Sophie Dupont

..Clinical features that may help to differentiate medial temporal lobe epilepsy (MTLE) from neocortical temporal lobe epilepsy (NTLE) are lacking...

..In the future, new emerging MR techniques will undoubtedly greatly contribute to improved presurgical management of patients with refractory partial epilepsy...

..The syndromic classification brings also major prognostic informations that may be useful to the practitioners and their patients...

..To assess the seizure-freedom rates and self-perceived psychosocial changes associated with the long-term outcome of epilepsy surgery in patients with refractory medial temporal lobe epilepsy associated with hippocampal sclerosis...

..These studies suggest that hippocampal resection carried out therapeutically in some epileptic patients may be a precipitating factor for TGA...

..Preliminary studies in epileptic patients have shown promising results. In the future, functional MRI will certainly contribute to partially replacing the Wada test or to evaluating the hippocampal memory capacities independently...

..Further randomized large cohort studies seem thus required to assess the effectiveness of new antiepileptic drugs to prevent and cure epilepsy in patients with brain tumors...

..This electro-clinical score is based on a systematic review of scientific literature and the recommendations are explicitly linked to supporting evidence. Further, clinical validation of the electro-clinical score is required...

..To assess the efficacy and tolerability of zonisamide in a study allowing flexible dosing in a more diverse and less refractory population than assessed in randomized controlled trials...

..Antiepileptic drugs monitoring is required during pregnancy. Natural delivery with peridural anaesthesiology is mandatory. The breast feeding must be considered individually...

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..These results show that memory is subserved by a more widely distributed cortical network than expected...

..These findings suggest that a reduction of temporal pole neocortical grey matter might contribute to temporal pole hypometabolism in temporal lobe epilepsy...

..Studies of epileptic, demented and schizophrenic patients have revealed that abnormal patterns of temporal pole function are typical in all these conditions...

..Continuing improvements in MRI techniques, widespread availability of technical facilities and new derived techniques contribute greatly to the usefulness of MRI for investigating partial epilepsy...

..To search for a recovery after surgery of mean diffusivity (MD) values in the contralateral nonsclerotic hippocampus of patients with medial temporal lobe epilepsy (MTLE) and hippocampal sclerosis (HS)...

..These encouraging, preliminary results, suggest that DTI examinations may provide accurate spatial data on the location and extent of the epileptogenic network in extratemporal lobe epilepsies...

..A multidisciplinary evaluation of the benefits and risks should be presented to the patient. Results of the surgery are usually excellent when a focus is clearly identified and the neuropsychological tests did not predict a deficit...

..To retrospectively determine whether blood oxygen level-dependent functional magnetic resonance (MR) imaging can aid prediction of postoperative memory changes in epileptic patients after temporal lobe surgery...

..Combining vPET and DTI was the more efficient strategy for extra-TLE, allowing the detection of pertinent abnormalities in FLE when FDG-PET alone was not contributive. Combining sPET or VBM with vPET was less useful...

..The spatial and temporal characteristics of these responses reveal fast interconnections between the two medial temporal lobes...

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..This pattern may indirectly reflect the epileptogenic network and may be interpreted as a cause or a consequence of epilepsy...

..To report complete change of seizure and spike lateralization over time in bilateral temporal lobe epilepsies (TLE)...

..Hypometabolism located in the insula did not influence postoperative outcome after anterior lobectomy...

..Altogether, these results provide direct evidence for the causal role of the left occipitotemporal cortex in the recognition of visual words...

..However, the benefit of SAH in terms of functional outcome is debated. In this study, we aimed to assess the metabolic consequences of SAH...

..In cases of failure and/or intolerance to one of these AED, the principal alternatives are oxcarbazepine, sodium valproate and topiramate...

..8%, Sp 88.6%). In conclusion, the present study validated the use of a revised diagnostic algorithm to help diagnosis epileptic seizures in the elderly. A prospective study is planned to further validate this algorithm...

..Neuropsychological performances of patients with atypical language patterns were better than those of patients with typical patterns, suggesting that this reorganization may represent a compensatory mechanism...

..CONCLUSION: This study provides a considerable amount of epidemiological and clinical information with a special emphasis on epilepsy syndromes, diagnostic assessment and factors that influence the initiation of treatment or not...

..FUNDAMENTAL RULE: The key to success however directly depends on rigorous application of the fundamental rule of anatomo-electro-clinical correlation...

..Dexetimide is a specific mAChR antagonist that has been labeled recently with 76Br. This first study in humans focused on regional distribution and binding kinetics of [76Br]4-bromodexetimide (BDEX) in patients with MTLE...

..This distributed neocortical and mesiotemporal network was very poorly activated during the 24-h-delayed retrieval in LTLE patients, suggesting the inability to reactivate areas that are keys to retrieving stored information...

..This may be interpreted as a dysfunctional response due to the epilepsy and left hippocampal sclerosis, and could reflect the early onset and progressive course of the disease...

..Functional MRI (fMRI ) was used to investigate right medial temporal lobe epilepsy (RTLE) effects on verbal memory...

..Myoclonus was evaluated semiquantitatively (territory, intensity, daily living activities). Five patients had improvement of their myoclonus score. Levetiracetam may benefit myoclonus in progressive myoclonic epilepsy...

..In this latter case, additional genetic or environmental factors likely modulate the severity of the expression of the mutation...

..Clinical-imaging manifestations were typical and two consecutive blood patches resulted in a complete and durable resolution of the symptomatology. We present a review of the various investigation and therapeutic techniques...