Research Topics
| Francois DubosSummaryCountry: France Publications
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Detail Information
Publications
[Efficacy and tolerance of mefloquine in the treatment of infants and children with Plasmodium falciparum malaria]F Dubos
Service de Pediatrie, Centre Hospitalier Andrée Rosemon, Clinique de Pediatrie, Hopital Jeanne de Flandre, Lille, France
Arch Pediatr 10:25-30. 2003..Only a limited number of treatments are available for use in young children with malaria...
[Mefloquine treatment in infants and children with Plasmodium falciparum malaria: an efficient and well tolerated treatment]F Dubos
Service de Réanimation Pédiatrique, Hopital Jeanne de Flandre, 2, Avenue Oscar Lambret, 59037 Lille Cedex, France
Pathol Biol (Paris) 51:534-9. 2003..The aim of this study was to evaluate the efficacy and tolerance of mefloquine treatment in children, especially in infants of less than 15 kg, in an endemic area of malaria (French Guiana)...
Safety of mefloquine in infants with acute falciparum malariaFrancois Dubos
Pediatric Intensive Care Unit, Jeanne de Flandre Hospital, Lille, France
Pediatr Infect Dis J 23:679-81. 2004..Side effects were recorded in 30.8% of patients and consisted chiefly of mild and transient gastrointestinal symptoms. Mefloquine was safe in infants weighing <15 kg in our experience...
[Interferon alpha production in the serum of very young infants after viral infections]F Dubos
Service de Pediatrie, Hopital Saint Vincent de Paul, 82, avenue Denfert Rochereau, 75014 Paris, France
Med Mal Infect 34:561-5. 2004..IFN-alpha detection is useful in some clinical circumstances, but its use has never been validated in young infants with viral infections...
Decline in pneumococcal meningitis after the introduction of the heptavalent-pneumococcal conjugate vaccine in northern FranceF Dubos
Paediatric Emergency and Infectious Diseases Unit, Department of Paediatrics, Jeanne de Flandre Hospital and Lille 2 University, Lille, France
Arch Dis Child 92:1009-12. 2007..The impact of the heptavalent-pneumococcal conjugate vaccine on the incidence of pneumococcal meningitis in Europe has not yet been assessed...
Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rulesFrancois Dubos
Department of Pediatrics, Saint Vincent de Paul Hospital, 74 82 Avenue Denfert Rochereau, 75014 Paris, France
Arch Dis Child 95:963-7. 2010..Clinical decision rules (CDRs) could be helpful to safely distinguish between bacterial and aseptic meningitis (AM)...
Predicting the risk of severe infection in children with chemotherapy-induced febrile neutropeniaFrancois Dubos
Univ Lille Nord de France, UDSL, Lille, France
Curr Opin Hematol 19:39-43. 2012..Clinical decision rules (CDRs) have been proposed to help predict the risk of severe infection in children with chemotherapy-induced febrile neutropenia, but none has been fully validated...
Increased detection rate of Kawasaki disease using new diagnostic algorithm, including early use of echocardiographyThérèse Heuclin
Lille University Hospital, faculté de médecine Henri Warembourg, Lille 2 University, Lille, France
J Pediatr 155:695-9.e1. 2009..To determine the incidence of Kawasaki disease (KD) in Northern France by using new American Heart Association (AHA) criteria...
Serum procalcitonin and other biologic markers to distinguish between bacterial and aseptic meningitisFrancois Dubos
Clinical Epidemiology Unit, Department of Pediatrics, Saint Vincent de Paul Hospital, AP HP, Paris Descartes University, and INSERM U149, Paris, France
J Pediatr 149:72-6. 2006..To identify the biologic tests that best distinguish between bacterial and aseptic meningitis in an emergency department (ED)...
[Performance of decision rules to predict need for computed tomography among children with blunt head trauma]A Martinot
, urgences et maladies infectieuses, , , , 59037 Lille Cedex, France
Arch Pediatr 15:721-3. 2008
[Clinical decision rules in the paediatric emergency department: when and how?]M Chalumeau
Laboratoire d Epidémiologie Clinique, urgences pédiatriques service de pédiatrie générale, Hopital Saint Vincent de Paul, 74, avenue Denfert Rochereau, 75014 Paris, France
Arch Pediatr 15:718-20. 2008
[Procalcitonin bedside testing in the pediatric emergency department]M Chalumeau
, , , , , 74, avenue Denfert-Rochereau, 75014 Paris, France
Arch Pediatr 14:529-31. 2007
Consensus in diagnostic definitions for bone or joint infections in children by a Delphi method with European French-speaking expertsAyoub Mitha
University Lille Nord de France, Lille, France
Acta Paediatr 101:e350-6. 2012..Various diagnostic criteria have been proposed for bone or joint infection. This study used a Delphi process to determine the consensual definitions for arthritis, osteomyelitis and bone or joint infections in general in children...
Predicting the risk of severe bacterial infection in children with chemotherapy-induced febrile neutropeniaEmilie Macher
Pediatric Hematology Unit, Lille Nord de France University Hospital, Lille, France
Pediatr Blood Cancer 55:662-7. 2010..The aim of this study was to evaluate the reproducibility of six clinical decision rules proposed in the literature and to compare their performance...
[Distinguishing between bacterial and aseptic meningitis in children in the emergency department]F Dubos
, , , CHRU Lille, 2, avenue Oscar-Lambret, 59037 Lille Cedex, France
Arch Pediatr 15:724-5. 2008
Infants refusing to walkFrancois Dubos
Hopital Jeanne de Flandre, Lille 59037, France
Lancet 366:93. 2005
Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort studyFrancois Dubos
Department of Pediatric Emergencies and Infectious Diseases, Roger Salengro Hospital, Centre Hopitalier Universitaire Lille and Lille 2 University, Lille, France
Arch Pediatr Adolesc Med 162:1157-63. 2008..To validate procalcitonin (PCT) level as the best biological marker to distinguish between bacterial and aseptic meningitis in children in the emergency department...
[Incidence of invasive meningococcal diseases in children in Northern France: usefulness and limits of the discharge code database for correcting compulsory notification data]F Dubos
Service de pédiatrie générale et maladies infectieuses, pôle enfant, Hopital Jeanne de Flandre, CHRU de Lille, avenue E Avinee, 59037 Lille Cedex, France
Arch Pediatr 16:984-90. 2009..Surveillance of invasive meningococcal diseases (IMD) is based on mandatory reporting. Evaluation of the exhaustivity of the surveillance with capture-recapture analysis can correct for underreporting...
[Evaluation of the antibiotic prescription in a paediatric intensive care unit]E Audry Degardin
Service de Réanimation Pédiatrique, hôpital Jeanne de Flandre et université de Lille II, avenue E Avinee, 59037 Lille Cedex, France
Arch Pediatr 14:157-63. 2007..The antibiotic prescription in intensive care units is frequent using often broad-spectrum antibiotics; its quality has never been evaluated in paediatric intensive care units...
Clinical decision rules to distinguish between bacterial and aseptic meningitisF Dubos
Clinical Epidemiology Unit, Department of Paediatrics, Saint Vincent-de-Paul Hospital, AP-HP, Paris Descartes University, Paris, France
Arch Dis Child 91:647-50. 2006..CONCLUSION: On our population, the rule derived by Nigrovic et al had the best balance between accuracy and simplicity of manual computation and could help to avoid two thirds of unnecessary antibiotic treatments and hospitalisations...
[Deceptive symptoms and analysis of diagnostic errors in pediatric emergencies]A Martinot
, , , 59037 Lille Cedex, France
Arch Pediatr 13:822-4. 2006
[Improvement in the management of acute diarrhoea in France?]A Martinot
Pediatrie Generale, urgences et maladies infectieuses, Clinique de pédiatrie et pôle de l urgence, CHRU de Lille, Hopital Jeanne de Flandre, Av E Avinée, 59037 Lille Cedex, France
Arch Pediatr 14:S181-5. 2007..Isolation and disinfection procedures are insufficient. Rotavirus nosocomial infections incidence is high: 1,6 to 6,3/1000 children less than 5 years of age, contributing to high direct costs...
Epidemiology of hospital admissions for paediatric varicella infections: a one-year prospective survey in the pre-vaccine eraF Dubos
Paediatric Emergency Department, Jeanne de Flandre University Hospital, Lille, France
Epidemiol Infect 135:131-8. 2007..7], complication at admission (aOR 5.8), recurrent fever (aOR 4.5), recent varicella in a sibling (aOR 4.0), and previous physician visit for the same condition (aOR 2.0)...
[Distinction between bacterial and aseptic meningitis in children: refinement of a clinical decision rule]F Dubos
Laboratoire d Epidémiologie Clinique, Service de Pediatrie Generale, Universite Paris Descartes, Hopital Saint Vincent de Paul, Assistance Publique Hopitaux de Paris, France
Arch Pediatr 14:434-8. 2007....
[Can clinical epidemiology in emergency care improve acute gastroenteritis management in infants?]A Martinot
Clinique de pédiatrie et université de Lille II, Hopital Jeanne de Flandre, avenue E Avinee, 59037 Lille Cedex, France
Arch Pediatr 13:555-7. 2006
[Rapid test performance characteristics evaluation]A Martinot
, urgences et maladies infectieuses, , CHRU de Lille, , , 59037 Lille Cedex, France
Arch Pediatr 14:524-6. 2007
[Diagnostic tests value at the emergency room: interpretation of results]A Martinot
, , CHU de Lille, , , 59037 Lille Cedex, France
Arch Pediatr 12:700-2. 2005
[Severity assessment of acute diarrhoea]A Martinot
Clinique de pédiatrie et université de Lille II, Hopital Jeanne de Flandre, avenue E Avinee, 59037 Lille Cedex, France
Arch Pediatr 13:1466-70. 2006..The presence of at least three signs better correlate with dehydration. Laboratory tests are not helpful. New studies are mandatory to validate severity scoring systems...
[Assessment of out-patient treatment of varicella in children]F Dubos
, , CHU Lille
Presse Med 33:992-6. 2004..CONCLUSION: It is crucial that practitioners be informed on the treatment of varicella and the risks of severe cutaneous surinfections enhanced by certain prescriptions...
