Hughes Duffau

Summary

Country: France

Publications

  1. pmc Intraoperative mapping of the cortical areas involved in multiplication and subtraction: an electrostimulation study in a patient with a left parietal glioma
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    J Neurol Neurosurg Psychiatry 73:733-8. 2002
  2. ncbi request reprint Extension of paralimbic low grade gliomas: toward an anatomical classification based on white matter invasion patterns
    Emmanuel Mandonnet
    Department of Neurosurgery, INSERM U678, Hopital de la Salpetriere, 47 83 Bd de l Hopital, 75651, Cedex, 13, Paris, France
    J Neurooncol 78:179-85. 2006
  3. ncbi request reprint Assessment of verbal working memory before and after surgery for low-grade glioma
    Pilar Teixidor
    Department of Neurosurgery, Hospital Germans Trias i Pujol, Ctra del Canyet s n, 08916, Badalona, Barcelona, Spain
    J Neurooncol 81:305-13. 2007
  4. ncbi request reprint Brain plasticity: from pathophysiological mechanisms to therapeutic applications
    Hugues Duffau
    Department of Neurosurgery, INSERM U678, Hôpital Gui de Chaulic, CHU de Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier, Cedex 5, France
    J Clin Neurosci 13:885-97. 2006
  5. ncbi request reprint Contribution of cortical and subcortical electrostimulation in brain glioma surgery: methodological and functional considerations
    H Duffau
    Departement de Neurochirurgie, INSERM U678, Hopital Gui de Chauliac, CHU de Montpellier, 80, avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Neurophysiol Clin 37:373-82. 2007
  6. doi request reprint A re-examination of neural basis of language processing: Proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming
    Hugues Duffau
    Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 avenue Augustin Fliche, 34295 Montpellier, France Institut of Neuroscience of Montpellier, INSERM U1051, Team Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors, Hopital Saint Eloi, CHU Montpellier, 80 avenue Augustin Fliche, 34091 Montpellier, France Electronic address
    Brain Lang 131:1-10. 2014
  7. doi request reprint The "onco-functional balance" in surgery for diffuse low-grade glioma: integrating the extent of resection with quality of life
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, Montpellier University Medical Center, 80 av Augustin Fliche, 34295, Montpellier, France
    Acta Neurochir (Wien) 155:951-7. 2013
  8. doi request reprint A new philosophy in surgery for diffuse low-grade glioma (DLGG): oncological and functional outcomes
    H Duffau
    Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80, avenue Augustin Fliche, 34295 Montpellier, France
    Neurochirurgie 59:2-8. 2013
  9. doi request reprint [Awake surgery for brain gliomas: plea for an increased involvement of anesthesiologists]
    H Duffau
    Departement de Neurochirurgie, Hopital Gui de Chauliac, CHU de Montpellier, 80, avenue Augustin Fliche, 34295 Montpellier, France
    Ann Fr Anesth Reanim 31:e81-6. 2012
  10. doi request reprint The challenge to remove diffuse low-grade gliomas while preserving brain functions
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, Montpellier University Medical Center, France
    Acta Neurochir (Wien) 154:569-74. 2012

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. pmc Intraoperative mapping of the cortical areas involved in multiplication and subtraction: an electrostimulation study in a patient with a left parietal glioma
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    J Neurol Neurosurg Psychiatry 73:733-8. 2002
    ....
  2. ncbi request reprint Extension of paralimbic low grade gliomas: toward an anatomical classification based on white matter invasion patterns
    Emmanuel Mandonnet
    Department of Neurosurgery, INSERM U678, Hopital de la Salpetriere, 47 83 Bd de l Hopital, 75651, Cedex, 13, Paris, France
    J Neurooncol 78:179-85. 2006
    ..We thus propose to analyze the extension of paralimbic low grade gliomas in terms of invaded subcortical pathways...
  3. ncbi request reprint Assessment of verbal working memory before and after surgery for low-grade glioma
    Pilar Teixidor
    Department of Neurosurgery, Hospital Germans Trias i Pujol, Ctra del Canyet s n, 08916, Badalona, Barcelona, Spain
    J Neurooncol 81:305-13. 2007
    ..We assessed verbal working memory (vWM) in patients with LGG in language areas, before and after surgery, to evaluate the effect of glioma and resection on cognition, respectively...
  4. ncbi request reprint Brain plasticity: from pathophysiological mechanisms to therapeutic applications
    Hugues Duffau
    Department of Neurosurgery, INSERM U678, Hôpital Gui de Chaulic, CHU de Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier, Cedex 5, France
    J Clin Neurosci 13:885-97. 2006
    ....
  5. ncbi request reprint Contribution of cortical and subcortical electrostimulation in brain glioma surgery: methodological and functional considerations
    H Duffau
    Departement de Neurochirurgie, INSERM U678, Hopital Gui de Chauliac, CHU de Montpellier, 80, avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Neurophysiol Clin 37:373-82. 2007
    ..In conclusion, IES enables to increase the impact of surgery on the natural history of gliomas, to preserve the quality of life, and to better understand the dynamic functional anatomy of the brain...
  6. doi request reprint A re-examination of neural basis of language processing: Proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming
    Hugues Duffau
    Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80 avenue Augustin Fliche, 34295 Montpellier, France Institut of Neuroscience of Montpellier, INSERM U1051, Team Plasticity of Central Nervous System, Human Stem Cells and Glial Tumors, Hopital Saint Eloi, CHU Montpellier, 80 avenue Augustin Fliche, 34091 Montpellier, France Electronic address
    Brain Lang 131:1-10. 2014
    ....
  7. doi request reprint The "onco-functional balance" in surgery for diffuse low-grade glioma: integrating the extent of resection with quality of life
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, Montpellier University Medical Center, 80 av Augustin Fliche, 34295, Montpellier, France
    Acta Neurochir (Wien) 155:951-7. 2013
    ..In other words, in the era of "evidence-based medicine", it is crucial to not forget "individual-based medicine" by offering tailored resections adapted to each patient...
  8. doi request reprint A new philosophy in surgery for diffuse low-grade glioma (DLGG): oncological and functional outcomes
    H Duffau
    Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, 80, avenue Augustin Fliche, 34295 Montpellier, France
    Neurochirurgie 59:2-8. 2013
    ..Discrepancies in the classical literature are mainly due to the lack of objective radiological assessment of the extent of resection (EOR). Here, the goal is to review the recent data on oncological and functional outcomes...
  9. doi request reprint [Awake surgery for brain gliomas: plea for an increased involvement of anesthesiologists]
    H Duffau
    Departement de Neurochirurgie, Hopital Gui de Chauliac, CHU de Montpellier, 80, avenue Augustin Fliche, 34295 Montpellier, France
    Ann Fr Anesth Reanim 31:e81-6. 2012
    ..In this state of mind, anaesthesiologists have to play a central role, through an increased involvement in this field...
  10. doi request reprint The challenge to remove diffuse low-grade gliomas while preserving brain functions
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, Montpellier University Medical Center, France
    Acta Neurochir (Wien) 154:569-74. 2012
    ....
  11. doi request reprint Awake surgery for incidental WHO grade II gliomas involving eloquent areas
    Hugues Duffau
    Department of Neurosurgery, Gui de Chauliac Hospital, CHU Montpellier, Montpellier University Medical Center, France
    Acta Neurochir (Wien) 154:575-84; discussion 584. 2012
    ..Here, the aim was to study for the first time the functional results and extent of resection in a prospective series of patients who underwent resection for incidental G2G within eloquent areas...
  12. doi request reprint The "frontal syndrome" revisited: lessons from electrostimulation mapping studies
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, CHU Montpellier, France
    Cortex 48:120-31. 2012
    ..These findings illustrate well the need to reinforce links between cognitive neuroscience and clinical neurology/neurosurgery...
  13. doi request reprint [Plea for a systematic initiation to research during neurosurgical educational program]
    H Duffau
    Service de Neurochirurgie, Hopital Gui de Chauliac, CHU de Montpellier, Montpellier, France
    Neurochirurgie 54:767-70. 2008
    ..The current reorganization of the education program should make this official and budget a systematic initiation to research during training, essential for the future of French neurosurgery...
  14. doi request reprint Evidence for the genesis of WHO grade II glioma in an asymptomatic young adult using repeated MRIs
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, CHU Montpellier, 80 av Augustin Fliche, 34295, Montpellier, France
    Acta Neurochir (Wien) 153:473-7. 2011
    ..In addition, estimation of the date of birth may serve as a reproducible "starting point" when analyzing survivals in series of G2G...
  15. doi request reprint A personal consecutive series of surgically treated 51 cases of insular WHO Grade II glioma: advances and limitations
    Hughes Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, Centre Hospitalier Universitaire Montpellier, France
    J Neurosurg 110:696-708. 2009
    ..On the basis of the functional and oncological results, advances and limitations of this challenging surgery are discussed...
  16. doi request reprint Awake surgery for nonlanguage mapping
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, CHU Montpellier, Montpellier, France
    Neurosurgery 66:523-8; discussion 528-9. 2010
    ....
  17. ncbi request reprint [Update on surgery for diffuse low-grade gliomas: brain mapping, hodotopy and neuroplasticity]
    Hugues Duffau
    Neurochirurgie, Hopital Gui de Chauliac, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier, France
    Bull Acad Natl Med 195:37-49; discussion 49-51. 2011
    ..It also preserves and may improve quality of life, even in patients whose gliomas involve eloquent areas, that were previously considered unresectable...
  18. doi request reprint Functional outcome after language mapping for insular World Health Organization Grade II gliomas in the dominant hemisphere: experience with 24 patients
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
    Neurosurg Focus 27:E7. 2009
    ....
  19. doi request reprint Cortico-subcortical organization of language networks in the right hemisphere: an electrostimulation study in left-handers
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, INSERM U678 and CNRS UMR 8189, CHU de Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Neuropsychologia 46:3197-209. 2008
    ....
  20. doi request reprint Surgery of low-grade gliomas: towards a 'functional neurooncology'
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, France
    Curr Opin Oncol 21:543-9. 2009
    ..Recently, new technical and conceptual advances in surgery have dramatically changed the management...
  21. doi request reprint Is the left uncinate fasciculus essential for language? A cerebral stimulation study
    Hugues Duffau
    Dept of Neurosurgery, Hopital Gui de Chauliac, CHU Montpellier, 80 av Augustin Fliche, 34295, Montpellier, France
    J Neurol 256:382-9. 2009
    ..However, we have to underline the fact not all language functions can be probed during surgery, and that more sensitive tasks have now to be added...
  22. ncbi request reprint [Management of low-grade gliomas]
    Hugues Duffau
    Département de neurochirurgie et Inserm U678, Hopital Gui de Chauliac, 34295 Monpellier Cedex 5
    Rev Prat 56:1771-7. 2006
    ..The objective is to avoid malignant transformation as long as possible while preserving the quality of life, since this tumour mostly occurs in young patients having a family life and a regular social and professional activity...
  23. doi request reprint Does post-lesional subcortical plasticity exist in the human brain?
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, CHU de Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier, France
    Neurosci Res 65:131-5. 2009
    ....
  24. doi request reprint White matter functional connectivity as an additional landmark for dominant temporal lobectomy
    H Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, CHU de Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    J Neurol Neurosurg Psychiatry 79:492-5. 2008
    ..We then discuss their implications for temporal lobectomy, by using white matter functional connectivity as an additional landmark...
  25. ncbi request reprint The anatomo-functional connectivity of language revisited. New insights provided by electrostimulation and tractography
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, CHU de Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
    Neuropsychologia 46:927-34. 2008
    ..Second, I propose an integrative view of connectivity, that considers language as the final product of the well-synchronized functioning of parallel distributed cortico-subcortical networks...
  26. doi request reprint Intraoperative subcortical stimulation mapping of language pathways in a consecutive series of 115 patients with Grade II glioma in the left dominant hemisphere
    Hugues Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, Montpellier, Paris, France
    J Neurosurg 109:461-71. 2008
    ....
  27. ncbi request reprint Functional compensation of the left dominant insula for language
    H Duffau
    Department of Neurosurgery, , , 75651 Paris, Cedex 13, France
    Neuroreport 12:2159-63. 2001
    ..This case illustrates the brain ability to maintain normal language without the left insula. The mechanisms of compensation are discussed...
  28. ncbi request reprint Postoperative speech disorder after medial frontal surgery: role of the supplementary motor area
    A Krainik
    Department of Neuroradiology, Hopital de la Salpetriere, Paris, France
    Neurology 60:587-94. 2003
    ..Patients undergoing surgical resection of medial frontal lesions may present transient postoperative speech disorders that remain largely unpredictable...
  29. ncbi request reprint The insular lobe: physiopathological and surgical considerations
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    Neurosurgery 47:801-10; discussion 810-1. 2000
    ..Using intraoperative direct cerebral stimulation, combined with neuronavigation, the authors operated on 12 insular gliomas. On the basis of this experience, the physiopathological and surgical implications are discussed...
  30. pmc Contribution of intraoperative electrical stimulations in surgery of low grade gliomas: a comparative study between two series without (1985-96) and with (1996-2003) functional mapping in the same institution
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    J Neurol Neurosurg Psychiatry 76:845-51. 2005
    ....
  31. doi request reprint Lack of complete 1p19q deletion in a consecutive series of 12 WHO grade II gliomas involving the insula: a marker of worse prognosis?
    C Goze
    Laboratoire de Biologie Cellulaire et Hormonale, Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France
    J Neurooncol 91:1-5. 2009
    ..We hypothesize that prognosis of insular GIIG is worse than in other locations, with reduced chemosensitivity. Thanks to minimization of surgical risks, surgery might be a first intention therapeutic option proposed in the GIIG...
  32. ncbi request reprint Successful resection of a left insular cavernous angioma using neuronavigation and intraoperative language mapping
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    Acta Neurochir (Wien) 147:205-8; discussion 208. 2005
    ....
  33. ncbi request reprint Correspondence between functional magnetic resonance imaging somatotopy and individual brain anatomy of the central region: comparison with intraoperative stimulation in patients with brain tumors
    S Lehericy
    Department of Neuroradiology, Hopital de la Salpetriere, Paris, France
    J Neurosurg 92:589-98. 2000
    ....
  34. ncbi request reprint Delayed onset of the supplementary motor area syndrome after surgical resection of the mesial frontal lobe: a time course study using intraoperative mapping in an awake patient
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    Stereotact Funct Neurosurg 76:74-82. 2001
    ....
  35. pmc Long term reshaping of language, sensory, and motor maps after glioma resection: a new parameter to integrate in the surgical strategy
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, 47 bd de l Hopital, 75651 Paris, Cedex 13, France
    J Neurol Neurosurg Psychiatry 72:511-6. 2002
    ..To describe cortical reorganisation and the effects of glioma infiltration on local brain function in three patients who underwent two operations 12-24 months apart...
  36. ncbi request reprint Intra-operative mapping of the subcortical visual pathways using direct electrical stimulations
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    Acta Neurochir (Wien) 146:265-9; discussion 269-70. 2004
    ....
  37. ncbi request reprint Functions of the left superior frontal gyrus in humans: a lesion study
    Foucaud du Boisgueheneuc
    Federation de Neurologie, Paris, France
    Brain 129:3315-28. 2006
    ..From a clinical perspective, this study provides new information on the impact of left SFG lesions on cognition that will be of use to neurologists and neurosurgeons...
  38. ncbi request reprint Medically intractable epilepsy from insular low-grade gliomas: improvement after an extended lesionectomy
    H Duffau
    Department of Neurosurgery, Hôpital Salpêtirère, 47 bd de l Hopital, Paris, Cedex, France
    Acta Neurochir (Wien) 144:563-72; discussion 572-3. 2002
    ....
  39. pmc Functional recovery after surgical resection of low grade gliomas in eloquent brain: hypothesis of brain compensation
    H Duffau
    Department of Neurosurgery, Hôf pital Salpêtriére, Paris, France
    J Neurol Neurosurg Psychiatry 74:901-7. 2003
    ..To describe functional recovery after surgical resection of low grade gliomas (LGG) in eloquent brain areas, and discuss the mechanisms of compensation...
  40. ncbi request reprint [A clinical study of the number processing system: decimal size effects on reading numbers in patients with left parieto-occipital gliomas]
    F M Gasparini
    Service de Neurochirurgie, Groupe Hospitalier de la Pitié Salpêtrière, Paris
    Rev Neurol (Paris) 161:427-35. 2005
    ..We tried to explain verbal disturbances as well as lexical errors as a consequence of lesion of the left-hemispheric perisylvian areas, while syntactic errors as a consequence of impairment of the intraparietal region...
  41. ncbi request reprint Role of the healthy hemisphere in recovery after resection of the supplementary motor area
    A Krainik
    Department of Neuroradiology, Hopital de la Pitie Salpetriere, Paris, France
    Neurology 62:1323-32. 2004
    ..To determine the compensatory mechanisms involved in the recovery of motor function following surgical lesions of the supplementary motor area (SMA) and their relation to the clinical characteristics of recovery...
  42. ncbi request reprint Role of the supplementary motor area in motor deficit following medial frontal lobe surgery
    A Krainik
    Department of Neuroradiology, , Paris, France
    Neurology 57:871-8. 2001
    ..The clinical characteristics of this deficit support the role of the SMA proper in the initiation and execution of the movement...
  43. ncbi request reprint [Proposing surgical management to a patient with low-grade glioma: controversies and ethical consequences]
    M Lopes
    Service de Neurochirurgie, Hopital de la Salpetriere, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Neurochirurgie 48:69-74. 2002
    ..Performing prospective studies able to analyse these different modalities is mandatory whenever we want to be enable to give to our patients the best answer in their precise case, and furthermore to justify back our acts too...
  44. ncbi request reprint [Surgery of intracranial epidermoid cysts. Report of 44 patients and review of the literature]
    M Lopes
    Service de Neurochirurgie, Hospital de la Salpetriere, 75651 Paris Cedex, France
    Neurochirurgie 48:5-13. 2002
    ..Prolonged cerebral retraction could be one of the responsible factors. One of the technical proposals could be to perform a transparenchymal approach in selected patients...
  45. ncbi request reprint Recovery from complete hemiplegia following resection of a retrocentral metastasis: the prognostic value of intraoperative cortical stimulation
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    J Neurosurg 95:1050-2. 2001
    ..Consequently, if motor responses can be elicited by CSs, it becomes mandatory for the surgeon to respect the primary motor area despite the preoperative hemiplegia, with the aim of preserving the chances of an eventual recovery...
  46. ncbi request reprint Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions
    K Hoang-Xuan
    Federation Neurologique Mazarin, Groupe Hospitalier Pitie Salpetriere, Paris, France
    J Clin Oncol 22:3133-8. 2004
    ..To determine the response rate of low-grade oligodendroglial tumors (LGOT) to temozolomide (TMZ) as initial treatment and to evaluate the predictive value of chromosome 1p deletion on the radiologic response...
  47. doi request reprint [Second surgery for glioblastoma. A 4-year retrospective study conducted in both the Montpellier and Nice Departments of Neurosurgery. A literature review]
    N Lonjon
    Departement de Neurochirurgie, Hopital Gui de Chauliac, 80, avenue Augustin Fliche, 34091 Montpellier Cedex 05, France
    Neurochirurgie 56:36-42. 2010
    ..Despite optimal treatment, nearly all malignant gliomas recur. If the tumor is symptomatic for mass effect, repeated surgery may be proposed...
  48. ncbi request reprint Initial chemotherapy in gliomatosis cerebri
    M Sanson
    Fédération de Neurologie Mazarin, Groupe hospitalier Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France
    Neurology 63:270-5. 2004
    ..Because of the diffuse nature of gliomatosis cerebri (GC), surgery is not suitable, and large field radiotherapy carries the risk of severe toxicity. In this setting, initial chemotherapy warrants further investigation...
  49. ncbi request reprint Correlations between molecular profile and radiologic pattern in oligodendroglial tumors
    F Laigle-Donadey
    Fédération de Neurologie Mazarin, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Neurology 63:2360-2. 2004
    ..To investigate possible correlations between tumor location and genetic alterations in a series of oligodendrogliomas...
  50. ncbi request reprint A new device for electrical stimulation mapping of the brainstem and spinal cord
    H Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    Minim Invasive Neurosurg 46:61-4. 2003
    ..Improvement of such a mapping first minimizes the risk of sequelae, second optimizes the quality of resection, and third may also give a prognostic value concerning the changes of postsurgical recovery in case of a preoperative deficit...
  51. ncbi request reprint Antisaccade deficit after anterior cingulate cortex resection
    D Milea
    Laboratoire Physiologie de la Perception et de l Action, College de France, Paris, France
    Neuroreport 14:283-7. 2003
    ..This same region was spared in the three remaining patients with no antisaccade deficit, suggesting that the anterior cingulate cortex, known as the cingulate eye field, could play a role in suppression of unwanted saccades...
  52. ncbi request reprint Brain plasticity and tumors
    H Duffau
    Department of Neurosurgery, Hopital Gui de Chauliac, CHU de Montpellier, Montpellier Cedex, France
    Adv Tech Stand Neurosurg 33:3-33. 2008
    ....
  53. ncbi request reprint A novel approach to clinical-radiological correlations: Anatomo-Clinical Overlapping Maps (AnaCOM): method and validation
    Serge Kinkingnehun
    INSERM U610, Paris, France
    Neuroimage 37:1237-49. 2007
    ..The method complements the functional imaging techniques, as it tells which regions are necessary for a given function and it explores cortical regions as well as the white matter...
  54. ncbi request reprint Resection of World Health Organization Grade II gliomas involving Broca's area: methodological and functional considerations
    Mohammed Benzagmout
    Department of Neurosurgery, University Hospital Hassan II, Fez, Morocco
    Neurosurgery 61:741-52; discussion 752-3. 2007
    ..We report the first surgical series of LGGs involving this area by focusing on methodological and functional considerations...
  55. doi request reprint Long-term brain plasticity allowing a multistage surgical approach to World Health Organization Grade II gliomas in eloquent areas
    Santiago Gil Robles
    Department of Neurosurgery, Hopital Gui de Chauliac, Centre Hospitalier Universitaire de Montpellier, France
    J Neurosurg 109:615-24. 2008
    ..Based on their experience with these cases, the authors suggest that in cases of incomplete glioma removal, a second operation before anaplasia should be considered, made possible by brain reorganization after the first operation...
  56. doi request reprint Visualization of disconnection syndromes in humans
    Michel Thiebaut de Schotten
    Hopital de la Salpetriere, Paris, France
    Cortex 44:1097-103. 2008
    ..This method will help researchers and clinicians to identify the neural bases of cognitive abilities and the behavioral consequences of brain lesions...
  57. ncbi request reprint Mapping of visuospatial functions during brain surgery: a new tool to prevent unilateral spatial neglect
    Paolo Bartolomeo
    Neurosurgery 61:E1340. 2007
  58. doi request reprint Computational modeling of the WHO grade II glioma dynamics: principles and applications to management paradigm
    Emmanuel Mandonnet
    Department of Neurosurgery, Lariboisiere Hospital, Paris, France
    Neurosurg Rev 31:263-9. 2008
    ..The role of these dynamics for both therapeutic management and biological research will be discussed...
  59. doi request reprint Regions, systems, and the brain: hierarchical measures of functional integration in fMRI
    Guillaume Marrelec
    INSERM, U678, Paris F 75013, France
    Med Image Anal 12:484-96. 2008
    ..We apply this method to fMRI datasets from patients with low-grade glioma and show how it can efficiently extract information related to both intra- and interhemispheric reorganization induced by lesional brain plasticity...
  60. ncbi request reprint Does the left inferior longitudinal fasciculus play a role in language? A brain stimulation study
    Emmanuel Mandonnet
    Department of Neurosurgery, Institut de Psychologie, 71 Av Edouard Vaillant, 92774 Boulogne Billancourt, France
    Brain 130:623-9. 2007
    ....
  61. ncbi request reprint Involuntary language switching in two bilingual patients during the Wada test and intraoperative electrocortical stimulation
    Kuan H Kho
    Department of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Lang 101:31-7. 2007
    ..These data complement the few lesion studies on (involuntary or unintentional) language switching, and add to the functional neuroimaging studies of switching, monitoring, and controlling the language in use...
  62. ncbi request reprint Contrasting acute and slow-growing lesions: a new door to brain plasticity
    Michel Desmurget
    Brain and Vision Research, INSERM U 371, Bron, France
    Brain 130:898-914. 2007
    ..Finally in a last section, we briefly discuss the main implications of these results...
  63. ncbi request reprint Episodic nocturnal wandering in a patient with epilepsy due to a right temporoinsular low-grade glioma: relief following resection. Case report
    Hugues Duffau
    Department of Neurosurgery, Hopital Salpetriere, Paris, France
    J Neurosurg 104:436-9. 2006
    ..Moreover, a temporoinsular origin of ENW can now be considered...
  64. ncbi request reprint The insular lobe and brain plasticity: Lessons from tumor surgery
    Hugues Duffau
    Departments of Neurosurgery and Inserm U678, Hopital Salpetriere, 47 83 Bd de l Hopital, 75651 Paris Cedex 13, France
    Clin Neurol Neurosurg 108:543-8. 2006
    ..Despite recent literature supporting the likely role of the insula in many functions, the actual participation of this multimodal lobe in the brain functioning remains unclear, i.e. has the insula an essential or compensable role?..
  65. ncbi request reprint Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans
    Michel Thiebaut de Schotten
    INSERM Unit 610, Assistance Publique Hopitaux de Paris, Hopital de la Salpetriere, 75013 Paris, France
    Science 309:2226-8. 2005
    ..These findings suggest that parietal-frontal communication is necessary for the symmetrical processing of the visual scene...
  66. ncbi request reprint Simulation of anisotropic growth of low-grade gliomas using diffusion tensor imaging
    Saad Jbabdi
    U678 INSERM UPMC, Paris, France
    Magn Reson Med 54:616-24. 2005
    ..Anisotropic brain tumor growth simulations provide a means to determine the initial location of a low-grade glioma as well as its cell diffusion tensor, both of which might reflect the biological characteristics of invasion...
  67. ncbi request reprint Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity
    Hugues Duffau
    Department of Neurosurgery, INSERM U678, Hopital Salpetriere, Paris, France
    Lancet Neurol 4:476-86. 2005
    ....
  68. ncbi request reprint Intraoperative cortico-subcortical stimulations in surgery of low-grade gliomas
    Hugues Duffau
    Department of Neurosurgery, INSERM U678, UPMC, Hopital Salpetriere, 47 83 Bd de l Hopital, 75013, Paris, France
    Expert Rev Neurother 5:473-85. 2005
    ....
  69. ncbi request reprint New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations
    Hugues Duffau
    Department of Neurosurgery, U 678, Hopital Salpetriere, 47 83 Bd de l Hopital, 75651 Paris, Cedex 13, France
    Brain 128:797-810. 2005
    ..Such a ventral stream might anatomically partly correspond to the inferior fronto-occipital fasciculus...
  70. ncbi request reprint Usefulness of intraoperative electrical subcortical mapping during surgery for low-grade gliomas located within eloquent brain regions: functional results in a consecutive series of 103 patients
    Hugues Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    J Neurosurg 98:764-78. 2003
    ..The authors in this report describe the importance of mapping cortical and subcortical functional regions by using intraoperative real-time direct electrical stimulations during resection of low-grade gliomas...
  71. ncbi request reprint Double dissociation between picture naming and comprehension: an electrostimulation study
    Peggy Gatignol
    Department of Neurology and Neurosurgery, Hopital de la Salpetriere, 47 83 Bd de l Hopital, 75651 Paris, Cedex 13, France
    Neuroreport 15:191-5. 2004
    ....
  72. ncbi request reprint Transient Foix-Chavany-Marie syndrome after surgical resection of a right insulo-opercular low-grade glioma: case report
    Hugues Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    Neurosurgery 53:426-31; discussion 431. 2003
    ..We describe an atypical case of transient Foix-Chavany-Marie syndrome, or faciopharyngoglossomasticatory diplegia with automatic voluntary dissociation, occurring after surgical resection of a right insulo-opercular glioma...
  73. ncbi request reprint Surgical removal of corpus callosum infiltrated by low-grade glioma: functional outcome and oncological considerations
    Hugues Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    J Neurosurg 100:431-7. 2004
    ..The aim of this paper was to analyze functional outcome following removal of corpus callosum invaded by LGG and to analyze the impact of this callosectomy on the quality of resection...
  74. ncbi request reprint The role of dominant premotor cortex in language: a study using intraoperative functional mapping in awake patients
    Hugues Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, APHP, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
    Neuroimage 20:1903-14. 2003
    ....
  75. ncbi request reprint Incontinence after brain glioma surgery: new insights into the cortical control of micturition and continence. Case report
    Hugues Duffau
    Department of Neurosurgery, Hopital Salpetriere, Paris, France
    J Neurosurg 102:148-51. 2005
    ..On the basis of these results, a preliminary model of a cortical network associated with micturition and continence is proposed...
  76. ncbi request reprint [Low grade gliomas and cerebral plasticity: fundamental and clinical implications]
    FranCois Bonnetblanc
    INSERM U371, Vision et Cerveau, Bron, France
    Med Sci (Paris) 22:389-94. 2006
    ..When considered together these results have obvious fundamental and clinical implications. They open new perspectives for understanding cerebral dynamics and the process of brain plasticity...
  77. ncbi request reprint New concepts in surgery of WHO grade II gliomas: functional brain mapping, connectionism and plasticity--a review
    Hugues Duffau
    Department of Neurosurgery, UMR S678 Inserm, Hopital Salpetriere, Paris, France
    J Neurooncol 79:77-115. 2006
    ..In addition, such a strategy has also fundamental applications, since it represents a new door to the connectionism and cerebral plasticity...
  78. pmc Preoperative estimation of residual volume for WHO grade II glioma resected with intraoperative functional mapping
    Emmanuel Mandonnet
    Department of Neurosurgery, Hopital de la Pitie Salpetriere, 75651 Paris, France
    Neuro Oncol 9:63-9. 2007
    ..This rationale will assist in decisions regarding surgical resection and may thus contribute to the elaboration of a therapeutic consensus for WHO grade II glioma...
  79. ncbi request reprint Prognostic value of initial magnetic resonance imaging growth rates for World Health Organization grade II gliomas
    Johan Pallud
    Service de Neurochirurgie, Hopital de la Pitie Salpetriere, Paris, France
    Ann Neurol 60:380-3. 2006
    ..0 years for a growth rate <8mm/year). Thus, individual magnetic resonance imaging tumor growth rates should be incorporated in the planning of the initial therapeutic strategy of grade II gliomas...
  80. ncbi request reprint Intraoperative mapping of the subcortical language pathways using direct stimulations. An anatomo-functional study
    Hugues Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, 47 83 Bd de l Hopital, 75651 Paris, Cedex 13, France
    Brain 125:199-214. 2002
    ....
  81. ncbi request reprint Somatotopy of the supplementary motor area: evidence from correlation of the extent of surgical resection with the clinical patterns of deficit
    Denys Fontaine
    Department of Neurosurgery, Hopital Pasteur, Nice, France
    Neurosurgery 50:297-303; discussion 303-5. 2002
    ..This study, which aimed to confirm or invalidate the somatotopic organization of the supplementary motor area (SMA), correlates the pattern of clinical symptoms observed after SMA removal with the extent of resection...
  82. ncbi request reprint The articulatory loop: study of the subcortical connectivity by electrostimulation
    Hugues Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, Cedex 13, France
    Neuroreport 14:2005-8. 2003
    ..This is the first report of direct tracking of the subcortical connectivity underlying the fronto-parietal articulatory loop, allowing to better understand the pathophysiology of this network and the consequences of its damage...
  83. ncbi request reprint Functional compensation of the claustrum: lessons from low-grade glioma surgery
    Hugues Duffau
    J Neurooncol 81:327-9. 2007
  84. ncbi request reprint Superior longitudinal fasciculus subserves vestibular network in humans
    Giannantonio Spena
    Department of Neurosurgery, University of Genova, San Martino Hospital, San Martino, Genova, Italy
    Neuroreport 17:1403-6. 2006
    ..We argue that this fasciculus plays a major role in the functional connectivity of the areas involved in the complex multimodal network that controls vestibular function...
  85. ncbi request reprint Intraoperative frontal eye field stimulation elicits ocular deviation and saccade suppression
    Dan Milea
    Laboratoire de Physiologie de la Perception et de l Action, College de France, 13, place Marcelin Berthelot, 75005 Paris, France
    Neuroreport 13:1359-64. 2002
    ..In humans, intraoperative FEF stimulation may elicit recordable contraversive SEM, and interfere with oculomotor behaviour, suppressing self-paced saccades...
  86. ncbi request reprint Absence of movement disorders after surgical resection of glioma invading the right striatum
    Hugues Duffau
    Department of Neurosurgery, Hopital de la Salpetriere, Paris, France
    J Neurosurg 97:363-9. 2002
    ....
  87. ncbi request reprint Radical surgery after chemotherapy: a new therapeutic strategy to envision in grade II glioma
    Hugues Duffau
    Department of Neurosurgery, UMR S678, Inserm UPMC, Hopital Salpetriere, 75651, Paris, Cedex 13, France
    J Neurooncol 80:171-6. 2006
    ..5 years since the first symptom). We propose a new therapeutic strategy in unresectable LGG, with preoperative chemotherapy, to make a radical surgery possible in a second step, while preserving the quality of life...
  88. ncbi request reprint Analysis of loss of chromosome 10q, DMBT1 homozygous deletions, and PTEN mutations in oligodendrogliomas
    Marc Sanson
    INSERM U495, Laboratoire de Biologie des Interactions Neurones Glie, Groupe hospitalier Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France
    J Neurosurg 97:1397-401. 2002
    ..Chromosomal deletions of 10q and candidate genes such as PTEN and DMBT1 have been thoroughly investigated in glioblastomas but few data specifically address oligodendrogliomas...
  89. ncbi request reprint Modeling of pathophysiological coupling between brain electrical activation, energy metabolism and hemodynamics: insights for the interpretation of intracerebral tumor imaging
    Agnès Aubert
    INSERM U 483, Universite Pierre et Marie Curie, Boite 23, 9 quai Saint Bernard, 75252 Paris 05, France
    Acta Biotheor 50:281-95. 2002
    ..In conclusion, we suggest that the coupled use of BOLD fMRI and MRS could contribute to a better understanding of the neurovascular and metabolic decoupling in gliomas...
  90. doi request reprint Awareness of intending to act following parietal cortex resection
    Gilles Lafargue
    Laboratoire Neurosciences Fonctionnelles and Pathologies, CNRS, Universite Lille Nord de France, France
    Neuropsychologia 46:2662-7. 2008
    ..A new perspective towards a hodological view for higher-order cognitive processes seems open...
  91. ncbi request reprint Continuous growth of mean tumor diameter in a subset of grade II gliomas
    Emmanuel Mandonnet
    Fédération de Neurologie Mazarin and INSERM U495, and Service de Neurochirurgie, Hôpital de la Salpêtrière AP HP, Paris
    Ann Neurol 53:524-8. 2003
    ..These findings could be of interest to optimize patients management and follow-up...
  92. ncbi request reprint Partial correlation for functional brain interactivity investigation in functional MRI
    Guillaume Marrelec
    INSERM U678, Paris F 75013, France
    Neuroimage 32:228-37. 2006
    ..We demonstrate the interest of this approach on real data...
  93. ncbi request reprint Preferential brain locations of low-grade gliomas
    Hugues Duffau
    Department of Neurosurgery, Hopital Salpetriere, Paris, France
    Cancer 100:2622-6. 2004
    ....
  94. doi request reprint Brain tumors and epilepsy
    Christian Brogna
    Department of Neuroscience Neurosurgery, Sapienza University of Rome, Viale del Policlinico, 155, 00185 Rome, Italy
    Expert Rev Neurother 8:941-55. 2008
    ..Moreover, the insula may participate more often than usually considered in (intractable) seizures. Therefore, in these patients, invasive EEG recordings and eventually a second epilepsy surgery might be proposed...
  95. ncbi request reprint Unruptured intracranial aneurysms treated by three-dimensional coil embolization: evaluation of the postoperative aneurysm occlusion volume
    Jean Noel Vallee
    Department of Diagnostic and Interventional Neuroradiology, Pitie Salpetriere Hospital, Medical Université of Paris 6, France
    Neuroradiology 47:438-45. 2005
    ..002). The use of the largest number of 3D coils per aneurysm was safe and may improve the postoperative volume and angiographic occlusion of aneurysms with a neck >4 mm, provided the sac-to-neck ratio is > or =1.5...
  96. ncbi request reprint Chromosome 1p loss: a favorable prognostic factor in low-grade gliomas
    Michele Kujas
    INSERM U711 et Université Pierre et Marie Curie Paris VI, France
    Ann Neurol 58:322-6. 2005
    ..521), indicating a major favorable prognostic role of this genetic alteration in low-grade gliomas...
  97. ncbi request reprint Proton magnetic resonance spectroscopy predicts proliferative activity in diffuse low-grade gliomas
    Remy Guillevin
    Department of Neuroradiology, Pitie Salpetriere Hospital, Paris, France
    J Neurooncol 87:181-7. 2008
    ..05). This study suggests that (1)HMRS is a reliable tool to evaluate the proliferation activity of WHO grade 2 glioma and to identify potentially more aggressive clinical behavior...
  98. ncbi request reprint A discrete area within the left dorsolateral prefrontal cortex involved in visual-verbal incongruence judgment
    Monique Plaza
    Laboratoire de Psychologie et de Neurosciences Cognitives, FRE 2987 CNRS Université de Paris V René Descartes, Institut de Psychologie, 71 Avenue Edouard Vaillant, 92774 Boulogne Billancourt, France
    Cereb Cortex 18:1253-9. 2008
    ....
  99. ncbi request reprint Brain lymphoma: usefulness of the magnetic resonance spectroscopy
    Sophie Taillibert
    Department of Neuro Oncology, Pitie Salpetriere Hospital, 47 83 boulevard de l Hopital, Paris, France
    J Neurooncol 86:225-9. 2008
    ..The case we report here illustrates the contribution of magnetic resonance spectroscopy in the diagnostic approach of a very atypical PCNSL...