Brigitte Dreno

Summary

Country: France

Publications

  1. ncbi request reprint Clinical benefit assessment of vismodegib therapy in patients with advanced Basal cell carcinoma
    Brigitte Dreno
    CHU de Nantes, Nantes, France Hôpital Saint Louis, Paris, France Genentech, Inc, South San Francisco, California, USA Universitätsklinikum Essen, Essen, Germany
    Oncologist 19:790-6. 2014
  2. pmc Tissue biomarkers in melanoma patients treated with TIL
    Anne Chantal Knol
    INSERM, U892, CRCNA, Nantes, France
    PLoS ONE 7:e48729. 2012
  3. pmc Fetal fibroblasts and keratinocytes with immunosuppressive properties for allogeneic cell-based wound therapy
    Thomas Zuliani
    Cell and Gene Therapy Unit, CIC biotherapy INSERM 0503, Hotel Dieu University Hospital, Nantes, France
    PLoS ONE 8:e70408. 2013
  4. pmc TG1042 (Adenovirus-interferon-γ) in primary cutaneous B-cell lymphomas: a phase II clinical trial
    Brigitte Dreno
    Department of Skin Câncer, University Hospital, Nantes, France
    PLoS ONE 9:e83670. 2014
  5. pmc Adoptive TIL transfer in the adjuvant setting for melanoma: long-term patient survival
    Amir Khammari
    Skin Cancer Unit, CHU Hotel Dieu, 1 Place Alexis Ricordeau, 44093 Nantes, France CRCNA, INSERM U892, CNRS 6299, 9 quai Moncousu, 44093 Nantes, France
    J Immunol Res 2014:186212. 2014
  6. doi request reprint Adult female acne: a new paradigm
    B Dreno
    Department of Dermato Oncology, University Hospital Hotel Dieu, Nantes, France
    J Eur Acad Dermatol Venereol 27:1063-70. 2013
  7. doi request reprint Hidradenitis suppurativa: the role of deficient cutaneous innate immunity
    Brigitte Dreno
    Institut National de la Santéet de la Recherche Médicale INSERM, U892, Centre de Recherche en Cancérologie Nantes Angers, France
    Arch Dermatol 148:182-6. 2012
  8. pmc Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas-permeable bag: interests for adoptive immunotherapy
    Thomas Zuliani
    Cell and Gene Therapy Unit UTCG CIC biotherapy INSERM 0503 Hôtel Dieu University Hospital 44093 Nantes cedex 01 France
    J Transl Med 9:63. 2011
  9. ncbi request reprint Acne: evolution of the clinical practice and therapeutic management of acne between 1996 and 2000
    Brigitte Dreno
    Acne Research and Study Group GREA, Dermatology Department, Nantes University Hospital Center, Place Alexis Ricordeau, France
    Eur J Dermatol 13:166-70. 2003
  10. ncbi request reprint [Recent data on epidemiology of acne]
    B Dreno
    Clinique Dermatologique, CHU Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Ann Dermatol Venereol 137:S49-51. 2010

Detail Information

Publications132 found, 100 shown here

  1. ncbi request reprint Clinical benefit assessment of vismodegib therapy in patients with advanced Basal cell carcinoma
    Brigitte Dreno
    CHU de Nantes, Nantes, France Hôpital Saint Louis, Paris, France Genentech, Inc, South San Francisco, California, USA Universitätsklinikum Essen, Essen, Germany
    Oncologist 19:790-6. 2014
    ..The primary endpoint (objective response rate [ORR]) was assessed 9 months after the last patient was enrolled. To confirm the clinical benefit of vismodegib, an additional analysis was performed 12 months after the primary analysis...
  2. pmc Tissue biomarkers in melanoma patients treated with TIL
    Anne Chantal Knol
    INSERM, U892, CRCNA, Nantes, France
    PLoS ONE 7:e48729. 2012
    ....
  3. pmc Fetal fibroblasts and keratinocytes with immunosuppressive properties for allogeneic cell-based wound therapy
    Thomas Zuliani
    Cell and Gene Therapy Unit, CIC biotherapy INSERM 0503, Hotel Dieu University Hospital, Nantes, France
    PLoS ONE 8:e70408. 2013
    ....
  4. pmc TG1042 (Adenovirus-interferon-γ) in primary cutaneous B-cell lymphomas: a phase II clinical trial
    Brigitte Dreno
    Department of Skin Câncer, University Hospital, Nantes, France
    PLoS ONE 9:e83670. 2014
    ....
  5. pmc Adoptive TIL transfer in the adjuvant setting for melanoma: long-term patient survival
    Amir Khammari
    Skin Cancer Unit, CHU Hotel Dieu, 1 Place Alexis Ricordeau, 44093 Nantes, France CRCNA, INSERM U892, CNRS 6299, 9 quai Moncousu, 44093 Nantes, France
    J Immunol Res 2014:186212. 2014
    ..Moreover, we confirmed that a prolonged survival was associated with the presence of specific TIL and a decrease in Foxp3 expression. ..
  6. doi request reprint Adult female acne: a new paradigm
    B Dreno
    Department of Dermato Oncology, University Hospital Hotel Dieu, Nantes, France
    J Eur Acad Dermatol Venereol 27:1063-70. 2013
    ..This article reviews the specific characteristics of adult female acne, and provides recommendations for acne therapy in this patient group. ..
  7. doi request reprint Hidradenitis suppurativa: the role of deficient cutaneous innate immunity
    Brigitte Dreno
    Institut National de la Santéet de la Recherche Médicale INSERM, U892, Centre de Recherche en Cancérologie Nantes Angers, France
    Arch Dermatol 148:182-6. 2012
    ..To evaluate the expression of innate immunity markers at the site of nodules caused by hidradenitis suppurativa (HS)...
  8. pmc Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas-permeable bag: interests for adoptive immunotherapy
    Thomas Zuliani
    Cell and Gene Therapy Unit UTCG CIC biotherapy INSERM 0503 Hôtel Dieu University Hospital 44093 Nantes cedex 01 France
    J Transl Med 9:63. 2011
    ..To address these problems we developed a specific compartmentalised bag allowing efficient expansion of tumour-specific T lymphocytes in an easy handling, closed system...
  9. ncbi request reprint Acne: evolution of the clinical practice and therapeutic management of acne between 1996 and 2000
    Brigitte Dreno
    Acne Research and Study Group GREA, Dermatology Department, Nantes University Hospital Center, Place Alexis Ricordeau, France
    Eur J Dermatol 13:166-70. 2003
    ..The profile of acne patients evolved slightly between 1996 and 2000 and interestingly the treatments were modified to take into account the information in the literature such as bacterial resistance or severe side effects...
  10. ncbi request reprint [Recent data on epidemiology of acne]
    B Dreno
    Clinique Dermatologique, CHU Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Ann Dermatol Venereol 137:S49-51. 2010
    ..Actually, acne is regarded today as a chronic disease requiring treatment of induction and maintenance...
  11. ncbi request reprint Effect of zinc gluconate on propionibacterium acnes resistance to erythromycin in patients with inflammatory acne: in vitro and in vivo study
    Brigitte Dreno
    Department of Dermatology, CHU Nantes, 44035 Nantes Cedex 01, France
    Eur J Dermatol 15:152-5. 2005
    ..Thus, association of zinc salts via a systemic route and topical erythromycin treatment seems an interesting option in the light of an increasing number of patients carrying erythromycin resistant Propionibacterium acnes strains...
  12. ncbi request reprint [The treatment of acne]
    Brigitte Dreno
    Service de Dermatologie, Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01
    Presse Med 34:540-3. 2005
    ..Zinc, which basically targets inflammatory acne, is a possible option for pregnant women and during the summer. Cosmetic care is also a fundamental part of acne treatment...
  13. ncbi request reprint [Pathophysiology of acne]
    Brigitte Dreno
    Service de Dermatologie, Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01
    Presse Med 34:537-9. 2005
    ..This finding provides physiological support to the clinical observation that stress can induce acne...
  14. doi request reprint Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study
    B Dreno
    Hopital Hotel Dieu, Department of Dermato Oncology, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France
    Br J Dermatol 165:383-90. 2011
    ..Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris...
  15. ncbi request reprint [A therapeutic algorithm in acne: why?]
    B Dreno
    Clinique Dermatologique, CHU Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Ann Dermatol Venereol 137:S66-8. 2010
    ....
  16. ncbi request reprint Topical antibacterial therapy for acne vulgaris
    Brigitte Dreno
    Department of Dermatology, Hotel Dieu, Nantes, France
    Drugs 64:2389-97. 2004
    ..Topical and oral antibacterials should not be used in combination for the treatment of acne vulgaris, since this association may increase the risk of bacterial resistance...
  17. ncbi request reprint European recommendations on the use of oral antibiotics for acne
    Brigitte Dreno
    Department of Dermatology, Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Eur J Dermatol 14:391-9. 2004
    ..Recommendations cover optimal choice of antibiotic, drug doses, duration of treatment, combination treatment, and maintenance therapy...
  18. ncbi request reprint Standard and new treatments in cutaneous B-cell lymphomas
    Brigitte Dreno
    Department of Dermatology, CHU Hotel Dieu, Nantes, France
    J Cutan Pathol 33:47-51. 2006
    ..Primary cutaneous B-cell lymphomas (PCBCL) are cutaneous non-Hodgkin lymphomas and can be classified clinically and by prognosis. The aim of this paper is to perform a review of standard and new treatments...
  19. ncbi request reprint Large-scale worldwide observational study of adherence with acne therapy
    Brigitte Dreno
    Department of Dermatolgy, Nantes University Hospital, Hotel Dieu, Nantes, France
    Int J Dermatol 49:448-56. 2010
    ....
  20. doi request reprint Development and evaluation of a Global Acne Severity Scale (GEA Scale) suitable for France and Europe
    B Dreno
    Department of Cancero Dermatology, Hotel Dieu, Nantes Cedex, France
    J Eur Acad Dermatol Venereol 25:43-8. 2011
    ..Many acne grading methods exist; however, there is no agreed-upon standard. Our objective was to create and validate a reproducible acne assessment scale for rating the severity of juvenile facial acne suitable for use in France and Europe...
  21. doi request reprint Management of skin ageing: how to combine cosmetic procedures
    Brigitte Dreno
    Unité de Cancérologie Cutanée, Hotel Dieu, Place Alexis Ricordeau, Nantes Cedex 01, France
    Eur J Dermatol 18:444-51. 2008
    ..This therapeutic strategy is based both on an analysis of the literature and the personal experience of the experts...
  22. doi request reprint Interest of the association retinaldehyde/glycolic acid in adult acne
    B Dreno
    Department of Dermatology, CHU Nantes, France
    J Eur Acad Dermatol Venereol 23:529-32. 2009
    ..The aim of this study was to evaluate the tolerance and the efficiency of RAL (0.1%)/GA (6%) in adult women with acne when used alone or in combination with their usual acne products except retinoids...
  23. ncbi request reprint [Immunotherapy of melanoma]
    Brigitte Dreno
    Dermato cancérologie, Unité thérapie cellulaire et génique, CHU Nantes, Place Alexis Ricordeau 44093 cedex 01
    Bull Acad Natl Med 194:1373-81. 2010
    ..If these treatments are to realize their full potential, it will be essential to understand how the tumor induces immune tolerance...
  24. doi request reprint Innate immunity: a crucial target for zinc in the treatment of inflammatory dermatosis
    A Brocard
    Skin Cancer Unit, Nantes University Hospital, Nantes, France
    J Eur Acad Dermatol Venereol 25:1146-52. 2011
    ..It has been shown by different data that it could play a crucial role not only in the regulation of adaptative immunity but also in innate immunity which plays a crucial role in skin...
  25. doi request reprint [Anatomy and physiology of skin and cutaneous annexes]
    B Dreno
    CHU de Nantes, Clinique Dermatologique, Place Alexis Ricordeau, Nantes Cedex 1, France
    Ann Dermatol Venereol 136:S247-51. 2009
    ....
  26. ncbi request reprint Combined 0.1% retinaldehyde/ 6% glycolic acid cream in prophylaxis and treatment of acne scarring
    Brigitte Dreno
    A Sygros Hospital, University of Athens, Athens, Greece
    Dermatology 214:260-7. 2007
    ..Acne often results in permanent, badly tolerated, difficult to treat scars...
  27. ncbi request reprint Assessing quality of life in patients with acne vulgaris: implications for treatment
    Brigitte Dreno
    Department of Dermatology, Hotel Dieu, Nantes, France
    Am J Clin Dermatol 7:99-106. 2006
    ..Finally, there are now validated quality of life scales that are easy to use during patient consultations (taking <2 minutes to complete) by clinicians wishing to evaluate quality of life in patients with acne...
  28. ncbi request reprint Frequent occurrence of high affinity T cells against MELOE-1 makes this antigen an attractive target for melanoma immunotherapy
    Yann Godet
    UMR INSERM U892, CRCNA, Nantes, France
    Eur J Immunol 40:1786-94. 2010
    ..This study documents the existence of a large TCR repertoire specific for the MELOE-1/A2 epitope and its capacity to give rise to antitumor CTL that supports the development of immunotherapies targeting this epitope...
  29. doi request reprint Treatment of metastatic melanoma with autologous Melan-A/MART-1-specific cytotoxic T lymphocyte clones
    Amir Khammari
    Skin Cancer Unit, Nantes CHU, Nantes, cedex 01 44093, France
    J Invest Dermatol 129:2835-42. 2009
    ..Thus, over the course of an adoptive cell transfer, monitoring this melanoma-specific T-cell expansion in patient blood appears crucial for predicting the clinical efficiency of such an immunological approach...
  30. doi request reprint A new tyrosinase epitope recognized in the HLA-B*4002 context by CTL from melanoma patients
    Yann Godet
    INSERM U892, 9 quai Moncousu, 44093, Nantes Cedex 1, France
    Cancer Immunol Immunother 58:271-80. 2009
    ..Our data show that this nonapeptide is a new tool that could be used to generate melanoma-specific T cells for adoptive immunotherapy or serve as a peptide vaccine for HLA-B*4002 melanoma patients...
  31. ncbi request reprint An additional ORF on meloe cDNA encodes a new melanoma antigen, MELOE-2, recognized by melanoma-specific T cells in the HLA-A2 context
    Yann Godet
    CRCNA, Institut de Recherche Therapeutique, Universite de Nantes, UMR INSERM U, France
    Cancer Immunol Immunother 59:431-9. 2010
    ..These results demonstrate that translation of meloe transcript in melanoma cells can produce at least two immunogenic polypeptides, MELOE-1 and MELOE-2, from two distinct ORFs that could be relevant target for melanoma immunotherapy...
  32. ncbi request reprint Therapeutic efficacy of melanoma-reactive TIL injected in stage III melanoma patients
    Nathalie Labarriere
    Unité INSERM U463, 9 quai Moncousu, 44093 Nantes Cedex 1, France
    Cancer Immunol Immunother 51:532-8. 2002
    ..Therefore, improved clinical outcome could be obtained after adoptive therapy by selecting appropriate groups of patients and monitoring the specificity of the injected TIL populations...
  33. ncbi request reprint Infusion of Melan-A/Mart-1 specific tumor-infiltrating lymphocytes enhanced relapse-free survival of melanoma patients
    Houssem Benlalam
    INSERM U601, 9 quai Moncousu, 44093, Nantes Cedex 1, France
    Cancer Immunol Immunother 56:515-26. 2007
    ..These results further support the relevance of Melan-A/MART-1 antigen as a prime target for immunotherapy protocols in melanoma...
  34. ncbi request reprint Physiopathology of acne vulgaris: recent data, new understanding of the treatments
    Henry Pawin
    Service de Dermatologie, Hopital du Haut leveque, Pessac, France
    Eur J Dermatol 14:4-12. 2004
    ..A lot of new data on the physiopathology have recently been published in the acne field. This paper summarizes the main points of these new facts...
  35. ncbi request reprint Long-term follow-up of patients treated by adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma
    Amir Khammari
    Skin Cancer Unit, CHU Hotel Dieu, Nantes, Place Alexis Ricordeau, 44093, Nantes Cedex 01, France
    Cancer Immunol Immunother 56:1853-60. 2007
    ....
  36. ncbi request reprint An expert view on the treatment of acne with systemic antibiotics and/or oral isotretinoin in the light of the new European recommendations
    Brigitte Dreno
    Department of Dermatology, Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Eur J Dermatol 16:565-71. 2006
    ....
  37. doi request reprint A fast and efficient HLA multimer-based sorting procedure that induces little apoptosis to isolate clinical grade human tumor specific T lymphocytes
    Régis Bouquié
    INSERM U892, 9 quai Moncousu, 44093, Nantes Cedex 1, France
    Cancer Immunol Immunother 58:553-66. 2009
    ..Altogether, these new multimers fulfill all the necessary requirements to select clinical grade T lymphocytes and should facilitate the development of ACT protocols in cancer patients...
  38. ncbi request reprint Melanoma gene expression and clinical course
    M Vourc'h-Jourdain
    Unit of Skin Cancer Nantes University Hospital, Nantes, France
    Arch Dermatol Res 301:673-9. 2009
    ..However, with regard to certain sub-groups, such as stage III samples, tumour gene expression was significantly associated with survival...
  39. doi request reprint Prognostic value of tumor-infiltrating Foxp3+ T-cell subpopulations in metastatic melanoma
    Anne C Knol
    INSERM, U892, CRCNA, Nantes, France
    Exp Dermatol 20:430-4. 2011
    ..High Foxp3 expression might thus enable the identification of patients most at risk of relapse...
  40. ncbi request reprint Adoptive transfer of tumor-reactive Melan-A-specific CTL clones in melanoma patients is followed by increased frequencies of additional Melan-A-specific T cells
    Virginie Vignard
    Unit Institut National de la Santé et de la Recherche Médicale INSERM Unité 601, Nantes, France
    J Immunol 175:4797-805. 2005
    ..Together, our results suggest that infused CTL clones may have initiated an antitumor response that may have resulted in the expansion of a Melan-A-specific CTL repertoire...
  41. doi request reprint Different strains of Propionibacterium acnes modulate differently the cutaneous innate immunity
    Fiona Jasson
    INSERM, U892, CRCNA, Nantes, France
    Exp Dermatol 22:587-92. 2013
    ..As such, the inflammatory potential of P. acnes strains on acne skin may influence the severity of inflammatory acne lesions and scars. ..
  42. doi request reprint Photodynamic therapy with methyl-aminolevulinic acid for paucilesional mycosis fungoides: a prospective open study and review of the literature
    Gaelle Quereux
    Skin Cancer Unit, Nantes University Hospital, Nantes, France
    J Am Acad Dermatol 69:890-7. 2013
    ..Publications reporting photodynamic therapy (PDT) in mycosis fungoides (MF) are rare, involve small samples, and are difficult to compare because of a lack of technical standardization...
  43. doi request reprint Sudden onset of an aggressive cutaneous lymphoma in a young patient with psoriasis: role of immunosuppressants
    Gaelle Quereux
    Nantes University Hospital, INSERM, Nantes, France
    Acta Derm Venereol 90:616-20. 2010
    ..Only eight cases of cutaneous lymphomas associated with treatment with TNF-α blockers have been published previously. Most of these eight cases related to anti-TNFα antibodies; only two were linked to etanercept...
  44. doi request reprint Adjuvant therapy with pegylated interferon alfa-2b (36 months) versus low-dose interferon alfa-2b (18 months) in melanoma patients without macrometastatic nodes: an open-label, randomised, phase 3 European Association for Dermato-Oncology (EADO) study
    Jean Jacques Grob
    Aix Marseille University, CRO2, Service de Dermatologie, hôpital de Timone, 264 rue St Pierre, 13885 Marseille cedex 05, Marseille, France
    Eur J Cancer 49:166-74. 2013
    ..Peg-IFN facilitates prolongation of treatment, which could provide additional benefit. This multicentre, open-label, randomised, phase 3 trial compared standard low-dose interferon IFN and prolonged treatment with Peg-IFN...
  45. doi request reprint Acne as seen by adolescents: results of questionnaire study in 852 French individuals
    Florence Poli
    Hopital Europeen Georges Pompidou, Paris, France
    Acta Derm Venereol 91:531-6. 2011
    ..Almost two-thirds of respondents wanted more information about acne. Providing more information about acne might increase the likelihood of them consulting a physician and getting better treatment for the condition...
  46. ncbi request reprint TLR expression in human melanoma cells
    Mélanie Saint-Jean
    Immuno dermatology laboratory, Onco dermatology unit, CIC biothérapie INSERM 0503, CHU Hotel Dieu, 1 place A Ricordeau, 44093 Nantes Cedex 1, France
    Eur J Dermatol 21:899-905. 2011
    ..TLR2, -3, -4, -7 and -9 mRNA expression was determined by quantitative RT-PCR. The TLR protein expression level was measured ex vivo by immunohistochemistry and in vitro by flow cytometry...
  47. doi request reprint Efficacy of cetuximab in the treatment of squamous cell carcinoma
    Sophie Preneau
    Department of Dermato Cancerology, Nantes University Hospital, 1 Place Alexis Ricordeau, 44000 Nantes, France CIC biothérapie, INSERM 0305, 44000 Nantes, France
    J Dermatolog Treat 25:424-7. 2014
    ..Cetuximab has recently been proposed to treat locally advanced CSCC when surgery or radiotherapy cannot be offered...
  48. pmc alpha v beta3-dependent cross-presentation of matrix metalloproteinase-2 by melanoma cells gives rise to a new tumor antigen
    Emmanuelle Godefroy
    Institut National de la Sante et de la Recherche Medicale, Unite 601, Nantes, France
    J Exp Med 202:61-72. 2005
    ..Because MMP-2 activity is critical for melanoma progression, the MMP-2 peptide should be cross-presented by most progressing melanomas and represents a unique antigen for vaccine therapy of these tumors...
  49. pmc MELOE-1 antigen contains multiple HLA class II T cell epitopes recognized by Th1 CD4+ T cells from melanoma patients
    Mathilde Bobinet
    INSERM, U892, Nantes, France
    PLoS ONE 7:e51716. 2012
    ..In conclusion, vaccination with MELOE-1 whole polypeptide should induce specific Th1 CD4 responses in a majority of melanoma patients, stimulating the amplification of CD8 effector cells, reactive against melanoma cells...
  50. doi request reprint Evaluation of quality of life after a medical corrective make-up lesson in patients with various dermatoses
    Lucie Peuvrel
    Department of Dermatology Cancerology, Nantes University Hospital, and CIC biothérapie INSERM 0305, Nantes, France
    Dermatology 224:374-80. 2012
    ..Apparent skin lesions can impair quality of life (QoL)...
  51. pmc Double positive CD4CD8 alphabeta T cells: a new tumor-reactive population in human melanomas
    Juliette Desfrançois
    UMR INSERM, U892, Nantes, France
    PLoS ONE 5:e8437. 2010
    ..This manuscript addresses the question of the existence and above all the role of this non-conventional DP sub-population among tumor associated lymphocytes in melanomas...
  52. doi request reprint Development of an individual score for melanoma risk
    Gaelle Quereux
    Skin Cancer Unit, INSERM, Nantes University Hospital, Nantes Cedex, France
    Eur J Cancer Prev 20:217-24. 2011
    ..It can be assessed without any computer or calculator and is based on the self-assessment of the melanoma risk factors by the patient and thus is not medical time consuming...
  53. doi request reprint Propionibacterium acnes activates the IGF-1/IGF-1R system in the epidermis and induces keratinocyte proliferation
    Olivia Isard
    INSERM U892, 9 quai Moncousu, Nantes, France
    J Invest Dermatol 131:59-66. 2011
    ..These observations were confirmed at the mRNA level for IGF-1R in NHEKs. These results demonstrate that P. acnes can induce the formation of comedones by stimulating the IGF/IGF-1R system. Moreover, zinc downregulates this pathway...
  54. ncbi request reprint In vitro induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 expression in keratinocytes by boron and manganese
    Nathalie Chebassier
    Department of Dermatology, INSERM U463, CHU Hotel Dieu, Nantes, France
    Exp Dermatol 13:484-90. 2004
    ..Gelatinase secretion was not associated with keratinocyte proliferation induced by trace elements. Thus, our results suggest that boron and manganese could play a role in the clinical efficiency of thermal water on wound healing...
  55. ncbi request reprint CD8(+) T lymphocytes reactive against Epstein-Barr virus antigens in skin lesions of a patient with Sézary syndrome
    Anne Chantal Knol
    Institut National de la Sante et de la Recherche Medicale, Nantes, France
    J Am Acad Dermatol 53:897-900. 2005
    ..This is, to our knowledge, the first description of the presence of EBV-specific T lymphocytes among tumor-infiltrating lymphocytes infiltrating the lesional skin of a patient with Sézary syndrome...
  56. ncbi request reprint [Treatment of melanoma]
    Brigitte Dreno
    Unité de cancéro dermatologie, Clinique Dermatologique, CHU Hotel Dieu, Nantes
    Presse Med 32:39-43. 2003
    ..Although clinical results are starting to be published, cellular immunotherapy remains in the field of clinical research, within the framework of clinical trials...
  57. ncbi request reprint Localized scleroderma and zinc: a pilot study
    Anabelle Brocard
    Unit of Skin Cancer, Nantes University Hospital, Place Alexis Ricordeau 44093 Cedex 01 Nantes, France
    Eur J Dermatol 20:172-4. 2010
    ..We conclude that high-dose zinc gluconate can therefore be a valuable alternative treatment for localized scleroderma, with good tolerability, although placebo-controlled studies are necessary to confirm our results...
  58. doi request reprint Prospective trial on a school-based skin cancer prevention project
    Gaelle Quereux
    Unit of Skin Cancer, Nantes University Hospital, INSERM 892, Nantes, France
    Eur J Cancer Prev 18:133-44. 2009
    ..The programme had a beneficial effect on the children's knowledge persisting for at least a few months but had no impact on their behaviour towards the sun...
  59. ncbi request reprint Lithium gluconate in the treatment of seborrhoeic dermatitis: a multicenter, randomised, double-blind study versus placebo
    Brigitte Dreno
    CHU Nantes, Clinique Dermatologique, Hotel Dieu, BP 1005, 44035 Nantes Cedex, France
    Eur J Dermatol 12:549-52. 2002
    ..3% and 29.1% of the patients in the lithium group, and 5.1% and 3.8% respectively in the placebo group. This study confirms the effectiveness of 8% lithium gluconate ointment in the treatment of seborrhoeic dermatitis...
  60. doi request reprint Temozolomide associated with PEG-interferon in patients with metastatic melanoma: a multicenter prospective phase I/II study
    Bernard Guillot
    Department of Dermatology, Hopital Saint Eloi, University of Montpellier I, Montpellier, France
    Melanoma Res 18:141-6. 2008
    ..At a lower level, this treatment was effective and deserves further investigations to define its indications in metastatic melanoma patients...
  61. doi request reprint Impact of a campaign to train general practitioners in screening for melanoma
    Lucie Peuvrel
    Réseau Mélanome Ouest, Dermatological Clinic, Nantes University Hospital Center, Nantes, France
    Eur J Cancer Prev 18:225-9. 2009
    ..As a result, after a short prior training, the ABCDE rule clearly seems to be a valuable tool. Dermatologists retain an important role both in the diagnostic confirmation of melanomas and in the training of general practitioners...
  62. doi request reprint Bexarotene in cutaneous T-cell lymphoma: third retrospective study of long-term cohort and review of the literature
    Gaelle Quereux
    Nantes University Hospital, Skin Cancer Unit, INSERM 892, 1 Place Alexis Ricordeau 44093, Nantes Cedex, France
    Expert Opin Pharmacother 14:1711-21. 2013
    ..Bexarotene was approved for cutaneous T-cell lymphoma (CTCL) in 1999. Apart from the two first clinical trials published ten years ago, very few data were published on the long-term use of bexarotene in CTCL patients...
  63. ncbi request reprint Prospective multicenter study of pegylated liposomal doxorubicin treatment in patients with advanced or refractory mycosis fungoides or Sézary syndrome
    Gaelle Quereux
    Departments of Dermatology, Centre Hospitalier Universitaire, Nantes, France
    Arch Dermatol 144:727-33. 2008
    ..To assess the rate of objective response to pegylated liposomal doxorubicin hydrochloride (Caelyx) in patients with advanced or refractory cutaneous T-cell lymphoma (CTCL)...
  64. ncbi request reprint Hidradenitis suppurativa and zinc: a new therapeutic approach. A pilot study
    Anabelle Brocard
    Department of Dermatology, INSERM U601, CHU Hotel Dieu, Nantes, France
    Dermatology 214:325-7. 2007
    ..Hidradenitis suppurativa (Verneuil's disease) is a chronic suppurative dermatosis involving apocrine glands with a severe impact on the quality of life, which is enhanced by the fact that the drugs usually prescribed are poorly effective...
  65. ncbi request reprint Validation of the Self-Assessment of Melanoma Risk Score for a melanoma-targeted screening
    Gaelle Quereux
    Skin Cancer Unit, INSERM, 892, Nantes University Hospital, Nantes Cedex, France
    Eur J Cancer Prev 21:588-95. 2012
    ..This is the first study to confirm the efficiency of a targeted screening on the basis of self-selection of high-risk individuals...
  66. ncbi request reprint Zinc gluconate is an agonist of peroxisome proliferator-activated receptor-α in the epidermis
    Carole Poiraud
    INSERM U892, Nantes University Hospital, Nantes, France
    Exp Dermatol 21:347-51. 2012
    ..These results suggest that zinc gluconate may be a PPAR-α agonist, which might play a role in the anti-inflammatory activity of this molecule...
  67. doi request reprint Routine bone marrow biopsy in the initial evaluation of primary cutaneous B-cell lymphoma does not appear justified
    Gaelle Quereux
    Dermatology Department, Nantes University Hospital Center, Place Alexis Ricordeau, 44093 Nantes, France
    Eur J Dermatol 19:216-20. 2009
    ..In conclusion, this study demonstrates that it is not indispensable to perform a routine BMB for a Primary cutaneous B-cell lymphoma with cutaneous lesions on examination and with negative CT Scan and blood laboratory evaluations...
  68. doi request reprint Systemic rituximab in multifocal primary cutaneous follicle centre lymphoma
    Gaelle Quereux
    Skin Cancer Unit, Nantes University Hospital, INSERM, Nantes, France
    Acta Derm Venereol 91:562-7. 2011
    ..This study is the largest series of patients with multifocal primary PCFCL treated with intravenous rituximab. This therapy is a safe and effective treatment and could represent an excellent alternative treatment to radiotherapy...
  69. doi request reprint Creation and test of a questionnaire for self-assessment of melanoma risk factors
    Gaelle Quereux
    Skin Cancer Unit, INSERM, Nantes University Hospital, Nantes Cedex, France
    Eur J Cancer Prev 19:48-54. 2010
    ..Furthermore, self-screening with the self-assessment questionnaire is easily feasible and is accurate for identifying high-risk individuals. This tool might be useful for carrying out melanoma-targeted screening...
  70. ncbi request reprint [The clinical diagnosis of melanoma]
    Gwénaëlle Wallon-Dumon
    Clinique Dermatologique, CHU Hotel Dieu, Nantes
    Presse Med 32:33-8. 2003
    ..Two further elements should also be taken into account: the results of a dermatoscopy and the analysis of the sentinel nodes...
  71. doi request reprint A comparison of two regimens of topical corticosteroids in the treatment of patients with bullous pemphigoid: a multicenter randomized study
    Pascal Joly
    Department of Dermatology, INSERM U901, University of Rouen, Rouen, France
    J Invest Dermatol 129:1681-7. 2009
    ..54; 95% confidence interval, 0.30-0.97; P=0.039). This mild regimen allows a 70% reduction of the cumulative doses of CS and improves BP patients' outcome...
  72. doi request reprint Fotemustine for the treatment of melanoma
    Gaelle Quereux
    Nantes University Hospital, Skin Cancer Unit, INSERM 892, 1 Place Alexis Ricordeau, 44093 Nantes Cedex, France
    Expert Opin Pharmacother 12:2891-904. 2011
    ..So far, dacarbazine has been the drug of reference, with an average response rate of 15 - 20% when used as a monotherapy. As single drugs go, fotemustine is considered the second-best treatment, after dacarbazine...
  73. ncbi request reprint Absence of modulation of CD4+CD25 regulatory T cells in CTCL patients treated with bexarotene
    Anne Chantal Knol
    INSERM, U892, Nantes Cedex 01, France
    Exp Dermatol 19:e95-102. 2010
    ..The treatment with bexarotene does not seem to affect the regulatory T-cell compartment...
  74. doi request reprint Anti-inflammatory effects of lithium gluconate on keratinocytes: a possible explanation for efficiency in seborrhoeic dermatitis
    F Ballanger
    Department of Dermatology, CHU Hotel Dieu, Nantes Cedex 01, France
    Arch Dermatol Res 300:215-23. 2008
    ..The diminution of TLR2 expression by Li may not allow MF to trigger inflammation response in lesional skin...
  75. doi request reprint [Specificity of acne in women older than 25 years]
    Gwenaelle Dumont-Wallon
    Clinique Dermatologique, CHU Hotel Dieu, F 44000, Nantes, France
    Presse Med 37:585-91. 2008
    ..Our aim was to examine the specific clinical and therapeutic characteristics of acne in women seen in our practice...
  76. ncbi request reprint The Cardiff Acne Disability Index: cultural and linguistic validation in French
    Brigitte Dreno
    Department of Dermatology Hôtel Dieu, Nantes, France
    Dermatology 208:104-8. 2004
    ..The Cardiff Acne Disability Index (CADI) evaluates the impact of acne on the patient's life...
  77. doi request reprint Evaluation of the role of human herpes virus 6 and 8 in parapsoriasis
    Gaelle Quereux
    Skin Cancer Unit, Nantes University Hospital, Nantes, France
    Exp Dermatol 18:357-61. 2009
    ..Previous recent studies have suspected the involvement of viral agents and particularly human herpes viruses (HHV).The aim of the present study was to screen for the presence of HHV-6 and HHV-8 genome in parapsoriasis samples...
  78. doi request reprint Human β-defensin-2 and psoriasin, two new innate immunity targets of zinc gluconate
    Carole Poiraud
    INSERM U892, Department of Dermato Oncology Nantes University Hospital, 1 Place Alexis Ricordeau, 44093 Nantes, France
    Eur J Dermatol 22:634-9. 2012
    ..Antimicrobial peptides (AMPs) are a large family of peptides implicated in innate immunity, especially in the epidermis. Zinc gluconate has been proven to be efficient to treat inflammatory dermatoses, such as acne vulgaris...
  79. pmc Serum soluble HLA-E in melanoma: a new potential immune-related marker in cancer
    Mathilde Allard
    UMR INSERM, U892, Nantes, France
    PLoS ONE 6:e21118. 2011
    ..In order to investigate sHLA-E production by various tumors and to address its potential value as a tumor-associated marker, we developed a specific ELISA for the quantification of sHLA-E in biological fluids...
  80. doi request reprint Is antigen specificity the key to efficient adoptive T-cell therapy?
    Nathalie Labarriere
    Unite Mixte de Recherche Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre de Recherche en Canerologie Nantes Angers, Nantes, France
    Immunotherapy 3:495-505. 2011
    ..Future improvements of adoptive melanoma immunotherapy may be achieved by its association with other therapeutic strategies such as targeted therapy against signaling pathways...
  81. doi request reprint Rituximab for primary cutaneous diffuse large B-cell lymphoma-leg type
    Marion Fenot
    Department of Dermato Oncology, Nantes University Hospital Centre, Nantes Cedex, France
    Eur J Dermatol 20:753-7. 2010
    ..The tolerance of rituximab monotherapy is higher than rituximab with polychemotherapy. The risk-benefit ratio is a bit lower but rituximab is well tolerated and may be useful for short term palliative treatment...
  82. ncbi request reprint Gluten intolerance and skin diseases
    Philippe Humbert
    Department of Dermatology, University of Franche Comte, CHU Saint Jacques, 25030 Besancon, France
    Eur J Dermatol 16:4-11. 2006
    ..Intestinal biopsy is usually needed to establish the diagnosis of CD or GI. Thus, gluten intolerance gives rise to a variety of dermatological manifestations which may benefit from a gluten-free diet...
  83. ncbi request reprint In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions
    Isabelle Tenaud
    Department of Dermatology, CHU, Nantes, France
    Exp Dermatol 16:500-6. 2007
    ..The decreased expression of TLR-2 by the keratinocytes can contribute to explain the anti-inflammatory activity of adapalene observed in clinical practice...
  84. ncbi request reprint Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes
    Véronique Jarrousse
    INSERM U601, 9, quai Moncousu, 44093, Nantes Cedex 01, France
    Eur J Dermatol 17:492-6. 2007
    ..However, this inhibition does not modify IL-8 secretion by keratinocytes. In conclusion the inhibition of TLR2 surface expression by keratinocytes could be one of the anti-inflammatory mechanisms of zinc salts in acne...
  85. ncbi request reprint [General antibiotic therapy in acne]
    Brigitte Dreno
    Clinique dermatologique Centre hospitalier universitaire Hôtel Dieu, 44093 Nantes
    Rev Prat 52:841-3. 2002
    ..Resistant strains of Propionibacterium acnes to antibiotics are increasing. Thus, general guidelines are useful when utilizing oral antibiotic therapy in acne...
  86. ncbi request reprint [Treatment of primary and regional melanoma]
    Brigitte Dreno
    CHRU de Nantes, unité de cancérologie dermatologique, Hotel Dieu, 44093 Nantes 1
    Rev Prat 54:1203-9. 2004
    ..Chemotherapy on the other hand never proved reliable of its effectiveness as adjuvant treatment. In the future, the approaches by vaccination and cellular therapy could be interesting at these stages of the disease...
  87. ncbi request reprint Randomized trial of adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma
    Brigitte Dreno
    Skin Cancer Unit, CHR Hotel Dieu, Nantes, 44093 Nantes, France
    Cancer Immunol Immunother 51:539-46. 2002
    ....
  88. ncbi request reprint [Acne scars: epidemiology, physiopathology, clinical features and treatment]
    M Chivot
    Ann Dermatol Venereol 133:813-24. 2006
  89. ncbi request reprint ECCA grading scale: an original validated acne scar grading scale for clinical practice in dermatology
    B Dreno
    Clinique Dermatologique, CHU, Nantes, France
    Dermatology 214:46-51. 2007
    ..The ECCA grading scale (échelle d'évaluation clinique des cicatrices d'acné) is a tool designed to help dermatologists to assess the severity of acne scars and to standardize the discussions about the treatments of scars...
  90. ncbi request reprint Lithium gluconate 8% vs ketoconazole 2% in the treatment of seborrhoeic dermatitis: a multicentre, randomized study
    B Dreno
    Clinique Dermatologique, CHU Nantes, Hotel Dieu, BP 1005, 44305 Nantes Cedex, France
    Br J Dermatol 148:1230-6. 2003
    ..Objectives This randomized controlled trial was designed to show a non-inferiority of 15% (primary end-point) of lithium gluconate 8% ointment compared with ketoconazole 2% emulsion...
  91. ncbi request reprint [Clinical and psychological correlation in acne: use of the ECLA and CADI scales]
    B Dreno
    Departement de Dermatologie, CHU Nantes, Hotel Dieu, Nantes, France
    Ann Dermatol Venereol 134:451-5. 2007
    ..The purpose of this study was to use both of these scales in individual applications in order to determine whether or not any correlation exists between the two specific tools and to determine the two groups of patients affected by acne...
  92. ncbi request reprint [Interferons and malignant melanoma]
    B Dreno
    Service de Dermatologie, Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes, France
    Rev Med Interne 23:489s-493s. 2002
    ..Alpha interferon is currently used in the treatment of malignant melanoma mainly as adjuvant therapy at the first stage of the illness (primary tumor) and at the second stage (lymph node invasion)...
  93. ncbi request reprint Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients
    B Dreno
    Department of Dermatology, CHU Nantes, Nantes, France
    Dermatology 210:22-9. 2005
    ..The aim of this study was to evaluate the tolerance of Diacneal used by 1,709 acne patients in combination with their usual acne products except retinoids...
  94. doi request reprint [Acne, pregnant women and zinc salts: a literature review]
    B Dreno
    Clinique Dermatologique, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44035 Nantes, France
    Ann Dermatol Venereol 135:27-33. 2008
    ....
  95. ncbi request reprint Effect of selenium intake on the prevention of cutaneous epithelial lesions in organ transplant recipients
    B Dreno
    CHU Nantes, Clinique Dermatologique, Hotel Dieu, BP 1005, 44305 Nantes Cedex, France
    Eur J Dermatol 17:140-5. 2007
    ..This was demonstrated by the high rate of epithelial lesions detected, which was more than twice the rate usually reported in the literature...
  96. ncbi request reprint [Lithium gluconate 8% in the treatment of seborrheic dermatitis]
    B Dreno
    Departement de Dermatologie, CHU de Nantes, 44035 Nantes Cedex
    Ann Dermatol Venereol 134:347-51. 2007
    ..Lithioderm 8% gel is applied twice daily over a recommended period of 2 months. It constitutes a new alternative in the treatment of facial seborrheic dermatitis, regardless of severity...
  97. doi request reprint Ex vivo demonstration of a synergistic effect of Adapalene and benzoyl peroxide on inflammatory acne lesions
    Thomas Zuliani
    Exp Dermatol 20:850-3. 2011
    ..These results contribute to explain the comedolytic and anti-inflammatory activities of this combined therapy observed in recent clinical trials...
  98. ncbi request reprint Skin cancers after transplantation
    Brigitte Dreno
    Centre Hospitalier Universitaire, Clinique Dermatologique, Nantes, France
    Nephrol Dial Transplant 18:1052-8. 2003
  99. ncbi request reprint Identification of five new HLA-B*3501-restricted epitopes derived from common melanoma-associated antigens, spontaneously recognized by tumor-infiltrating lymphocytes
    Houssem Benlalam
    Unit Institut National de la Santé et de la Recherche Médicale Unité 463, Nantes, France
    J Immunol 171:6283-9. 2003
    ..These data have important implications for the formulation of polypeptide-based vaccines as well as for the monitoring of melanoma-specific CTL response in HLA-B*3501 melanoma patients...
  100. ncbi request reprint Epidemiology of acne
    Brigitte Dreno
    Department of Dermatology, Hospital Hotel Dieu, Nantes, France
    Dermatology 206:7-10. 2003
  101. ncbi request reprint [Epidemiology of melanoma]
    Brigitte Dreno
    Unité de cancéro dermatologie, Clinique Dermatologique, CHU Hotel Dieu, Nantes
    Presse Med 32:30-2. 2003
    ..However, till now, the impact of educational and preventive campaigns with regard to sun exposure, which plays a major role in the development of a melanoma, are still insufficient..