Beatrice Dubern

Summary

Country: France

Publications

  1. doi request reprint Leptin and leptin receptor-related monogenic obesity
    Beatrice Dubern
    Institute of Cardiometabolism and Nutrition ICAN, INSERM UMRS U872 Eq7 Nutriomique, University Pierre et Marie Curie Paris 6, Cordelier Research Center, Paris, France
    Biochimie 94:2111-5. 2012
  2. doi request reprint [Childhood obesity and sleep breathing disorders]
    B Dubern
    Service de nutrition pédiatrique, Hopital Armand Trousseau, 26, avenue du Dr Arnold Netter, 75012 Paris, France
    Arch Pediatr 18:1247-50. 2011
  3. pmc Genome wide association study identifies KCNMA1 contributing to human obesity
    Hong Jiao
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    BMC Med Genomics 4:51. 2011
  4. ncbi request reprint [Genetic aspects of obesity]
    Beatrice Dubern
    Service de gastro entérologie et de nutrition pédiatriques, Hopital Armand Trousseau, AP HP, Paris
    Presse Med 36:1598-605. 2007
  5. doi request reprint [Management of childhood obesity]
    Béatrice Dubern
    Hôpital Armand Trousseau, service de gastroentérologie et nutrition pédiatriques, 26, avenue du Dr Arnold Netter, 75012 Paris, France
    Presse Med 39:960-8. 2010
  6. doi request reprint Influence of polymorphisms in candidate genes on early vascular alterations in obese children
    Agnès Tounian
    Département de gastro entérologie et nutrition pédiatriques, Hopital Armand Trousseau, AP HP, 26, avenue du Dr A Netter, 75012 Paris, France
    Arch Cardiovasc Dis 103:10-8. 2010
  7. doi request reprint Arterial alterations in severely obese children with obstructive sleep apnoea
    Beatrice Dubern
    Pediatric Gastroenterology and Nutrition Department, Armand Trousseau Hospital, AP HP, Paris, France
    Int J Pediatr Obes 5:230-6. 2010
  8. doi request reprint Association of arterial stiffness and endothelial dysfunction with metabolic syndrome in obese children
    Emmanuelle Mimoun
    Department of Pediatric Gastroenterology and Nutrition, Armand Trousseau Hospital, AP HP, and INSERM, U872 Nutriomique, University Pierre and Marie Curie Paris 6, Paris, France
    J Pediatr 153:65-70. 2008
  9. ncbi request reprint Insulin resistance and ferritin as major determinants of abnormal serum aminotransferase in severely obese children
    Beatrice Dubern
    Pierre et Marie Curie University Paris 6, Paris, France
    Int J Pediatr Obes 1:77-82. 2006
  10. pmc Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene
    Karine Clement
    Center of Research on Human Nutrition Ile de France, Paris, 75013, France
    J Clin Endocrinol Metab 93:4955-62. 2008

Collaborators

Detail Information

Publications17

  1. doi request reprint Leptin and leptin receptor-related monogenic obesity
    Beatrice Dubern
    Institute of Cardiometabolism and Nutrition ICAN, INSERM UMRS U872 Eq7 Nutriomique, University Pierre et Marie Curie Paris 6, Cordelier Research Center, Paris, France
    Biochimie 94:2111-5. 2012
    ..Thus, LEPR gene screening might be also considered in subjects with the association of severe obesity with endocrine dysfunctions such as hypogonadism and with leptin related to corpulence level...
  2. doi request reprint [Childhood obesity and sleep breathing disorders]
    B Dubern
    Service de nutrition pédiatrique, Hopital Armand Trousseau, 26, avenue du Dr Arnold Netter, 75012 Paris, France
    Arch Pediatr 18:1247-50. 2011
    ..It confirms that it is crucial to evaluate sleep for all obese children with questionnaire in order to improve their management and their quality of life...
  3. pmc Genome wide association study identifies KCNMA1 contributing to human obesity
    Hong Jiao
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83 Huddinge, Sweden
    BMC Med Genomics 4:51. 2011
    ..Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity...
  4. ncbi request reprint [Genetic aspects of obesity]
    Beatrice Dubern
    Service de gastro entérologie et de nutrition pédiatriques, Hopital Armand Trousseau, AP HP, Paris
    Presse Med 36:1598-605. 2007
    ..Most human obesity nonetheless results from the interaction of multiple genetic factors and the environment. Molecules acting on the melanocortin pathway are currently under development by the pharmaceutical industry...
  5. doi request reprint [Management of childhood obesity]
    Béatrice Dubern
    Hôpital Armand Trousseau, service de gastroentérologie et nutrition pédiatriques, 26, avenue du Dr Arnold Netter, 75012 Paris, France
    Presse Med 39:960-8. 2010
    ..Weight loss surgery in obese children may be discussed in some cases with multidisciplinary expert team (doctors, surgeons, psychologist...) and close collaboration between adults teams and paediatricians...
  6. doi request reprint Influence of polymorphisms in candidate genes on early vascular alterations in obese children
    Agnès Tounian
    Département de gastro entérologie et nutrition pédiatriques, Hopital Armand Trousseau, AP HP, 26, avenue du Dr A Netter, 75012 Paris, France
    Arch Cardiovasc Dis 103:10-8. 2010
    ..To date, no study has assessed the co-involvement of gene polymorphisms as cardiovascular risk factors in children...
  7. doi request reprint Arterial alterations in severely obese children with obstructive sleep apnoea
    Beatrice Dubern
    Pediatric Gastroenterology and Nutrition Department, Armand Trousseau Hospital, AP HP, Paris, France
    Int J Pediatr Obes 5:230-6. 2010
    ..Vascular alterations exist in children with obesity and may constitute the first stage in the development of adulthood cardiovascular disease...
  8. doi request reprint Association of arterial stiffness and endothelial dysfunction with metabolic syndrome in obese children
    Emmanuelle Mimoun
    Department of Pediatric Gastroenterology and Nutrition, Armand Trousseau Hospital, AP HP, and INSERM, U872 Nutriomique, University Pierre and Marie Curie Paris 6, Paris, France
    J Pediatr 153:65-70. 2008
    ..We investigated whether metabolic syndrome, defined in 3 different ways (2 commonly used and 1 novel) is associated with arterial alterations in obese children...
  9. ncbi request reprint Insulin resistance and ferritin as major determinants of abnormal serum aminotransferase in severely obese children
    Beatrice Dubern
    Pierre et Marie Curie University Paris 6, Paris, France
    Int J Pediatr Obes 1:77-82. 2006
    ..The aim was to determine the prevalence of liver enzyme abnormalities in severely obese children and to look for relationships between fat mass distribution, insulin resistance, and plasma ferritin...
  10. pmc Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene
    Karine Clement
    Center of Research on Human Nutrition Ile de France, Paris, 75013, France
    J Clin Endocrinol Metab 93:4955-62. 2008
    ..Mutations that inactivate the POMC gene have been described in children, causing a pleiotropic syndrome that includes secondary hypocortisolism, severe obesity, and variable changes in skin and hair pigmentation...
  11. doi request reprint Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
    Laurent Beaugerie
    Department of Gastroenterology, Assistance Publique Hopitaux de Paris AP HP, Hopital Saint Antoine, Universite Pierre et Marie Curie Paris VI, Paris, France
    Lancet 374:1617-25. 2009
    ..Reports of an increased risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease are controversial. We assessed this risk in a prospective observational cohort study...
  12. doi request reprint Plasma citrulline concentration reflects enterocyte mass in children with short bowel syndrome
    Céline Bailly-Botuha
    Gastroentérologie et Nutrition Pédiatriques, Hopital Armand Trousseau, APHP, Paris 75012, France
    Pediatr Res 65:559-63. 2009
    ..Our findings constitute the first evidence that serial plasma citrulline assays help to monitor residual small bowel adaptation in children...
  13. doi request reprint Intractable diarrhea with tufting enteropathy: a favorable outcome is possible
    Julie Lemale
    Gastroenterology and Nutrition, Department of Pediatrics, APHP, Hopital Armand Trousseau, Universite Pierre et Marie Curie, Paris, France
    J Pediatr Gastroenterol Nutr 52:734-9. 2011
    ..A few patients have had a more favorable outcome. The objective of this study was to evaluate possible correlations between histological lesion severity in duodenal biopsies and clinical outcomes in children with TE...
  14. doi request reprint Therapeutic strategies for idiopathic chylothorax
    Ralph Epaud
    Hopital Armand Trousseau, Universite Pierre et Marie Curie Paris 6, Paris, France
    J Pediatr Surg 43:461-5. 2008
    ..The objectives of the study were to present our institutional experience of idiopathic chylothorax in children and to propose therapeutic strategies...
  15. ncbi request reprint Homozygous null mutation of the melanocortin-4 receptor and severe early-onset obesity
    Beatrice Dubern
    INSERM UMRS U872 Eq 7 Nutriomique, Paris, France
    J Pediatr 150:613-7, 617.e1. 2007
    ..To describe the clinical and biological phenotype of a child who is severely obese and is homozygous for a new melanocortin-4 receptor (MC4R) gene mutation leading to a truncated receptor...
  16. doi request reprint Pulmonary and hepatic nodular lesions precede the diagnosis of Crohn's disease in an 8-year-old girl: a case study and review of the literature
    Eloïse Pain-Prado
    Centre Hospitalier Intercommunal de Creteil, Service de Pediatrie, France
    Acta Paediatr 101:e86-9. 2012
    ..To describe a novel clinical observation and to provide a review the literature about lung involvement in children with Crohn disease (CD)...
  17. ncbi request reprint Pulmonary function and sleep-related breathing disorders in severely obese children
    Beatrice Dubern
    Armand Trousseau Teaching Hospital, Department of Pediatric Gastroenterology and Nutrition, avenue du Dr Arnold Netter, Paris, France
    Clin Nutr 25:803-9. 2006
    ..To evaluate the frequency of pulmonary function and sleep-breathing disorders in severely obese children and to search for their association with obesity phenotypes...