathol Exp Neurol 66:251-7. 2007
  83. ncbi request reprint Patients with a novel neurofilamentopathy: dementia with neurofilament inclusions
    Nigel J Cairns
    Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Neurosci Lett 341:177-80. 2003
    ....
  84. pmc alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease
    Nigel J Cairns
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Pathol 164:2153-61. 2004
    ..The discovery of alpha-internexin in the cytoplasmic inclusions implicates novel mechanisms of pathogenesis in NIFID and other neurological diseases with pathological accumulations of IFs...
  85. ncbi request reprint Exclusive induction of tau2 epitope in microglia/macrophages in inflammatory lesions-tautwopathy distinct from degenerative tauopathies
    Toshiki Uchihara
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashi dai, Fuchu, 183 8526, Tokyo, Japan
    Acta Neuropathol 109:159-64. 2005
    ....
  86. ncbi request reprint Behavioral disorder, dementia, ataxia, and rigidity in a large family with TATA box-binding protein mutation
    Amalia C Bruni
    Regional Neurogenetic Center AS6, Lamezia Terme, Italy
    Arch Neurol 61:1314-20. 2004
    ..Spinocerebellar ataxia type 17 is an autosomal dominant cerebellar ataxia caused by a CAG repeat expansion in the TATA box-binding protein gene. Ataxia is typically the first sign whereas behavioral symptoms occur later...
  87. ncbi request reprint A non-DM1, non-DM2 multisystem myotonic disorder with frontotemporal dementia: phenotype and suggestive mapping of the DM3 locus to chromosome 15q21-24
    Isabelle Le Ber
    Departement de Neurologie, centre hospitalo universitaire Charles Nicolle, Rouen, France
    Brain 127:1979-92. 2004
    ..We propose to designate this disease myotonic dystrophy type 3, DM3...
  88. ncbi request reprint Global democratic consensus on neuropathological disease criteria
    Cristian Achim
    Lancet Neurol 1:340. 2002
  89. ncbi request reprint Dopamine depletion impairs precursor cell proliferation in Parkinson disease
    Günter U Höglinger
    INSERM U289 Hôpital de la Salpetrière, F 75651 Paris, France
    Nat Neurosci 7:726-35. 2004
    ..These observations suggest that the generation of neural precursor cells is impaired in Parkinson disease as a consequence of dopaminergic denervation...
  90. pmc alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases
    Nigel J Cairns
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 108:213-23. 2004
    ..The discovery of alpha-internexin in neuronal cytoplasmic inclusions implicates novel mechanisms of pathogenesis in NIFID and other neurological diseases with pathological filamentous neuronal inclusions...
  91. doi request reprint Promyelocytic leukemia nuclear bodies provide a scaffold for human polyomavirus JC replication and are disrupted after development of viral inclusions in progressive multifocal leukoencephalopathy
    Yukiko Shishido-Hara
    Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, Tokyo
    J Neuropathol Exp Neurol 67:299-308. 2008
    ....