Bruno Dubois

Summary

Country: France

Publications

  1. ncbi request reprint A multicentre, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate Alzheimer's disease: the MALT study
    B Dubois
    Hopital de la Pitie Salpetriere, Paris, France
    Int J Geriatr Psychiatry 14:973-82. 1999
  2. ncbi request reprint "Applause sign" helps to discriminate PSP from FTD and PD
    B Dubois
    INSERM U 610, Federation de Neurologie, Hopital de la Salpetriere, Paris, France
    Neurology 64:2132-3. 2005
  3. ncbi request reprint Amnestic MCI or prodromal Alzheimer's disease?
    Bruno Dubois
    Fédération de Neurologie and Inserm E007, Hopital de la Salpetriere, Paris, France
    Lancet Neurol 3:246-8. 2004
  4. doi request reprint Visuospatial deficits and hemispheric perfusion asymmetries in posterior cortical atrophy
    Katia Andrade
    INSERM UMR_S 975, Centre de Recherche de l Institut du Cerveau et de la Moelle épinière CRICM, Paris, France
    Cortex 49:940-7. 2013
  5. doi request reprint Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study
    Isabelle Le Ber
    1INSERM, UMR_S679 Neurologie and Thérapeutique Expérimentale, F 75013, Paris, France
    Brain 131:732-46. 2008
  6. pmc Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging
    Emilie Gerardin
    UPMC Universite Paris 06, UMR 7225, UMR_S 975, Centre de Recherche de l Institut Cerveau Moelle CRICM, Paris, France
    Neuroimage 47:1476-86. 2009
  7. ncbi request reprint Is hippocampal volume a good marker to differentiate Alzheimer's disease from frontotemporal dementia?
    Leonardo Cruz de Souza
    CRicm, UPMC Univ Paris 06, INSERM, UMR S 678, Paris, France
    J Alzheimers Dis 36:57-66. 2013
  8. doi request reprint CSF tau markers are correlated with hippocampal volume in Alzheimer's disease
    Leonardo C de Souza
    Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de Moelle épinière, UMR S975, Paris, France
    Neurobiol Aging 33:1253-7. 2012
  9. doi request reprint The functional architecture of the left posterior and lateral prefrontal cortex in humans
    Emmanuelle Volle
    Institut National de la Sante et de la Recherche Medicale, U610, Paris, France
    Cereb Cortex 18:2460-9. 2008
  10. doi request reprint Support vector machine-based classification of Alzheimer's disease from whole-brain anatomical MRI
    Benoît Magnin
    UMR S 678, INSERM, Paris, France
    Neuroradiology 51:73-83. 2009

Detail Information

Publications100

  1. ncbi request reprint A multicentre, randomized, double-blind, placebo-controlled study to evaluate the efficacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate Alzheimer's disease: the MALT study
    B Dubois
    Hopital de la Pitie Salpetriere, Paris, France
    Int J Geriatr Psychiatry 14:973-82. 1999
    ..Metrifonate is a long-lasting acetylcholinesterase inhibitor being developed for the symptomatic treatment of Alzheimer's disease (AD)...
  2. ncbi request reprint "Applause sign" helps to discriminate PSP from FTD and PD
    B Dubois
    INSERM U 610, Federation de Neurologie, Hopital de la Salpetriere, Paris, France
    Neurology 64:2132-3. 2005
    ..It discriminated PSP from FTD (p < 0.001) and PD (p < 0.00). The "three clap test" correctly identified 81.8% of the patients in the comparison PSP and FTD and 75% of the patients in the comparison of PSP and PD...
  3. ncbi request reprint Amnestic MCI or prodromal Alzheimer's disease?
    Bruno Dubois
    Fédération de Neurologie and Inserm E007, Hopital de la Salpetriere, Paris, France
    Lancet Neurol 3:246-8. 2004
    ..Accordingly, this paper proposes diagnostic criteria for "prodromal AD"...
  4. doi request reprint Visuospatial deficits and hemispheric perfusion asymmetries in posterior cortical atrophy
    Katia Andrade
    INSERM UMR_S 975, Centre de Recherche de l Institut du Cerveau et de la Moelle épinière CRICM, Paris, France
    Cortex 49:940-7. 2013
    ..Overall, the results indicate that spatial neglect in PCA is related to inter-hemispheric perfusion asymmetries in fronto-parietal networks, with partially different neural correlates for line bisection and target cancellation...
  5. doi request reprint Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study
    Isabelle Le Ber
    1INSERM, UMR_S679 Neurologie and Thérapeutique Expérimentale, F 75013, Paris, France
    Brain 131:732-46. 2008
    ..Since all the mutations cause a progranulin haploinsufficiency, additional factors probably explain the variable clinical presentation of the disease...
  6. pmc Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging
    Emilie Gerardin
    UPMC Universite Paris 06, UMR 7225, UMR_S 975, Centre de Recherche de l Institut Cerveau Moelle CRICM, Paris, France
    Neuroimage 47:1476-86. 2009
    ..This new method may become a useful tool to assist in the diagnosis of Alzheimer's disease...
  7. ncbi request reprint Is hippocampal volume a good marker to differentiate Alzheimer's disease from frontotemporal dementia?
    Leonardo Cruz de Souza
    CRicm, UPMC Univ Paris 06, INSERM, UMR S 678, Paris, France
    J Alzheimers Dis 36:57-66. 2013
    ..However, these studies did not include patients selected according to clinico-biological criteria, using pathophysiological biomarkers...
  8. doi request reprint CSF tau markers are correlated with hippocampal volume in Alzheimer's disease
    Leonardo C de Souza
    Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de Moelle épinière, UMR S975, Paris, France
    Neurobiol Aging 33:1253-7. 2012
    ..The CSF tau and P-tau levels, but not the CSF Aβ(42) level, correlated with HV, suggesting that CSF tau markers reflect the neuronal loss associated with the physiopathological process of AD...
  9. doi request reprint The functional architecture of the left posterior and lateral prefrontal cortex in humans
    Emmanuelle Volle
    Institut National de la Sante et de la Recherche Medicale, U610, Paris, France
    Cereb Cortex 18:2460-9. 2008
    ....
  10. doi request reprint Support vector machine-based classification of Alzheimer's disease from whole-brain anatomical MRI
    Benoît Magnin
    UMR S 678, INSERM, Paris, France
    Neuroradiology 51:73-83. 2009
    ....
  11. pmc A critical role for the hippocampus in the valuation of imagined outcomes
    Maël Lebreton
    Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Paris, France Service de neuroradiologie, Hopital Pitie Salpetriere, Centre de NeuroImagerie de Recherche CENIR, Institut du Cerveau et de la Moëlle épinière ICM, Paris, France INSERM UMRS 975, CNRS UMR 7225, Université Pierre et Marie Curie UPMC Paris 6, Paris, France
    PLoS Biol 11:e1001684. 2013
    ..We conclude that hippocampus-mediated simulation plays a critical role in providing the motivation to pursue goals that are not present to our senses. ..
  12. ncbi request reprint Working memory in Parkinson's disease patients: clinical features and response to levodopa
    Rogério Beato
    INSERM U610, Groupe Hospitalier de la Pitié Salpêtrière, Paris, France
    Arq Neuropsiquiatr 66:147-51. 2008
    ..To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM...
  13. doi request reprint Visuospatial deficits in posterior cortical atrophy: structural and functional correlates
    Katia Andrade
    INSERM UMR_S 975, Centrede Recherche de l Institut du Cerveau et de la Moelle épinière CRICM, Paris, France
    J Neurol Neurosurg Psychiatry 83:860-3. 2012
    ..To determine the neural substrates of biased spatial orienting in posterior cortical atrophy (PCA) by using a combined structural and functional neuroimaging approach...
  14. doi request reprint Similar amyloid-β burden in posterior cortical atrophy and Alzheimer's disease
    Leonardo Cruz de Souza
    Fédération des Maladies du Système Nerveux, Research and Resource Memory Centre, Pavillon Jean Lhermitte, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Brain 134:2036-43. 2011
    ....
  15. doi request reprint The amnestic syndrome of hippocampal type in Alzheimer's disease: an MRI study
    Marie Sarazin
    CRICM UPMC Inserm UMR 975 Pitié Salpêtrière Hospital, Paris, France
    J Alzheimers Dis 22:285-94. 2010
    ..In AD, the FCSRT may be considered as a useful clinical marker of memory disorders due to medial temporal damage, specially the CA1 field of the hippocampus...
  16. doi request reprint Cerebrospinal fluid biomarkers in the differential diagnosis of Alzheimer's disease from other cortical dementias
    Leonardo Cruz de Souza
    CRicm, UPMC Univ Paris 06, Pitie Salpetriere Hospital, Paris, France
    J Neurol Neurosurg Psychiatry 82:240-6. 2011
    ..Additionally, biomarkers may be useful for identifying patients with atypical phenotypic presentations of AD, such as posterior cortical atrophy (PCA) and primary progressive non-fluent or logopenic aphasia (PNFLA)...
  17. ncbi request reprint Visualization of disconnection syndromes in humans
    Michel Thiebaut de Schotten
    Hopital de la Salpetriere, Paris, France
    Cortex 44:1097-103. 2008
    ..This method will help researchers and clinicians to identify the neural bases of cognitive abilities and the behavioral consequences of brain lesions...
  18. doi request reprint Neural dynamics of neglected targets in patients with right hemisphere damage
    Federica Rastelli
    Inserm U975 UPMC Paris 6, UMR_S 975 CNRS UMR 7225, Brain and Spine Institute, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Cortex 49:1989-96. 2013
    ..Furthermore, our data suggest that prefrontal activity is not necessarily beneficial to target detection, but can be detrimental to it...
  19. ncbi request reprint Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
    Bruno Dubois
    centre des maladies cognitives et comportementales, institut du cerveau et de la moelle épinière, Paris, France Université Pierre et Marie Curie Paris 6, AP HP, Hopital de la Salpetriere, Paris, France Electronic address
    Lancet Neurol 13:614-29. 2014
    ..This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD. ..
  20. doi request reprint Social Cognition and Emotional Assessment (SEA) is a marker of medial and orbital frontal functions: a voxel-based morphometry study in behavioral variant of frontotemporal degeneration
    Maxime Bertoux
    Universite Pierre et Marie Curie, Sorbonne Université, Paris 6, Paris, France
    J Int Neuropsychol Soc 18:972-85. 2012
    ..2012). Taken together, these results suggest a differential involvement of orbital and medial prefrontal subregions in SEA subscores and support the use of the SEA to evaluate the integrity of these regions in the early stages of bvFTD...
  21. ncbi request reprint A novel approach to clinical-radiological correlations: Anatomo-Clinical Overlapping Maps (AnaCOM): method and validation
    Serge Kinkingnehun
    INSERM U610, Paris, France
    Neuroimage 37:1237-49. 2007
    ..The method complements the functional imaging techniques, as it tells which regions are necessary for a given function and it explores cortical regions as well as the white matter...
  22. ncbi request reprint Functions of the left superior frontal gyrus in humans: a lesion study
    Foucaud du Boisgueheneuc
    Federation de Neurologie, Paris, France
    Brain 129:3315-28. 2006
    ..From a clinical perspective, this study provides new information on the impact of left SFG lesions on cognition that will be of use to neurologists and neurosurgeons...
  23. ncbi request reprint Distinct patterns of antiamyloid-β antibodies in typical and atypical Alzheimer disease
    Guillaume Dorothee
    INSERM, UMRS938, St Antoine Hospital, Paris, France
    Arch Neurol 69:1181-5. 2012
    ..To compare serum antiamyloid-β (Aβ) antibodies in typical and atypical Alzheimer disease (AD)...
  24. doi request reprint The SEA (Social cognition and Emotional Assessment): a clinical neuropsychological tool for early diagnosis of frontal variant of frontotemporal lobar degeneration
    Aurélie Funkiewiez
    INSERM UPMC UMRS 975, Federation de Neurologie, AP HP Hôpital de la Pitié Salpêtrière, Universite Paris, France
    Neuropsychology 26:81-90. 2012
    ..Here, we propose a new tool, the SEA (Social cognition and Emotional Assessment), for use in evaluating the functions of the orbital and ventral-medial portions of the prefrontal cortex...
  25. doi request reprint Confabulation in Alzheimer's disease: poor encoding and retrieval of over-learned information
    Eve Attali
    INSERM Unit 610, Pavillon Claude Bernard, Hopital de la Salpetriere, 47, Bd de l Hopital, Paris, France
    Brain 132:204-12. 2009
    ..g. Little Red Riding Hood is eaten by the wolf). This is the first experimental evidence showing that poor encoding and over-learned information are involved in confabulation in Alzheimer's disease...
  26. ncbi request reprint Sensitivity and specificity of ventromedial prefrontal cortex tests in behavioral variant frontotemporal dementia
    Maxime Bertoux
    Sorbonne Université Paris 6, Paris, France Institut du Cerveau et de la Moëlle épinière, UMRS 975, Paris, France Institut de la Mémoire et de la Maladie d Alzheimer IMMA, Hopital de la Pitie Salpetriere, Paris, France Reference Centre on Rare Dementias, Hopital de la Pitie Salpetriere, Paris, France Electronic address
    Alzheimers Dement 9:S84-94. 2013
    ..To date, however, there is no consensus regarding which tests are most sensitive and specific to assess VMPFC dysfunction in this condition...
  27. ncbi request reprint An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and execution
    Mathias Pessiglione
    Hopital de la Salpetriere, Paris, France
    J Cogn Neurosci 17:1886-96. 2005
    ..We suggest that such coupling may be related to the loss of dopamine-mediated functional segregation between basal ganglia circuits processing different stages of goal-directed behavior...
  28. ncbi request reprint Neural correlates of primary and reflective consciousness of spatial orienting
    Paolo Bartolomeo
    INSERM UPMC UMR S 610, Hopital Salpetriere, Paris, France
    Neuropsychologia 46:348-61. 2008
    ..The extensive pattern of connectivity of the ACC is ideally suited to integrate the activity of the large neural assemblies necessary for reflective consciousness to emerge...
  29. ncbi request reprint Demographic, neurological and behavioural characteristics and brain perfusion SPECT in frontal variant of frontotemporal dementia
    Isabelle Le Ber
    AP HP, Hopital de la Salpetriere, Centre de Neuropsychologie UPMC, Paris, France
    Brain 129:3051-65. 2006
    ..Finally, it demonstrates the prognostic value of brainstem hypoperfusion in a subgroup of patients with a short survival...
  30. doi request reprint Revising the definition of Alzheimer's disease: a new lexicon
    Bruno Dubois
    Pierre and Marie Curie University, Research Centre of the Institute of the Brain and Spinal Cord, UMR, AP HP, Pitié Salpêtrière Hospital Group, Paris, France
    Lancet Neurol 9:1118-27. 2010
    ..The cornerstone of this lexicon is to consider AD solely as a clinical and symptomatic entity that encompasses both predementia and dementia phases...
  31. doi request reprint Brain perfusion SPECT with an automated quantitative tool can identify prodromal Alzheimer's disease among patients with mild cognitive impairment
    Marie Odile Habert
    Universite Pierre et Marie Curie Paris 6, INSERM, UMR S 678, Paris, F 75013, France
    Neurobiol Aging 32:15-23. 2011
    ..e., prodromal AD, by an automated quantitative tool combining brain perfusion single-photon emission computed tomography (SPECT) images and memory tests scores in order to be applied in clinical practice...
  32. doi request reprint Deciphering logopenic primary progressive aphasia: a clinical, imaging and biomarker investigation
    Marc Teichmann
    1 Department of Neurology, centre de référence Démences Rares, Hopital de la Pitie Salpetriere, AP HP, Paris, France
    Brain 136:3474-88. 2013
    ..The present data therefore provide novel insight into the cognition and brain damage of logopenic patients while unveiling the existence of distinct diseases constituting a 'logopenic aphasia complex'. ..
  33. doi request reprint Poor creativity in frontotemporal dementia: a window into the neural bases of the creative mind
    Leonardo Cruz de Souza
    Universite Pierre et Marie Curie Paris 6, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, UMR S975, Paris, France
    Neuropsychologia 48:3733-42. 2010
    ..Damage to the PFC is expected to impair creativity. Yet, previous works suggested the emergence of artistic talent in patients with frontotemporal lobar degeneration (FTLD), which was interpreted as increased creativity...
  34. ncbi request reprint C9ORF72 repeat expansions in the frontotemporal dementias spectrum of diseases: a flow-chart for genetic testing
    Isabelle Le Ber
    CRicm UMRS975, Paris, France AP HP, Hopital de la Pitie Salpetriere, Centre de Référence des Démences Rares, Paris, France
    J Alzheimers Dis 34:485-99. 2013
    ..Penetrance was age- and gender-dependent: by age 50, 78% of male carriers were symptomatic, but only 52% of females. This can also guide genetic testing and counseling. A flowchart for genetic testing is thus proposed...
  35. pmc Visual neglect in posterior cortical atrophy
    Katia Andrade
    INSERM UMR_S 975, Centre de Recherche de l Institut du Cerveau et de Moelle épinière, Cognition, neuro imagerie et maladies du cerveau, Paris, France
    BMC Neurol 10:68. 2010
    ..In this prospective study, we aimed at establishing the side, the frequency and the severity of visual neglect, visual extinction, and primary visual field defects in an unselected sample of PCA patients...
  36. pmc Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection
    Beatrice Garcin
    CR ICM UPMC, Inserm UMR_S 975 CNRS UMR 7225, Groupe Hospitalier Pitie Salpetriere, Paris, France
    PLoS ONE 7:e34164. 2012
    ....
  37. doi request reprint Brain hemispheres selectively track the expected value of contralateral options
    Stefano Palminteri
    Institut du Cerveau et de la Moëlle èpinière CR ICM, INSERM UMR 975, Paris, France
    J Neurosci 29:13465-72. 2009
    ..We therefore suggest that expected values are represented in a distributed manner that respects the topography of the brain systems elicited by the available options...
  38. doi request reprint TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration
    Lina Benajiba
    Institut National de la Santé et de la Recherche Médicale UMRS975 CRicm formerly INSERM UMR_S679, F 75013, Paris, France
    Ann Neurol 65:470-3. 2009
    ..We now describe TARDBP mutations in two patients with FTLD-MND, presenting with a behavioral variant of FTLD and semantic dementia, suggesting that TDP-43 may also have a direct pathogenic role in FTLD disorders...
  39. doi request reprint Can we still dream when the mind is blank? Sleep and dream mentations in auto-activation deficit
    Smaranda Leu-Semenescu
    1 Sleep Disorders Unit, Pitie Salpetriere Hospital, AP HP, Paris 6 University, Paris, France
    Brain 136:3076-84. 2013
    ..The absence of sleep spindles in localized lesions in the basal ganglia highlights the role of the pallidum and striatum in spindling activity during non-REM sleep. ..
  40. doi request reprint Brain networks in posterior cortical atrophy: a single case tractography study and literature review
    Raffaella Migliaccio
    INSERM UPMC UMRS 975, CR Icm, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Hopital de la Pitie Salpetriere, Paris, France
    Cortex 48:1298-309. 2012
    ..These data suggest that selective visuo-spatial deficits typical of PCA might not result from cortical damage alone, but by a right-lateralized network-level dysfunction including WM damage along the major visual pathways...
  41. doi request reprint Fronto-temporal lobar degeneration: neuropathology in 60 cases
    Danielle Seilhean
    Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Inserm UMR_S975, CNRS UMR7225, Groupe Hospitalier Pitie Salpetriere, AP HP and UPMC Sorbonne Universités, Paris, France
    J Neural Transm 118:753-64. 2011
    ..The prevalence of the different types of FTD is tightly linked to the recruitment. This series was enriched in motor neuron disease (explaining the overall predominance of type 2 TDP inclusions)...
  42. ncbi request reprint Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits
    Richard Levy
    Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
    Cereb Cortex 16:916-28. 2006
    ..In both situations (direct basal ganglia lesions and nigro-striatal dopaminergic loss), the capacity of the frontal cortex to select, initiate, maintain and shift programs of actions is impaired...
  43. ncbi request reprint Get aroused and be stronger: emotional facilitation of physical effort in the human brain
    Liane Schmidt
    Institut du Cerveau et de la Moëlle épinière ICM, INSERM UMRS 975, Paris, France
    J Neurosci 29:9450-7. 2009
    ..We suggest that this region, by driving the motor cortex, constitutes a brain pathway that allows emotional arousal to facilitate physical effort...
  44. ncbi request reprint Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force
    Bruno Dubois
    INSERM UPMC UMRS 610, Federation of Neurology, AP HP, Salpêtrière Hospital Université Paris6, Paris, France
    Mov Disord 22:2314-24. 2007
    ..We accept, however, that further validation of certain tests and modifications in the recommended cut off values will be required through future studies...
  45. doi request reprint Intrusions in story recall: when over-learned information interferes with episodic memory recall. Evidence from Alzheimer's disease
    Francesca De Anna
    INSERM Unit 610, Paris, France
    Cortex 44:305-11. 2008
    ..We suggest that in AD patients intrusions may be traced back to the interference of strongly represented, over-learned information in episodic memory recall...
  46. ncbi request reprint Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease
    Andrea Slachevsky
    Institut National de la Santé et de la Récherche Médicale E 007 and Fédération de Neurologie, Hopital de la Salpetriere, Paris, France
    Arch Neurol 61:1104-7. 2004
    ..The Frontal Assessment Battery (FAB) has previously been validated in diseases associated with a frontal lobe dysfunction...
  47. ncbi request reprint Cognitive control and brain resources in major depression: an fMRI study using the n-back task
    Philippe Olivier Harvey
    INSERM U610, Pitie Salpetriere Hospital, Paris, France Service de Psychiatrie d Adultes, Pitie Salpetriere Hospital, Paris, France
    Neuroimage 26:860-9. 2005
    ..Our findings suggest that depression may impair the cognitive capacity of depressed patients by recruiting more brain resources than controls during cognitive control...
  48. ncbi request reprint Distinct striatal regions support movement selection, preparation and execution
    Emmanuel Gerardin
    Inserm U610 2Inserm U289, Hopital de la Salpetriere, Paris, France
    Neuroreport 15:2327-31. 2004
    ..These results suggest that these three aspects of movement are represented within distinct basal ganglia regions...
  49. doi request reprint Distinct brain perfusion pattern associated with CSF biomarkers profile in primary progressive aphasia
    Aurélie Kas
    Alzheimerb s Institute, AP HP, Pitie Salpetriere Hospital, Paris, France
    J Neurol Neurosurg Psychiatry 83:695-8. 2012
    ..Single photon emission computed tomography (SPECT) was used to investigate brain hypoperfusion differences among PPA subtypes according to their CSF AD profiles...
  50. doi request reprint Social Cognition and Emotional Assessment differentiates frontotemporal dementia from depression
    Maxime Bertoux
    Université Pierre et Marie Curie UPMC Paris 6, Paris, France
    J Neurol Neurosurg Psychiatry 83:411-6. 2012
    ..Its diagnosis remains a clinical challenge, and depression is one of the main causes of misdiagnoses due to the prevalence of apathy in bvFTD...
  51. doi request reprint Apathy following subthalamic stimulation in Parkinson disease: a dopamine responsive symptom
    Virginie Czernecki
    Center d Investigation Clinique, Federation de Neurologie, INSERM Unit 679, Paris, France
    Mov Disord 23:964-9. 2008
    ....
  52. doi request reprint CHMP2B mutations are rare in French families with frontotemporal lobar degeneration
    Mustapha Ghanim
    CRicm INSERM UMRS_975, 75013, Paris, France
    J Neurol 257:2032-6. 2010
    ..The previously reported C-truncating CHMP2B mutations may be private to the Danish and Belgian pedigrees...
  53. ncbi request reprint Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans
    Michel Thiebaut de Schotten
    INSERM Unit 610, Assistance Publique Hopitaux de Paris, Hopital de la Salpetriere, 75013 Paris, France
    Science 309:2226-8. 2005
    ..These findings suggest that parietal-frontal communication is necessary for the symmetrical processing of the visual scene...
  54. ncbi request reprint Subtle cognitive impairment but no dementia in patients with spastin mutations
    Chantal M E Tallaksen
    Institut National de la Santé et de la Recherche Médicale Unit 289, Federation de Neurologie, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Arch Neurol 60:1113-8. 2003
    ..Mutations of the SPG4 gene have been increasingly associated with reports of cognitive impairment...
  55. ncbi request reprint Progranulin null mutations in both sporadic and familial frontotemporal dementia
    Isabelle Le Ber
    INSERM, UMR679, Paris, France
    Hum Mutat 28:846-55. 2007
    ..Taking this into account, genetic testing should be now considered more systematically, even in patients without obvious familial history of FTD...
  56. doi request reprint Neuroimaging in dementias
    Leonardo Cruz de Souza
    Alzheimer and Memory Institute Research and Resource Memory Centre, AP HP, Paris, France
    Curr Opin Psychiatry 25:473-9. 2012
    ..To critically review data on the use of neuroimaging tools in the clinical diagnostic investigation of dementias...
  57. doi request reprint How cognitive performance-induced stress can influence right VLPFC activation: an fMRI study in healthy subjects and in patients with social phobia
    Lejla Koric
    INSERM U610, Paris, France
    Hum Brain Mapp 33:1973-86. 2012
    ..In patients, the differential modulation between these dorsal and ventral PFC regions disappears. This absence of modulation may limit anxious patients' ability to adapt to demanding cognitive control tasks...
  58. pmc Early detection of Alzheimer's disease: new diagnostic criteria
    Bruno Dubois
    INSERM UPMC UMRS 975, Federation of Neurology, APHP, Salpetriere Hospital, University Paris 6, Paris, France
    Dialogues Clin Neurosci 11:135-9. 2009
    ..Accordingly, new criteria for the diagnosis have been proposed that capture both the prodromal and the more advanced dementia stages of the disease in the same diagnostic framework...
  59. ncbi request reprint Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease
    Severine Perbal
    Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, Hopital de la Salpetriere, Paris, France
    Brain Cogn 58:35-48. 2005
    ..The whole results indicate that dopamine administration in patients might have overshadowed the slowing rate of the internal clock usually reported in non medicated PD patients, without entirely restoring all of the memory functions...
  60. ncbi request reprint Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria
    Bruno Dubois
    INSERM U610, Hopital de la Salpetriere, Paris, France
    Lancet Neurol 6:734-46. 2007
    ..Validation studies in existing and prospective cohorts are needed to advance these criteria and optimise their sensitivity, specificity, and accuracy...
  61. ncbi request reprint Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus
    Olivier Colliot
    Cognitive Neuroscience and Brain Imaging Laboratory, Centre National de la Recherche Scientifique, UPR640 LENA, Universite Pierre et Marie Curie Paris 6, Hopital de la Pitie Salpetriere, Paris, France
    Radiology 248:194-201. 2008
    ....
  62. ncbi request reprint FUS mutations in frontotemporal lobar degeneration with amyotrophic lateral sclerosis
    Oriane Broustal
    CRicm INSERM UMRS_975, Hopital de la Pitie Salpetriere, Paris, France
    J Alzheimers Dis 22:765-9. 2010
    ..Although the frequency of mutations is low, our study enlarges the phenotypes associated with FUS mutations and shows that FUS could also play a direct pathogenic role in FTLD spectrum of diseases...
  63. pmc Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study
    Julien Lagarde
    Department of Neurology, AP HP, Groupe Hospitalier Pitie Salpetriere, Paris, France INSERM, UMR 975, CNRS, UMR 7225, Paris, France
    PLoS ONE 8:e80353. 2013
    ..However, executive dysfunction in these diseases may stem from partially divergent cortical and subcortical neural circuits. ..
  64. doi request reprint Effect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer's disease
    Bruno Dubois
    Institute for Memory and Alzheimer s Disease, ICM, UMR S975, AP HP, Pitié Salpêtrière Hospital Group, Pierre and Marie Curie University, Paris, France
    J Alzheimers Dis 29:527-35. 2012
    ..Lessons learned in AD study design optimization, including those presented in this paper, could be valuable for further investigation with pro-cholinergic drugs such as V0191...
  65. doi request reprint Brain perfusion SPECT correlates with CSF biomarkers in Alzheimer's disease
    Marie Odile Habert
    Universite Pierre et Marie Curie Paris 6, INSERM, UMR S 678, 75013, Paris, France
    Eur J Nucl Med Mol Imaging 37:589-93. 2010
    ....
  66. ncbi request reprint Dopamine and cognitive function
    Bernard Pillon
    INSERM EMI 007 and Fédération de Neurologie, Hopital de la Salpetriere, Paris, France
    Curr Opin Neurol 16:S17-22. 2003
    ..Although the cognitive deficits of idiopathic Parkinson's disease are now relatively well known, their neuropsychological and neurobiological basis are still discussed...
  67. ncbi request reprint Is the saitohin gene involved in neurodegenerative diseases?
    Patrice Verpillat
    INSERM U535, Le Kremlin Bicetre Cedex, University Hospital Bichat, University Paris, Paris, France
    Ann Neurol 52:829-32. 2002
    ..Thus, the saitohin Q allele, which is a novel determinant of the tau H1 haplotypes, might represent a causative factor involved in the determinism of several tauopathies...
  68. ncbi request reprint Metabolic correlates of behavioral and affective disturbances in frontal lobe pathologies
    Marie Sarazin
    Inserm E 007 and Federation of Neurology, Salpetriere Hospital, Paris, France
    J Neurol 250:827-33. 2003
    ..The aim of this study was to investigate the metabolic correlates of these deficits in a group of non-selected consecutive patients with frontal lobe lesions...
  69. ncbi request reprint Association between the extended tau haplotype and frontotemporal dementia
    Patrice Verpillat
    Département d Epidémiologie, de Biostatistique, et de Recherche Clinique, Hopital Bichat Claude Bernard, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Arch Neurol 59:935-9. 2002
    ..In FTD, the pathological accumulation of the microtubule-associated protein tau suggests that the tau gene may be a genetic risk factor for this disorder...
  70. doi request reprint Clinical investigations in primary care
    Leonardo Cruz de Souza
    Research and Resource Memory Centre, INSERM UMR S 610, Universite Pierre et Marie Curie Paris 06, Pitie Salpetriere Hospital, Paris, France
    Front Neurol Neurosci 24:1-11. 2009
    ..Other medical, neurological, or psychiatric disorders which could account for the impairment in memory and related symptoms must be always investigated...
  71. ncbi request reprint Procedural learning and striatofrontal dysfunction in Parkinson's disease
    Marie Sarazin
    Institut National de la Santé et de la Recherche Médicale E 007, Paris, France
    Mov Disord 17:265-73. 2002
    ..These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task...
  72. ncbi request reprint Behavioral changes in patients with focal lesions of the basal ganglia
    Bruno Dubois
    INSERM U 610 and Federation de Neurologie, Hopital de la Salpetriere, Paris, France
    Adv Neurol 96:17-25. 2005
  73. ncbi request reprint Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis
    Patrice Verpillat
    INSERM U535, Le Kremlin Bicetre, France, and Département d EpidAmiologie, de Biostatistique et de Recherche Clinique, Centre Hospitalier Universitaire Bichat Claude Bernard, AP HP Université Paris VII, Paris, France
    Eur J Hum Genet 10:399-405. 2002
    ..If this finding was confirmed, it could provide new insights into the mechanisms of differential risk related to APOE in neurodegenerative diseases...
  74. ncbi request reprint [An anatomofunctional brain database]
    Bénédicte Batrancourt
    INSERM E 007, Centre de Neuropsychologie, Hopital de la Salpetriere, 47, Bd de l Hopital, 75651 Paris, France
    C R Biol 325:439-55. 2002
    ..A direct application would be the improvement of cognitive and/or behavioural rehabilitation of patients with brain damage...
  75. ncbi request reprint Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
    ..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...
  76. ncbi request reprint A risk for early-onset Alzheimer's disease associated with the APBB1 gene (FE65) intron 13 polymorphism
    Emmanuelle Cousin
    Aventis Pharma, Evry Genetics Center and Neurodegenerative Disease Group, Paris Research Center, 13 quai Jules Guesde, 94400, Vitry sur Seine, France
    Neurosci Lett 342:5-8. 2003
    ..47, 95% confidence interval=1.05-2.04). Stratification by age showed that the risk effect associated with the deletion concerned subjects aged less than 65 years...
  77. ncbi request reprint Screening for Alzheimer's disease with the short cognitive evaluation battery
    Philippe H Robert
    Centre Mémoire, Unité d Evaluation des Cognitions, Universite de Nice Sophia Antipolis, Nice, France
    Dement Geriatr Cogn Disord 15:92-8. 2003
    ..Furthermore, in combination with clinical evaluation, the SCEB could improve the specificity of the difficult discrimination between mild AD and depression...
  78. ncbi request reprint Deficit of verb generation in nondemented patients with Parkinson's disease
    Patrice Peran
    Institut National de la Santé et de la Recherche Médicale U 455, Centre Hospitalier Universitaire Purpan, Toulouse, France
    Mov Disord 18:150-6. 2003
    ..The specific deficit for verb production in PD patients is discussed in relation to deficits affecting either action or grammatical representations...
  79. doi request reprint Disconnecting force from money: effects of basal ganglia damage on incentive motivation
    Liane Schmidt
    Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, F 75013 Paris, France
    Brain 131:1303-10. 2008
    ..We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards...
  80. pmc Disruptive behavior as a predictor in Alzheimer disease
    Nikolaos Scarmeas
    Gertrude H Sergievsky Center, Columbia University Medical Center, New York, NY 10032, USA
    Arch Neurol 64:1755-61. 2007
    ..Disruptive behavior is common in Alzheimer disease (AD). There are conflicting reports regarding its ability to predict cognitive decline, functional decline, institutionalization, and mortality...
  81. ncbi request reprint Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    ..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...
  82. ncbi request reprint Apathy in patients with mild cognitive impairment and the risk of developing dementia of Alzheimer's disease: a one-year follow-up study
    Philippe H Robert
    Centre Memoire de Ressources et de Recherche, CHU de Nice, INSERM JE 2441, France
    Clin Neurol Neurosurg 108:733-6. 2006
    ..To evaluate the relation between apathy and development of dementia in patients with amnestic mild cognitive impairment (MCI)...
  83. ncbi request reprint Pure topographical disorientation following a right forceps major of the splenium lesion: a case study
    Itaru Tamura
    Department of Communication Disorders, School of Psychological Science, Health Sciences University of Hokkaido, Sapporo, Japan
    Neurocase 13:178-84. 2007
    ..These results suggested the heading disorientation was accompanied with impaired sense of quarters, although disabled sense of quarters continued beyond the recovery of heading disorientation...
  84. ncbi request reprint [A guide to diagnosis of Alzheimer's disease]
    Marie Sarazin
    Centre de mémoire de ressource et de recherche d Ile de France, centre de neuropsychologie et du langage et unité Inserm U 610, Fédération des Maladies du Système Nerveux, groupe hospitalier La Pitié La Salpêtrière, 75651 Paris
    Rev Prat 55:1879-90. 2005
    ..Standard biological parameters are normal. According to the context of occurrences of the disease or to the existence of atypical clinical or radiological changes, additional investigations can be proposed...
  85. pmc Delusions and hallucinations are associated with worse outcome in Alzheimer disease
    Nikolaos Scarmeas
    Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, The Gertrude H Sergievsky Center, New York, NY 10032, USA
    Arch Neurol 62:1601-8. 2005
    ..According to all previous literature, they are not associated with mortality...
  86. ncbi request reprint No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease
    Emmanuelle Cousin
    Aventis Pharma, Evry Genetics Center and Neurodegenerative Disease Group, Paris Research Center, 13 quai Jules Guesde, 94400 Vitry sur Seine, France
    Neurosci Lett 353:153-5. 2003
    ....
  87. ncbi request reprint Cognition, behavior and the frontal lobes
    Bruno Dubois
    Int Psychogeriatr 16:379-87. 2004
  88. ncbi request reprint [Frontotemporal dementia]
    Isabelle Le Ber
    INSERM U679, Neurology and Experimental Therapeutics, Paris 75
    Presse Med 36:1477-84. 2007
    ..The genetic component is important: 30-50% of patients have a family history of this disease. Cholinergic effects are not associated with frontotemporal dementia and therefore anticholinesterase treatment is not indicated...
  89. ncbi request reprint Relationship between attentional performance and corpus callosum morphometry in patients with Alzheimer's disease
    Agnès A Dorion
    Laboratoire de Développement Normal et Troublé, Universite Paul Valery, route de Mende, 34199 Montpellier Cedex 5, France
    Neuropsychologia 40:946-56. 2002
    ..Moreover, these patients with probable AD seem heterogeneous for performances in the attentional test of the CANTAB and for callosal atrophies...
  90. ncbi request reprint Riluzole in Huntington's disease: a 3-year, randomized controlled study
    G Bernhard Landwehrmeyer
    Department of Neurology, University of Ulm, Ulm, Germany
    Ann Neurol 62:262-72. 2007
    ..We conducted a randomized double-blind trial of riluzole in Huntington's disease to investigate the efficacy of this antiexcitotoxic drug in slowing disease progression...
  91. ncbi request reprint Is PD-MCI a useful concept?
    Bruno Dubois
    Mov Disord 22:1215-6. 2007
  92. ncbi request reprint A review of compliance to treatment in Alzheimer's disease: potential benefits of a transdermal patch
    Gary Small
    UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024 1759, USA
    Curr Med Res Opin 23:2705-13. 2007
    ..Compliance in Alzheimer's disease (AD), a chronic neurodegenerative disease typically afflicting older adults, is especially challenging...
  93. ncbi request reprint Anatomically constrained region deformation for the automated segmentation of the hippocampus and the amygdala: Method and validation on controls and patients with Alzheimer's disease
    Marie Chupin
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, UK
    Neuroimage 34:996-1019. 2007
    ..The proposed approach provides a new framework for further developments in quantitative analyses of the pathological hippocampus and amygdala in MRI scans...
  94. doi request reprint Revised research diagnostic criteria for Alzheimer's disease
    Serge Gauthier
    Lancet Neurol 7:668-70. 2008
  95. ncbi request reprint [Alzheimer's disease: therapeutic perspectives]
    Bruno Dubois
    Centre des Maladies Cognitives et Comportementales et Inserm U 610, Hopital de la Salpetriere, 47, Boulevard de l Hopital, 75013 Paris
    Bull Acad Natl Med 192:333-42; discussion 343-4. 2008
    ..Future treatments may be curative, acting specifically on the amyloid cascade. Secretase inhibitors and immunotherapy are in the pipeline. Trials will begin within a few months and will open up new perspectives...
  96. ncbi request reprint Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan
    Christopher G Goetz
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 22:41-7. 2007
    ....
  97. ncbi request reprint Early piribedil monotherapy of Parkinson's disease: A planned seven-month report of the REGAIN study
    Olivier Rascol
    INSERM U455, Clinical Investigation Center and Departments of Clinical Pharmacology and Neurosciences, Faculte de Medecine, Toulouse, France
    Mov Disord 21:2110-5. 2006
    ..001). Safety was consistent with that reported for other dopamine agonists, gastrointestinal side effects being the most common (22% of patients in piribedil group vs. 14% on placebo). Piribedil is effective and safe as early PD therapy...
  98. ncbi request reprint Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia
    Tiziana Zalla
    Institut de Sciences Cognitives, Bron, France
    Psychiatry Res 121:207-17. 2004
    ..Enhanced susceptibility to interference and reduced inhibition could be transnosographical markers for a shared familial vulnerability common to schizophrenia and bipolar disorders...
  99. ncbi request reprint Neuropsychological performance in mild cognitive impairment with and without apathy
    Philippe H Robert
    Centre Memoire de Ressources et de Recherche, CHU de Nice, INSERM JE 2441, Nice, France
    Dement Geriatr Cogn Disord 21:192-7. 2006
    ..To investigate the neuropsychological characteristics of patients diagnosed with mild cognitive impairment (MCI) with and without apathy...
  100. ncbi request reprint Depressive symptoms in Alzheimer's disease: natural course and temporal relation to function and cognitive status
    Roee Holtzer
    Cognitive Neuroscience Division, Taub Institute, G H Gertrude Sergievsky Center and Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA
    J Am Geriatr Soc 53:2083-9. 2005
    ..To examine the natural course of depressive symptoms in patients with probable Alzheimer's disease (AD), specifically, the temporal relationship between depressive symptoms, function, and cognitive status...