Sophie Dupont

Summary

Country: France

Publications

  1. ncbi request reprint Association of ipsilateral motor automatisms and contralateral dystonic posturing: a clinical feature differentiating medial from neocortical temporal lobe epilepsy
    S Dupont
    Clinique Neurologique Paul Castaigne, Hopital de la Pitie Salpetriere, Paris, France
    Arch Neurol 56:927-32. 1999
  2. ncbi request reprint [The anatomy of episodic memory: evolution of concepts]
    S Dupont
    Service d anatomie, Faculté de Médecine Pitié Salpêtrière, Unité d épileptologie, Clinique Neurologique, Hopital Pitie Salpetriere, Paris, France
    Morphologie 87:5-9. 2003
  3. ncbi request reprint Functional anatomy of the insula: new insights from imaging
    S Dupont
    CEA, SHFJ, Orsay, France
    Surg Radiol Anat 25:113-9. 2003
  4. doi request reprint [Can functional MRI replace the Wada test?]
    S Dupont
    unité d épilepsie, Hopital de la Pitie Salpetriere, 41 83 boulevard de l Hôpital, 75013 Paris, France
    Neurochirurgie 54:208-11. 2008
  5. ncbi request reprint [Contribution of MRI to the exploration of partial refractory epilepsy]
    S Dupont
    Unité d épileptologie, Clinique Neurologique, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Rev Neurol (Paris) 160:5S91-7. 2004
  6. ncbi request reprint Long-term prognosis and psychosocial outcomes after surgery for MTLE
    Sophie Dupont
    Unité d épileptologie, Clinique Neurologique Paul Castaigne, Paris, France
    Epilepsia 47:2115-24. 2006
  7. ncbi request reprint Is anterior temporal lobectomy a precipitating factor for transient global amnesia?
    S Dupont
    Epilepsy Unit, Pitie Salpetriere Hospital, APHP, Paris, France
    J Neurol Neurosurg Psychiatry 79:309-11. 2008
  8. ncbi request reprint [Epilepsy. Important progress in diagnosis and therapy]
    Sophie Dupont
    Unité d épileptologie, groupe hospitalier La Pitié La Salpêtrière, 75651 Paris Cedex 13
    Rev Prat 55:249-50. 2005
  9. ncbi request reprint [Syndromic approach of epilepsy: usefulness for therapeutic choices]
    Sophie Dupont
    Unité d épileptologie, Clinique Paul Castaigne, groupe hospitalier La Pitié La Salpêtrière, 75651 Paris Cedex 13
    Rev Prat 55:251-8. 2005
  10. ncbi request reprint Temporal pole hypometabolism may be linked to a reduction of grey matter in temporal lobe epilepsy
    Sophie Dupont
    Epilepsy Unit, Salpetriere Hospital, Paris, France
    Neuroreport 13:2537-41. 2002

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Association of ipsilateral motor automatisms and contralateral dystonic posturing: a clinical feature differentiating medial from neocortical temporal lobe epilepsy
    S Dupont
    Clinique Neurologique Paul Castaigne, Hopital de la Pitie Salpetriere, Paris, France
    Arch Neurol 56:927-32. 1999
    ..Clinical features that may help to differentiate medial temporal lobe epilepsy (MTLE) from neocortical temporal lobe epilepsy (NTLE) are lacking...
  2. ncbi request reprint [The anatomy of episodic memory: evolution of concepts]
    S Dupont
    Service d anatomie, Faculté de Médecine Pitié Salpêtrière, Unité d épileptologie, Clinique Neurologique, Hopital Pitie Salpetriere, Paris, France
    Morphologie 87:5-9. 2003
    ..These results show that memory is subserved by a more widely distributed cortical network than expected...
  3. ncbi request reprint Functional anatomy of the insula: new insights from imaging
    S Dupont
    CEA, SHFJ, Orsay, France
    Surg Radiol Anat 25:113-9. 2003
    ....
  4. doi request reprint [Can functional MRI replace the Wada test?]
    S Dupont
    unité d épilepsie, Hopital de la Pitie Salpetriere, 41 83 boulevard de l Hôpital, 75013 Paris, France
    Neurochirurgie 54:208-11. 2008
    ..Preliminary studies in epileptic patients have shown promising results. In the future, functional MRI will certainly contribute to partially replacing the Wada test or to evaluating the hippocampal memory capacities independently...
  5. ncbi request reprint [Contribution of MRI to the exploration of partial refractory epilepsy]
    S Dupont
    Unité d épileptologie, Clinique Neurologique, Hopital Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Rev Neurol (Paris) 160:5S91-7. 2004
    ..In the future, new emerging MR techniques will undoubtedly greatly contribute to improved presurgical management of patients with refractory partial epilepsy...
  6. ncbi request reprint Long-term prognosis and psychosocial outcomes after surgery for MTLE
    Sophie Dupont
    Unité d épileptologie, Clinique Neurologique Paul Castaigne, Paris, France
    Epilepsia 47:2115-24. 2006
    ..To assess the seizure-freedom rates and self-perceived psychosocial changes associated with the long-term outcome of epilepsy surgery in patients with refractory medial temporal lobe epilepsy associated with hippocampal sclerosis...
  7. ncbi request reprint Is anterior temporal lobectomy a precipitating factor for transient global amnesia?
    S Dupont
    Epilepsy Unit, Pitie Salpetriere Hospital, APHP, Paris, France
    J Neurol Neurosurg Psychiatry 79:309-11. 2008
    ..These studies suggest that hippocampal resection carried out therapeutically in some epileptic patients may be a precipitating factor for TGA...
  8. ncbi request reprint [Epilepsy. Important progress in diagnosis and therapy]
    Sophie Dupont
    Unité d épileptologie, groupe hospitalier La Pitié La Salpêtrière, 75651 Paris Cedex 13
    Rev Prat 55:249-50. 2005
  9. ncbi request reprint [Syndromic approach of epilepsy: usefulness for therapeutic choices]
    Sophie Dupont
    Unité d épileptologie, Clinique Paul Castaigne, groupe hospitalier La Pitié La Salpêtrière, 75651 Paris Cedex 13
    Rev Prat 55:251-8. 2005
    ..The syndromic classification brings also major prognostic informations that may be useful to the practitioners and their patients...
  10. ncbi request reprint Temporal pole hypometabolism may be linked to a reduction of grey matter in temporal lobe epilepsy
    Sophie Dupont
    Epilepsy Unit, Salpetriere Hospital, Paris, France
    Neuroreport 13:2537-41. 2002
    ..These findings suggest that a reduction of temporal pole neocortical grey matter might contribute to temporal pole hypometabolism in temporal lobe epilepsy...
  11. ncbi request reprint [Epilepsy and brain tumors]
    S Dupont
    Unité d épileptologie, Clinique Neurologique Paul Castaigne, Hopital de la Salpetriere, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Rev Neurol (Paris) 164:517-22. 2008
    ..Further randomized large cohort studies seem thus required to assess the effectiveness of new antiepileptic drugs to prevent and cure epilepsy in patients with brain tumors...
  12. ncbi request reprint [MRI exploration of partial epilepsy]
    S Dupont
    Unité d épileptologie, Hopital Pitie Salpetriere, Paris, France
    Rev Neurol (Paris) 158:4S19-26. 2002
    ..Continuing improvements in MRI techniques, widespread availability of technical facilities and new derived techniques contribute greatly to the usefulness of MRI for investigating partial epilepsy...
  13. doi request reprint [Specificity of epileptic seizures in the elderly: A proposed electro-clinical scale]
    S Dupont
    Clinique Paul Castaigne, Hopital Pitie Salpetriere, AP HP, Universite Pierre et Marie Curie, Paris, France
    Rev Neurol (Paris) 165:803-11. 2009
    ..This electro-clinical score is based on a systematic review of scientific literature and the recommendations are explicitly linked to supporting evidence. Further, clinical validation of the electro-clinical score is required...
  14. doi request reprint Flexible dosing of adjunctive zonisamide in the treatment of adult partial-onset seizures: a non-comparative, open-label study (ZEUS)
    S Dupont
    unité d épilepsie, Clinique Neurologique, Hopital de la Pitie Salpetriere, APHP, UPMC, Paris, France
    Acta Neurol Scand 121:141-8. 2010
    ..To assess the efficacy and tolerability of zonisamide in a study allowing flexible dosing in a more diverse and less refractory population than assessed in randomized controlled trials...
  15. ncbi request reprint Investigating temporal pole function by functional imaging
    Sophie Dupont
    Epileptology Unit, Neurology Department Pitié Salpêtrière Hospital, 47, Boulevard de l Hopital, 75013 Paris, France
    Epileptic Disord 4:S17-22. 2002
    ..Studies of epileptic, demented and schizophrenic patients have revealed that abnormal patterns of temporal pole function are typical in all these conditions...
  16. doi request reprint [Specificities of the epileptic women (oral contraceptives, pregnancy)]
    Sophie Dupont
    Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, UMR S975, 75651 Paris Cedex 13, France
    Presse Med 40:279-86. 2011
    ..Antiepileptic drugs monitoring is required during pregnancy. Natural delivery with peridural anaesthesiology is mandatory. The breast feeding must be considered individually...
  17. ncbi request reprint Interictal diffusion MRI in partial epilepsies explored with intracerebral electrodes
    Lionel Thivard
    Epileptology Unit, INSERM U739, Faculté de Médecine Pitié Salpêtrière, Paris, France
    Brain 129:375-85. 2006
    ..These encouraging, preliminary results, suggest that DTI examinations may provide accurate spatial data on the location and extent of the epileptogenic network in extratemporal lobe epilepsies...
  18. ncbi request reprint Postoperative recovery of hippocampal contralateral diffusivity in medial temporal lobe epilepsy
    Lionel Thivard
    Epileptology Unit, Hopital de la Salpetriere, Paris, France
    Epilepsia 48:599-604. 2007
    ..To search for a recovery after surgery of mean diffusivity (MD) values in the contralateral nonsclerotic hippocampus of patients with medial temporal lobe epilepsy (MTLE) and hippocampal sclerosis (HS)...
  19. doi request reprint [Epilepsy surgery: when thinking about? Who are the good candidates?]
    Vincent Navarro
    AP HP, Hopital de la Pitie Salpetriere, unité d épilepsie, 75651 Paris Cedex 13, France
    Presse Med 40:293-300. 2011
    ..A multidisciplinary evaluation of the benefits and risks should be presented to the patient. Results of the surgery are usually excellent when a focus is clearly identified and the neuropsychological tests did not predict a deficit...
  20. doi request reprint Functional MR imaging or Wada test: which is the better predictor of individual postoperative memory outcome?
    Sophie Dupont
    Epilepsy Unit, Neurology Clinic Paul Castaigne, Hopital de la Pitie Salpetriere, APHP, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Radiology 255:128-34. 2010
    ..To retrospectively determine whether blood oxygen level-dependent functional magnetic resonance (MR) imaging can aid prediction of postoperative memory changes in epileptic patients after temporal lobe surgery...
  21. doi request reprint Pure alexia as a disconnection syndrome: new diffusion imaging evidence for an old concept
    Stéphane Epelbaum
    Hopital de la Salpetriere, Department of Neurology, Paris, France
    Cortex 44:962-74. 2008
    ....
  22. doi request reprint Diffusion tensor imaging can localize the epileptogenic zone in nonlesional extra-temporal refractory epilepsies when [(18)F]FDG-PET is not contributive
    Lionel Thivard
    Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, UMR S975, Paris, France
    Epilepsy Res 97:170-82. 2011
    ..Combining vPET and DTI was the more efficient strategy for extra-TLE, allowing the detection of pertinent abnormalities in FLE when FDG-PET alone was not contributive. Combining sPET or VBM with vPET was less useful...
  23. ncbi request reprint Fast contralateral propagation of after-discharges induced by stimulation of medial temporal lobe
    Claude Adam
    Neurology 1, Epileptology Unit, Hopital de la Pitie Salpetriere, Paris, France
    J Clin Neurophysiol 21:399-403. 2004
    ..The spatial and temporal characteristics of these responses reveal fast interconnections between the two medial temporal lobes...
  24. ncbi request reprint Diffusion tensor imaging in medial temporal lobe epilepsy with hippocampal sclerosis
    Lionel Thivard
    Epileptology Unit, Hopital de la Salpetriere, 75013 Paris, France
    Neuroimage 28:682-90. 2005
    ..This pattern may indirectly reflect the epileptogenic network and may be interpreted as a cause or a consequence of epilepsy...
  25. doi request reprint Management and monitoring of patients treated with zonisamide: the OZONE study
    Sophie Dupont
    Epileptology Unit, Hopital Pitie Salpetriere, Paris
    Epileptic Disord 15:278-88. 2013
    ..To characterise patients treated with zonisamide in everyday practice and describe the effectiveness and tolerability of treatment...
  26. ncbi request reprint Direct intracranial, FMRI, and lesion evidence for the causal role of left inferotemporal cortex in reading
    Raphael Gaillard
    INSERM, U562, CEA DSV, IFR 49, Orsay, France
    Neuron 50:191-204. 2006
    ..Altogether, these results provide direct evidence for the causal role of the left occipitotemporal cortex in the recognition of visual words...
  27. ncbi request reprint Insular cortex involvement in mesiotemporal lobe epilepsy: a positron emission tomography study
    Viviane Bouilleret
    Service Hospitalier Frederic Joliot, CEA, Orsay, France
    Ann Neurol 51:202-8. 2002
    ..Hypometabolism located in the insula did not influence postoperative outcome after anterior lobectomy...
  28. ncbi request reprint Complete change of seizure and spike lateralization in temporal lobe epilepsy at two separate monitorings
    Areti Koukou
    AP HP, Epileptology Unit, Hopital de la Pitie Salpetriere, Service de Neurologie 1, Hôpital de La Pitié Salpêtrière 47 83 Bd de 1 Hôpital 75651, Paris Cedex 13, France
    Clin Neurophysiol 118:255-61. 2007
    ..To report complete change of seizure and spike lateralization over time in bilateral temporal lobe epilepsies (TLE)...
  29. doi request reprint Characterization of seizure-induced syncopes: EEG, ECG, and clinical features
    Vi Huong Nguyen-Michel
    Epileptology Unit, Department of Neurology and Neurophysiology, Assistance Publique Hopitaux de Paris, Pitié Salpêtrière Hospital and Pierre et Marie Curie Paris 6 University, CRicm, Paris, France
    Epilepsia 55:146-55. 2014
    ..They are difficult to recognize within a seizure and their consequences remain unclear. Herein we aimed to extend the description of electrical and clinical features of seizures with IA and/or syncope...
  30. ncbi request reprint Is amygdalohippocampectomy really selective in medial temporal lobe epilepsy? A study using positron emission tomography with (18)fluorodeoxyglucose
    S Dupont
    Service Hospitalier Frederic Joliot, CEA, 4 Place du General Leclerc, 91406 Orsay, France
    Epilepsia 42:731-40. 2001
    ..However, the benefit of SAH in terms of functional outcome is debated. In this study, we aimed to assess the metabolic consequences of SAH...
  31. ncbi request reprint Productive and perceptive language reorganization in temporal lobe epilepsy
    Lionel Thivard
    Department of Neurology, Hopital de la Salpetriere, 75013 Paris, France
    Neuroimage 24:841-51. 2005
    ..Neuropsychological performances of patients with atypical language patterns were better than those of patients with typical patterns, suggesting that this reorganization may represent a compensatory mechanism...
  32. doi request reprint Seizures in the elderly: development and validation of a diagnostic algorithm
    Sophie Dupont
    Epilepsy Unit, Clinique Paul Castaigne, Pitie Salpetriere Hospital, APHP, Paris, France
    Epilepsy Res 89:339-48. 2010
    ..8%, Sp 88.6%). In conclusion, the present study validated the use of a revised diagnostic algorithm to help diagnosis epileptic seizures in the elderly. A prospective study is planned to further validate this algorithm...
  33. ncbi request reprint The choice of antiepileptic drugs in newly diagnosed epilepsy: a national French survey
    Franck Semah
    Neurology Department, Hopital Sainte Anne, Paris and Service Hospitalier Frédéric Joliot, CEA, Orsay, France
    Epileptic Disord 6:255-65. 2004
    ..In cases of failure and/or intolerance to one of these AED, the principal alternatives are oxcarbazepine, sodium valproate and topiramate...
  34. ncbi request reprint [Surgery of epilepsy: current status]
    S Clemenceau
    Service de Neurochirurgie, Hopital de la Salpetriere, Paris
    Presse Med 29:619-24. 2000
    ..Preoperative explorations are shorter and less invasive, allowing surgery without implantation of intracranial electrodes in more than 70% of the cases...
  35. ncbi request reprint In vivo imaging of muscarinic cholinergic receptors in temporal lobe epilepsy with a new PET tracer: [76Br]4-bromodexetimide
    S Dupont
    CEA, SHFJ, Orsay, France
    J Nucl Med 40:935-41. 1999
    ..Dexetimide is a specific mAChR antagonist that has been labeled recently with 76Br. This first study in humans focused on regional distribution and binding kinetics of [76Br]4-bromodexetimide (BDEX) in patients with MTLE...
  36. ncbi request reprint [Newly treated epilepsy: a French observational study]
    S Dupont
    Unité d épileptologie, Clinique Neurologique Paul Castaigne, Hopital de la Pitie Salpetriere, Paris, France
    Rev Neurol (Paris) 162:200-7. 2006
    ..Data were available from a structured questionnaire delivered to all participating neurologists...
  37. ncbi request reprint Delayed verbal memory retrieval: a functional MRI study in epileptic patients with structural lesions of the left medial temporal lobe
    S Dupont
    , CNRS UPR640, Paris, France
    Neuroimage 14:995-1003. 2001
    ..This distributed neocortical and mesiotemporal network was very poorly activated during the 24-h-delayed retrieval in LTLE patients, suggesting the inability to reactivate areas that are keys to retrieving stored information...
  38. ncbi request reprint Levetiracetam in progressive myoclonic epilepsy: an exploratory study in 9 patients
    C Crest
    Unité d épileptologie, Hopital de la Pitie Salpetriere, Paris, France
    Neurology 62:640-3. 2004
    ..Myoclonus was evaluated semiquantitatively (territory, intensity, daily living activities). Five patients had improvement of their myoclonus score. Levetiracetam may benefit myoclonus in progressive myoclonic epilepsy...
  39. ncbi request reprint Episodic memory in left temporal lobe epilepsy: a functional MRI study
    S Dupont
    Unité d épileptologie, Clinique Neurologique Paul Castaigne, CNRS UPR640, Hopital de la Pitie Salpetriere, Paris, France
    Brain 123:1722-32. 2000
    ..This may be interpreted as a dysfunctional response due to the epilepsy and left hippocampal sclerosis, and could reflect the early onset and progressive course of the disease...
  40. pmc Bilateral hemispheric alteration of memory processes in right medial temporal lobe epilepsy
    S Dupont
    CEA, SHFJ, Orsay, France
    J Neurol Neurosurg Psychiatry 73:478-85. 2002
    ..Functional MRI (fMRI ) was used to investigate right medial temporal lobe epilepsy (RTLE) effects on verbal memory...
  41. doi request reprint Mechanisms for variable expressivity of inherited SCN1A mutations causing Dravet syndrome
    Christel Depienne
    INSERM U975 CRicm, Bâtiment Pharmacie 4 étage, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    J Med Genet 47:404-10. 2010
    ..In this latter case, additional genetic or environmental factors likely modulate the severity of the expression of the mutation...
  42. ncbi request reprint [Acute orthostatic intracranial hypotension]
    A Carpentier
    Service de Neurochirurgie, Hopital de la Salpetriere, Paris, France
    Rev Neurol (Paris) 158:218-20. 2002
    ..Clinical-imaging manifestations were typical and two consecutive blood patches resulted in a complete and durable resolution of the symptomatology. We present a review of the various investigation and therapeutic techniques...